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zadetkov: 41
1.
  • Mouse models of pediatric h... Mouse models of pediatric high-grade gliomas with MYCN amplification reveal intratumoral heterogeneity and lineage signatures
    Schoof, Melanie; Godbole, Shweta; Albert, Thomas K. ... Nature communications, 11/2023, Letnik: 14, Številka: 1
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    Abstract Pediatric high-grade gliomas of the subclass MYCN (HGG-MYCN) are highly aggressive tumors frequently carrying MYCN amplifications, TP53 mutations, or both alterations. Due to their rarity, ...
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Dostopno za: UL
2.
  • Opposing Effects of CREBBP ... Opposing Effects of CREBBP Mutations Govern the Phenotype of Rubinstein-Taybi Syndrome and Adult SHH Medulloblastoma
    Merk, Daniel J.; Ohli, Jasmin; Merk, Natalie D. ... Developmental cell, 03/2018, Letnik: 44, Številka: 6
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    Recurrent mutations in chromatin modifiers are specifically prevalent in adolescent or adult patients with Sonic hedgehog-associated medulloblastoma (SHH MB). Here, we report that mutations in the ...
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3.
  • MYC overexpression and SMAR... MYC overexpression and SMARCA4 loss cooperate to drive medulloblastoma formation in mice
    Göbel, Carolin; Godbole, Shweta; Schoof, Melanie ... Acta neuropathologica communications, 11/2023, Letnik: 11, Številka: 1
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    Group 3 medulloblastoma is one of the most aggressive types of childhood brain tumors. Roughly 30% of cases carry genetic alterations in MYC, SMARCA4, or both genes combined. While overexpression of ...
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Dostopno za: UL
4.
  • G2 checkpoint targeting via... G2 checkpoint targeting via Wee1 inhibition radiosensitizes EGFRvIII-positive glioblastoma cells
    Cetin, Meryem H; Rieckmann, Thorsten; Hoffer, Konstantin ... Radiation oncology, 01/2023, Letnik: 18, Številka: 1
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    The gene of the Epidermal growth factor receptor (EGFR) is one of the most frequently altered genes in glioblastoma (GBM), with deletions of exons 2-7 (EGFRvIII) being amongst the most common genomic ...
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5.
  • hGFAP-mediated GLI2 overexp... hGFAP-mediated GLI2 overexpression leads to early death and severe cerebellar malformations with rare tumor formation
    Niesen, Judith; Hermans-Borgmeyer, Irm; Krüger, Christina ... iScience, 09/2023, Letnik: 26, Številka: 9
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    The zinc-finger transcription factor GLI2 is frequently amplified in childhood medulloblastoma of the Sonic-hedgehog type (SHH-MB), with or without amplification of NMYC or deletion of TP53. Despite ...
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Dostopno za: UL
6.
  • The tumor suppressor CREBBP... The tumor suppressor CREBBP and the oncogene MYCN cooperate to induce malignant brain tumors in mice
    Schoof, Melanie; Epplen, Gefion Dorothea; Walter, Carolin ... Oncogenesis, 07/2023, Letnik: 12, Številka: 1
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    The tumor suppressor and chromatin modifier cAMP response element-binding protein binding protein (CREBBP) and v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (MYCN), a ...
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7.
  • The transcriptional coactiv... The transcriptional coactivator and histone acetyltransferase CBP regulates neural precursor cell development and migration
    Schoof, Melanie; Launspach, Michael; Holdhof, Dörthe ... Acta neuropathologica communications, 12/2019, Letnik: 7, Številka: 1
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    CREB (cyclic AMP response element binding protein) binding protein (CBP, CREBBP) is a ubiquitously expressed transcription coactivator with intrinsic histone acetyltransferase (KAT) activity. ...
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8.
  • SMARCA4 Loss and Mutated β-... SMARCA4 Loss and Mutated β-Catenin Induce Proliferative Lesions in the Murine Embryonic Cerebellum
    Göbel, Carolin; Schoof, Melanie; Holdhof, Dörthe ... The Journal of neuroscience, 2024-Apr-10, 2024-04-10, 20240410, Letnik: 44, Številka: 15
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    Almost all medulloblastomas (MB) of the Wingless/Int-1 (WNT) type are characterized by hotspot mutations in , and mouse models have convincingly demonstrated the tumor-initiating role of these ...
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Dostopno za: CMK
9.
  • MEDB-11. MYC overexpression... MEDB-11. MYC overexpression and SMARCA4 loss in cerebellar granule cell precursors cooperate to drive medulloblastoma formation in mice
    Göbel, Carolin; Holdhof, Dörthe; Schoof, Melanie ... Neuro-oncology, 06/2022, Letnik: 24, Številka: Supplement_1
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    Abstract Group 3 medulloblastoma is one of the most aggressive types of childhood brain tumors. Roughly 30 % of cases carry genetic alterations in MYC, SMARCA4 or both genes combined. While ...
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Dostopno za: UL
10.
  • MEDB-12. Severe development... MEDB-12. Severe developmental abnormalities and proliferative cerebellar lesions induced by combined activity of Wnt signalling and loss of SMARCA4
    Göbel, Carolin; Holdhof, Dörthe; Schoof, Melanie ... Neuro-oncology, 06/2022, Letnik: 24, Številka: Supplement_1
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    Recenzirano
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    Abstract Almost all medulloblastomas (MB) of the WNT subgroup are characterized by hotspot mutations in CTNNB1, and mouse models have convincingly demonstrated the tumor-initiating role of these ...
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Dostopno za: UL
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zadetkov: 41

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