Documenting the patterns of oral anticoagulation therapy (OAT) is essential to prevent thromboembolic complications of nonvalvular atrial fibrillation (NVAF).
To report the patterns of OAT according ...to age and thromboembolic risk in patients included in CARMEN-AF, a nationwide registry of NVAF in Mexico, an upper middle-income country.
There were 1,423 consecutive patients ≥18 years old and with at least one thromboembolic risk factor enrolled in the CARMEN-AF Registry at their regular clinical visit during a three-year period. They were analyzed according to 1) age, 2) AF type, and 3) CHA
DS
-VASc score.
Overall, 16.4% of patients did not receive antithrombotic treatment, 19.4% received antiplatelet drugs (APD), 29.2% vitamin K antagonists (VKA), and 34.6% direct oral anticoagulants (DOAC). With increasing age, the proportion of subjects treated with VKA decreased significantly from 36.2% in subjects <65 years to 22.5% in those ≥75 years old (
<0.0001). Concomitantly, an increase in both APD and no antithrombotic treatment was observed with increasing age. DOAC were prescribed equally among all age groups (34.2% in <65, 36.0% in 65-74, and 33.9% in ≥75). According to the type of AF, VKA use was more common in patients with permanent AF (32.7%). A lower use of DOAC was observed in high thromboembolic risk subjects (33.6% in CHA
DS
-VASc ≥2) compared with the moderate risk group (41% in CHA
DS
-VASc = 1).
VKA use for NVAF in Mexico decreased in relation to increasing age. The proportion of DOAC therapy was the same in all age groups. Nevertheless, elderly patients with high thromboembolic risk received a suboptimal thromboprophylaxis. These data could help to improve gaps in the implementation of global guidelines.
http://www.clinicaltrials.gov. Unique identifier: NCT02334852.
CARMEN-AF is a nationwide multi-centric registry seeking to bridge the data gap on anticoagulation therapy for NVAF in Mexico.Elderly patients are more prone to receive suboptimal OAT for NVAF.DOAC were less frequently used in high thromboembolic risk patients (CHA
DS
-VASc ≥2).
Introduction: among the oral pathologies afflicting children with HIV/AIDS is dental caries, a preventable disease if detected and controlled in its early stages to avoid further complications. The ...aim of this study was to determine the prevalence of caries in children and youths with vertically-transmitted HIV/AIDS from the Pediatric HIV Clinic in Cali, Colombia, in 2013, and to explore relationships with biological factors. Methods: descriptive prevalence study in 101 clinical records of children and youths aged 1 to 17 years with vertically-transmitted HIV/AIDS from the Pediatric HIV Clinic in Cali. The ICDAS and DMF/def classification systems were used. Multivariate analysis and confounding variable adjustment were included to explore relationships with demographic, paraclinical, nutritional, and dental factors. The institutional ethics committees endorsed the study. Results: the prevalence of caries experience in children with HIV was 34.65% DMF/deft (5-6) 3.29 ± 3.06. This prevalence increases 83.17% with the ICDAS 2-6 system. The point prevalence of active caries was 74.26% DMFT 5.68 ± 5.48. No statistically significant association was found with any socioeconomic or immunologic variables. Patients with moderate to severe immunosuppression had OR 1.13 CI95% (0.33-3.81) p = 0.84. A probable association was found with plaque index OR 4.58 CI95% (1.44-14.55) p = 0.006 and caries experience OR 4.21 CI95% (1,09-16.13) Conclusion: HIV patients from the Pediatric Clinic show high caries prevalence when pre-cavitated lesions are assessed. No probable association was found between caries and immunological or clinical status, and therefore this aspect is not an additional risk factor.
The crystallization of nonsteroidal anti-inflammatory drug 2-(4-isobutyl-phenyl) propionic acid ibuprofen (IBP) on a hydroxypropyl cellulose (HPC) and polyacrylamide (PAAm) gel was studied as well as ...the release kinetics of the drug. The IBP was crystallized on the gel surface of HPC/PAAm. It had a prismatic shape and the growth was made in an aqueous medium; the crystallinity grade of the gels HPC/PAAm and HPC/PAAm-IBU increased to 68% and to 58%, respectively. The release of IBP is performed by two means: by a non-Fickian diffusion process and by relaxation of the chains of the gel; without regard to temperature and the diffusion media, this correlates with the lower critical solution temperature (LCST) of the proposed gel. This polymer matrix provides an option for releasing nonsteroidal anti-inflammatory drugs in a temperature range of 35–39°C. Korsmeyer and Peppas mathematical model was simulated for data releases, statistically significant at 95% confidence level.
Introduction: The pathogenesis of functional gastrointestinal disorders involves infectious agents such as viruses.
Objective: To study the development of functional gastrointestinal disorders 3, 6, ...9 and 12 months after an episode of non-severe dengue without warning signs in children.
Materials and methods: We conducted a cohort study in 73 children diagnosed with non-severe dengue without warning signs at Hospital Universitario del Valle “Evaristo García” and 62 healthy children from Cali, Colombia. Using the Questionnaire for Pediatric Gastrointestinal Symptoms Rome III (QPGS-III) in Spanish we identified functional gastrointestinal disorders 3, 6, 9, and 12 months after non-severe dengue without warning signs. Measurements of central tendency, relative risk, chi square, and Fisher’s exact test were performed, with p<0.05 being significant.
Results: We included 135 children who were 10.7±1.9 years old; 51.1% of them were male and 19.3% had a functional gastrointestinal disorder (9.6% of them had abdominal pain related to functional gastrointestinal disorders). There was a greater risk to present a functional gastrointestinal disorder and related abdominal pain in children after non-severe dengue without warning signs at 3, 6, 9, and 12 months of follow-up, but without significant differences.
Conclusion: Our study suggests that non-severe dengue without warning signs does not increase the risk of functional gastrointestinal disorders and related abdominal pain for up to 12 months of follow-up.
El artículo analiza la percepción del territorio entre agentes clave del campo turístico local para indagar cómo incide en el abordaje del turismo en Ameca, Jalisco, municipio al occidente de México ...marcado por la migración, cuyo potencial turístico plantea una alternativa para su desarrollo socioeconómico. La metodología utilizada es fenomenológica, recurriendo a la entrevista semiestructurada y el análisis interpretativo para profundizar en la percepción de los participantes, complementada de etnografía y análisis documental para contextualizar el lugar. Los resultados indican que, al interiorizar componentes socioeconómicos y culturales que afectan sus experiencias en el territorio, los agentes forman una imagen del lugar que puede ser condicionante al desarrollo turístico, orientando sus disposiciones en un sentido negativo a pesar de cualquier potencialidad, así mismo, a través de su percepción pueden encontrarse estrategias endógenas correctivas
Resumen Introducción En niños, los resultados que muestran asociación entre la presencia de hiperlaxitud articular generalizada (HAG) y trastornos digestivos funcionales (TDF) son limitados y ...polémicos. Objetivo Determinar la asociación entre HAG y TDF y la búsqueda de factores de riesgo para la HAG en niñas de una Institución Educativa Pública de Tuluá, Colombia. Pacientes y métodos Las escolares completaron el Cuestionario de Roma IV para identificar TDF. Cada niña con diagnóstico de algún TDF fue apareado con control sano de la misma edad. La laxitud articular se evaluó según el puntaje de Beighton y se consideró HAG cuando fue ≥ 4. Se comparó la prevalencia de HAG en niñas con y sin TDF. Resultados En el estudio participaron 921 niñas entre los 10 y 18 años de edad. Doscientas diecinueve (23,8%) niñas presentaron algún TDF. Fueron analizadas 169 niñas con TDF y 169 niñas controles sanas. No hubo diferencias significativas en la HAG entre las niñas con y sin diagnóstico de algún TDF (OR=1,12 IC95%=0,71-1,77 p=0,5838) ni se presentaron factores de riesgo. Conclusión En este estudio no se logró determinar asociación entre HAG y la presencia de TDF, ni ningún factor de riesgo.
Objetivo: analizar la relación entre la intención emprendedora y un conjunto de variables explicativas (deseabilidad, control interno, normas sociales) según el modelo propuesto por Liñán (2009). ... Método: Estudio exploratorio y transversal, con dos fases: 1) fase orientada a la validación de los instrumentos a partir de la revisión teórica de la literatura, 2) análisis confirmatorio del modelo teórico a partir de los supuestos teóricos estadísticos (el análisis de validez discriminante, el análisis de normalidad multivariante, la homocedasticidad y los índices de bondad de ajustes del modelo) usados para evaluar la hipótesis del modelo. Originalidad / Relevancia: Si bien el análisis de las intenciones emprendedoras ha sido ampliamente estudiado en la literatura, este estudio permite confirmar la validez de los constructos del modelo en un contexto de economías emergentes. Por ello, la relevancia de sus resultados está vinculada a las implicaciones que esto pudiera tener en los cursos de formación en emprendimiento que se imparten en el colectivo analizado. Resultados: El principal constructo explicado fue la intención emprendedora. Fue estudiado a través de tres variables: deseabilidad, control percibido y normas sociales. El análisis arrojó que los ítems de cada una de las variables se agrupan conforme a la teoría. Así mismo, los resultados permitieron validar positivamente las hipótesis formuladas sobre el papel de la deseabilidad (H1) y el control percibido (H2) en la predicción de la intención emprendedora. Contribuciones teóricas / metodológicas: La principal contribución metodológica fue la validación del instrumento “Evaluación y Desarrollo del Potencial Emprendedor” (PEUL) fundamentado teóricamente en el modelo de Liñán (2009) utilizando el modelo de ecuaciones estructurales.
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