Modernism for the Middle Class Smith, Erin A.
Journal of Modern Literature,
06/2019, Letnik:
42, Številka:
4
Journal Article, Book Review
Recenzirano
Lise Jaillant's Cheap Modernism: Expanding Markets, Publishers' Series and the Avant-Garde is the first study of the European reprint series that made Anglophone modernist writers such as Virginia ...Woolf, James Joyce, D.H. Lawrence, and Wyndham Lewis available to a non-elite audience. Jaillant brings together history of the book and the new modernist studies to illuminate the diffusion of modernism into the mainstream. Her goal is to refocus our history of modernism from its origins in limited editions and little magazines to its interwar popularization through affordable reprints. Based on archival research into business records, advertising and marketing materials, reviews in periodicals, books as material artefacts, and texts themselves, Cheap Modernism tells fascinating stories about the encounter between modernist writers and middle-class audiences.
Violent trauma has lasting psychological impacts. Our institution’s Community Violence Response Team (CVRT) offers mental health services to trauma victims. We characterized implementation and ...determined factors associated with utilization by pediatric survivors of interpersonal violence-related penetrating trauma.
Analysis included survivors (0–21 years) of violent penetrating injury at our institution (2011–2017). Injury and demographic data were collected. Nonparametric regression models determined factors associated with utilization.
There was initial rapid uptake of CVRT (2011–2013) after which it plateaued, serving >80% of eligible patients (2017). White race and higher injury severity were associated with receipt and duration of services. In post-hoc analysis, race was found to be associated with continued treatment but not with initial consultation.
Successful implementation required three years, aiding >80% of patients. CVRT is a blueprint to strengthen existing violence intervention programs. Efforts should be made to ensure that barriers to providing care, including those related to race, are overcome.
•Mental Health Services program successfully implemented in 3 years.•Strengthens existing hospital-based violence intervention programs.•Race associated with continued use of services but not initial engagement.•More work is needed to ensure that barriers to providing care are overcome.
Interspinous process devices (IPDs) were developed as minimally invasive alternatives to open decompression surgery for spinal stenosis. However, given high treatment failure and reoperation rates, ...there has been minimal adoption by spine surgeons. This study leveraged a national claims database to characterize national IPD usage patterns and postoperative outcomes after IPD implantation.
Using the PearlDiver database, we identified all patients who underwent 1- or 2-level IPD implantation between 2010 and 2018. Univariate and multivariable logistic regression was performed to identify predictors of the number of IPD levels implanted and reoperation up to 3 years after the index surgery. Right-censored Kaplan-Meier curves were plotted for duration of reoperation-free survival and compared with log-rank tests.
Patients (n = 4865) received 1-level (n = 3246) or 2-level (n = 1619) IPDs. Patients who were older (adjusted odds ratio aOR 1.02, 95% confidence interval CI 1.01-1.03, P < .001), male (aOR 1.31, 95% CI 116-1.50, P < .001), and obese (aOR 1.19, 95% CI 1.05-1.36, P < .01) were significantly more likely to receive a 2-level IPD than to receive a 1-level IPD. The 3-year reoperation rate was 9.3% of patients when mortality was accounted for during the follow-up period. Older age decreased (aOR 0.97, 95% CI 0.97-0.99, P = .0039) likelihood of reoperation, whereas 1-level IPD (aOR 1.37, 95% CI 1.01-1.89, P = .048), Charlson Comorbidity Index (aOR 1.07, 95% CI 1.01-1.14, P = .018), and performing concomitant open decompression increased the likelihood of reoperation (aOR 1.68, 95% CI 1.35-2.09, P = .0014).
Compared with 1-level IPDs, 2-level IPDs were implanted more frequently in older, male, and obese patients. The 3-year reoperation rate was 9.3%. Concomitant open decompression with IPD placement was identified as a significant risk factor for subsequent reoperation and warrants future investigation.
•A variety of existing datasets are being used to examine effects of opioid policies.•Linking data sources enables studies that cannot be done with single data source.•Federal investments can enhance ...the quality and availability of linked data.•Better access to linked data can help guide effective policies to reduce harms.
Better opioid prescribing practices, promoting effective opioid use disorder treatment, improving naloxone access, and enhancing public health surveillance are strategies central to reducing opioid-related morbidity and mortality. Successfully advancing and evaluating these strategies requires leveraging and linking existing secondary data sources.
We conducted a scoping study in Fall 2017 at RAND, including a literature search (updated in December 2018) complemented by semi-structured interviews with policymakers and researchers, to identify data sources and linking strategies commonly used in opioid studies, describe data source strengths and limitations, and highlight opportunities to use data to address high-priority public health research questions.
We identified 306 articles, published between 2005 and 2018, that conducted secondary analyses of existing data to examine one or more public health strategies. Multiple secondary data sources, available at national, state, and local levels, support such research, with substantial breadth in data availability, data contents, and the data’s ability to support multi-level analyses over time. Interviewees identified opportunities to expand existing capabilities through systematic enhancements, including greater support to states for creating and facilitating data use, as well as key data challenges, such as data availability lags and difficulties matching individual-level data over time or across datasets.
Multiple secondary data sources exist that can be used to examine the impact of public health approaches to addressing the opioid crisis. Greater data access, improved usability for research purposes, and data element standardization can enhance their value, as can improved data availability timeliness and better data comparability across jurisdictions.
The utility of comprehensive surgical staging in patients with low risk disease has been questioned. Thus, a reliable means of determining risk would be quite useful. The aim of our study was to ...create the best performing prediction model to classify endometrioid endometrial cancer (EEC) patients into low or high risk using a combination of molecular and clinical-pathological variables. We then validated these models with publicly available datasets. Analyses between low and high risk EEC were performed using clinical and pathological data, gene and miRNA expression data, gene copy number variation and somatic mutation data. Variables were selected to be included in the prediction model of risk using cross-validation analysis; prediction models were then constructed using these variables. Model performance was assessed by area under the curve (AUC). Prediction models were validated using appropriate datasets in The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. A prediction model with only clinical variables performed at 88%. Integrating clinical and molecular data improved prediction performance up to 97%. The best prediction models included clinical, miRNA expression and/or somatic mutation data, and stratified pre-operative risk in EEC patients. Integrating molecular and clinical data improved the performance of prediction models to over 95%, resulting in potentially useful clinical tests.
•The SI SPD group has greater impairment compared with the non-SI SPD group.•Depression and social networking drive the difference between SI and non-SI groups.•Both SI and non-SI SPD groups are ...impaired in comparison to the HC group.
This study compared demographic and clinical features in a sample of 384 participants: healthy controls (HC; n = 166) and individuals with schizotypal personality disorder (SPD) with (n = 50) and without (n = 168) suicidal ideation (SI) to examine specific risk factors for suicidality in SPD. Compared to the non-SI group, the SI group showed significantly greater severity of depression, aggression, impulsivity, affective lability, schizotypal features, poorer social adjustment, and had fewer social contacts. Individuals in the SI group were also more likely to have a history of a suicide attempt and comorbid borderline personality disorder in comparison to the non-SI group. Logistic regression analysis indicated that severity of depression and the number of social contacts drove the difference between the SI and non-SI groups. Compared with both SPD subgroups, the HC group was significantly less depressed, aggressive, impulsive, affectively labile, had fewer schizotypal features, was better socially adjusted, and had more social contacts. This study indicates that overall, the SI group is a more severely impaired group of individuals with SPD compared to the non-SI group. Better educating medical professionals about the diagnosis and management of SPD and its associations with suicidality is warranted.
The US Geological Survey National Seismic Hazard Models (NSHMs) are used to calculate earthquake ground-shaking intensities for design and rehabilitation of structures in the United States. The most ...recent 2014 and 2018 versions of the NSHM for the conterminous United States included major updates to ground-motion models (GMMs) for active and stable crustal tectonic settings; however, the subduction zone GMMs were largely unchanged. With the recent development of the next generation attenuation-subduction (NGA-Sub) GMMs, and recent progress in the utilization of “M9” Cascadia earthquake simulations, we now have access to improved models of ground shaking in the US subduction zones and the Seattle basin. The new NGA-Sub GMMs support multi-period response spectra calculations. They provide global models and regional terms specific to Cascadia and terms that account for deep-basin effects. This article focuses on the updates to subduction GMMs for implementation in the 2023 NSHM and compares them to the GMMs of previous NSHMs. Individual subduction GMMs, their weighted averages, and their impact on the estimated mean hazard relative to the 2018 NSHM are discussed. The updated logic trees include three of the new NGA-Sub GMMs and retain two older models to represent epistemic uncertainty in both the median and standard deviation of ground-shaking intensities at all periods of interest. Epistemic uncertainty is further represented by a three-point logic tree for the NGA-Sub median models. Finally, in the Seattle region, basin amplification factors are adjusted at long periods based on the state-of-the-art M9 Cascadia earthquake simulations. The new models increase the estimated mean hazard values at short periods and short source-to-site distances for interface earthquakes, but decrease them otherwise, relative to the 2018 NSHM. On softer soils, the new models cause decreases to the estimated mean hazard for long periods in the Puget Lowlands basin but increases within the deep Seattle portion of this basin for short periods relative to the 2018 NSHM.
Obesity is thought to increase renal hyperfiltration, thereby increasing albuminuria and the progression of renal disease. The effect of pharmacologically mediated weight loss on renal outcomes is ...not well-described. Lorcaserin, a selective serotonin 2C receptor agonist that promotes appetite suppression, led to sustained weight loss without any increased risk for major adverse cardiovascular (CV) events in the CAMELLIA-TIMI 61 trial (Cardiovascular and Metabolic Effects of Lorcaserin in Overweight and Obese Patients-Thrombolysis in Myocardial Infarction 61).
CAMELLIA-TIMI 61 randomly assigned 12 000 overweight or obese patients with or at high risk for atherosclerotic CV disease to lorcaserin or placebo on a background of lifestyle modification. The primary renal outcome was a composite of new or worsening persistent micro- or macroalbuminuria, new or worsening chronic kidney disease, doubling of serum creatinine, end-stage renal disease, renal transplant, or renal death.
At baseline, 23.8% of patients had an estimated glomerular filtration rate (eGFR) <60 mL·min
·1.73 m
and 19.0% had albuminuria (urinary albumin:creatinine ratio ≥30 mg/g). Lorcaserin reduced the risk of the primary renal composite outcome (4.2% per year versus 4.9% per year; hazard ratio HR, 0.87; 95% confidence interval CI, 0.79-0.96; P=0.0064). The benefit was consistent across subpopulations at increased baseline CV and renal risk. Lorcaserin improved both eGFR and urinary albumin:creatinune ratio within the first year after randomization. The effect of lorcaserin on weight, hemoglobin A1c, and systolic blood pressure was consistent regardless of baseline renal function. Likewise, there was no excess in cardiovascular events in patients assigned to lorcaserin in comparison with placebo, regardless of renal function. After adjustment for baseline characteristics, those with evidence of kidney disease were at increased risk of major CV events. Compared with patients with an eGFR ≥90 mL·min
·1.73 m
, those with an eGFR 60-90 and those <60 mL·min
·1.73 m-2 had HRs of 1.25 (95% CI, 1.01, 1.56) and 1.51 (95% CI, 1.17, 1.95), respectively ( P for trend 0.0015). Likewise, compared with patients with no albuminuria (<30 mg/g), those microalbuminuria and those with macroalbuminuria had HRs of 1.46 (95% CI, 1.22, 1.74) and 2.10 (95% CI, 1.58, 2.80), respectively ( P for trend <0.0001).
Renal dysfunction was associated with increased CV risk in overweight and obese patients. When added to diet and lifestyle, lorcaserin reduced the rate of new-onset or progressive renal impairment in comparison with placebo.
URL: https://www.clinicaltrials.gov . Unique identifier: NCT02019264.
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