The nature of dark matter in the Universe is one of the hardest unsolved problems in modern physics. Indeed, on one hand, the overwhelming indirect evidence from astrophysics seems to leave no doubt ...about its existence; on the other hand, direct search experiments, especially those conducted with low-background detectors in underground laboratories all over the world, seem to deliver only null results with a few debated exceptions. Furthermore, the lack of predicted candidates on the LHC energy scale has made this dichotomy even more puzzling. We will recall the most important phases of this novel branch of experimental astro-particle physics, analyzing the interconnections among the main projects involved in this challenging quest, and we will draw conclusions slightly different from how the problem is commonly understood.
Shrimp processing generates substantial waste, which is rich in valuable components such as polysaccharides, proteins, carotenoids, and fatty acids. This review provides a comprehensive overview of ...the valorization of shrimp waste, mainly shrimp shells, focusing on extraction methods, bioactivities, and potential applications of these bioactive compounds. Various extraction techniques, including chemical extraction, microbial fermentation, enzyme-assisted extraction, microwave-assisted extraction, ultrasound-assisted extraction, and pressurized techniques are discussed, highlighting their efficacy in isolating polysaccharides, proteins, carotenoids, and fatty acids from shrimp waste. Additionally, the bioactivities associated with these compounds, such as antioxidant, antimicrobial, anti-inflammatory, and antitumor properties, among others, are elucidated, underscoring their potential in pharmaceutical, nutraceutical, and cosmeceutical applications. Furthermore, the review explores current and potential utilization avenues for these bioactive compounds, emphasizing the importance of sustainable resource management and circular economy principles in maximizing the value of shrimp waste. Overall, this review paper aims to provide insights into the multifaceted aspects of shrimp waste valorization, offering valuable information for researchers, industries, and policymakers interested in sustainable resource utilization and waste-management strategies.
A multiple sclerosis patient infected by SARS-CoV-2 during fingolimod therapy was hospitalized with moderate clinical features, and recovered in 15 days. High levels of CCL5 and CCL10 chemokines and ...of antibody-secreting B cells were detected, while the levels other B- and T-cell subsets were comparable to that of appropriate controls. However, CD4+ and CD8+ cells were oligoclonally expanded and prone to apoptosis when stimulated in vitro. This study suggests that fingolimod-immunosuppressed patients, despite the low circulating lymphocytes, may rapidly expand antibody-secreting cells and mount an effective immune response that favors COVID-19 recovery after drug discontinuation.
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•The host's immune response plays an essential role in limiting and eliminating SARS-CoV-2 infection.•Multiple sclerosis-treated patients could be among those most at risk of severe COVID-19.•A fingolimod-immunosuppressed patient was able mount an immune response that favors COVID-19 recovery.
Abstract
Cactaceae are American members of arid and semi-arid regions and are also present in tropical forests and temperate climates. The taxonomy is complex owing to large morphological ...variability, and polyploidy is a significant mechanism in cactus speciation associated with geographical and environmental range expansions. In South America, Cactaceae have a wide distributional range and provide an informative model in which to examine the correlation between ploidy levels and genome sizes with geographical and bioclimatic variables. We tested whether ploidy levels and DNA contents are related to elevation and the 19 WorldClim variables, and we mapped chromosome numbers and amounts of DNA on a molecular phylogeny to interpret their evolution. We performed Pearson correlation tests between the response variables and each climatic variable and used a multivariate analysis to assess the pattern of variation among variables and chromosome numbers. Our data suggest that polyploidy had independent origins within each subfamily. Chromosome numbers were related to variables associated with temperature, whereas DNA contents were related mostly to precipitation. A negative correlation was observed between the amount of DNA in one chromosome set and the increase in the ploidy level. Based on the results, the small genome can be considered ecologically important as an adaptation to higher temperatures and droughts.
Self-assembled nanowire (NW) crystals can be grown into nearly defect-free nanomechanical resonators with exceptional properties, including small motional mass, high resonant frequency and low ...dissipation. Furthermore, by virtue of slight asymmetries in geometry, a NW's flexural modes are split into doublets oscillating along orthogonal axes. These characteristics make bottom-up grown NWs extremely sensitive vectorial force sensors. Here, taking advantage of its adaptability as a scanning probe, we use a single NW to image a sample surface. By monitoring the frequency shift and direction of oscillation of both modes as we scan above the surface, we construct a map of all spatial tip-sample force derivatives in the plane. Finally, we use the NW to image electric force fields distinguishing between forces arising from the NW charge and polarizability. This universally applicable technique enables a form of atomic force microscopy particularly suited to mapping the size and direction of weak tip-sample forces.
Liquid xenon and liquid argon detectors are leading the direct dark matter search and are expected to be the candidate technology for the forthcoming generation of ultra-sensitive large-mass ...detectors. At present, scintillation light detection in those experiments is based on ultra-pure low-noise photo-multipliers. To overcome the issues in terms of the extreme radio-purity, costs, and technological feasibility of the future dark matter experiments, the novel silicon photomultiplier (SiPM)-based photodetector modules seem to be promising candidates, capable of replacing the present light detection technology. However, the intrinsic features of SiPMs may limit the present expectations. In particular, interfering phenomena, especially related to the optical correlated noise, can degrade the energy and pulse shape resolutions. As a consequence, the projected sensitivity of the future detectors has to be reconsidered accordingly.
Discontinuation of natalizumab in patients with relapsing-remitting multiple sclerosis (RRMS) at risk of progressive multifocal leukoencephalopathy (PML) is associated with disease reactivation. ...Forty-two RRMS patients, who switched from an extended interval dose (EID) of natalizumab to ocrelizumab, underwent magnetic resonance imaging (MRI) and clinical monitoring during washout and after ocrelizumab starting. During the first 3 months, disease reactivation was observed in five (12%) patients; 6 months after ocrelizumab starting, no further relapses were recorded, and Expanded Disability Status Scale (EDSS) remained stable in 38 (90%) patients. In conclusion, ocrelizumab could be considered a choice to mitigate the risk of disease reactivation in patients previously treated with natalizumab-EID.
The monoclonal antibody natalizumab (NTZ) is a highly effective treatment for patients with multiple sclerosis (MS). However, this drug is associated with increased risk of developing Progressive ...Multifocal Leukoencephalopathy (PML), an opportunistic infection of central nervous system (CNS) caused by the John Cunningham polyomavirus (JCV).
To describe the 12-month clinical course of 39 patients with MS (28 women, 11 men) who developed NTZ-related PML after a mean exposure of 39 infusions.
An Italian independent collaborative repository initiative collected and analyzed socio-demographic, clinical, magnetic resonance imaging (MRI) data and number of JCV-DNA copies detected on cerebrospinal fluid (CSF) samples of patients diagnosed as affected by NTZ-related PML. The evolution of disability, measured by the Expanded Disability Status Scale, was assessed at NTZ start, at PML diagnosis and after 2, 6 and 12 months from PML diagnosis. The effect of clinical and paraclinical characteristics at PML diagnosis on the final outcome was also investigated.
Ten patients (25.6%) were diagnosed before 24 NTZ infusions. In six cases (15.4%) the PML suspect was made on the basis of highly suggestive MRI findings in absence of any detectable change of clinical conditions (asymptomatic PML). In patients with symptomatic PML, the diagnosis was quicker for those who presented with cognitive symptoms (n = 12) rather than for those with other neurological pictures (n = 21) (p = 0.003). Three patients (7.7%) died during the 12-month observation period, resulting in a survival rate of 92.3%. Asymptomatic PML, more localized brain involvement and gadolinium-enhancement detected at MRI, as well as lower viral load were associated with a better disability outcome (p-values<0.01).
Our findings support that early PML diagnosis, limited CNS involvement and initial signs of immune restoration are associated with a better outcome and higher survival rate, and confirm the utility of MRI as a surveillance tool for NTZ-treated patients.
A
bstract
The DAMA collaboration reported an annually modulated rate with a phase compatible with a Dark Matter induced signal. We point out that a slowly varying rate can bias or even simulate an ...annual modulation if data are analyzed in terms of residuals computed by subtracting approximately yearly averages starting from a fixed date, rather than a background continuous in time. In the most extreme case, the amplitude and phase of the annual modulation reported by DAMA could be alternatively interpreted as a decennial growth of the rate. This possibility appears mildly disfavoured by a detailed study of the available data, but cannot be safely excluded. In general, a decreasing or increasing rate could partially reduce or enhance a true annual modulation, respectively. The issue could be clarified by looking at the full time-dependence of the DAMA total rate, not explicitly published so far.
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