Kisspeptin is involved in the control of human reproduction bridging the gap between the sex steroid levels and feedback mechanisms that control the gonadotropin releasing hormone (GnRH) secretion; ...however, studies considering this peptide and infertility are limited. We conducted a review and critical assessment of available evidence considering kisspeptin structure, physiology, function in puberty and reproduction, its role in assisted reproduction treatments, kisspeptin dosage and the impact on KISS1 and GPR54 genes. Literature searches were conducted in PubMed using keywords related to: (i) kisspeptin or receptors, kisspeptin-1 (ii) reproduction or infertility or fertility (iii) gene and (iv) dosage or measurement or quantification or serum level, in human. Kisspeptin is a product of KISS1 gene that binds to a G-protein-coupled receptor (GPR54/KISS1R) stimulating the release of GnRH by hypothalamic neurons, leading to secretion of pituitary gonadotropins (LH and FSH) and sexual steroids, which in turn will act in the gonads to produce the gametes. Kisspeptin is being recognized as a crucial regulator of the onset of puberty, the regulation of sex hormone mediated secretion of gonadotropins, and the control of fertility. Inactivating and activating mutations in both KISS1 or GPR54 genes were associated with hypogonadotropic hypogonadism and precocious puberty. Despite this, studies considering kisspeptin and infertility are scarce. The understanding of the role of kisspeptin may lead to its use as a biomarker in infertility treatments and use in controlled ovarian hyperstimulation.
We perform a spectroscopic study to constrain the stellar initial mass function (IMF) by using a large sample of 24 781 early-type galaxies from the Sloan Digital Sky Survey-based Spheroids ...Panchromatic Investigation in Different Environmental Regions survey. Clear evidence is found of a trend between IMF and central velocity dispersion (σ0), evolving from a standard Kroupa/Chabrier IMF at σ0 ∼ 100 km s−1 towards a more bottom-heavy IMF with increasing σ0, becoming steeper than the Salpeter function at σ0 220 km s−1. We analyse a variety of spectral indices, combining gravity-sensitive features, with age- and metallicity-sensitive indices, and we also consider the effect of non-solar abundance variations. The indices, corrected to solar scale by means of semi-empirical correlations, are fitted simultaneously with the (nearly solar-scaled) extended MILES (MIUSCAT) stellar population models. Similar conclusions are reached when analysing the spectra with a hybrid approach, combining constraints from direct spectral fitting in the optical with those from IMF-sensitive indices. Our analysis suggests that σ0, rather than α/Fe, drives the variation of the IMF. Although our analysis cannot discriminate between a single power-law (unimodal) IMF and a low-mass ( 0.5 M) tapered (bimodal) IMF, robust constraints can be inferred for the fraction in low-mass stars at birth. This fraction (by mass) is found to increase from ∼20 per cent at σ0 ∼ 100 km s−1, up to ∼80 per cent at σ0 ∼ 300 km s−1. However, additional constraints can be provided with stellar mass-to-light (M/L) ratios: unimodal models predict M/L significantly larger than dynamical M/L, across the whole σ0 range, whereas a bimodal IMF is compatible. Our results are robust against individual abundance variations. No significant variation is found in Na and Ca in addition to the expected change from the correlation between α/Fe and σ0.
Abstract A large evidence-based review on the effects of a moderate consumption of beer on human health has been conducted by an international panel of experts who reached a full consensus on the ...present document. Low-moderate (up to 1 drink per day in women, up to 2 in men), non-bingeing beer consumption, reduces the risk of cardiovascular disease. This effect is similar to that of wine, at comparable alcohol amounts. Epidemiological studies suggest that moderate consumption of either beer or wine may confer greater cardiovascular protection than spirits. Although specific data on beer are not conclusive, observational studies seem to indicate that low-moderate alcohol consumption is associated with a reduced risk of developing neurodegenerative disease. There is no evidence that beer drinking is different from other types of alcoholic beverages in respect to risk for some cancers. Evidence consistently suggests a J-shaped relationship between alcohol consumption (including beer) and all-cause mortality, with lower risk for moderate alcohol consumers than for abstainers or heavy drinkers. Unless they are at high risk for alcohol-related cancers or alcohol dependency, there is no reason to discourage healthy adults who are already regular light-moderate beer consumers from continuing. Consumption of beer, at any dosage, is not recommended for children, adolescents, pregnant women, individuals at risk to develop alcoholism, those with cardiomyopathy, cardiac arrhythmias, depression, liver and pancreatic diseases, or anyone engaged in actions that require concentration, skill or coordination. In conclusion, although heavy and excessive beer consumption exerts deleterious effects on the human body, with increased disease risks on many organs and is associated to significant social problems such as addiction, accidents, violence and crime, data reported in this document show evidence for no harm of moderate beer consumption for major chronic conditions and some benefit against cardiovascular disease.
ABSTRACT We present an extended morphometric system to automatically classify galaxies from astronomical images. The new system includes the original and modified versions of the CASGM coefficients ...(Concentration C1, Asymmetry A3, and Smoothness S3), and the new parameters entropy, H, and spirality . The new parameters A3, S3, and H are better to discriminate galaxy classes than A1, S1, and G, respectively. The new parameter captures the amount of non-radial pattern on the image and is almost linearly dependent on T-type. Using a sample of spiral and elliptical galaxies from the Galaxy Zoo project as a training set, we employed the Linear Discriminant Analysis (LDA) technique to classify EFIGI (Baillard et al. 4458 galaxies), Nair & Abraham (14,123 galaxies), and SDSS Legacy (779,235 galaxies) samples. The cross-validation test shows that we can achieve an accuracy of more than 90% with our classification scheme. Therefore, we are able to define a plane in the morphometric parameter space that separates the elliptical and spiral classes with a mismatch between classes smaller than 10%. We use the distance to this plane as a morphometric index (Mi) and we show that it follows the human based T-type index very closely. We calculate morphometric index Mi for ∼780k galaxies from SDSS Legacy Survey-DR7. We discuss how Mi correlates with stellar population parameters obtained using the spectra available from SDSS-DR7.
We describe the dynamics of Zika virus (ZIKV) infection in a man in his early 40s who developed fever and rash after returning from Haiti to Italy, in January 2016. Follow-up laboratory testing ...demonstrated detectable ZIKV RNA in plasma up to day 9 after symptom onset and in urine and saliva up to days 15 and 47, respectively. Notably, persistent shedding of ZIKV RNA was demonstrated in semen, still detectable at 181 days after onset.
We investigate how the stellar populations of the inner regions of the first and the second brightest group galaxies (respectively BGGs and SBGGs) vary as a function of magnitude gap, using a Sloan ...Digital Sky Survey-based sample of 550 groups with elliptical BGGs. The sample is complete in redshift, luminosity, and for ... up to 2.5 mag, and contains 59 large-gap groups (LGGs, with ... > 2.0 mag). We determine ages, metallicities, and star formation histories (SFHs) of BGGs and SBGGs using the STARLIGHT code with two different single stellar population models (which lead to important disagreements in SFHs), and also compute a/Fe from spectral indices. After removing the dependence with galaxy velocity dispersion or with stellar mass, there is no correlation with magnitude gap of BGG ages, metallicities, a/Fe, and SFHs. The lack of trends of BGG SFHs with magnitude gap suggests that BGGs in LGGs have undergone more mergers than those in small-gap groups, but these mergers are either dry or occurred at very high redshift, which in either case would leave no detectable imprint in their spectra. We show that SBGGs in LGGs lie significantly closer to the BGGs (in projection) than galaxies with similar stellar masses in normal groups, which appears to be a sign of the earlier entry of the former into their groups. Nevertheless, the stellar population properties of the SBGGs in LGGs are compatible with those of the general population of galaxies with similar stellar masses residing in normal groups. (ProQuest: ... denotes formulae/symbols omitted.)
Knowledge of how congenital Zika syndrome (CZS) impacts motor development of children longitudinally is important to guide management. The objective of the present study was to describe the evolution ...of gross motor function in children with CZS in a Rio de Janeiro hospital. In children with CZS without arthrogryposis or other congenital osteoarticular malformations who were followed in a prospective cohort study, motor performance was evaluated at two timepoints using the Gross Motor Function Classification System (GMFCS) and the Gross Motor Function Measurement test (GMFM-88). Among 74 children, at the baseline evaluation, the median age was 13 (8–24) months, and on follow-up, 28 (24–48) months. According to GMFCS at the second timepoint, 6 children were classified as mild, 11 as moderate, and 57 as severe. In the GMFM-88 assessment, children in the severe group had a median score of 10.05 in the baseline evaluation and a follow-up score of 12.40, the moderate group had median scores of 25.60 and 29.60, and the mild group had median scores of 82.60 and 91.00, respectively. Although a small developmental improvement was observed, the motor impairment of children was mainly consistent with severe cerebral palsy. Baseline motor function assessments were predictive of prognosis.
Abstract Background & Aims Proton pump inhibitors (PPI) have been associated with acute kidney injury (AKI) and recent studies suggest that they may be associated with the risk of chronic kidney ...disease (CKD). Methods We performed a retrospective analysis using the Stockholm creatinine measurements database, which contains information on diagnoses, dispensation claims, and laboratory test results for all citizens in the Stockholm region from 2007 through 2010. We identified new users of PPIs (n= 105305) and new users of H2 blockers (H2B; n= 9578); data on renal outcomes were collected for a median 2.7 years. The primary outcome was progression CKD, defined as doubling of creatinine or decrease in estimated glomerular filtration rate of 30% or more. Secondary outcomes were end-stage renal disease and acute kidney injury (AKI). Complete collection of repeated PPI and H2B dispensations at pharmacies in Sweden allowed modeling the time-dependent risk associated to cumulative PPI exposure. Results Users of PPIs, compared to users of H2Bs, had an increased risk for doubled levels of creatinine (1985 events; adjusted hazard ratio HR, 1.26; 95% CI, 1.05–1.51) and decrease in estimated glomerular filtration rate of 30% or more (11045 events; 1.26; 95% CI, 1.16–1.36). PPI use also associated with development of end-stage renal disease (HR, 2.40; 0.76–7.58) and AKI (HR, 1.30; 95% CI, 1.00–1.69). There was a graded association between cumulative exposure to PPIs and risk of CKD progression. This was not the case for cumulative H2B use. Conclusions Initiation of PPI therapy and cumulative PPI exposure associate with increased risk of CKD progression in a large, North European healthcare system. Although consistent, the association was modest in magnitude, and cannot exclude residual confounding.
ABSTRACT We investigated the stellar population properties of a sample of 1858 massive compact galaxies (MCGs) extracted from the Sloan Digital Sky Survey (SDSS). Motivated by previous results ...showing that older compact galaxies tend to have larger velocity dispersion at fixed stellar mass, we used the distance to the σe versus Re and M⋆ versus σe relations as selection criteria. We found that MCGs are old (≳10 Gyr), α-enhanced (α/Fe ∼ 0.2), and have solar to supersolar stellar metallicities. Metallicity increases with σe, while age and α/Fe do not vary significantly. Moreover, at fixed σe, metallicity and stellar mass are correlated. Compared with a control sample of typical quiescent galaxies, MCGs have, on average, lower metallicities than control sample galaxies (CSGs) of similar σe. For σe ≲ 225 km s−1, MCGs are older and more α-enhanced than CSGs, while for higher σe ages and α-enhancement are similar. The differences in age and α-enhancement can be explained by lower σe CSGs being an amalgam of quiescent galaxies with a variety of ages. The origin of the differences in metallicity, however, is not clear. Lastly, we compared the stellar mass within the region probed by the SDSS fibre finding that, at fixed fibre velocity dispersion, MCGs have lower stellar masses on average. Since the velocity dispersion is a tracer of the dynamical mass, this raises the possibility that MCGs have, on average, a bottom-heavier initial mass function or a larger dark matter fraction within the inner ∼1−2 kpc.
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