La discusión que presenta el artículo parte de la tesis de que la educación superior, especialmente la universidad pública colombiana, se ha configurado como uno de los escenarios por excelencia de ...producción y reproducción de geometrías del poder. La política de vinculación de docentes implementada en las universidades estatales ha conducido a que la mayoría de los profesores que trabajan en ellas sean temporales, lo que ha derivado, entre otras situaciones, en un alto grado de inestabilidad y pérdida de garantías laborales. Ello constituye una violación de los derechos laborales puesto que desconoce la igualdad y afecta la calidad académica de la oferta educativa en dieciocho universidades públicas analizadas.
The joint study of multiple datasets has become a common technique for increasing statistical power in detecting biomarkers obtained from smaller studies. The approach generally followed is based on ...the fact that as the total number of samples increases, we expect to have greater power to detect associations of interest. This methodology has been applied to genome-wide association and transcriptomic studies due to the availability of datasets in the public domain. While this approach is well established in biostatistics, the introduction of new combinatorial optimization models to address this issue has not been explored in depth. In this study, we introduce a new model for the integration of multiple datasets and we show its application in transcriptomics.
We propose a new combinatorial optimization problem that addresses the core issue of biomarker detection in integrated datasets. Optimal solutions for this model deliver a feature selection from a panel of prospective biomarkers. The model we propose is a generalised version of the (α,β)-k-Feature Set problem. We illustrate the performance of this new methodology via a challenging meta-analysis task involving six prostate cancer microarray datasets. The results are then compared to the popular RankProd meta-analysis tool and to what can be obtained by analysing the individual datasets by statistical and combinatorial methods alone.
Application of the integrated method resulted in a more informative signature than the rank-based meta-analysis or individual dataset results, and overcomes problems arising from real world datasets. The set of genes identified is highly significant in the context of prostate cancer. The method used does not rely on homogenisation or transformation of values to a common scale, and at the same time is able to capture markers associated with subgroups of the disease.
Treatment of renal angiomyolipoma (AML) seeks to reduce related complications and preserve kidney function. The purpose of this article was to perform an updated literature review on the diagnosis, ...therapeutic options, and criteria for invasive intervention in patients with renal AML. Computerized tomography is the standard diagnostic method for renal AML, while definitive diagnosis is made by histopathology. The management of choice in most cases is active surveillance (AS), with a clinical and imaging follow-up protocol. In high-risk cases, therapeutic management should be considered, with alternatives such as selective arterial embolization (SAE), nephron-sparing surgery (NSS), and mTOR inhibitors in selected patients. Renal AML in women of childbearing age, those with growth >0.25 cm/year, intralesional aneurysms >5 mm, and clinically significant symptoms may qualify for active treatment. Despite the limitations derived from the available evidence, it is possible to consider SAE, NSS, and the use of mTOR inhibitors as management alternatives for selected patients.
Abstract
Machine learning is a powerful tool to design accurate, highly non-local, exchange-correlation functionals for density functional theory. So far, most of those machine learned functionals ...are trained for systems with an integer number of particles. As such, they are unable to reproduce some crucial and fundamental aspects, such as the explicit dependency of the functionals on the particle number or the infamous derivative discontinuity at integer particle numbers. Here we propose a solution to these problems by training a neural network as the universal functional of density-functional theory that (a) depends explicitly on the number of particles with a piece-wise linearity between the integer numbers and (b) reproduces the derivative discontinuity of the exchange-correlation energy. This is achieved by using an ensemble formalism, a training set containing fractional densities, and an explicitly discontinuous formulation.
In 2014, vaccinia virus (VACV) infections were identified among farmworkers in Caquetá Department, Colombia; additional cases were identified in Cundinamarca Department in 2015. VACV, an ...orthopoxvirus (OPXV) used in the smallpox vaccine, has caused sporadic bovine and human outbreaks in countries such as Brazil and India. In response to the emergence of this disease in Colombia, we surveyed and collected blood from 134 farmworkers and household members from 56 farms in Cundinamarca Department. We tested serum samples for OPXV antibodies and correlated risk factors with seropositivity by using multivariate analyses. Fifty-two percent of farmworkers had OPXV antibodies; this percentage decreased to 31% when we excluded persons who would have been eligible for smallpox vaccination. The major risk factors for seropositivity were municipality, age, smallpox vaccination scar, duration of time working on a farm, and animals having vaccinia-like lesions. This investigation provides evidence for possible emergence of VACV as a zoonosis in South America.
In this paper we analyse the word frequency profiles of a set of works from the Shakespearean era to uncover patterns of relationship between them, highlighting the connections within authorial ...canons. We used a text corpus comprising 256 plays and poems from the 16th and 17th centuries, with 17 works of uncertain authorship. Our clustering approach is based on the Jensen-Shannon divergence and a graph partitioning algorithm, and our results show that authors' characteristic styles are very powerful factors in explaining the variation of word use, frequently transcending cross-cutting factors like the differences between tragedy and comedy, early and late works, and plays and poems. Our method also provides an empirical guide to the authorship of plays and poems where this is unknown or disputed.
Massively parallel genetic sequencing allows rapid testing of known intellectual disability (ID) genes. However, the discovery of novel syndromic ID genes requires molecular confirmation in at least ...a second or a cluster of individuals with an overlapping phenotype or similar facial gestalt. Using computer face-matching technology we report an automated approach to matching the faces of non-identical individuals with the same genetic syndrome within a database of 3681 images 1600 images of one of 10 genetic syndrome subgroups together with 2081 control images. Using the leave-one-out method, two research questions were specified: 1) Using two-dimensional (2D) photographs of individuals with one of 10 genetic syndromes within a database of images, did the technology correctly identify more than expected by chance: i) a top match? ii) at least one match within the top five matches? or iii) at least one in the top 10 with an individual from the same syndrome subgroup? 2) Was there concordance between correct technology-based matches and whether two out of three clinical geneticists would have considered the diagnosis based on the image alone?
The computer face-matching technology correctly identifies a top match, at least one correct match in the top five and at least one in the top 10 more than expected by chance (P < 0.00001). There was low agreement between the technology and clinicians, with higher accuracy of the technology when results were discordant (P < 0.01) for all syndromes except Kabuki syndrome.
Although the accuracy of the computer face-matching technology was tested on images of individuals with known syndromic forms of intellectual disability, the results of this pilot study illustrate the potential utility of face-matching technology within deep phenotyping platforms to facilitate the interpretation of DNA sequencing data for individuals who remain undiagnosed despite testing the known developmental disorder genes.
Hypersurfaces of the spherical type degenerated Corro, Armando M. V; G. Dias, Diogo; Carrión Riveros, Carlos
Selecciones matemáticas : revista científica del Departamento Académico de Matemáticas,
12/2020, Letnik:
7, Številka:
2
Journal Article
Recenzirano
Odprti dostop
In this work, we dene the hypersurfaces of the spherical type degenerated (in short DST-hypersurfaces), these hypersurfaces has the geometric property that the middle spheres pass through the origin ...of the Euclidean space. We present a representation for these hypersurfaces in the case where the stereographic projection of the Gauss map N is given by the identity application. We characterizethe DST-hypersurfaces through a diferential equation and we give an explicit example of a two-parameter family of DST-hypersurfaces with planar lines of curvature foliated by (n-1)-dimensional spheres. Moreover, we classify the DST-hypersurfaces of rotation.
En este artículo, definimos las hipersuperficies de tipo esférico degenerado (en abreviatura DST-hipersuperficies), estas hipersuperficies tienen la propiedad geométrica de que las esferas medias pasan por el origen del espacio Euclidiano. Presentamos una representación para estas hipersuperficies para el caso en que la proyección estereográfica de la aplicación de Gauss N es dada por la aplicación identidad. Caracterizamos las DST-hipersuperficies a través de una ecuación diferencial y damos un ejemplo explícito de una familia a dos parámetros de DST-hipersuperficies con líneas de curvatura planas foliadas por esferas de dimensión (n-1). Además, clasificamos las DST-hipersuperficies de rotación.
We develop an orbital-free functional framework to compute one-body quasiprobabilities for both fermionic and bosonic systems. Since the key variable is a quasidensity, this theory circumvents the ...problems of finding the Pauli potential or approximating the kinetic energy that are known to limit the applicability of standard orbital-free density functional theory. We present a set of strategies to (a) compute the one-body Wigner quasiprobability in an orbital-free manner from the knowledge of the universal functional and (b) obtain those functionals from the functionals of the one-body reduced density matrix (1-RDM). We find that the universal functional of optical lattices results from a translation, a contraction, and a rotation of the corresponding functional of the 1-RDM, revealing the strong connection between these two functional theories. Furthermore, we relate the key concepts of Wigner negativity and v representability.
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