Coordination polymers (CPs) are a diverse class of multi-dimensional compounds that show promise as photocatalysts for degrading dyes in polluted water. Herein, a new 1D Cd(II)-based coordination ...polymer with the formula Cd(bpyp)(nba)2 (1) (bpyp = 2,5-bis(pyrid-4-yl)pyridine and Hnba = 4-nitrobenzoic acid) is synthesized and characterized. In 1, the two carboxyl groups of two different nba− ligands show μ2-η1:η1 and μ1-η1:η1 coordination modes to connect the CdII centers and sit on either side of the chain along the b direction. The produced CP 1 was utilized as the photocatalyst in the process of the photodegradation of methyl blue (MB), methyl orange (MO), rhodamine B (RhB), and methyl violet (MV) dyes when exposed to UV light. The photocatalytic degradation activities of CP 1 were analyzed, and the results suggest that it exhibits an extraordinary efficiency in the degradation of MB, MV, MO, and RhB. RhB has a 95.52% efficiency of degradation, whereas MV has a 58.92% efficiency, MO has 35.44%, and MB has 29.24%. The photodecomposition of dyes is catalyzed mostly by •O2− and •OH−, as shown by research involving the trapping of radicals.
The importance of singlet oxygen (
O
) in the environmental and biomedical fields has motivated research for effective
O
production. Electrocatalytic processes hold great potential for ...highly-automated and scalable
O
synthesis, but they are energy- and chemical-intensive. Herein, we present a Janus electrocatalytic membrane realizing ultra-efficient
O
production (6.9 mmol per m
of permeate) and very low energy consumption (13.3 Wh per m
of permeate) via a fast, flow-through electro-filtration process without the addition of chemical precursors. We confirm that a superoxide-mediated chain reaction, initiated by electrocatalytic oxygen reduction on the cathodic membrane side and subsequently terminated by H
O
oxidation on the anodic membrane side, is crucial for
O
generation. We further demonstrate that the high
O
production efficiency is mainly attributable to the enhanced mass and charge transfer imparted by nano- and micro-confinement effects within the porous membrane structure. Our findings highlight a new electro-filtration strategy and an innovative reactive membrane design for synthesizing
O
for a broad range of potential applications including environmental remediation.
Abstract
Solid nanogenerators often have limited charge transfer due to their low contact area. Liquid–liquid nanogenerators can transfer a charge better than the solid–solid and solid–liquid ...counterparts. However, the precise manipulation of the liquid morphology remains a challenge because of the fluidity limits of the liquid. In this work, using the surface tension of a droplet to fix its shape, a liquid-liquid triboelectric nanogenerator in Contact-Separation mode is designed using an immiscible aqueous-aqueous interface, achieving a contact surface charge transfer of 129 nC for a single droplet. The configuration is proven to be applicable in humid environments, and the two-phase materials have good biocompatibility and can be used as an effective drug carrier. Therefore, this nanogenerator is useful for designing future implantable devices. Meanwhile, this design also establishes the foundation of aqueous electronics, and additional applications can be achieved using this route.
Current research on knowledge graph construction is focused chiefly on general-purpose fields, whereas constructing knowledge graphs in vertically segmented professional fields faces numerous ...difficulties. To solve the problems of complex relation types of domain entities, the lack of a large amount of annotated corpus, and the difficulty of extraction, this study proposed a method for constructing domain-annotated datasets based on publicly available texts on the web, which integrates remote supervision and semi-supervision. For the relational triad extraction of a given core entity (an entity lexicon defined semi-automatically by experts), an inflated gate attention network structure for increasing the perceptual field of the model is proposed. In addition, a relational extraction model, Ro-DGANet, was designed based on this structure, incorporating the idea of a probability graph. The Ro-DGANet model was experimentally evaluated on the publicly available Chinese datasets LIC2019 and CHIP2020 and compared with the mainstream relation extraction models, achieving the best results with F1 values of 82.99% and 66.39%, respectively. Finally, the Ro-DGANet model was applied to the relation extraction task of equipment components in industrial scenarios and to the relation extraction task of core knowledge points of programming languages. The analysis results show that the proposed method is applicable to open relation extraction among core entities in different domains with reliable performance and portability.
Microalgae usually co-exist with bacteria, which may influence the microalgal growth, in aquatic environment. In this study, thirteen strains that can promote microalgal growth were isolated from ...Scenedesmus sp. LX1 culture. Additional results showed that these strains could secrete gibberellin (GA), which is a phytohormones, promoting the growth and metabolism of the Scenedesmus sp. LX1. Low concentration (0.1 mg L−1) of GA can increase the microalgae biomass by 51% after 4 days. GA could enhance the photosynthetic activity by increasing the photosynthetic pigment content, such as culture after 2 h with low GA concentration (0.1 mg L−1), chlorophyll a and β-carotene increased from 0.59 μg per 106 cells to 0.72 μg per 106 cells and from 0.20 μg per 106 cells to 0.38 μg per 106 cells, respectively. In addition, GA could also stimulate the dehydrogenase activity, ATP accumulation, and carbonic anhydrase activity to increase the metabolic activity of the microalgae. Interestingly, the microalgae can selectively enhance the bacterial GA secretion in turn, indicating that there was a specific feedback regulation mechanism between the microalgae and the bacteria. The results of this study show a new mechanism of symbiotic-bacteria that enhances microalgal growth. It's a great significance to understand the microalgal growth and water bloom in aquatic environment.
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•Symbiotic bacteria enhanced Scenedesmus sp. growth by secreting gibberellin.•Scenedesmus sp. selectively enhanced the bacterial gibberellin secretion in turn.•Gibberellin affected Scenedesmus sp. in a concentration-dependent manner.
•Trichostatin A reversed EMT and consequently attenuated invasion and migration of SW480 and PC3 cells.•Trichostatin A-induced suppression of Slug was involved in reversing EMT.•Trichostatin A ...specially induced increase of HDAC1 and HDAC2 on promoter of Slug gene.
Trichostatin A (TSA) is a kind of classical histone deacetylase (HDAC) inhibitor. In this study, we reported the reversal effects of TSA on EMT and investigated the possible involved molecular mechanisms in SW480 and PC3 cells. Firstly, we observed that TSA induced the reversal process of epithelial–mesenchymal transition (EMT) in SW480 and PC3 cells, resulting in attenuated cell invasion and migration abilities. TSA-induced EMT reversal was characterized by up-regulation of E-cadherin and down-regulation of Vimentin. Then, treatment with TSA also decreased the expression of transcription factor Slug. Furthermore, over-expression of Slug significantly caused down-regulation of E-cadherin and up-regulation of Vimentin. Meanwhile, TSA treatment in Slug-expressing cells could prevent these changes. These findings suggested that Slug played a crucial role in TSA-induced EMT reversal. Additionally, the study showed that TSA could induce the increase of HDAC1 and HDAC2 on the Slug gene promoter, which might be responsible for the suppression of Slug. Overall, TSA could reverse EMT in SW480 and PC3 cells and TSA-mediated down-regulation of Slug was involved in the reversal process.
Polyvinyl alcohol/poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PVA/PEDOT:PSS) composite ultrafine fibers were successfully fabricated by high pressure airflow assisted electrospinning. ...The electrical properties of PVA/PEDOT:PSS nanofibers with different diameters were characterized. The average diameter of the nanofibers can be down to 68 nm. Due to its large specific surface area, ammonia sensing of the ultrafine nanofibers is more sensitive than the traditional electrospun fibers (average fiber diameter of 263 nm). The ammonia sensing properties of the samples were tested by impedance analysis. The results show that ultrafine PVA/PEDOT:PSS nanofibers are more suitable for detecting low concentrations of ammonia with higher sensitivity.
In this paper, a novel electrostatic-assisted melt blown process was reported to produce polypropylene (PP) microfibers with a diameter as fine as 600 nm. The morphology, web structure, pore size ...distribution, filtration efficiency, and the stress and strain behavior of the PP nonwoven fabric thus prepared were characterized. By introducing an electrostatic field into the conventional melt-blown apparatus, the average diameter of the melt-blown fibers was reduced from 1.69 to 0.96 μm with the experimental setup, and the distribution of fiber diameters was narrower, which resulted in a filter medium with smaller average pore size and improved filtration efficiency. The polymer microfibers prepared by this electrostatic-assisted melt blown method may be adapted in a continuous melt blown process for the production of filtration media used in air filters, dust masks, and so on.
Preinjury of peripheral nerves triggers dorsal root ganglia (DRG) axon regeneration, a biological change that is more pronounced in young mice than in old mice, but the complex mechanism has not been ...clearly explained. Here, we aim to gain insight into the mechanisms of axon regeneration after conditioning lesion in different age groups of mice, thereby providing effective therapeutic targets for central nervous system (CNS) injury.
The microarray GSE58982 and GSE96051 were downloaded and analyzed to identify differentially expressed genes (DEGs). The protein-protein interaction (PPI) network, the miRNA-TF-target gene network, and the drug-hub gene network of conditioning lesion were constructed. The L4 and L5 DRGs, which were previously axotomized by the sciatic nerve conditioning lesions, were harvested for qRT-PCR. Furthermore, histological and behavioral tests were performed to assess the therapeutic effects of the candidate drug telmisartan in spinal cord injury (SCI).
A total of 693 and 885 DEGs were screened in the old and young mice, respectively. Functional enrichment indicates that shared DEGs are involved in the inflammatory response, innate immune response, and ion transport. QRT-PCR results showed that in DRGs with preinjury of peripheral nerve, Timp1, P2ry6, Nckap1l, Csf1, Ccl9, Anxa1, and C3 were upregulated, while Agtr1a was downregulated. Based on the bioinformatics analysis of DRG after conditioning lesion, Agtr1a was selected as a potential therapeutic target for the SCI treatment. In vivo experiments showed that telmisartan promoted axonal regeneration after SCI by downregulating AGTR1 expression.
This study provides a comprehensive map of transcriptional changes that discriminate between young and old DRGs in response to injury. The hub genes and their related drugs that may affect the axonal regeneration program after conditioning lesion were identified. These findings revealed the speculative pathogenic mechanism involved in conditioning-dependent regenerative growth and may have translational significance for the development of CNS injury treatment in the future.
High-grade glioma is the most common and aggressive primary brain tumor in adults with poor therapeutic efficiency and survival prognosis. Cell division cycle associated 8 (CDCA8) has been well known ...as a cell cycle regulator and tumor promotor in various malignant tumors. However, its biological role in glioma still remains unclear. Our results showed that high level of CDCA8 was significantly correlated with advanced WHO grade and poor overall survival and disease-free survival prognosis. In vitro and in vivo investigations demonstrated that CDCA8 promoted the glioma malignancy by promoting cell proliferation, cell migration, and inhibiting cell apoptosis. Moreover, we found its synergetic biological protein-E2F1 by the gene microarray chip. In this study, we revealed that CDCA8 synergized with E2F1 facilitated the proliferation and migration of glioma. In conclusion, our study provides a novel promising therapeutic targets and prognostic biomarkers for malignant glioma treatment.
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