Dissolved organic matter (DOM) exists ubiquitously in environments and plays critical roles in pollutant mitigation, transformation, and organic geochemical cycling. Understanding its properties and ...environmental behaviors is critically important to develop water treatment processes and environmental remediation strategies. Generalized two-dimensional correlation spectroscopy (2DCOS), which has numerous advantages, including enhancing spectral resolution and discerning specific order of structural change under an external perturbation, could be used as a powerful tool to interpret a wide range of spectroscopic signatures relating to DOM. A suite of spectroscopic signatures, such as UV–vis, fluorescence, infrared, and Raman spectra that can be analyzed by 2DCOS, is able to provide additional structural information hiding behind the conventional one-dimensional spectra. In this article, the most recent advances in 2DCOS applications for analyzing DOM-related environmental processes are reviewed, and the state-of-the-art novel spectroscopic techniques in 2DCOS are highlighted. Furthermore, the main limitations and requirements of current approaches for exploring DOM-related environmental processes and how these limitations and drawbacks can be addressed are explored. Finally, suggestions and new approaches are proposed to significantly advance the development of 2DCOS in analyzing the properties and behaviors of DOM in natural and engineered environments.
Bioremediation is a process mediated by microorganisms and represents a sustainable and eco-friendly way to degrade and detoxify environmental contaminants. Soil microbiomes clearly become a key ...component of bioremediation as they are more stable and efficient than pure cultures, being recognized as one of the scientific frontiers of the soil environmental science and technology fields. Recently, many advancements have been made regarding the investigation of remediation mechanisms by soil microbiomes and the interactions inside them. This has greatly expanded our ability to characterize the remediating function of soil microbiomes and identify the factors that influence their efficiency for remediation. Here, we suggest that soil microbiomes are a promising strategy for soil remediation. Research is now needed to identify how we can manipulate and manage soil microbiomes to improve remediation efficiency and increase soil fertility at the same time. Therefore, this review aims to emphasize the importance of soil microbiomes in bioremediation and promote further development of this strategy into a widely accepted technique.
The concentrations of six priority phthalic acid esters (PAEs) in intensively managed suburban vegetable soils in Nanjing, east China, were analyzed using gas chromatography–mass spectrometry ...(GC–MS). The total PAE concentrations in the soils ranged widely from 0.15 to 9.68 mg kg−1 with a median value of 1.70 mg kg−1, and di-n-butyl phthalate (DnBP), bis-(2-ethylhexyl) phthalate (DEHP) and di-n-octyl phthalate (DnOP) were the most abundant phthalate esters. Soil PAE concentrations depended on the mode of use of plastic film in which PAEs were incorporated as plasticizing agents and both the plastic film and poultry manure appeared to be important sources of soil PAEs. Vegetables in rotation with flooded rice led to lower concentrations of PAEs in soil. The results indicate that agricultural plastic film can be an important source of soil PAE contamination and further research is required to fully elucidate the mechanisms of PAE contamination of intensive agricultural soils with different use modes of use of plastic film.
•Phthalate esters in soils from suburban intensive vegetable production systems were investigated.•Phthalate levels and risks of the vegetable soils with different plastic film use modes were examined.•Sources of phthalate esters in vegetable production soils were analyzed.
PAE contamination of intensively managed vegetable soils varied widely depending on the mode of use of plastic film in different production systems.
Resveratrol (RSV) is a natural extract that has been extensively studied for its significant anti-inflammatory and antioxidant effects, which are closely associated with a variety of injurious ...diseases and even cosmetic medicine. In this review, we have researched and summarized the role of resveratrol and its different forms of action in wound healing, exploring its role and mechanisms in promoting wound healing through different modes of action such as hydrogels, fibrous scaffolds and parallel ratio medical devices with their anti-inflammatory, antioxidant, antibacterial and anti-ageing properties and functions in various cells that may play a role in wound healing. This will provide a direction for further understanding of the mechanism of action of resveratrol in wound healing for future research.
The incidence of acute and chronic wound diseases is rising due to various reasons. With complicated pathogenesis, long course, difficult treatment and high disability, wound diseases have become a ...major burden for patients, their families, and society. Therefore, the focus of research is to identify new ideas and methods for treatment. Fat grafting has gained increased attention because of its effectiveness in wound treatment, and further analysis has uncovered that the stem cells derived from fat may be the main factor affecting wound healing. We summarize the function of adipose stem cells and analyze their possible mechanisms in tissue repair, helping to provide new ideas for the treatment of wound healing.
Herein, a summary of the function of adipose stem cells and their possible mechanisms in tissue repair, hoping to provide new ideas for the treatment of wound healing is presented.
Phthalate esters (PAEs) are suspected of having adverse effects on human health and have been frequently detected in soils and vegetables. The present study investigated their occurrence and ...composition in plastic film greenhouse soil–vegetable systems and assessed their potential health risks to farmers exposed to these widespread pollutants. Six priority control phthalates, namely dimethyl phthalate (DMP), diethyl phthalate (DEP), di-n-butyl phthalate (DnBP), butyl benzyl phthalate (BBP), di-(2-ethylhexyl) phthalate (DEHP) and di-n-octyl phthalate (DnOP), were determined in 44 plastic film greenhouse vegetables and corresponding soils. Total PAEs ranged from 0.51 to 7.16mgkg−1 in vegetables and 0.40 to 6.20mgkg−1 in soils with average concentrations of 2.56 and 2.23mgkg−1, respectively. DnBP, DEHP and DnOP contributed more than 90% of the total PAEs in both vegetables and soils but the proportions of DnBP and DnOP in vegetables were significantly (p<0.05) higher than in soils. The average concentrations of PAEs in pot herb mustard, celery and lettuce were >3.00mgkg−1 but were <2.50mgkg−1 in the corresponding soils. Stem and leaf vegetables accumulated more PAEs. There were no clear relationships between vegetable and soil PAEs. Risk assessment indicates that DnBP, DEHP and DnOP exhibited elevated non-cancer risk with values of 0.039, 0.338 and 0.038, respectively. The carcinogenic risk of DEHP was about 3.94×10−5 to farmers working in plastic film greenhouses. Health risks were mainly by exposure through vegetable consumption and soil ingestion.
•We concurrently study phthalate esters (PAEs) in vegetables and soils in greenhouses of China.•We found that PAEs concentrations had no significant correlation between soil and vegetable.•PAEs had a potential carcinogenic risk to farmers working in greenhouses.
There are growing trends of combined contaminations in agricultural soils, and therefore it is urgently needed to remediate contaminated soils with eco-friendly approaches. This study aimed to ...evaluate the effects of Medicago sativa L. (alfalfa) planting, alone or together with biochar additions, on contaminant removals and bacterial properties in an agricultural soil contaminated by heavy metal and organic fungicide. The treatments in this study included: the control (CK), alfalfa planting (AP), alfalfa planting +1.5% biochar addition (w/w) (AP + 1.5B), alfalfa planting +3.0% biochar addition (AP + 3.0B), and alfalfa planting +6.0% biochar addition (AP + 6.0B). Relative to the alfalfa planting only, extra biochar additions increased alfalfa biomass and heavy metal cadmium (Cd) phytoextraction. The alfalfa planting, alone or together with biochar additions, significantly decreased soil iprodione concentrations. After 90 days of remediation, bacterial 16S rRNA gene abundances of the AP, AP + 1.5B, AP + 3.0B and AP + 6.0B treatments were 1.69, 3.84, 3.34 and 3.13 times as great as that obtained from the CK treatment, respectively. The AP + 1.5B treatment had the highest richness estimators and Shannon diversity index, but the AP + 6.0B treatment had the lowest invsimpson diversity index among the five treatments. The relative abundances of Bacteroidetes and Nitrospirae were enhanced by the alfalfa phytoremediation, alone or together with biochar additions. Our results suggest that the alfalfa has promising potentials in the remediation of co-contaminated soil and in the increases of soil bacterial biomass and community diversity. Simultaneously, biochar is beneficial to enhance Cd phytoextraction, however, biochar addition rate would need to be optimized.
The alfalfa, alone or together with the biochar addition, has promising potentials in the remediation of co-contaminated soil and in the increase of soil bacterial biomass. Biochar is beneficial to enhance phytoremediation performance, however, biochar addition rates would need to be optimized. Display omitted
•Relative to alfalfa planting only, biochar additions increased Cd phytoextraction•Alfalfa planting with/without biochar decreased soil iprodione concentrations•Soil bacterial biomass was increased by alfalfa planting with/without biochar.•Biochar addition at a higher rate tended to decrease bacterial community diversity•Alfalfa with/without biochar positively stimulated Bacteroidetes and Nitrospirae
Disturbances or defects in the process of wound repair can disrupt the delicate balance of cells and molecules necessary for complete wound healing, thus leading to chronic wounds or fibrotic scars. ...Myofibroblasts are one of the most important cells involved in fibrotic scars, and reprogramming provides a potential avenue to increase myofibroblast clearance. Although myofibroblasts have long been recognized as terminally differentiated cells, recent studies have shown that myofibroblasts have the capacity to be reprogrammed into adipocytes. This review intends to summarize the potential of reprogramming myofibroblasts into adipocytes. We will discuss myofibroblast lineage tracing, as well as the known mechanisms underlying adipocyte regeneration from myofibroblasts. In addition, we investigated different changes in myofibroblast gene expression, transcriptional regulators, signalling pathways and epigenetic regulators during skin wound healing. In the future, myofibroblast reprogramming in wound healing will be better understood and appreciated, which may provide new ideas for the treatment of scarless wound healing.
The loss of dermal white adipose tissue (dWAT) is vital to the formation of dermal fibrosis (DF), but the specific mechanism is not well understood. A few studies are reviewed to explore the role of ...dWAT in the formation of DF. Recent findings indicated that the adipocytes‐to‐myofibroblasts transition in dWAT reflects the direct contribution to the DF formation. While adipose‐derived stem cells (ADSCs) contained in dWAT express antifibrotic cytokines, the loss of ADSCs leads to skin protection decreased, which indirectly exacerbates DF and tissue damage. Therefore, blocking or reversing the adipocytes‐to‐myofibroblasts transition or improving the survival of ADSCs in dWAT and the expression of antifibrotic cytokines may be an effective strategy for the treatment of DF.
The loss of adipocytes in dermal white adipose tissue (dWAT) reflects the direct contribution to dermal fibrosis. While the loss of adipose‐derived stem cells (ADSCs) in dWAT reflect indirect contribution to the development of DF. The loss of dWAT was accompanied with ADSCs paracrine antifibrosis function reduced.
Bone remodeling is a continuous process that maintains the homeostasis of the skeletal system, and it depends on the homeostasis between bone-forming osteoblasts and bone-absorbing osteoclasts. A ...large number of studies have confirmed that the Smad signaling pathway is essential for the regulation of osteoblastic and osteoclastic differentiation during skeletal development, bone formation and bone homeostasis, suggesting a close relationship between Smad signaling and bone remodeling. It is known that Smads proteins are pivotal intracellular effectors for the members of the transforming growth factor-β (TGF-β) and bone morphogenetic proteins (BMP), acting as transcription factors. Smad mediates the signal transduction in TGF-β and BMP signaling pathway that affects both osteoblast and osteoclast functions, and therefore plays a critical role in the regulation of bone remodeling. Increasing studies have demonstrated that a number of Smad signaling regulators have potential functions in bone remodeling. Therefore, targeting Smad dependent TGF-β and BMP signaling pathway might be a novel and promising therapeutic strategy against osteoporosis. This article aims to review recent advances in this field, summarizing the influence of Smad on osteoblast and osteoclast function, together with Smad signaling regulators in bone remodeling. This will facilitate the understanding of Smad signaling pathway in bone biology and shed new light on the modulation and potential treatment for osteoporosis.
PDF
