Colloidal all‐inorganic perovskites nanocrystals (NCs) have emerged as a promising material for display and lighting due to their excellent optical properties. However, blue emissive NCs usually ...suffer from low photoluminescence quantum yields (PLQYs) and poor stability, rendering them the bottleneck for full‐color all‐perovskite optoelectronic applications. Herein, a facile approach is reported to enhance the emission efficiency and stability of blue emissive perovskite nano‐structures via surface passivation with potassium bromide. By adding potassium oleate and excess PbBr2 to the perovskite precursor solutions, potassium bromide‐passivated (KBr‐passivated) blue‐emitting (≈450 nm) CsPbBr3 nanoplatelets (NPLs) is successfully synthesized with a respectably high PLQY of 87%. In sharp contrast to most reported perovskite NPLs, no shifting in emission wavelength is observed in these passivated NPLs even after prolonged exposures to intense irradiations and elevated temperature, clearly revealing their excellent photo‐ and thermal‐stabilities. The enhancements are attributed to the formation of K‐Br bonding on the surface which suppresses ion migration and formation of Br‐vacancies, thus improving both the PL emission and stability of CsPbBr3 NPLs. Furthermore, all‐perovskite white light‐emitting diodes (WLEDs) are successfully constructed, suggesting that the proposed KBr‐passivated strategy can promote the development of the perovskite family for a wider range of optoelectronic applications.
High‐quality blue‐emitting CsPbBr3 nanoplatelets (NPLs) are synthesized via a facile potassium bromide‐enriched surface passivation. The resultant blue‐emitting (≈450 nm) CsPbBr3 NPLs show a high PLQY of 87% with excellent thermal stability and photostability. Furthermore, white light LEDs based on the mixture perovskite materials including the blue‐emitting NPLs are constructed, demonstrating a wide color gamut.
Incorporating biomolecules into metal‐organic frameworks (MOFs) as exoskeletons to form biomolecules‐MOFs biohybrids has attracted great attention as an emerging class of advanced materials. Organic ...devices have been shown as powerful platforms for next‐generation bioelectronics, such as wearable biosensors, tissue engineering constructs, and neural interfaces. Herein, biomolecules‐incorporated MOFs as innovative gating module is realized for the first time, which is exemplified by biocatalytic precipitation (BCP)‐oriented horseradish peroxidase (HRP)‐embedded zeolitic imidazolate framework‐90 (HRP@ZIF‐90)/CdIn2S4 gated organic photoelectrochemical transistor under light illumination. In connection to a sandwich immunocomplexing targeting the model analyte human IgG, the IgG‐dependent generation of H2O2 and the tandem HRP‐triggered BCP reaction can cause the in situ blocking of the pore network of ZIF‐90, leading to variant gating effect with corresponding responses of the device. This representative biodetection achieved good analytical performance with a wide linear range and a low detection limit of 100 fg mL−1. In the view of the plentiful biomolecule‐MOF complexes and their potential interactions with organic systems, this study provides a proof‐of‐concept study for the generic development of biomolecules‐MOFs‐gated electronics and beyond.
Herein, biomolecules‐incorporated MOFs as innovative gating module is realized for the first time, which is exemplified by biocatalytic precipitation‐oriented horseradish peroxidase (HRP)‐embedded zeolitic imidazolate framework‐90 (HRP@ZIF‐90)/CdIn2S4 gated organic photoelectrochemical transistor under light illumination. By linking with a sandwich immunoassay, the proposed biosensor achieved good analytical performance at zero gate bias.
Formation and progression of atherosclerotic vulnerable plaque (VP) is the primary cause of many cardio-cerebrovascular diseases such as acute coronary syndrome and stroke. It has been reported that ...bone marrow mesenchymal stem cells (MSC) exhibit protective effects against many kinds of diseases including myocardial infarction. Here, we examined the effects of intravenous MSC infusion on a VP model and provide novel evidence of its influence as a therapy in this animal disease model.
Thirty healthy male New Zealand white rabbits were randomly divided into a MSC, VP or stable plaque (SP) group (n = 10/group) and received high fat diet and cold-induced common carotid artery intimal injury with liquid nitrogen to form atherosclerotic plaques. Serum hs-CRP, TNF-α, IL-6 and IL-10 levels were measured by ELISA at 1, 2, 3, 7, 14, 21 and 28 days after MSC transplantation. The animals were sacrificed at 4 weeks after MSC transplantation. Lesions in the right common carotid were observed using H&E and Masson staining, and the fibrous cap/lipid core ratio of atherosclerotic plaques were calculated. The expression of nuclear factor κB (NF-κB) and matrix metalloproteinase 1, 2, 9 (MMP-1,2,9) in the plaque were detected using immunohistochemistry, and apoptotic cells in the plaques were detected by TUNEL. In addition, the level of TNF-α stimulated gene/protein 6 (TSG-6) mRNA and protein were measured by quantitative Real-Time PCR and Western blotting, respectively.
Two rabbits in the VP group died of lung infection and cerebral infarction respectively at 1 week after plaque injury by liquid nitrogen. Both H&E and Masson staining revealed that the plaques from the SP and MSC groups had more stable morphological structure and a larger fibrous cap/lipid core ratio than the VP group. Serum hs-CRP, TNF-α and IL-6 were significantly down-regulated, whereas IL-10 was significantly up-regulated in the MSC group compared with the VP group. .Immunohistochemistry analysis revealed that NF-κB and MMP expression was reduced in the MSC and SP groups compared to the VP group. Cell apoptosis decreased significantly in both the MSC and SP groups in comparison to the VP group. TSG-6 mRNA and protein expression were higher in the plaques of the MSC group compared to the VP and SP groups.
Our study results suggest that MSC transplantation can effectively stabilize vulnerable plaques in atherosclerotic rabbits. This may potentially offer a new clinical application of MSC in atherosclerosis.
Adsorption, storage, and conversion of gases (e.g., carbon dioxide, hydrogen, and iodine) are the three critical topics in the field of clean energy and environmental mediation. Exploring new methods ...to prepare high-performance materials to improve gas adsorption is one of the most concerning topics in recent years. In this work, an ionic liquid solution process (ILSP), which can greatly improve the adsorption kinetic performance of covalent organic framework (COF) materials for gaseous iodine, is explored. Anionic COF TpPaSO
H is modified by amino-triazolium cation through the ILSP method, which successfully makes the iodine adsorption kinetic performance (K
rate) of ionic liquid (IL) modified COF AC
tirmTpPaSO
quintuple compared with the original COF. A series of experimental characterization and theoretical calculation results show that the improvement of adsorption kinetics is benefited from the increased weak interaction between the COF and iodine, due to the local charge separation of the COF skeleton caused by the substitution of protons by the bulky cations of ILs. This ILSP strategy has competitive help for COF materials in the field of gas adsorption, separation, or conversion, and is expected to expand and improve the application of COF materials in energy and environmental science.
Telluride molybdenum (MoTe2) nanosheets with wide near‐infrared (NIR) absorbance are functionalized with polyethylene glycol‐cyclic arginine‐glycine‐aspartic acid tripeptide (PEG‐cRGD). After loading ...a chemotherapeutic drug (doxorubicin, DOX), MoTe2‐PEG‐cRGD/DOX is used for combined photothermal therapy and chemotherapy. With the high photothermal conversion efficiency, MoTe2‐PEG‐cRGD/DOX exhibits favorable cells killing ability under NIR irradiation. Owing to the cRGD‐mediated specific tumor targeting, MoTe2‐PEG‐cRGD/DOX shows efficient accumulation in tumors to induce a strong tumor ablation effect. MoTe2‐PEG‐cRGD nanosheets, which are relatively stable in the circulation, could be degraded under NIR ray. The in vitro and in vivo experimental results demonstrate that this theranostic nanoagent, which could accumulate in tumors to allow photothermal imaging and combined therapy, is readily degradable in normal organs to enable rapid excretion and avoid long‐term retention/toxicity, holding great potential to treat tumor effectively.
A degradable photothermal agent‐mediated, drug‐loaded nanocarrier is developed for photothermal imaging and chemical/photothermal combined therapy. The in vitro and in vivo experimental results demonstrate that this theranostic nanoagent can accumulate in tumors to allow photothermal imaging and combined therapy, and be readily degradable in normal organs to enable rapid excretion and avoid long‐term retention/toxicity.
Multiple myeloma, a plasma cell malignancy, is the second most common blood cancer. Despite extensive research, disease heterogeneity is poorly characterized, hampering efforts for early diagnosis ...and improved treatments. Here, we apply single cell RNA sequencing to study the heterogeneity of 40 individuals along the multiple myeloma progression spectrum, including 11 healthy controls, demonstrating high interindividual variability that can be explained by expression of known multiple myeloma drivers and additional putative factors. We identify extensive subclonal structures for 10 of 29 individuals with multiple myeloma. In asymptomatic individuals with early disease and in those with minimal residual disease post-treatment, we detect rare tumor plasma cells with molecular characteristics similar to those of active myeloma, with possible implications for personalized therapies. Single cell analysis of rare circulating tumor cells allows for accurate liquid biopsy and detection of malignant plasma cells, which reflect bone marrow disease. Our work establishes single cell RNA sequencing for dissecting blood malignancies and devising detailed molecular characterization of tumor cells in symptomatic and asymptomatic patients.
Abstract
Blue/deep-blue emission is crucial for organic optoelectronics but remains a formidable challenge in organic afterglow due to the difficulties in populating and stabilizing the high-energy ...triplet excited states. Here, a facile strategy to realize the efficient deep-blue organic afterglow is proposed via host molecules to sensitize the triplet exciton population of guest and water implement to suppress the non-radiative decays by matrices rigidification. A series of highly luminescent deep-blue (405–428 nm) organic afterglow materials with lifetimes up to 1.67 s and quantum yields of 46.1% are developed. With these high-performance water-responsive materials, lifetime-encrypted rewritable paper has been constructed for water-jet printing of high-resolution anti-counterfeiting patterns that can retain for a long time (>1 month) and be erased by dimethyl sulfoxide vapor in 15 min with high reversibility for many write/erase cycles. These results provide a foundation for the design of high-efficient blue/deep-blue organic afterglow and stimuli-responsive materials with remarkable applications.
Automatic image registration is a vital yet challenging task, particularly for remote sensing images. A fully automatic registration approach which is accurate, robust, and fast is required. For this ...purpose, a novel coarse-to-fine scheme for automatic image registration is proposed in this paper. This scheme consists of a preregistration process (coarse registration) and a fine-tuning process (fine registration). To begin with, the preregistration process is implemented by the scale-invariant feature transform approach equipped with a reliable outlier removal procedure. The coarse results provide a near-optimal initial solution for the optimizer in the fine-tuning process. Next, the fine-tuning process is implemented by the maximization of mutual information using a modified Marquardt-Levenberg search strategy in a multiresolution framework. The proposed algorithm is tested on various remote sensing optical and synthetic aperture radar images taken at different situations (multispectral, multisensor, and multitemporal) with the affine transformation model. The experimental results demonstrate the accuracy, robustness, and efficiency of the proposed algorithm.
Organic electrochemical transistors showing maximum transconductance (gm) at zero gate bias (VG) is desired but has long been a challenge. To date, few solutions to this issue are available. ...Light‐matter interplay is shown as rich sources for optogenetics, photodynamic therapy, and advanced electronics, but its potential in gm modulation are largely untapped. Herein, the challenge is addressed by unique light‐matter interplay in the newly emerged technique of organic photoelectrochemical transistor (OPECT), which is exemplified by dual‐ligand photosensitive metal–organic frameworks (DL‐PS‐MOFs)/TiO2 nanorods (NRs) gated poly(ethylene dioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) OPECT under 425 nm light irradiation. Interestingly, the light stimulation on the DL‐PS‐MOFs can de‐dope PEDOT:PSS with altered transistor physics, achieving device showing maximum gm at zero VG and the simultaneous superior output of channel current. In connection to a cascade catalytic hairpin assembly‐rolling circle amplification strategy, such a device is then biologically interfaced with a miRNA‐triggered growth of DNA spheres for the sensitive detection of miRNA‐21 down to 0.12 fm. This work features a proof‐of‐concept study using light‐matter interplay to enable organic transistors showing maximum gm at zero VG and its sensitive biological interfacing application.
Herein, light‐matter interplay tune PEDOT:PSS OPECT showing maximum transconductance at zero gate bias and its biological interfacing application is realized for the first time, which is exemplified by dual ligand photosensitive metal–organic frameworks/TiO2 nanorods gated OPECT under 425 nm light irradiation. The proposed device exhibits good analytical performance for miRNA‐21 with a detection limit of 0.12 fm.
The tuberculosis vaccine bacillus Calmette-Guérin (BCG) has heterologous beneficial effects against non-related infections. The basis of these effects has been poorly explored in humans. In a ...randomized placebo-controlled human challenge study, we found that BCG vaccination induced genome-wide epigenetic reprograming of monocytes and protected against experimental infection with an attenuated yellow fever virus vaccine strain. Epigenetic reprogramming was accompanied by functional changes indicative of trained immunity. Reduction of viremia was highly correlated with the upregulation of IL-1β, a heterologous cytokine associated with the induction of trained immunity, but not with the specific IFNγ response. The importance of IL-1β for the induction of trained immunity was validated through genetic, epigenetic, and immunological studies. In conclusion, BCG induces epigenetic reprogramming in human monocytes in vivo, followed by functional reprogramming and protection against non-related viral infections, with a key role for IL-1β as a mediator of trained immunity responses.
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•BCG vaccination of humans induces genome-wide epigenetic reprogramming in monocytes•BCG-induced changes correlate with protection against experimental virus infection•Viremia reduction correlates with IL-1β upregulation, indicative of trained immunity•SNPs in IL1B affect the induction of trained immunity by BCG
In this paper, Arts et al. describe that BCG vaccination induces genome-wide epigenetic reprogramming of human monocytes that correlates with protection against experimental viral infection. Reduction of viremia correlated with upregulation of non-specific IL-1β production, and genetic polymorphisms in the IL-1 pathway affect the induction of trained immunity by BCG.
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