Abstract Objective: To compare the recovery of cornea endothelia after phacoemulsification (phaco) with anterior chamber irrigation at different temperatures. Study Design: A between-group design was ...used. Participants: Thirty-eight patients with cataract. Methods: Phaco was done on 40 eyes in these patients with exactly the same procedure except for the temperature of the anterior chamber: cryoirrigation at 12°C for group 1 and at room temperature (25°C) for group 2, 20 eyes in each group, randomly distributed. The cornea edema, keratic precipitate (KP), and anterior chamber flare were observed with micro-slit lamp and graded on a 4-point scale at 1, 3, and 7 days after surgery and compared between groups. Results: The corneas in group 1 were found to be clearer than those in group 2 at 1 and 3 days after surgery. The difference was statistically significant ( p < 0.05) in favour of group 1, suggesting a lighter reaction of cornea endothelia and a quicker recovery in group 1 after the surgery with cryoirrigation. Corresponding recovery in group 2 was found to occur latterly between day 3 and day 7. However, the recovery in both groups was complete, yielding no difference between groups, at day 7 after surgery. In addition, no significant difference was found in Tyndall phenomenon and KP between groups. Conclusions: Cryoirrigation during phaco could reduce postoperative cornea edema and promote recovery. The result advocates the use of cryoirrigation in clinic.
Overweight Women and Management of Asthma Valerio, Melissa A., PhD; Gong, Z. Molly, MD; Wang, Sijian, MPH, PhD ...
Women's health issues,
09/2009, Letnik:
19, Številka:
5
Journal Article
Recenzirano
Odprti dostop
Purpose We sought to describe clinical and psychosocial characteristics of overweight women with asthma. Methods Telephone interview and medical record review involving 808 women with asthma ...participating in a randomized study to identify those who were overweight. We assessed the relationship of their weight to asthma symptoms, health care use, quality of life, self-esteem, need for social support, and demographic characteristics. Regression analyses were used to investigate relationships between overweight and asthma. Findings Sixty-eight percent of the women in the study were overweight or obese. Demographic characteristics associated with overweight in women with asthma included being minority ( p = .000), having a lower education level ( p = .000), and a lower household income ( p = .024). Overweight was associated with greater health care use, comorbidities (acid reflux, urinary incontinence), and persistent disease ( p = .001). Overweight women exhibited lower self-esteem ( p = .002) and lower perceived quality of life ( p = .000). Conclusion Overweight females with asthma experience significant challenges because of their weight, more persistent and severe disease, specific comorbidities, and lower rates of obtaining psychosocial resources. Clinical consultations and interventions should account for the influence of overweight on asthma control and health status in female patients.
Background Familial hypobetalipoproteinemia (FHBL) is a co-dominant disorder associated with low circulating levels of low-density lipoprotein (LDL) cholesterol and apolipoprotein B100 (ApoB). A ...proband was identified in whom the condition was due to an E110X mutation of APOB , creating a particularly early truncation of ApoB in the region of the molecule necessary for very-low-density lipoprotein (VLDL) assembly. The mutation was also associated with nonalcoholic fatty liver disease. Objective To assess the effect of the mutation on metabolism and the formation of VLDL and LDL subfractions. Results Both the proband and his son, who had the same mutation, had low LDL cholesterol and decreased ApoB, but an increased small-dense LDL level. Lipoprotein profiles were normal in the proband's sister and grandson, in whom the mutation was absent. In the proband. there was a profoundly diminished rate of production of VLDL-2. VLDL-1 production, however, was relatively preserved and, because of its decreased catabolism, its pool size was increased. Direct formation of intermediate-density lipoprotein (IDL) and LDL was undetectable. Intermediate-density lipoprotein catabolism was greatly increased and its conversion to LDL was increased. The LDL produced was entirely small-dense LDL. High-density lipoprotein cholesterol levels were low, perhaps also related to the relative increase in VLDL-1, which is an avid acceptor of cholesteryl ester. Conclusions This novel mutation provides evidence to support the hypothesis that hepatic production of large VLDL-1 leads to the creation of small-dense LDL.
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