Microplastic pollution caused by washing processes of synthetic textiles has recently been assessed as the main source of primary microplastics in the oceans. Therefore, understanding the effective ...contribution of the washing process of synthetic clothes to this environmental problem, is of great importance. In this study, wash trials at real scale were performed on commercial clothes by using a household washing machine in order to gain reliable data about the release of microplastics, and to identify possible influences of textile characteristics on the release. The wastewater was collected and filtered through subsequent filters with decreasing porosity, and the amount and dimensions of microfibres were determined. Microfibre release was analysed in relation to the nature and characteristics of the washed clothes. Results showed that microfibres released during washing range from 124 to 308 mg for kg of washed fabric depending from the type of washed garment that corresponds to a number of microfibres ranging from 640,000 to 1,500,000. Some textile characteristics, such as the type of fibres constituting the yarns and their twist, influenced the release of microfibres during washing. A great amount of microfibres of cellulosic nature was also released during washing of clothes made with a blend of polyester/cellulose. Finally the most abundant fraction of microfibres shed was retained by filters with pore size of 60 µm, presenting an average length of 360-660 μm and an average diameter of 12-16 μm, indicating dimensions that could pass through wastewater treatment plants and pose a threat for marine organisms.
•Inter-urban carsharing program may be a valid transport alternative for systematic users.•Conditional switching approach is the most effective modelling solution.•The transport mode usually chosen ...considerably affect carsharing choice determinants.•Access time to parking slots is the most important design attribute.•Users’ socio-economic characteristics considerably affect carsharing choice probabilities.
In this paper, the effects of a inter-urban carsharing program on users’ mode choice behaviour were investigated and modelled through specification, calibration and validation of different modelling approaches founded on the behavioural paradigm of the random utility theory. To this end, switching models conditional on the usually chosen transport mode, unconditional switching models and holding models were investigated and compared. The aim was threefold: (i) to analyse the feasibility of a inter-urban carsharing program; (ii) to investigate the main determinants of the choice behaviour; (iii) to compare different approaches (switching vs. holding; conditional vs. unconditional); (iv) to investigate different modelling solutions within the random utility framework (homoscedastic, heteroscedastic and cross-correlated closed-form solutions). The set of models was calibrated on a stated preferences survey carried out on users commuting within the metropolitan area of Salerno, in particular with regard to the home-to-work trips from/to Salerno (the capital city of the Salerno province) to/from the three main municipalities belonging to the metropolitan area of Salerno. All of the involved municipalities significantly interact each other, the average trip length is about 30km a day and all are served by public transport. The proposed carsharing program was a one-way service, working alongside public transport, with the possibility of sharing the same car among different users, with free parking slots and free access to the existent restricted traffic areas. Results indicated that the inter-urban carsharing service may be a substitute of the car transport mode, but also it could be a complementary alternative to the transit system in those time periods in which the service is not guaranteed or efficient. Estimation results highlighted that the conditional switching approach is the most effective one, whereas travel monetary cost, access time to carsharing parking slots, gender, age, trip frequency, car availability and the type of trip (home-based) were the most significant attributes. Elasticity results showed that access time to the parking slots predominantly influences choice probability for bus and carpool users; change in carsharing travel costs mainly affects carpool users; change in travel costs of the usually chosen transport mode mainly affects car and carpool users.
A new and more alarming source of marine contamination has been recently identified in micro and nanosized plastic fragments. Microplastics are difficult to see with the naked eye and to biodegrade ...in marine environment, representing a problem since they can be ingested by plankton or other marine organisms, potentially entering the food web. An important source of microplastics appears to be through sewage contaminated by synthetic fibres from washing clothes. Since this phenomenon still lacks of a comprehensive analysis, the objective of this contribution was to investigate the role of washing processes of synthetic textiles on microplastic release. In particular, an analytical protocol was set up, based on the filtration of the washing water of synthetic fabrics and on the analysis of the filters by scanning electron microscopy. The quantification of the microfibre shedding from three different synthetic fabric types, woven polyester, knitted polyester, and woven polypropylene, during washing trials simulating domestic conditions, was achieved and statistically analysed. The highest release of microplastics was recorded for the wash of woven polyester and this phenomenon was correlated to the fabric characteristics. Moreover, the extent of microfibre release from woven polyester fabrics due to different detergents, washing parameters and industrial washes was evaluated. The number of microfibres released from a typical 5 kg wash load of polyester fabrics was estimated to be over 6,000,000 depending on the type of detergent used. The usage of a softener during washes reduces the number of microfibres released of more than 35%. The amount and size of the released microfibres confirm that they could not be totally retained by wastewater treatments plants, and potentially affect the aquatic environment.
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•A successful procedure to evaluate microplastics release from fabrics was set up.•The amount of microplastics depends on the fabrics, laundry products and washes.•An increased amount of microfibres is released by woven polyester.•Softener and bleach reduce fibre's damage and breaks.•High temperature, washing time and mechanical action increase the microfibre release.
A successful procedure to quantify the microfibre release from synthetic fabrics was developed. The effect of detergents and washing conditions on the extent of microfibre release was evaluated.
Breast cancer survivorship: A viewpoint Di Pace, Bruno; Padley, Roxanne H.
Journal of surgical oncology,
August 2024, Letnik:
130, Številka:
2
Journal Article
Therapeutic drug monitoring studies have generally concentrated on controlling compliance and avoiding side effects by maintaining long-term exposure to minimally effective blood concentrations. The ...rationale for using therapeutic drug monitoring in relation to second-generation antipsychotics is still being discussed at least with regard to the real clinical utility, but there is evidence that it can improve efficacy, especially when patients do not respond or develop side effects using therapeutic doses. Furthermore, drug plasma concentration determinations can be of some utility in medico-legal problems. This review concentrates on the clinical pharmacokinetic data related to clozapine, risperidone, paliperidone, olanzapine, quetiapine, amisulpride, ziprasidone, aripiprazole, sertindole, asenapine, iloperidone, lurasidone, brexpiprazole and cariprazine and briefly considers the main aspects of their pharmacodynamics. Optimal plasma concentration ranges are proposed for clozapine, risperidone, paliperidone and olanzapine because the studies of quetiapine, amisulpride, asenapine, iloperidone and lurasidone provide only limited information and there is no direct evidence concerning ziprasidone, aripiprazole, sertindole, brexpiprazole and cariprazine: the few reported investigations need to be confirmed and extended.
•The proposed strategy for network traffic control allows for multi-criteria optimisation of green timings at each single junction and for mono-criterion offsets optimisation.•The embedded mesoscopic ...traffic flow model allows to properly simulate queue and spillback phenomena.•Optimal strategy is obtained through metaheuristics: genetic algorithms, hill climbing.
The paper focuses on Network Traffic Control based on aggregate traffic flow variables, aiming at signal settings which are consistent with within-day traffic flow dynamics. The proposed optimisation strategy is based on two successive steps: the first step refers to each single junction optimisation (green timings), the second to network coordination (offsets). Both of the optimisation problems are solved through meta-heuristic algorithms: the optimisation of green timings is carried out through a multi-criteria Genetic Algorithm whereas offset optimisation is achieved with the mono-criterion Hill Climbing algorithm. To guarantee proper queuing and spillback simulation, an advanced mesoscopic traffic flow model is embedded within the network optimisation method. The adopted mesoscopic traffic flow model also includes link horizontal queue modelling. The results attained through the proposed optimisation framework are compared with those obtained through benchmark tools.
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