O presente artigo examina como o capítulo Um certo capitão Rodrigo, do romance O tempo e o vento do literato Érico Verissimo, representa literariamente a história. Para isso examino, por um lado, ...como a fonte se articula com a historiografia da sua época e, por outro lado, como a fonte articula a historiografia e a literatura. Para dar conta do objetivo, a metodologia utilizada para analisar a fonte é a operação literária da história. A hipótese que norteia o artigo diz respeito a ligação intelectual de Verissimo com a historiografia do seu período. Por fim, constato que a fonte/obra analisada potencializa a representação da história pela literatura, como também, faz da escrita literária da história uma reflexão teórica sobre a historiografia.
BackgroundThe McKenzie Method of Mechanical Diagnosis and Therapy (MDT) is one of the exercise approaches recommended by low back pain (LBP) guidelines. We investigated the efficacy of MDT compared ...with placebo in patients with chronic LBP.MethodsThis was a prospectively registered, two-arm randomised placebo controlled trial, with a blinded assessor. A total of 148 patients seeking care for chronic LBP were randomly allocated to either MDT (n=74) or placebo (n=74). Patients from both groups received 10 treatment sessions over 5 weeks. Patients from both groups also received an educational booklet. Clinical outcomes were obtained at the end of treatment (5 weeks) and 3, 6 and 12 months after randomisation. Primary outcomes were pain intensity and disability at the end of treatment (5 weeks). We also conducted a subgroup analysis to identify potential treatment effect modifiers that could predict a better response to MDT treatment.ResultsThe MDT group had greater improvements in pain intensity at the end of treatment (mean difference (MD) −1.00, 95% CI −2.09 to −0.01) but not for disability (MD −0.84, 95% CI −2.62 to 0.93). We did not detect between-group differences for any secondary outcomes, nor were any treatment effect modifiers identified. Patients did not report any adverse events.ConclusionWe found a small and likely not clinically relevant difference in pain intensity favouring the MDT method immediately at the end of 5 weeks of treatment but not for disability. No other difference was found for any of the primary or secondary outcomes at any follow-up times.Trial registration numberClinicalTrials.gov (NCT02123394)
Objetivo: analisar a escrita literária da história e como se articula à construção de sentido histórico na novela Farrapo: memórias dum cavalo (1935), do literato brasileiro Félix Contreiras ...Rodrigues (1884-1960). Metodologia: no contexto histórico da inserção política do estado do Rio Grande do Sul nas instituições e na política nacional do Brasil entre 1920 e 1935, o artigo averigua a articulação entre texto e contexto, por intermédio da operação literária da história através de analise do lugar social da obra literária, das práticas literárias da obra e, por fim, da escrita do texto literário. A fonte primária desta investigação é da novela Farrapo: memórias de um cavalo. Originalidade: ademais do método, o artigo trabalha com a hipótese de que Farrapo: memórias dum cavalo articula e cristaliza a nacionalização da história regional sulina em um período de ascensão política sul-rio-grandense em nível nacional. Conclusão: o texto literário sobre a história foi permeado por questões teóricas e políticas do seu presente examinadas a partir da operação literária da história, isto é, a novela estudada acolhe a hipótese deste artigo.
O presente artigo examina como o capítulo “O Rio Grande e o Prata: Contrastes”, do livro Capitania d’El-Rei do historiador e político Moysés Vellinho, representa historiograficamente a Farroupilha. ...Para isso, examino, por um lado, como a fonte se articula com a historiografia da sua época e, por outro lado, como a fonte articula a historiografia e as questões políticas e de identidade. Para dar conta do objetivo, a metodologia utilizada para analisar a fonte é a operação historiográfica de Michel de Certeau. A hipótese que norteia o artigo diz respeito a nacionalização da história regional no período de 1940 a 1960. Por fim, constato que a fonte/obra analisada foi um objeto tanto de luta política como de uma escrita da história em que a Farroupilha é o ápice da brasilidade da identidade do sul-rio-grandense.
To analyze possible clinical-pathological parameters and predictors of lymph node metastasis and evaluate the impact of lymphadenectomy in the survival of these patients.A retrospective study of ...patients diagnosed with penile cancer and submitted to regional lymphadenectomy at two reference hospitals in Maranhão, Northeast, Brazil, an area where the disease has a high incidence. We described here clinical and histopathological characteristics of patients diagnosed between January 2009 and September 2017.Fifty-five patients with an average age of 55.4 years (range: 25-84 years) were analyzed, with 24.4 months being the average time between the onset of symptoms and start of treatment. Among patients without palpable lymph nodes at the first examination, 51% were affected by inguinal metastasis. In the multivariate analysis, the presence of angiolymphatic invasion (P = .029) and absence of koilocytosis (P = .001) were found to be predictive factors for lymph node metastasis. Patients submitted to prophylactic lymphadenectomy presented with a disease-free period of 25.4 months (±5.81), whereas those who underwent therapeutic lymphadenectomy presented with a disease-free period of 19.9 months (±3.12).Angiolymphatic invasion and absence of koilocytosis appeared to be predictive factors for lymph node metastasis. Therefore, the submission of patients with metastatic risk to prophylactic lymphadenectomy may improve their survival. Thus, prophylactic lymphadenectomy in patients at risk for inguinal metastasis may create a positive impact in survival rates.
In a world rich in interconnected and complex data, the non-relational database paradigm can better handle large volumes of data at high speed with a scale-out architecture, which are two essential ...requirements for large industries and world-class applications. This article presents AMANDA, a flexible middleware for automatic migration between relational and non-relational databases based on a user-defined schema that offers support for multiple sources and target databases. We evaluate the performance of AMANDA by assessing the migration speed, query execution, query performance, and migration correctness, from two Relational Database Management Systems (RBMSs), i.e., Postgres and MySQL, to a non-relational database (NoSQL), i.e., DGpraph. The results show that AMANDA successfully migrates data 26 times faster than previous approaches, when considering Northwind. Regarding the IMDB database, it took 7 days to migrate 5.5 GB of data.
•Midnight plasma melatonin levels are lower in schizophrenia patients than in healthy controls.•Pineal gland enlarged calcifications are more prevalent in schizophrenia patients.•Pineal gland volume ...is apparently smaller in schizophrenia patients.•Melatonin therapy fosters slight improvements of sleep and of antipsychotic Sequels.•Treatment with low-dose melatonin is chronobiotically effective, but for antioxidant purposes higher doses are required.
Melatonin (MLT), the main hormone of the pineal gland (PG), is assumed to support initiation and maintenance of sleep, and a stable sleep-wake cycle, exerting antioxidative and neuroprotective actions. Evidence demonstrates that sleep and circadian rhythm abnormalities are very common in schizophrenia patients. Some imaging studies suggest structural abnormalities of the PG in these patients as well. We aimed to critically appraise the literature on PG imaging and melatonin secretion in schizophrenia patients, in comparison to matched healthy controls, and to review placebo-controlled trials of add-on exogenous MLT treatment in schizophrenia patients. In this systematic review, twenty-nine studies were included. Meta-analytical evaluation of data was possible only for MLT secretion finding that midnight plasma levels were significantly reduced in individuals with schizophrenia as compared to healthy controls (Hedge`s g = 1.32, p < 0.01). Imaging studies demonstrated greater prevalence of enlarged calcifications (>1 cm) of the PG (2 out of 2 computed tomography studies) and smaller PG volume (2 out of 3 magnetic resonance studies) compared with healthy controls. Anatomic and functional abnormalities of the PG were not associated with duration of illness or with treatment factors, maybe suggesting them to be primary characteristics of the disease and genetically based. Add-on MLT treatment leads to a modest improvement of objective and subjective sleep quality, of metabolic adverse effects of antipsychotics, and of tardive dyskinesia symptoms in schizophrenia patients. It remains to be established whether MLT treatment in prodromal phases of the disease could prevent neurostructural abnormalities.
O presente trabalho quer examinar como o lugar social, da operação historiográfica, se articula com a construção de sentido narrativa da historiografia. Duas fontes bibliográficas foram selecionadas ...para tal investigação. Ambas são de períodos históricos específicos. Uma fonte é A História da República Rio-Grandense lançada em 1882 de J. F. de Assis Brasil, a outra é O Sentido e o Espírito da Revolução Farroupilha, de J. P. Coelho de Souza, publicada pela primeira vez em 1936. Portanto, o problema que norteia o artigo é saber como cada lugar social distinto contribuiu, em épocas diferentes, a sua maneira para a construção de sentido da Farroupilha. Por fim, o artigo infere que a operacionalidade do lugar social de produção da historiografia foi decisiva como elemento da constituição de sentido das narrativas sobre a Farroupilha nas duas fontes analisadas.
O presente artigo examina como o capítulo Um certo capitão Rodrigo, do romance O tempo e o vento do literato Érico Verissimo, representa literariamente a história. Para isso examino, por um lado, ...como a fonte se articula com a historiografia da sua época e, por outro lado, como a fonte articula a historiografia e a literatura. Para dar conta do objetivo, a metodologia utilizada para analisar a fonte é a operação literária da história. A hipótese que norteia o artigo diz respeito a ligação intelectual de Verissimo com a historiografia do seu período. Por fim, constato que a fonte/obra analisada potencializa a representação da história pela literatura, como também, faz da escrita literária da história uma reflexão teórica sobre a historiografia.
Nonsyndromic orofacial clefts (NSOC) are the craniofacial most common congenital malformations. There are evidences that the nonsyndromic cleft palate (NSCP) development differs from other NSOC. ...However, most of the publications treat NSCP without considering that information. Furthermore, few studies focus on NSCP. The aim of this study was to describe epidemiological findings of patients with isolated NSCP in Brazil.
In this cross-sectional multicenter study, four reference Centers for treatment in three different Brazilian states was investigated. Data were obtained from clinical records of patients, between November 2021 and June 2022. Researched variables were sociodemographic, clinical characteristics and pregnancy and family history. Pearson's chi-square and ANOVA One-way tests were used for associations.
Majority were female (58.1%), white (60.7%) with incomplete NSCP (61.2%). There was an association between complete NSCP and a positive history of medical problems during pregnancy (p = 0.016; 27.9%; OR: 1.94; 1.12-3.35). Systemic alterations were perceived in 40.6% of the sample with odds ratio for development of the complete type (OR: 1.21; 0.74-1.97). Higher OR was visualized in medication use during pregnancy (OR: 1.35; 0.76-2.37) and positive family history of oral cleft (OR: 1.44; 0.80-2.55). Dental and surgical care was associated with higher age groups (p < 0.050).
NSCP was most prevalent in white skin color female. Complete NSCP is associated with medical problems during pregnancy. Medication use during pregnancy and positive family history of oral cleft increase the chance of developing complete NSCP.
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