Ensuring high vaccination and even booster vaccination coverage is critical in preventing severe Coronavirus Disease 2019 (COVID-19). Among the various COVID-19 vaccines currently in use, the mRNA ...vaccines have shown remarkable effectiveness. However, systemic adverse events (AEs), such as postvaccination fatigue, are prevalent following mRNA vaccination, and the underpinnings of which are not understood. Herein, we found that higher baseline expression of genes related to T and NK cell exhaustion and suppression were positively correlated with the development of moderately severe fatigue after Pfizer-BioNTech BNT162b2 vaccination; increased expression of genes associated with T and NK cell exhaustion and suppression reacted to vaccination were associated with greater levels of innate immune activation at 1 day postvaccination. We further found, in a mouse model, that altering the route of vaccination from intramuscular (i.m.) to subcutaneous (s.c.) could lessen the pro-inflammatory response and correspondingly the extent of systemic AEs; the humoral immune response to BNT162b2 vaccination was not compromised. Instead, it is possible that the s.c. route could improve cytotoxic CD8 T-cell responses to BNT162b2 vaccination. Our findings thus provide a glimpse of the molecular basis of postvaccination fatigue from mRNA vaccination and suggest a readily translatable solution to minimize systemic AEs.
Using 2.93 fb−1 of e+e− collision data collected at a center-of-mass energy of 3.773 GeV with the BESIII detector, the first observation of the doubly Cabibbo-suppressed decay D+ → K+π+π−π0 is ...reported. After removing decays that contain narrow intermediate resonances, including D+ → K+η, D+ → K+ω, and D+ → K+ϕ, the branching fraction of the decay D+ → K+π+π−π0 is measured to be ( 1.13 ± 0.0 8stat ± 0.0 3syst) × 10−3. The ratio of branching fractions of D+ → K+π+π−π0 over D+ → K−π+π+π0 is found to be ( 1.81 ± 0.15 )%, which corresponds to ( 6.28 ± 0.52 ) tan4θC, where θC is the Cabibbo mixing angle. This ratio is significantly larger than the corresponding ratios for other doubly Cabibbo-suppressed decays. The asymmetry of the branching fractions of charge-conjugated decays D± → K±π±π∓π0 is also determined, and no evidence for C P violation is found. In addition, the first evidence for the D+ → K+ω decay, with a statistical significance of 3.3σ, is presented and the branching fraction is measured to be B (D+ → K+ω) = ( 5. 7−2.1 stat+2.5 ± 0.2syst ) × 10−5.
Based on ( 10 087 ± 44 ) × 10 6 J / ψ events collected with the BESIII detector, a partial wave analysis of the decay J / ψ → γ K S 0 K S 0 η ′ is performed. The mass and width of the X ( 2370 ) are ...measured to be 2395 ± 11 ( stat ) − 94 + 26 ( syst ) MeV / c 2 and 188 − 17 + 18 ( stat ) − 33 + 124 ( syst ) MeV , respectively. The corresponding product branching fraction is B J / ψ → γ X ( 2370 ) × B X ( 2370 ) → f 0 ( 980 ) η ′ × B f 0 ( 980 ) → K S 0 K S 0 = ( 1.31 ± 0.22 ( stat ) − 0.84 + 2.85 ( syst ) ) × 10 − 5 . The statistical significance of the X ( 2370 ) is greater than 11.7 σ and the spin parity is determined to be 0 − + for the first time. The measured mass and spin parity of the X ( 2370 ) are consistent with the predictions of the lightest pseudoscalar glueball. Published by the American Physical Society 2024
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