Zinc is an essential trace element for living organisms and their biological processes. Zinc plays a key role in more than 300 enzymes and it is involved in cell communication, proliferation, ...differentiation and survival. Zinc plays also a role in regulating the immune system with implications in pathologies where zinc deficiency and inflammation are observed. In order to examine the experimental evidence reported in the literature regarding zinc levels in the body of patients with autoimmune disorders compared to control individuals, a systematic review and meta-analysis were performed. From 26,095 articles identified by literature search, only 179 of them were considered potentially relevant for our study and then examined. Of the 179 articles, only 62 satisfied the inclusion criteria. Particularly for Fixed Model, Zn concentration in both serum (mean effect = -1.19; confidence interval: -1.26 to -1.11) and plasma (mean effect = -3.97; confidence interval: -4.08 to -3.87) samples of autoimmune disease patients was significantly lower than in controls. The data presented in our work, although very heterogeneous in the manner of collecting and investigating samples, have proved to be extremely consistent in witnessing a deficiency of zinc in serum and plasma of patients compared to controls.
Trace elements produce double-edged effects on the lives of animals and particularly of humans. On one hand, these elements represent potentially toxic agents; on the other hand, they are essentially ...needed to support growth and development and confer protection against disease. Certain trace elements and metals are particularly involved in humoral and cellular immune responses, playing the roles of cofactors for essential enzymes and antioxidant molecules. The amount taken up and the accumulation in human tissues decisively control whether the exerted effects are toxic or beneficial. For these reasons, there is an urgent need to re-consider, harmonize and update current legislative regulations regarding the concentrations of trace elements in food and in drinking water. This review aims to provide information on the interrelation of certain trace elements with risk of autoimmune disease, with a particular focus on type 1 diabetes and multiple sclerosis. In addition, an overview of the current regulations and regulatory gaps is provided in order to highlight the importance of this issue for everyday nutrition and human health.
Megalithism in Sardinia (Italy) had its highest expression during the Bronze Age with the creation of monumental complexes known as Nuraghes. These unique monuments have recently been the subject of ...in-depth investigations for their potential to be recognized as World Heritage Sites (by UNESCO). The main purpose of our research was to make a contribution to obtain a more in-depth characterization of these monuments by testing a 3D model of a complex Nuraghe, integrated with an analysis of the geolithological context. This work first focused on the geological and typological investigation of the materials used in its construction, which was then compared with the geolithological characteristics of the region. A survey of the outcropping remains was carried out by means of Structure-from-Motion Multi-View Stereo (SfM-MVS) photogrammetry with UAV ground and aerial acquisition using APS-C photo sensors, georeferenced with an RTK-GNSS ground survey. The level of accuracy of our digital models shows the potential of the proposed method, giving accurate and geometrically consistent 3D reconstructions in terms of georeferencing error, shape and surface. The survey method allows for the virtualization of the current state of conservation of the Nuraghe, giving a solid basis to set up further (future) archaeological excavations and to contribute to knowledge on the architecture of the structures. This study also provides useful information on the nature and origin of the construction materials and proposes a hypothesis on the original dimensions of the monument, which is often a topic of debate in the world of archaeology.
Stone moulds were basic elements of metallurgy during the Bronze Age, and their analysis and characterization are very important to improve the knowledge on these artefacts useful for typological ...characterization. The stone moulds investigated in this study were found during an archaeological field survey in several Nuragic (Bronze Age) settlements in Central Sardinia. Recent studies have shown that photogrammetry can be effectively used for the 3D reconstruction of small and medium-sized archaeological finds, although there are still many challenges in producing high-quality digital replicas of ancient artefacts due to their surface complexity and consistency. In this paper, we propose a multidisciplinary approach using mineralogical (X-ray powder diffraction) and petrographic (thin section) analysis of stone materials, as well as an experimental photogrammetric method for 3D reconstruction from multi-view images performed with recent software based on the CMPMVS algorithm. The photogrammetric image dataset was carried out using an experimental rig equipped with a 26.2 Mpix full frame digital camera. We also assessed the accuracy of the reconstruction models in order to verify their precision and readability according to archaeological goals. This allowed us to provide an effective tool for more detailed study of the geometric-dimensional aspects of the moulds. Furthermore, this paper demonstrates the potentialities of an integrated minero-petrographic and photogrammetric approach for the characterization of small artefacts, providing an effective tool for more in-depth investigation of future typological comparisons and provenance studies.
In order to understand the distribution of fluorine in surface environments, also linked to fluoride deposits, this paper discusses the role of rift systems in fluorine enrichment of surface waters, ...with two examples: the Sardinia Island and the East African Rift. The main goal of this study is aimed to highlighting the areas that could potentially host fluorine in the surface waters in order to make it easier the lecture also for people to search and read not experts in the field, such as the biomedical field. Furthermore, potentialities and limitations of the currently available defluoridation techniques were examined, in order to identify the best intervention technology.
From a careful review of the literature, to the addition of the extensive field observations in Sardinia and Ethiopia carried by the authors in the previous decades, we highlight the origin, processes and evolution of F-migration in Rift systems.
The given examples of Sardinia and Ethiopia show that the origin and consequent behaviour of fluorine is strictly controlled by the rift systems. In this framework, the availability of fluorine for surface waters depends on two possible types of sources: a direct supply and an indirect supply. Directly from spring waters and ground waters fed by hydrothermal systems related to rifting, and indirectly from the leaching of products of rift-related activities, such as fluorite-bearing deposits, sedimentary or meta-sedimentary rift-related sequences, and volcanic or metavolcanic complexes emplaced along rift structures. The whole geological history of a given area must be taken into account in interpreting its present fluorine geochemistry.
In conclusion, we underline the aspects of a possible control of these areas where fluoride exposure might lead to a long-term harm to local communities and we point out the nowadays best remediation-technologies, discussing their pro and cons in their applicability to different scales and social-contexts.
Objectives. Higher natural concentrations of lithium in drinking water may be associated with lower local rates of suicide. Methods. Lithium concentrations in drinking water were assayed by mass ...spectrometry at 145 sites in Italy, and compared with reported local suicide rates for men and women between 1980 and 2011. Results. Lithium concentrations in drinking water averaged 5.28 CI: 4.08-6.48 μg/L (0.761 0.588-0.934 μEq/L) and ranged from 0.110 to 60.8 μg/L (1.58 to 8.76 μEq/L). Lithium concentrations and local suicide rates were not significantly inversely related, except in 1980-1989, particularly among women. Conclusions. A proposed association between trace lithium concentrations in drinking water and risk of suicide was only partially supported, and mechanisms for potential clinical effects of trace levels of lithium are unknown.
Type 1 diabetes incidence presents a decreasing gradient in Europe from the Nordic countries to the Mediterranean ones. Exception to this gradient is represented by Sardinia, the second largest ...Mediterranean island whose population shows the highest incidence in Europe, after Finland. The genetic features of this population have created a fertile ground for the epidemic of the disease, however, as well as being strikingly high, the incidence rate has suddenly presented a continuous increase from the '50s, not explainable by accumulation of new genetic variants. Several environmental factors have been taken into account, possibly interacting with the genetic/epigenetic scenario, but there are no strong evidences to date.
The present study investigated the hypothesis that geochemical elements could create permissive environmental conditions for autoimmune diabetes. An ecological analysis was performed to test possible correlations between the values of eight elements in stream sediments and type 1 diabetes incidence rate in Sardinia.
Analyses revealed negative associations between elements, such as Co, Cr, Cu, Mn, Ni, Zn, and type 1 diabetes incidence.
The results suggest a possible protective role of some elements against the onset of the disease.
Several studies have shown the presence of fluoride levels much higher than the 1.5 mg/L threshold concentration recommended by WHO in the spring waters and wells of the Ethiopian Rift Valley. ...Available defluoridation techniques can be costly, present complicated technical aspects, and show limited effectiveness. Therefore, it is necessary to devise innovative, sustainable, and effective solutions. This study proposes an alternative method of intervention to the known techniques for removing fluoride from water, particularly suitable for smaller rural communities. In particular, in this work, the possibility to use electromagnetic fields as a physical method for removing the excess fluoride was investigated. The study was carried out by developing a multiphysics model used for studying and envisaging the design of a device. In this framework, the combination of this approach with the use of highly reactive smectite clay was numerically studied. The results obtained, although preliminary, indicate that the proposed system could significantly impoverish the waters of the Rift Valley from fluoride, with the consequence of obtaining a resource suitable for human consumption, in particular for rural communities. However, further theoretical investigations and experimental phases will be necessary to achieve the desired results.
South-Western Sardinia (SWS) is a high risk area for Multiple Sclerosis (MS) with high prevalence and spatial clustering; its population is genetically representative of Sardinians and presents a ...peculiar environment. We evaluated the MS environmental risk of specific heavy metals (HM) and geographical factors such as solar UV exposure and urbanization by undertaking a population-based cross-sectional study in SWS.
Geochemical data on HM, UV exposure, urbanization and epidemiological MS data were available for all SWS municipalities. Principal Component Analysis (PCA) was applied to the geochemical data to reduce multicollinearity and confounding criticalities. Generalized Linear Mixed Models (GLMM) were applied to evaluate the causal effects of the potential risk factors, and a model selection was performed using Akaike Information Criterion.
The PCA revealed that copper (Cu) does not cluster, while two component scores were extracted: 'basic rocks', including cobalt, chromium and nickel, and 'ore deposits', including lead and zinc. The selected multivariable GLMM highlighted Cu and sex as MS risk factors, adjusting for age and 'ore deposits'. When the Cu concentration increases by 50 ppm, the MS odds are 2.827 (95% CI: 1.645; 5.07) times higher; females have a MS odds 2.04 times (95% CI: 1.59; 2.60) higher than males.
The high frequency of MS in industrialized countries, where pollution by HM and CO poisoning is widespread, suggests a relationship between environmental exposure to metals and MS. Hence, we suggested a role of Cu homeostasis in MS. This is a preliminary study aimed at generating hypotheses that will need to be confirmed further.
In this work we compare the inorganic content of bottled mineral water, steadily increasing as a source of drinking water, and tap water which is often affected by intensive chemical treatment ...Bottled mineral water should be representative of the hydrogeochemical composition of groundwater, whereas tap water could derive from multiple sources such as groundwater or surface water including rivers and reservoirs. The data of this paper were collected within a project carried out by the EuroGeoSurvey Geochemistry Expert Group aimed at the characterization of groundwater geochemistry using bottled mineral waters purchased in supermarkets all over Europe which included also the analysis, for comparative purposes, of tap water.
The comparison of two extensive databases of 69 elements on 157 tap water samples and 178 bottled mineral waters on Italian territory enabled the recognition of very wide ranges of variation in both databases. The elements with the highest variation are Y, Li, U, I, HCO
3
−, Be, Yb, Tm, Zr, Lu, F, and Cs in the bottled mineral database and Ga, PO
4
3−, Zn, Mg, Ti, Th, Cd, Pb, and Cu in the tap water database. The first group of elements in bottled mineral water includes elements with localized very high concentration due to prolonged interaction with unusual rock types, whereas the second group of elements in tap water includes elements that are released by corrosion reaction with the material of the distributing systems. Aside from these differences, tap water displayed a much more restricted range of variation for major ions compared to bottled mineral water because of quality guidelines imposed by Italian Law for selected major ions (Ca, Cl
−, SO
4
2−).
Some elements do not display statistically different distributions between the two databases (As, Cr, I, Li, Mo, Rb, Sr, Se, U, V) and for some of these (e.g., Cr and V) non-natural sources cannot be excluded in both databases (e.g. pipeline corrosion or container leaching). The spatial distribution of the ionic species provides similar information as far as the role of geology, groundwater condition and, additional sources is concerned. Among the elements displaying significant differences, Al, Cd, Cu, Fe, Ni, Pb and Zn are strongly enriched in tap water samples, whereas Be, Cs, Sb, Sn and Tl are significantly enriched in the bottled mineral water. The group of elements enriched in tap water is controlled also by corrosion processes, so their spatial distribution is random and virtually unrelated to geological or geochemical conditions. Among the elements enriched in the bottled mineral water group, Sb derives from PET container leaching, whereas the other elements likely derive from water–rock interaction.
►The research compares bottled mineral water and tap water from Italy ►69 chemical parameters were analyzed in 157 tap water and 178 bottled mineral water ►Major element distribution limited in tap water compared to bottled mineral water ►As, Cr, I, Li, Mo, Rb, Se, U and V have similar distributions ►Distribution system cause tap water enrichment of Al, Cd, Cu, Fe, Ni, Pb and Zn
PDF
