First results on
-dependence measurements in inclusive
meson production in
interactions (
, Al, Cu, Sn, and W) are presented at
GeV/
c
. The ratios of the differential cross sections of four of these ...nuclei to the differential cross section on aluminum were measured and the dependence of these cross sections on the atomic of the nucleus was studied. The measurements were carried out in the kinematic region of the Feynman variable
and transverse momentum
GeV/
c
.
mesons were detected in the decay mode
at the SPASCHARM experimental setup using negative charged beams at beamline 14 of the U-70 accelerator complex.
Drug rash with eosinophilia and systemic symptoms is a drug hypersensitivity reaction. Hepatitis and nephritis are the most common visceral manifestations. Myocarditis is important to recognise, ...given the high mortality rate. We describe a child with drug rash with eosinophilia and systemic symptoms and discuss the role of N-terminal pro-hormone of basic natriuretic peptide in early recognition of associated myocarditis.
Photoelectron yields of extruded scintillation counters with titanium dioxide coating and embedded wavelength shifting fibers read out by silicon photomultipliers have been measured at the Fermilab ...Test Beam Facility using 120 GeV protons. The yields were measured as a function of transverse, longitudinal, and angular positions for a variety of scintillator compositions, reflective coating mixtures, and fiber diameters. Timing performance was also studied. These studies were carried out by the Cosmic Ray Veto Group of the Mu2e collaboration as part of their R&D program.
CORE needle biopsy of orbital tumors Yarovoy, Andrey A.; Bulgakova, Evgeniya S.; Shatskikh, Anna V. ...
Graefe's archive for clinical and experimental ophthalmology,
08/2013, Letnik:
251, Številka:
8
Journal Article
Recenzirano
Background
In some orbital mass lesions, histology may be the only way to establish an accurate diagnosis. Core needle biopsy (CNB) is widely performed in oncology, and unlike fine needle aspiration ...biopsy (FNAB), it can provide sufficient tissue sample for histology and immunohistochemistry. The purpose of this study was to evaluate the usefulness and possible complications of CNB of orbital tumors.
Methods
Fifty orbital lesions from 46 patients (age: 2–84 years) were biopsied using 20-gauge and 18-gauge semi-automated needles; 11 procedures were performed under ultrasound guidance. All 50 samples received routine histopathological examination and immunohistochemical analysis.
Results
Specimens diagnostically sufficient for histological analysis were obtained in all biopsies. The histopathological diagnosis was established in 94 % of specimens: 30 tumors were malignant: lymphoma (20); rhabdomyosarcoma (six); lacrimal gland carcinoma (one); breast carcinoma metastasis (two); melanoma (one); three were benign; ten inflammatory; and four were orbital fibrosis. Three biopsies were nondiagnostic: two (lymphoma, angiofibroma) showed undetermined identification and one was a false-negative (lacrimal gland adenocarcinoma was misdiagnosed as fibrous tissue). The diagnoses were confirmed by excisional or incisional biopsy in 26 patients. The concordance rate in patients with a surgically confirmed diagnosis was 88 %. The sensitivity, specificity and accuracy for differentiating malignant from benign lesions were 94 %, 100 %, and 96 %, respectively. Two patients suffered complications: mild retrobulbar hematoma with no decreased visual acuity. There was no damage to the globe or optic nerve, motility disorder, or infection.
Conclusions
CNB of orbital mass lesions is a safe procedure that provides a sufficient amount of tissue for histology and immunohistochemistry, and may be useful for improving the quality of the pathological diagnosis of orbital tumors.
Relevance. There are many causes of spontaneous hemorrhage into the vitreous cavity. Sometimes spontaneous nontraumatic vitreous hemorrhage can be rhegmatogenous in nature, occurring as a result of a ...ruptured retinal vessel running through the site of a retinal tear. Usually, a patient with spontaneous nontraumatic vitreous hemorrhage is managed with a conservative approach, but it is questionable whether conservative management of patients with this pathology is advisable. Purpose. To evaluate the results of surgical treatment of patients with idiopathic, presumably rhegmatogenous vitreous hemorrhage. Material and methods. Surgical treatment of 10 patients diagnosed with idiopathic vitreous hemorrhage, presumably of rhegmatogenous nature, was performed and the results of treatment were evaluated. The best corrected visual acuity (BCVA) before treatment was on average 0.03. Slit lamp examination revealed dispersed vitreous hemorrhage into the vitreous body with a total obscuration of the posterior pole. According to B-scan data there was no retinal detachment in all cases. All patients underwent surgical treatment. Results. By the third month of follow-up after surgical treatment, visual acuity was 0.9±0.04 on average. B-scan data showed no pathology in all cases. Light sensitivity was 28.7±0.15 dB on average. Conclusion. If other obvious causes of vitreous hemorrhage are excluded, urgent surgical treatment is, in our opinion, the most preferable approach and can be recommended as a first line of treatment instead of conservative therapy.
Purpose. To study the acoustic density (ADS) and the thickness of the sclera in patients with primary open-angle glaucoma (POAG) taking into account the stage the glaucoma process and refraction. ...Material and methods. The study involved in 273 eyes of 138 examined patients with the POAG of stage 1-3. The mean age was 66...4, the IOP - 21±4mmHg in the hypotensive mode, the axial length of the eye - 23.56±2.31. The comparative group included 90 eyes of 45 patients aged 65±6.5 years without the diagnosed glaucoma, the IOP was 20±3mmHg. All patients underwent the ultrasound bio-microscopy (UBM). Scanning the thickness of sclera was performed in the limbus area and 4mm from the scleral spur in 4 segments at the 3,6,9,12 o'clock positions. The ADS determination was carried out in dB by a reduction of the power of ultrasound to the disappearance of echoes from scleral capsule of the eye on the screen. Results. The sclera of the eyes was not uniform in its thickness in different zones of measurement. The maximum thickness of the sclera was detected in the limbus area at the 9 o'clock position in the comparative group and was 0.63±0.02mm; the smallest thickness was detected in patients with myopia at the 12 o'clock position and was 0.51±0.04mm. Thinning of the sclera in the equatorial zone was significantly (p<0.05) more pronounced in glaucoma eyes and achieved 0.23±0.01mm in patients with emmetropia, 0.21±0.01mm--in myopia, 0.25±0.01mm--in hyperopia. Significant (p<0.001) ADS changes in all studied segments were determined in patients with the first and third stages of glaucoma and were 56±0.74 dB and 62dB±0.58 in patients with emmetropia; 56±0.67dB and 60±0.71dB--in myopia; 60±0.43dB and 63±0.57dB--in hyperopia, respectively. Conclusion. A gradual reduction of the thickness of sclera and an ADS increase reflects an involvement of the sclera into a pathologic glaucoma process what can indicate a change in its biomechanical properties. The most pronounced acoustic changes of sclera are detected in individuals with myopic type of refraction that is caused by morphologic changes of fibrous tunica of the eye at first.
Purpose. The goal is to expand the currently known classifications of the capsular block syndrome (CBS) based on the analysis of publications and own experience, taking into account the data of ...modern research methods.Material and methods. All cases of the capsular block syndrome described in the available scientific literature were analyzed, as well as observations from our own practice with the use of optical coherence tomography of the IOL-capsular bag complex (Optovue).Results. An extended classification of the CBS is based on the classification according the time of onset (intraoperative, early and late postoperative) proposed by Miyake K. et al. (1998). The enlarged classification reflects the possible causes of intraoperative CBS, a variety of clinical and morphological manifestations of CBS in the postoperative period.Conclusion. The proposed classification integrates our own experience and analysis of clinical cases from the literature and can be used for a uniform description of all detected cases of CBS.
Purpose. To study the efficiency of a combined method for laser treatment – the laser iridectomy in combination with the selective laser trabeculoplasty (LIE+SLTP) – in patients with primary ...narrow-angle (mixed) glaucoma.Material and methods. The study included 72 patients (72 eyes) with initial stage of primary narrow-angle (mixed) glaucoma. The average age of the patients was 65.1±6.56 years: 27 males, 43 females. The followup period was up to 4 years after laser treatment.The level of intraocular pressure (Р0) before the treatment was on average 24.47±1.85mmHg. The mean quantity of antihypertensive drugs used by the patients before the laser operation was 2.2±0.4.Stages of the combined treatment: laser iridectomy and selective laser trabeculoplasty were performed immediately one after the other in all patients.Results. All laser interventions were carried out without complications.An extension of the anterior chamber angle (ACA) was achieved in all patients, which was confirmed by data of gonioscopy and anterior optical coherence tomography (OCT).On the 1st day after the combined laser treatment, the reactive elevation of IOP was observed in 9.7% of cases and was stopped by an additional antihypertensive therapy within 1-2 days. Other complications such as inflammatory, hemorrhagic were not detected. A week after laser treatment there was a significant decrease (p<0.05) of intraocular pressure (IOP) by 6.9mmHg on average (28.2%) of the original. In the long-term postoperative follow-up period, the average decrease of IOP was 23.4%. Ophthalmotonus normalization occurred with increasing the coefficient of aqueous humor outflow facility (C) from 0.09±0.01 to 0.18±0.01 (p<0.05).In the long-term postoperative follow-up the IOP normalization was achieved in 87.5% of cases (63 eyes of 72).The IOP decrease to normal occurred in 9 eyes after the repeated SLT.The average number of antihypertensive agents that were used by the examined patients after the treatment decreased and averaged 1.02±0.1.The visual acuity remained unchanged in 80.5% of cases. The decrease of the vision was due to the progression of complicated cataract.Limits of peripheral visual field remained stable by the end of the follow-up period in 96% of cases.Within the observation period, according to computer perimetry data, negative dynamics was recorded in 6 patients (6 eyes out of 72 – 8.3%).According to HRT, negative dynamics in the form of a decrease in the volume of the neural rim, an increase in the area of the optic disc excavation was noted in 7% of cases (5 eyes of 72).Conclusion. The proposed method of combined laser treatment allows to achieve the IOP normalization due to an expansion of ACA after LIE with a subsequent activation of trabecula by SLT in 87.5% of patients.Ophthalmotonus normalization, stabilization of visual functions and indicators of the optic nerve conditions in the vast majority of patients in the long-term postoperative period proves the efficiency of the proposed technique in the treatment of patients with the initial stage of primary narrow-angle (mixed) glaucoma. The simultaneous operation of two stages – laser iridectomy and SLT is safely and enables significantly to reduce the duration of treatment and rehabilitation of patients.
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