The COVID-19 outbreak required the significantly increased working time and intensity for health professionals in China, which may cause stress signs.
From March 2-13 of 2020, 4,618 health ...professionals in China were included in an anonymous, self-rated online survey regarding their concerns on exposure to the COVID-19 outbreak. The questionnaires consisted of five parts: basic demographic information and epidemiological exposure; occupational and psychological impact; concerns during the episode; coping strategies; and the Huaxi Emotional-Distress Index (HEI).
About 24.2% of respondents experienced high levels of anxiety or/and depressive symptoms since the COVID-19 outbreak. Respondents who worried about their physical health and those who had COVID-19 infected friends or close relatives were more likely to have high HEI levels, than those without these characteristics. Further, family relationship was found to have an independent protective effect against high HEI levels. Their main concerns were that their families would not be cared for and that they would not be able to work properly. Compared to respondents with clear emotional problems, those with somewhat hidden emotional issues adopted more positive coping measures.
About a quarter of medical staff experienced psychological problems during the pandemic of COVID-19. The psychological impact of stressful events was related to worrying about their physical health, having close COVID-19 infected acquaintances and family relationship issues. Therefore, the psychological supprot for medical staff fighting in the COVID-19 pandemic may be needed.
Extrachromosomal telomere repeat (ECTR) DNA is unique to cancer cells that maintain telomeres through the alternative lengthening of telomeres (ALT) pathway, but the role of ECTRs in ALT development ...remains elusive. We found that induction of ECTRs in normal human fibroblasts activated the cGAS-STING-TBK1-IRF3 signaling axis to trigger IFNβ production and a type I interferon response, resulting in cell-proliferation defects. In contrast, ALT cancer cells are commonly defective in sensing cytosolic DNA. We found that STING expression was inhibited in ALT cancer cell lines and transformed ALT cells. Notably, the ALT suppressors histone H3.3 and the ATRX-Daxx histone chaperone complex were also required to activate the DNA-sensing pathway. Collectively, our data suggest that the loss of the cGAS-STING pathway may be required to evade ECTR-induced anti-proliferation effects and permit ALT development, and this requirement may be exploited for treatments specific to cancers utilizing the ALT pathway.
...the symptoms of cough and fever persisted, and he later developed right chest pain. ...he was transferred to our hospital. On admission, the patient’s vital signs were recorded (temperature 39 °C, ...respiratory rate 22 breaths/minute, pulse rate 102 beats/minute, blood pressure 110/72 mmHg 1 mmHg=0.133 kPa). Laboratory test results revealed: white blood cell counts 11.5×109/L (with an 89.2% neutrophil ratio), C-reactive protein 92 mg/L (normal range 0-10 mg/L), and erythrocyte sedimentation rate 44 mm/hour (normal range 0-15 mm/hour). According to Saraya et al,12 a pleural LDH to ADA ratio greater than 15.5 is indicative of parapneumonic effusion (PPE) or empyema rather than TBPE or MPE.
The patient's physical examination results were normal, with a blood pressure of 105/68 mmHg, a pulse rate of 80 beats/min, a respiratory rate of 18 breaths/min, and a normal body temperature. On ...October 10, 2019, the patient visited our hospital and underwent a scheduled methacholine inhalation challenge test. The severity, frequency, duration, and onset time of chest pain can vary among patients with CPVA. Because this is a subjective sensation, the location and the severity of chest pain are not necessarily the same for all diseases. ...chest pain appears as patients engage in physical activity (eg, climbing stairs), but symptoms cannot be relieved using anti-anginal drugs. ...most patients experience chest tightness, cough, and mild dyspnea, but in these cases, symptoms are mild and may be overlooked by doctors and patients themselves.
Aim
To evaluate the effects of an at‐home artificial intelligence (AI)‐assisted dental monitoring application on treatment outcomes in patients with periodontitis.
Materials and Methods
Participants ...with periodontitis were recruited and randomly assigned to an AI (n = 16), AI and human counselling (AIHC; n = 17), or control (CG; n = 20) group. All participants received non‐surgical periodontal treatment. We employed an AI‐assisted tool called DENTAL MONITORING® (DM) intervention, a new technological AI monitoring product that utilizes smartphone cameras for intra‐oral scanning and assessment. Patients in the AI and AIHC groups received additional (a) DM or (b) DM, respectively, with real‐person counselling over 3 months. Periodontal parameters were collected at baseline and follow‐ups. A mixed‐design model analysed the follow‐up effects over time.
Results
The AI and AIHC groups, respectively, exhibited greater improvement in probing pocket depth (PPD) (mean diff = −0.9 ± 0.4 and −1.4 ± 0.3, effect size ES = 0.76 and 1.98), clinical attachment level (mean diff = −0.8 ± 0.3 and −1.4 ± 0.3, ES = 0.84 and 1.77), and plaque index (mean diff = −0.5 ± 0.2 and − 0.7 ± 0.2, ES = 0.93 and 1.81) at 3‐month follow‐up than the CG did. The AIHC group had a greater reduction in PPD (ES = 0.46) and clinical attachment level (ES = 0.64) at the 3‐month follow‐up compared with the AI group.
Conclusions
Using AI monitoring at home had a positive effect on treatment outcomes for patients with periodontitis. Patients who received AI‐assisted health counselling exhibited better treatment outcomes than did patients who received AI monitoring alone.
According to recent studies, the Plantaginaceae, which are traditional Chinese herbal remedies, have potential for use in viral infection treatment and cancer therapy. Linalool and p-coumaric acid ...are two of the biologically active compounds that can be isolated from the Plantaginaceae. This study mainly focused on investigating the bioactivity of linalool as well as the bioactivity of p-coumaric acid in terms of their cytotoxic effects on cancer cells. Whether the mechanisms of such effects are generated through apoptosis and immunoregulatory activity were also investigated. By using WST-1 analysis, it was shown that linalool and p-coumaric acid have good inhibitory effects against breast, colorectal and liver cancer cells. The IC50 values of linalool for those cancer cell types were 224 μM, 222 μM, and 290 μM, respectively, and the IC50 values of p-coumaric acid were 693 μM, 215 μM and 87 μM, respectively. Cell cycle analysis also confirmed that linalool and p-coumaric acid can lead to apoptosis. By using flow cytometry, it was determined that treatment with linalool rather than p-coumaric acid significantly increased the sub-G1 phase and that there were more cells concentrated in the G1 phase. Furthermore, by using cytokine array analysis, we found that linalool can stimulate IFN-γ, IL-13, IL-2, IL-21, IL-21R, IL-4, IL-6sR and TNF-α secretion. This demonstrated that in addition to the bidirectional regulation capabilities found in linalool, it also induces Th1 cellular immune response in T-47D cells. These results showed that linalool holds great potential for use in cancer therapy, and we believe that it could provide an alternative way to take action against tumors.
Two binuclear heteroleptic Cu
complexes, namely Cu-NIR1 and Cu-NIR2, bearing rigid chelating diphosphines and π-conjugated 2,5-di(pyridin-2-yl)thiazolo5,4-dthiazole as the bis-bidentate ligand are ...presented. The proposed dinuclearization strategy yields a large bathochromic shift of the emission when compared to the mononuclear counterparts (M1-M2) and enables shifting luminescence into the near-infrared (NIR) region in both solution and solid state, showing emission maximum at ca. 750 and 712 nm, respectively. The radiative process is assigned to an excited state with triplet metal-to-ligand charge transfer (
MLCT) character as demonstrated by in-depth photophysical and computational investigation. Noteworthy, X-ray analysis of the binuclear complexes unravels two interligand π-π-stacking interactions yielding a doubly locked structure that disfavours flattening of the tetrahedral coordination around the Cu
centre in the excited state and maintain enhanced NIR luminescence. No such interaction is present in M1-M2. These findings prompt the successful use of Cu-NIR1 and Cu-NIR2 in NIR light-emitting electrochemical cells (LECs), which display electroluminescence maximum up to 756 nm and peak external quantum efficiency (EQE) of 0.43 %. Their suitability for the fabrication of white-emitting LECs is also demonstrated. To the best of our knowledge, these are the first examples of NIR electroluminescent devices based on earth-abundant Cu
emitters.
An aniline-functionalized naphthalene dialdehyde Schiff base fluorescent probe
with aggregation-induced enhanced emission (AIEE) characteristics was synthesized via a simple one-step condensation ...reaction and exhibited excellent sensitivity and selectivity towards copper(II) ions in aqueous media with a fluorescence " turn-off " phenomenon. The detection limit of the probe is 1.64 × 10
mol·L
. Furthermore, according to the results of the UV-vis/fluorescence titrations, Job's plot method and
H-NMR titrations, a 1:2 stoichiometry was identified. The binding constant between
and Cu
was calculated to be
= 1.222 × 10
. In addition, the AIEE fluorescent probe
could be applied to detection in real water samples with satisfactory recoveries in the range 99.10-102.90% in lake water and 98.49-102.37% in tap water.
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