We perform three-dimensional hydrodynamic simulations of a moving substructure in a cluster of galaxies. We investigate dynamical evolution of the intracluster medium (ICM) in and around the ...substructure moving radially in the larger cluster's gravitational potential, and its observational consequences. After the substructure passes the larger cluster's center, a bow shock and clear contact discontinuity form in front of it. The contact discontinuity looks like a sharp cold front in the X-ray image synthesized from the simulation results. This agrees with a structure found in 1E 0657-56. The flow structure remains laminar before the first turnaround because the ram pressure stripping is dominant over the development of Kelvin-Helmholtz instabilities on the boundary between the substructure and the ambient ICM. When a subcluster oscillates radially around the larger cluster's center, both Kelvin-Helmholtz and Rayleigh-Taylor instabilities develop well and the flow structure becomes highly turbulent. Around the turnaround, the subcluster's cold gas is pushed out of its potential well. Therefore, the cold gas component appears to be in front of the subcluster. A relatively blunt cold front appears in the simulated X-ray image because the contact discontinuity is perturbed by Rayleigh-Taylor instabilities. This can explain the ICM structure found in A168.
The last decade has seen a marked shift in how the internal structure of hadrons is understood. Modern experimental facilities, new theoretical techniques for the continuum bound-state problem and ...progress with lattice-regularised QCD have provided strong indications that soft quark+quark (diquark) correlations play a crucial role in hadron physics. For example, theory indicates that the appearance of such correlations is a necessary consequence of dynamical chiral symmetry breaking, viz. a corollary of emergent hadronic mass that is responsible for almost all visible mass in the universe; experiment has uncovered signals for such correlations in the flavour-separation of the proton’s electromagnetic form factors; and phenomenology suggests that diquark correlations might be critical to the formation of exotic tetra- and penta-quark hadrons. A broad spectrum of such information is evaluated herein, with a view to consolidating the facts and therefrom moving toward a coherent, unified picture of hadron structure and the role that diquark correlations might play.
Background:Intra-articular injection of hyaluronan (HA) has been suggested to have a disease-modifying effect in osteoarthritis, but little is known about the possible mechanisms.Objective:To ...investigate the effects of HA species of different molecular mass, including 800 kDa (HA800) and 2700 kDa (HA2700), on the expression of aggrecanases (ie, ADAMTS species), which play a key role in aggrecan degradation.Methods:The effects of HA species on the expression of ADAMTS1, 4, 5, 8, 9 and 15 in interleukin 1α (IL1α)-stimulated osteoarthritic chondrocytes were studied by reverse transcription PCR and real-time PCR. Expression of ADAMTS4 protein and aggrecanase activity and signal transduction pathways of IL1, CD44 and intracellular adhesion molecule 1 (ICAM1) were examined by immunoblotting.Results:IL1α treatment of chondrocytes induced ADAMTS4, and HA800 and HA2700 significantly decreased IL1α-induced expression of ADAMTS4 mRNA and protein. IL1α-stimulated aggrecanase activity in osteoarthritic chondrocytes was reduced by treatment with HA2700 or transfection of small interfering RNA for ADAMTS4. A similar result was obtained when HA2700 was added to explant cultures of osteoarthritic cartilage. HA2700 neither directly inhibited nor bound to ADAMTS4. Downregulation of ADAMTS4 expression by HA2700 was attenuated by treatment of IL1α-treated chondrocytes with antibodies to CD44 and/or ICAM1. The increased phosphorylation of IL1 receptor-associated kinase-1 and extracellular signal-regulated protein kinase1/2 induced by the IL1α treatment was downregulated by enhanced IRAK-M expression after HA2700 treatment.Conclusion:These data suggest that HA2700 suppresses aggrecan degradation by downregulating IL1α-induced ADAMTS4 expression through the CD44 and ICAM1 signalling pathways in osteoarthritic chondrocytes.
Parkinson disease is related to neurodegeneration and iron deposition in the substantia nigra pars compacta and nigrosome 1. However, visualization of nigrosome 1 via MR imaging is poor owing to the ...bilateral asymmetry, regardless of whether it is healthy. We focused on the magic angle and susceptibility effect and evaluated the anatomic slant structure of nigrosome 1 by tilting subjects' heads in the B
direction.
To investigate the effectiveness of the magic angle, we tilted the volunteers' heads to the right and left in the B
direction or not at all for evaluating correlations between the degree of head tilting and visualization of the right nigrosome 1 and left nigrosome 1 using 3D spoiled gradient-echo sequences with multiecho acquisitions. We evaluated the susceptibility of nigrosome 1 and the local field using quantitative susceptibility mapping to assess static magnetic field inhomogeneity.
The heads tilted to the right and left showed significantly higher contrasts of nigrosome 1 and the substantia nigra pars compacta than the nontilted heads. No significant differences were observed in the visualization and susceptibility between the right nigrosome 1 and left nigrosome 1 for each head tilt. The effect of the magic angle was remarkable in the nontilted heads. This finding was supported by quantitative susceptibility mapping because the anatomic slant structure of nigrosome 1 was coherent between the axis of nigrosome 1 and the magic angle.
The asymmetric visualization of nigrosome 1 is affected by the magic angle and susceptibility. The anatomic slant structure of nigrosome 1 causes these challenges in visualization.
Double-wall carbon nanotubes (DWNTs) were prepared in quantitative amount from the chains of C
60 molecules generated inside single-wall carbon nanotubes (SWNTs). The C
60 molecules inside the SWNT ...unchange up to ∼800°C without dedoping. Further heating at ∼1200°C induces the coalescence between C
60 and eventually the C
60 molecules transform into a tubular structure. The DWNTs thus prepared show radial breathing mode (RBM) Raman scattering associated with inner tubes as well as those from parent outer tubes, which are all explained by a model of diameter pairing in DWNT with an inner tube diameter smaller by 0.71±0.05 nm than an outer one.
We perform a weak-lensing study of the nearby cool-core galaxy clusters, Hydra A (z = 0.0538) and A478 (z = 0.0881), of which the brightest cluster galaxies (BCGs) host the powerful activities of ...active galactic nuclei (AGNs). For each cluster, the observed tangential shear profile is described well by either a single Navarro–Frenk–White model or a two-component model including the BCG as an unresolved point mass. For A478, we determine the BCG and its host-halo masses from a joint fit to weak-lensing and stellar photometry measurements. We find that the choice of initial mass functions (IMFs) can introduce a factor of 2 uncertainty in the BCG mass, whereas the BCG host-halo mass is constrained well by data. We perform a joint analysis of the weak-lensing and stellar kinematics data available for the Hydra A cluster, which allows us to constrain the central mass profile without assuming specific IMFs. We find that the central mass profile (r < 300 kpc) determined from the joint analysis is in excellent agreement with those from independent measurements, including dynamical masses estimated from the cold gas disc component, X-ray hydrostatic total mass estimates, and the central stellar mass estimated with the Salpeter IMF. The observed dark matter fraction around the BCG for Hydra A is found to be smaller than those predicted by adiabatic contraction models, suggesting the importance of other physical processes, such as AGN feedback and/or dissipationless mergers.
The aim of this study was to examine anatomical properties of the adductor magnus through a detailed classification, and to hypothesize its function and size to gather enough information about ...morphology. Ten cadaveric specimens of the adductor magnus were used. The muscle was separated into four portios (AM1–AM4) based on the courses of the corresponding perforating arteries, and its volume, muscle length, muscle fiber length and physiological cross‐sectional area were assessed. The architectural characteristics of these four portions of the adductor magnus were then classified with the aid of principal component analysis. The results led us into demarcating the most proximal part of the adductor magnus (AM1) from the remaining parts (AM2, AM3, and AM4). Classification of the adductor magnus in terms of architectural characteristics differed from the more traditional anatomical distinction. The AM2, AM3, and AM4, having longer muscle fiber lengths than the AM1, appear to be designed as displacers for moving the thigh through a large range of motion. The AM1 appears instead to be oriented principally toward stabilizing the hip joint. The large mass of the adductor magnus should thus be regarded as a complex of functionally differentiable muscle portions.
We present the results from Suzaku observations of the Perseus Cluster, which is relatively close, the brightest in the X-ray sky, and a relaxed object with a cool core. A number of exposures of ...central regions and offset pointing with the X-ray Imaging Spectrometer cover a region within radii of 20'-30'. The central data are used to evaluate the instrumental energy-scale calibration with accuracy confirmed to within around 300 km s super(-1) by the spatial and temporal variation of the instruments. These deep and well-calibrated data are used to measure X-ray redshifts of the intracluster medium. A hint of gas bulk motion, with radial velocity of about -(150-300) km s super(-1) relative to the main system, was found at 2'-4' (45-90 kpc) west of the cluster center, where an X-ray excess and a cold front were found previously. No other velocity structure was discovered. Over spatial scales of 50-100 kpc and within 200 kpc radii of the center, the gas-radial-velocity variation is below 300 km s super(-1), while over scales of 400 kpc within 600 kpc radii, the variation is below 600 km s super(-1). These X-ray redshift distributions are compared spatially with those of optical member galaxies for the first time in galaxy clusters. Based on X-ray line widths, gas turbulent velocities within these regions are also constrained within 1000-3000 km s super(-1). These results of gas dynamics in the core and larger scales in association with cluster merger activities are discussed, and the future potential of high-energy resolution spectroscopy with ASTRO-H is considered.
Recent developments in the literature on Employment Protection Legislation (EPL) have revealed that changing the stringency of employment protection can lead to extensive consequences outside the ...labour market, by affecting firms' production decisions or workers' commitment levels. This article provides the first empirical evaluation of the comprehensive effect of restrictions on firing employees in Japan, by exploiting the variations in court decisions. We find that judgements lenient to workers significantly reduce firms' total-factor productivity growth rate. The effect on capital is mixed and inconclusive, although we obtain modest evidence that an increase in firing costs induces a negative scale effect on capital inputs.
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