We introduce a fast and robust spatial-spectral encoding method, which enables acquisition of high resolution short echo time (13 ms) proton spectroscopic images from human brain with acquisition ...times as short as 64 s when using surface coils. The encoding scheme, which was implemented on a clinical 1.5 Tesla whole body scanner, is a modification of an echo-planar spectroscopic imaging method originally proposed by Mansfield Magn. Reson. Med. 1, 370-386 (1984), and utilizes a series of read-out gradients to simultaneously encode spatial and spectral information. Superficial lipid signals are suppressed by a novel double outer volume suppression along the contours of the brain. The spectral resolution and the signal-to-noise per unit time and unit volume from resonances such as N-acetyl aspartate, choline, creatine, and inositol are comparable with those obtained with conventional methods. The short encoding time of this technique enhances the flexibility of in vivo spectroscopic imaging by reducing motion artifacts and allowing acquisition of multiple data sets with different parameter settings.
The Author reports 2 cases presenting vertebro-basilar insufficiency. In the first one, surgery was interrupted due to the hyperflexed positioning of the head which caused cardiorespiratory disorders ...and increased vertebro-basilar insufficiency. In the second case the patient, placed in a different position, survived the operation. The postoperative angiographic control confirmed the disobstruction of the vertebral flow at the level of the malformation. Electromyography detected the presence of innervation of tongue muscles.
L-Aspartate oxidase is a flavoprotein catalyzing the first step in the de novo biosynthesis of pyridine nucleotides in E. coli. Binding of FAD to L-aspartate oxidase is relatively weak (K(d) 6.7 x ...10(-7) M), resulting in partial loss of the coenzyme under many experimental conditions. Only the three-dimensional structure of the apo-enzyme has been obtained so far. In order to probe the flavin-binding site of the enzyme, apo-L-aspartate oxidase has been reacted with N6-(6-carboxyhexyl)-FAD succinimidoester. The structural characterization of the resulting N6-(6-carbamoylxyhexyl)FAD-L-aspartate oxidase shows the covalent incorporation of 1 FAD-analog/monomer. Residue Lys38 was identified as the target of the covalent modification. N6-(6-carbamoylxyhexyl)-FAD-L-aspartate oxidase shows only 2% catalytic activity as compared to the native enzyme. Comparison of some properties of the flavinylated and native enzymes suggests that, although the flavin is covalently bound to the former in the region predicted from molecular modeling studies, the microenvironment around the isoallossazine is different in the two forms.
The cases of 35 cervical spondylotic myelopathy patients exhibiting areas of high signal intensity within the cervical cord on T2 and proton density weighted MR images were reviewed. In each case, ...the ratio of the anteroposterior diameter to the transverse diameter (anteroposterior compression ratio or APCR) at the most compressed segment of the cervical cord was measured on axial MR images and compared with the patient's neurological status. The patients with APCR of 40% or more had a better neurological condition than those with APCR of 38% or less. At the same time, the neurological condition was worse in the patients with APCR of 10% or less than in those with APCR of 15% or more. All patients underwent surgery. The preoperative APCR was compared with the outcomes. The patients with preoperative APCR of 15% or more improved after the operation, but the degree of recovery varied considerably from case to case. The patients with preoperative APCR of 10% or less remained unchanged postoperatively.
Interstitial myocarditis in children TEDESCHI, C G; STEVENSON, Jr, T D
The New England journal of medicine,
1951-Mar-08, Letnik:
244, Številka:
10
Journal Article
Posttraumatic Growth Tedeschi, Richard G
Military Psychologists' Desk Reference,
07/2013
Book Chapter
Posttraumatic growth is the process by which survivors of trauma recognize important positive personal transformations in the aftermath of traumatic events, yielding five types of changes. Expert ...companions can help to facilitate this process. These concepts are described in the context of combat trauma.
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