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zadetkov: 60
1.
  • Disruption of a self-amplif... Disruption of a self-amplifying catecholamine loop reduces cytokine release syndrome
    Staedtke, Verena; Bai, Ren-Yuan; Kim, Kibem ... Nature, 12/2018, Letnik: 564, Številka: 7735
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    Cytokine release syndrome (CRS) is a life-threatening complication of several new immunotherapies used to treat cancers and autoimmune diseases . Here we report that atrial natriuretic peptide can ...
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Dostopno za: UL

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2.
  • Molecular targeting of glio... Molecular targeting of glioblastoma: Drug discovery and therapies
    Bai, Ren-Yuan; Staedtke, Verena; Riggins, Gregory J Trends in molecular medicine, 06/2011, Letnik: 17, Številka: 6
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    Despite advances in treatment for glioblastoma multiforme (GBM), patient prognosis remains poor. Although there is growing evidence that molecular targeting could translate into better survival for ...
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Dostopno za: UL

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3.
  • Feasibility of using NF1-GR... Feasibility of using NF1-GRD and AAV for gene replacement therapy in NF1-associated tumors
    Bai, Ren-Yuan; Esposito, Dominic; Tam, Ada J ... Gene therapy, 06/2019, Letnik: 26, Številka: 6
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    Neurofibromatosis type 1, including the highly aggressive malignant peripheral nerve sheath tumors (MPNSTs), is featured by the loss of functional neurofibromin 1 (NF1) protein resulting from genetic ...
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4.
  • Antiparasitic mebendazole s... Antiparasitic mebendazole shows survival benefit in 2 preclinical models of glioblastoma multiforme
    Bai, Ren-Yuan; Staedtke, Verena; Aprhys, Colette M ... Neuro-oncology, 09/2011, Letnik: 13, Številka: 9
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    Glioblastoma multiforme (GBM) is the most common and aggressive brain cancer, and despite treatment advances, patient prognosis remains poor. During routine animal studies, we serendipitously ...
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5.
  • Brain Penetration and Effic... Brain Penetration and Efficacy of Different Mebendazole Polymorphs in a Mouse Brain Tumor Model
    Bai, Ren-Yuan; Staedtke, Verena; Wanjiku, Teresia ... Clinical cancer research, 08/2015, Letnik: 21, Številka: 15
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    Mebendazole (MBZ), first used as an antiparasitic drug, shows preclinical efficacy in models of glioblastoma and medulloblastoma. Three different mebendazole polymorphs (A, B, and C) exist, and a ...
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Dostopno za: CMK, UL

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6.
  • Gene-targeted therapy for n... Gene-targeted therapy for neurofibromatosis and schwannomatosis: The path to clinical trials
    Staedtke, Verena; Anstett, Kara; Bedwell, David ... Clinical trials, 02/2024, Letnik: 21, Številka: 1
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    Numerous successful gene-targeted therapies are arising for the treatment of a variety of rare diseases. At the same time, current treatment options for neurofibromatosis 1 and schwannomatosis are ...
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Dostopno za: UL
7.
  • Alpha-1 adrenergic receptor... Alpha-1 adrenergic receptor antagonists to prevent hyperinflammation and death from lower respiratory tract infection
    Koenecke, Allison; Powell, Michael; Xiong, Ruoxuan ... eLife, 06/2021, Letnik: 10
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    In severe viral pneumonia, including Coronavirus disease 2019 (COVID-19), the viral replication phase is often followed by hyperinflammation, which can lead to acute respiratory distress syndrome, ...
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8.
  • OTX2 Represses Myogenic and... OTX2 Represses Myogenic and Neuronal Differentiation in Medulloblastoma Cells
    BAI, Ren-Yuan; STAEDTKE, Verena; LIDOV, Hart G ... Cancer research, 11/2012, Letnik: 72, Številka: 22
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    The brain development transcription factor OTX2 is overexpressed and/or genomically amplified in most medulloblastomas, but the mechanistic basis for its contributions in this setting are not ...
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9.
  • Preventative Effect of Mebe... Preventative Effect of Mebendazole against Malignancies in Neurofibromatosis 1
    Staedtke, Verena; Gray-Bethke, Tyler; Riggins, Gregory J ... Genes, 07/2020, Letnik: 11, Številka: 7
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    Patients with RASopathy Neurofibromatosis 1 (NF1) are at a markedly increased risk of the development of benign and malignant tumors. Malignant tumors are often recalcitrant to treatments and ...
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10.
  • Podocalyxin-like protein is... Podocalyxin-like protein is expressed in glioblastoma multiforme stem-like cells and is associated with poor outcome
    Binder, Zev A; Siu, I-Mei; Eberhart, Charles G ... PloS one, 10/2013, Letnik: 8, Številka: 10
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    Glioblastoma multiforme (GBM) is the most common primary malignant adult brain tumor and is associated with poor survival. Recently, stem-like cell populations have been identified in numerous ...
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Dostopno za: UL

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zadetkov: 60

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