Battery is one of the most reliable sources of energy in most of the modern electronic products. In modern medicine, there is a lot of medical devices use battery as their power source. Strangled by ...the long period of time needed to charge battery is one of the difficulties faced by most of the battery supported biomedical devices. Therefore, we come up with a solution to solve the charging time weakness. By combining the fast charging property of super-capacitor and high energy density lithium ion battery, a new hybrid battery is produced. Giving a breakthrough in charging process, this hybrid battery reduced significant amount of time needed during charging without reduces the performance and lifespan of the battery. The energy must be able to withstand for a longer period and the hybrid battery capacity is equivalent to standard lithium ion battery. In the initial 7 minutes charging, hybrid battery charge 3.7 times faster than regular battery. As for fully charge case, hybrid battery saves 21.45 minutes to achieve fully charged status. This hybrid battery has faster charging speed without reducing too much on the energy density compared to the commercial lithium ion battery.
Swarthmore College (Pennsylvania) graduates are known to be well-educated and capable, so the career center focuses more closely on finding the right job fit for graduates than on just finding jobs. ...Program components include an expanded staff, access to a database of alumni contacts, seminars on job searches and networking, resume reviews, and early guidance for pre-professional students. (MSE)
Career planning Samson, Sarah D
U.S. news & world report,
09/1996, Letnik:
121, Številka:
11
Magazine Article
Tom Francis, the director of career planning and placement at Swarthmore College, tries to make sure his students are placed in jobs they really want and will enjoy. He urges students to follow their ...instincts and not some trendy data on where the jobs will be.
This paper aims to examine the relationship between climate changes and Hand-Foot-Mouth Disease (HFMD) incidences. A study to examine the relationship between the weather and the HFMD cases in ...Sarawak, Malaysia had been done. However, the weather data obtained from the five meteorological stations in Sarawak were too few to represent the whole Sarawak, which account for unreliable results. To reach a better understanding of the effect of climate changes on the transmission of HFMD, this paper aims to quantify the relationship between climate changes and HFMD incidences in Singapore instead of Sarawak due to the smaller area of Singapore and the similar weather conditions for Singapore and Sarawak. The weather variables and incidences of HFMD during the period 2006-2008 had been collected on a weekly basis. The correlation analysis was conducted between weather variables and HFMD cases. Air temperature, pressure and wind speed were found to be significantly correlated with the number of HFMD cases in Singapore. This shows that weather variations may affect the transmission of HFMD in Singapore. It is suggested that air temperature could be used as a predictor of the number of HFMD cases in tropical countries. Thus, public health interventions should be conducted during this stage in order to adapt and overcome the possible affects of climate change in the future.
Mixed lineage kinase domain-like (MLKL) is the terminal protein in the pro-inflammatory necroptotic cell death program. RIPK3-mediated phosphorylation is thought to initiate MLKL oligomerization, ...membrane translocation and membrane disruption, although the precise choreography of events is incompletely understood. Here, we use single-cell imaging approaches to map the chronology of endogenous human MLKL activation during necroptosis. During the effector phase of necroptosis, we observe that phosphorylated MLKL assembles into higher order species on presumed cytoplasmic necrosomes. Subsequently, MLKL co-traffics with tight junction proteins to the cell periphery via Golgi-microtubule-actin-dependent mechanisms. MLKL and tight junction proteins then steadily co-accumulate at the plasma membrane as heterogeneous micron-sized hotspots. Our studies identify MLKL trafficking and plasma membrane accumulation as crucial necroptosis checkpoints. Furthermore, the accumulation of phosphorylated MLKL at intercellular junctions accelerates necroptosis between neighbouring cells, which may be relevant to inflammatory bowel disease and other necroptosis-mediated enteropathies.
We describe a novel heterothallic species in Aspergillus section Fumigati, namely A. felis (neosartorya-morph) isolated from three host species with invasive aspergillosis including a human patient ...with chronic invasive pulmonary aspergillosis, domestic cats with invasive fungal rhinosinusitis and a dog with disseminated invasive aspergillosis. Disease in all host species was often refractory to aggressive antifungal therapeutic regimens. Four other human isolates previously reported as A. viridinutans were identified as A. felis on comparative sequence analysis of the partial β-tubulin and/or calmodulin genes. A. felis is a heterothallic mold with a fully functioning reproductive cycle, as confirmed by mating-type analysis, induction of teleomorphs within 7 to 10 days in vitro and ascospore germination. Phenotypic analyses show that A. felis can be distinguished from the related species A. viridinutans by its ability to grow at 45°C and from A. fumigatus by its inability to grow at 50°C. Itraconazole and voriconazole cross-resistance was common in vitro.
7.7% Efficient All-Polymer Solar Cells Hwang, Ye-Jin; Courtright, Brett A. E.; Ferreira, Amy S. ...
Advanced materials (Weinheim),
August 19, 2015, Letnik:
27, Številka:
31
Journal Article
Recenzirano
By controlling the polymer/polymer blend self‐organization rate, all‐polymer solar cells composed of a high‐mobility, crystalline, naphthalene diimide‐selenophene copolymer acceptor and a ...benzodithiophene‐thieno3,4‐bthiophene copolymer donor are achieved with a record 7.7% power conversion efficiency and a record short‐circuit current density (18.8 mA cm−2).
Phosphorylation of the MLKL pseudokinase by the RIPK3 kinase leads to MLKL oligomerization, translocation to, and permeabilization of, the plasma membrane to induce necroptotic cell death. The ...precise choreography of MLKL activation remains incompletely understood. Here, we report Monobodies, synthetic binding proteins, that bind the pseudokinase domain of MLKL within human cells and their crystal structures in complex with the human MLKL pseudokinase domain. While Monobody-32 constitutively binds the MLKL hinge region, Monobody-27 binds MLKL via an epitope that overlaps the RIPK3 binding site and is only exposed after phosphorylated MLKL disengages from RIPK3 following necroptotic stimulation. The crystal structures identified two distinct conformations of the MLKL pseudokinase domain, supporting the idea that a conformational transition accompanies MLKL disengagement from RIPK3. These studies provide further evidence that MLKL undergoes a large conformational change upon activation, and identify MLKL disengagement from RIPK3 as a key regulatory step in the necroptosis pathway.
The ancestral origins of the lytic cell death mode, necroptosis, lie in host defense. However, the dysregulation of necroptosis in inflammatory diseases has led to widespread interest in targeting ...the pathway therapeutically. This mode of cell death is executed by the terminal effector, the MLKL pseudokinase, which is licensed to kill following phosphorylation by its upstream regulator, RIPK3 kinase. The precise molecular details underlying MLKL activation are still emerging and, intriguingly, appear to mechanistically-diverge between species. Here, we report the structure of the human RIPK3 kinase domain alone and in complex with the MLKL pseudokinase. These structures reveal how human RIPK3 structurally differs from its mouse counterpart, and how human RIPK3 maintains MLKL in an inactive conformation prior to induction of necroptosis. Residues within the RIPK3:MLKL C-lobe interface are crucial to complex assembly and necroptotic signaling in human cells, thereby rationalizing the strict species specificity governing RIPK3 activation of MLKL.
Base excision repair (BER) initiated by alkyladenine DNA glycosylase (AAG) is essential for removal of aberrantly methylated DNA bases. Genome instability and accumulation of aberrant bases accompany ...multiple diseases, including cancer and neurological disorders. While BER is well studied on naked DNA, it remains unclear how BER efficiently operates on chromatin. Here, we show that AAG binds to chromatin and forms complex with RNA polymerase (pol) II. This occurs through direct interaction with Elongator and results in transcriptional co-regulation. Importantly, at co-regulated genes, aberrantly methylated bases accumulate towards the 3'end in regions enriched for BER enzymes AAG and APE1, Elongator and active RNA pol II. Active transcription and functional Elongator are further crucial to ensure efficient BER, by promoting AAG and APE1 chromatin recruitment. Our findings provide insights into genome stability maintenance in actively transcribing chromatin and reveal roles of aberrantly methylated bases in regulation of gene expression.
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