Using the water eliminated mechanism, reactions of 4-pyridinecarboxylic acid hydrazide and salicylaldehyde, benzaldehyde, cinnamaldehyde, and formaldehyde afforded the corresponding ...N(4)(E)-1-(2-hydroxyphenyl) methylidene (NHPM), N(4)-(E)-2-phenylethylidene (NPI), N(4)(E,2E)-3-phenyl-2-propenylidene (NPPI), and N(4)(E) ethylidene (NEI) isonicotinohydrazide, in high yields, after several minutes, as reported. These new compounds have shown antitumor activity against two kinds of cancer cells, which are K562 (human chronic myeloid leukemia) and Jurkat (human T lymphocyte carcinoma).
Using the water eliminated mechanism, reactions of 4-pyridinecarboxylic acid hydrazide and salicylaldehyde, benzaldehyde, cinnamaldehyde, and formaldehyde afforded the corresponding N 4 ...(E)-1-(2-hydroxyphenyl) methylidene (NHPM), N 4 -(E)-2-phenylethylidene (NPI), N 4 (E,2E)-3-phenyl-2-propenylidene (NPPI), and N 4 (E) ethylidene (NEI) isonicotinohydrazide, in high yields, after several minutes, as reported. These new compounds have shown antitumor activity against two kinds of cancer cells, which are K562 (human chronic myeloid leukemia) and Jurkat (human T lymphocyte carcinoma).
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