School of Medicine, Kumamoto University Antibacterial activities of carbenicillin (CB-PC) were examined in vitro against gram negative bacilli in comparison with those of ampicillin (AB-PC) and ...gentamicin (GM). Serum level was studied following an intramuscular dose of CB-PC 1 g, and some clinical assessments also performed. 1) Antibacterial activity: CB-PC was superior against Proteus mirabilis to the other two, and GM was the best against both E. coli and Pseudomonas aeruginosa. 2) Serum level: The maximum level of 20-25 m cg/ml reached at 1 hour following an intramuscular dose of CB-PC 1 g may suggest its clinical effectiveness against infections caused by Proteus mirabilis and/or E. coll. 3) Clinic al trial: Three of the four patients given CB-PC showed favorable response to CB-PC. No noticeable side-reactions were encountered but for local pain at the site of injection.
Compound I-XVI were isolated from the water-extractive of Cinnamomi Cortex (Cinnamomum cassia Blume), which exhibits anti-complement activity. Among of them, the structures of I-VIII, XI and XII were ...clarified on the basis of chemical and spectral evidences. I and II were identified respectively as Cinnzeylanine and Cinnzeylanol, which are unique diterpenoides being highly oxygenated, namely the ones of Ryanodine type. III and IV were proved to be dehydrated compounds resp. of I and II. V and XI were evidenced to be 19-hydroxylated compounds correponding to IV and II, resp. Furthermore, VI and XII were decided to be 19-0-monoglucosides resp. of V and XI. The structure of VII was substantiated by X-ray crystallographic analysis. VII and VIII include eight-membered ring carring two ketone functions in each molecule and seem probably to be derived from XI and II, resp., via glycol fission between C-7 and C-8 in plant.