We present the experience of a brief Art Therapy Workshop conducted with a group of women with dermatological conditions, conducted at the Hospital General Universitario Reina Sofía of Murcia. We ...will focus on one of the patients, recognizing the importance of group relationships for therapy. The main objective was to establish a link between emotions and experiences of patients and their own body, specifically their skin condition. Thus, personal, family and social will constitute the basis on which these emotions and experiences are embedded. The relationships and their status as mothers are guides for the therapeutic work carried out.
Presentamos la experiencia de un Taller de Arteterapia breve, realizado con un grupo de mujeres con afecciones dermatológicas, llevado a cabo en el Hospital General Universitario Reina Sofía de ...Murcia. Centraremos la atención en una de las pacientes, reconociendo la importancia de las relaciones grupales para su terapia. El objetivo principal del taller fue establecer un vínculo entre las emociones y vivencias de las pacientes y su propio cuerpo, más específicamente su afección de piel. Así, lo personal, lo familiar y lo social se constituyen como base en la que se inscriben esas emociones y vivencias. Las relaciones de pareja y su condición de madres son guías del trabajo terapéutico llevado a cabo.
The authors present the experience of a brief Art Therapy Workshop conducted with a group of women with dermatological conditions, conducted at the Hospital General Universitario Reina Sofia of ...Murcia. They will focus on one of the patients, recognizing the importance of group relationships for therapy. The main objective of this study is to establish a link between emotions and experiences of patients and their own body, specifically their skin condition. Thus, personal, family and social will constitute the basis on which these emotions and experiences are embedded. The relationships and their status as mothers are guides for the therapeutic work carried out.
The Arabidopsis thaliana response regulator 4, expressed in response to phytochrome B action, specifically interacts with the extreme amino-terminus of the photoreceptor. The response regulator 4 ...stabilizes the active Pfr form of phytochrome B in yeast and in planta, thus elevates the level of the active photoreceptor in vivo. Accordingly, transgenic Arabidopsis plants overexpressing the response regulator 4 display hypersensitivity to red light but not to light of other wavelengths. We propose that the response regulator 4 acts as an output element of a two-component system that modulates red light signaling on the level of the phytochrome B photoreceptor.
Sex differences in nitrosative stress during renal ischemia Rodríguez, Francisca; Nieto-Cerón, Susana; Fenoy, Francisco J ...
American journal of physiology. Regulatory, integrative and comparative physiology,
11/2010, Letnik:
299, Številka:
5
Journal Article
Recenzirano
Females suffer a less severe ischemic acute renal failure than males, apparently because of higher nitric oxide (NO) bioavailability and/or lower levels of oxidative stress. Because the renal ...ischemic injury is associated with outer medullary (OM) endothelial dysfunction, the present study evaluated sex differences in OM changes of NO and peroxynitrite levels (by differential pulse voltammetry and amperometry, respectively) during 45 min of ischemia and 60 min of reperfusion in anesthetized Sprague-Dawley rats. Endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase (nNOS) protein expression and their phosphorylated forms peNOS(Ser1177) and pnNOS(Ser1417), 3-nitrotyrosine, reduced sulfhydryl groups (-SH), and glomerular filtration rate (GFR) were also determined. No sex differences were observed in monomeric eNOS and nNOS expression, NO, or 3-nitrotyrosine levels in nonischemic kidneys, but renal -SH content was higher in females. Ischemia increased dimeric/monomeric eNOS and nNOS ratio more in females, but the dimeric phosphorylated peNOS(Ser1177) and pnNOS(Ser1417) forms rose similarly in both sexes, indicating no sex differences in nitric oxide synthase activation. However, NO levels increased more in females than in males (6,406.0 ± 742.5 and 4,058.2 ± 272.35 nmol/l respectively, P < 0.05), together with a lower increase in peroxynitrite current (5.5 ± 0.7 vs. 12.7 ± 1.5 nA, P < 0.05) and 3-nitrotyrosine concentration, (28.7 ± 3.7 vs. 48.7 ± 3.7 nmol/mg protein, P < 0.05) in females than in males and a better preserved GFR after ischemia in females than in males (689.7 ± 135.0 and 221.4 ± 52.5 μl·min(-1)·g kidney wt(-1), P < 0.01). Pretreatment with the antioxidants N-acetyl-L-cysteine or ebselen abolished sex differences in peroxynitrite, nitrotyrosine, and GFR, suggesting that a greater oxidative and nitrosative stress worsens renal damage in males.
Compare prevalence and profile of post-intensive care patient (P-PICS) and family/caregiver (F-PICS) syndrome in two cohorts (COVID and non-COVID) and analyse risk factors for P-PICS.
Prospective, ...observational cohort (March 2018–2023), follow-up at three months and one year.
14-bed polyvalent Intensive Care Unit (ICU), Level II Hospital.
265 patients and 209 relatives. Inclusion criteria patients: age > 18 years, mechanical ventilation > 48 h, ICU stay > 5 days, delirium, septic shock, acute respiratory distress syndrome, cardiac arrest. Inclusion criteria family: those who attended.
Follow-up 3 months and 1 year after hospital discharge.
Patients: sociodemographic, clinical, evolutive, physical, psychological and cognitive alterations, dependency degree and quality of life. Main caregivers: mental state and physical overload.
64.9% PICS-P, no differences between groups. COVID patients more physical alterations than non-COVID (P = .028). These more functional deterioration (P = .005), poorer quality of life (P = .003), higher nutritional alterations (P = .004) and cognitive deterioration (P < .001). 19.1% PICS-F, more frequent in relatives of non-COVID patients (17.6% vs. 5.5%; P = .013). Independent predictors of PICS-P: first years of the study (OR: 0.484), higher comorbidity (OR: 1.158), delirium (OR: 2.935), several reasons for being included (OR: 3.171) and midazolam (OR: 4.265).
Prevalence PICS-P and PICS-F between both cohorts was similar. Main factors associated with the development of SPCI-P were: higher comorbidity, delirium, midazolan, inclusion for more than one reason and during the first years.
Comparar prevalencia y características del síndrome post-cuidados intensivos paciente (SPCI-P) y familiar/cuidador (SPCI-F) en dos cohortes (COVID y no COVID) y analizar factores riesgo de SPCI-P.
Prospectivo, observacional cohortes (Marzo 2018–2023), seguimiento a tres meses y año.
Unidad de Cuidados Intensivos (UCI) polivalente 14 camas, Hospital Nivel II.
Pacientes: 265, familiares: 209. Criterios inclusión pacientes: edad > 18 años, ventilación mecánica > 48 horas, estancia UCI > 5 días, delirium, shock séptico, síndrome distrés respiratorio agudo, parada cardiaca. Criterios inclusión familiares: acudir consulta.
Seguimiento 3 meses y año del alta hospitalaria.
Pacientes: sociodemográficas, clínicas, evolutivas, alteraciones físicas, psíquicas y cognitivas, dependencia y calidad de vida. Familiares: estado mental y sobrecarga física.
SPCI-P 64,9%, sin diferencias entre grupos. Pacientes COVID más alteraciones físicas que los no-COVID (P =,028). Estos últimos más deterioro funcional (P =,005), peor calidad de vida (P =,003), más alteraciones nutricionales (P =,004) y deterioro cognitivo (P <,001). 19,1% SPCI-F, más frecuente en familiares de pacientes no COVID (17,6% vs 5,5%; P =,013). Factores predictivos independientes de SPCI-P: primeros años estudio (OR: 0,484), mayor comorbilidad (OR: 1,158), delirium (OR: 2,935), varios motivos de inclusión consulta (OR: 3,171) y midazolan (OR: 4,265).
Prevalencia de SPCI-P y SPCI-F similar en ambas cohortes. Principales factores asociados a SPCI-P: mayor comorbilidad, delirium, midazolan, haber sido incluido en la consulta por más de un motivo y primeros años del estudio.
ABSTRACT Background: Hospital costs associated with Hepatitis C (HCC) arise in the final stages of the disease. Its quantification is very helpful in order to estimate and check the burden of the ...disease and to make financial decisions for new antivirals. The highest costs are due to the decompensation of cirrosis. Methods: Cross-sectional observational study of hospital costs of HCC diagnoses in the Valencian Community in 2013 (n= 4.486 hospital discharges). Information source: Minimum basic set of data/Basic Minimum Data Set. The costs were considered according to the rates established for the DRG associated with the episodes with diagnosis of hepatitis C. The average survival of patients since the onset of the decompensation of their cirrhosis was estimated by a Markov model, according to the probabilities of evolution of the disease existing in Literatura. Results: There were 4.486 hospital episodes, 1,108 due to complications of HCC, which generated 6,713 stays, readmission rate of 28.2% and mortality of 10.2%. The hospital cost amounted to 8,788.593EUR: 3,306.333EUR corresponded to Cirrhosis (5,273EUR/patient); 1,060,521EUR to Carcinoma (6,350EUR/patient) and 2,962,873EUR to transplantation (70.544EUR/paciente. Comorbidity was 1,458,866EUR. These costs are maintained for an average of 4 years once the cirrhosis decompensation begins. Conclusions: Cirrhosis due to HCC generates a very high hospitalization’s costs. The methodology used in the estimation of these costs from the DRG can be very useful to evaluate the trend and economic impact of this disease.
RESUMEN Fundamentos: Los costes hospitalarios asociados a la Hepatitis Crónica C (HCC) surgen en los estadíos finales de la enfermedad. Su cuantificación es de gran utilidad para estimar la carga de la enfermedad y establecer decisiones de financiación de los nuevos antivirales. Los costes más elevados son motivados por la descompensación de la cirrosis. Métodos: Estudio observacional de corte transversal de los costes hospitalarios de episodios con diagnóstico de HCC en la Comunidad Valenciana en 2013. Fuente de información: Conjunto mínimo básico de datos. Se estimaron los costes según las tarifas establecidas para los GRD (Grupos relacionados por el diagnóstico) asociados a los episodios con diagnóstico de hepatitis C. La supervivencia media de los pacientes desde que se inició la descompensación de su cirrosis se estimó mediante un modelo de Markov, según las probabilidades de evolución de la enfermedad existentes en la literatura. Resultados: Se registraron 4.486 episodios de hospitalización con diagnóstico de HCC, 1.108 fueron debidos a complicaciones de la HCC que generaron 6.713 estancias, tasa de reingresos del 28,2 % y mortalidad del 10,2%. El coste hospitalario ascendió a 8.788.593EUR: 3.306.333EUR correspondieron a Cirrosis (5.273EUR/paciente); 1.060.521EUR a Carcinoma (6.350EUR/paciente) y 2.962.873EUR a trasplante (70.544EUR/paciente). La comorbilidad por Hepatitis C supuso 1.458.866EUR. Estos costes se mantienen durante una media de 4 años una vez comienza la descompensación de la cirrosis. Conclusiones: La cirrosis por HCC genera un coste muy elevado por hospitalización, la metodología utilizada en la estimación de estos costes a partir de los GRD puede ser de gran utilidad para evaluar la tendencia e impacto económico de esta enfermedad.
Notas bibliográficas Luis Gómez Canseco; Ana M. Rodado Ruiz; Cristina Sánchez López ...
Revista de filología española,
06/2019, Letnik:
99, Številka:
1
Journal Article
PDF
