•The significance of the luminescence thermochromism is illustrated.•Representative studies about metal-containing crystalline luminescent thermochromic materials are illustrated.•Crystalline ...materials provide direct insights into the chromic mechanisms of luminescence thermochromism.
Stimuli-responsive functional materials with specific properties have been garnering recent attention. Various external stimulations, such as light, mechanical or pressure, vapor, solvent or temperature, have been extensively utilized to induce physical property changes. Temperature, the most fundamental parameter, is believed to serve as an efficient stimulus for triggering luminescence changes. This thermal, stimuli-responsive luminescence change is known as luminescence thermochromism. This review focuses on the systematic developments of metal-containing crystalline luminescence thermochromic materials, which will be of interest to researchers attempting to design and develop new temperature-induced luminescence-changing materials. Additionally, focusing on crystalline materials provides direct insight into the chromic mechanisms of luminescence thermochromism, which are also discussed.
A novel 2D zinc(
ii
) metal-organic framework, formulated as Zn(L)(H
2
O)·H
2
O (
1
) (H
2
L = 4-(pyridine-4-yl) phthalic acid), has been successfully obtained under solvothermal conditions. This ...metal-organic framework (MOF) material exhibits efficient photocatalytic activity towards the degradation of organic dyes in the absence of any photosensitizer or cocatalyst. Its catalytic performance for rhodamine B (RhB) and methyl orange (MO) degradation was superior to most reported MOFs with a degradation efficiency of 98.5% for RhB and 83.8% for MO within 120 min in the absence of H
2
O
2
, which could be attributed to its high efficiency in generating ·O
2
−
(an effective oxidant for the degradation of dyes). The possible mechanism of the reaction was discussed in detail. In addition,
1
shows stable catalytic efficiency after five reaction cycles, which indicates that
1
exhibits efficient catalytic activity and good reusability toward the degradation of organic dyes, enabling it to be a potential candidate for environmental governance.
A new 2D zinc(
ii
) metal-organic framework exhibits efficient photocatalytic activity and recyclability towards the degradation of organic dyes in the absence of any photosensitizer or cocatalyst.
Macrophages are highly heterogeneous and exhibit a diversity of functions and phenotypes. They can be divided into pro‐inflammatory macrophages (M1) and anti‐inflammatory macrophages (M2). Diabetic ...wounds are characterized by a prolonged inflammatory phase and difficulty in healing due to the accumulation of pro‐inflammatory (M1) macrophages in the wound. Therefore, hydrogel dressings with macrophage heterogeneity regulation function hold great promise in promoting diabetic wound healing in clinical applications. However, the precise conversion of pro‐inflammatory M1 to anti‐inflammatory M2 macrophages by simple and biosafe approaches is still a great challenge. Here, an all‐natural hydrogel with the ability to regulate macrophage heterogeneity is developed to promote angiogenesis and diabetic wound healing. The protocatechuic aldehyde hybridized collagen‐based all‐natural hydrogel exhibits good bioadhesive and antibacterial properties as well as reactive oxygen species scavenging ability. More importantly, the hydrogel is able to convert M1 macrophages into M2 macrophages without the need for any additional ingredients or external intervention. This simple and safe immunomodulatory approach shows great application potential for shortening the inflammatory phase of diabetic wound repair and accelerating wound healing.
An all‐natural hydrogel composed of small molecules pro‐catechol and collagen is developed to promote diabetic wound healing by modulating macrophage heterogeneity. The hydrogel exhibits good bioadhesive, antibacterial, and reactive oxygen species scavenging abilities. In vitro and in vivo experiments show that the hydrogel is able to promote the conversion of pro‐inflammatory (M1) macrophages to anti‐inflammatory (M2) macrophages and the expression of anti‐inflammatory factors.
This research was intended to investigate the fetal origins of changed birth weight of the offspring born through assisted reproductive technology (ART). The association between hormone and lipid ...metabolism or body weight has been generally accepted, and as the basic and specific treatment in ART procedure, gonadotropin stimulation might have potential effects on intrauterine lipid metabolism. In our studies, the mice were superovulated with two doses of gonadotropin. The cholesterol metabolism in ovaries and the triglyceride metabolism in embryos were analyzed. The results showed gonadotropin probably accelerated luteinization and induced a longer time follicle development and ovulation, which resulted in histological and morphological alteration of ovary, and increased the cholesterol content and the expressions of steroidogenesis-related genes. In embryos, gonadotropin increased lipid accumulation and decreased fatty acid synthesis in a dose-dependent manner. Moreover, the changes of fatty acid composition were also shown in superovulation groups. Our studies firstly provided the evidence that the superovulation might affect the maternal and fetal lipid metabolism. These variations of lipid metabolism in our results may be associated with birth weight of ART infants.
Combining the porous structure and fluorescence properties of metal-organic frameworks (MOFs) with rational design to realize multifunction application is of great significance from an energy and ...environmental standpoint. Herein, a new series of lanthanide metal-organic frameworks (Ln-MOFs), {Ln(L)(H
2
O)·4H
2
O }
n
(
1-Ln
, where Ln = Eu, Tb, Gd, and Eu
x
Tb
1−
x
), were constructed by using a rigid 5-(2′,5′-dicarboxylphenyl) picolinic acid ligand and Ln
3+
ions.
1-Ln
was isostructural and exhibited a similar porous framework. Thermogravimetry analysis (TGA), powder X-ray diffraction (PXRD) and N
2
adsorption measurements revealed that
1-Eu
exhibits excellent thermal, water and chemical stabilities. As expected,
1-Eu-a
(activated
1-Eu
) shows a high adsorption capacity for C
2
H
2
(109.2 cm
3
g
−1
) as well as excellent selective separation with ideal adsorbed solution theory (IAST) selectivity for C
2
H
2
/CO
2
(4.1-3.3), C
2
H
2
/CH
4
(23-17) and CO
2
/CH
4
(5.6-5.4) at room temperature. More importantly, density functional theory (DFT) calculations and breakthrough experiments were carried out, which highlight its great potential to address challenging industrially important separation. Moreover, a series of bimetallic MOFs
1-Eu
x
Tb
1−
x
were constructed by changing the ratio of Eu
3+
and Tb
3+
and showed excellent linear color tunability (from green to red), indicating that they are suitable for barcode applications. Furthermore, luminescence studies revealed that
1-Eu
is an excellent fluorescent probe for sensing Fe
3+
(LOD: 0.57 μM) and CrO
4
2−
/Cr
2
O
7
2−
(LOD: 0.79/0.42 μM) ions in water, with a fast response, high sensitivity, selectivity and recyclability. To the best of our knowledge,
1-Eu
is the first reported Ln-MOF material with all-in-one multifunction, including excellent gas adsorption and separation, tunable light emission and efficient luminescence sensing.
A robust lanthanide MOF platform displays all-in-one multifunction, including excellent gas uptake and separation, tunable light emission and efficient luminescence sensing.
Intracellular tau accumulation forming neurofibrillary tangles is hallmark pathology of Alzheimer's disease (AD), but how tau accumulation induces synapse impairment is elusive. By overexpressing ...human full‐length wild‐type tau (termed hTau) to mimic tau abnormality as seen in the brain of sporadic AD patients, we find that hTau accumulation activates JAK2 to phosphorylate STAT1 (signal transducer and activator of transcription 1) at Tyr701 leading to STAT1 dimerization, nuclear translocation, and its activation. STAT1 activation suppresses expression of N‐methyl‐D‐aspartate receptors (NMDARs) through direct binding to the specific GAS element of GluN1, GluN2A, and GluN2B promoters, while knockdown of STAT1 by AAV‐Cre in STAT1flox/flox mice or expressing dominant negative Y701F‐STAT1 efficiently rescues hTau‐induced suppression of NMDAR expression with amelioration of synaptic functions and memory performance. These findings indicate that hTau accumulation impairs synaptic plasticity through JAK2/STAT1‐induced suppression of NMDAR expression, revealing a novel mechanism for hTau‐associated synapse and memory deficits.
Synopsis
Tau accumulation, one hallmark of Alzheimer's disease, induces synaptic impairment by activating JAK2/STAT1 signaling, which transcriptionally suppresses N‐methyl‐D‐aspartate receptors. Downregulation of STAT1 ameliorates synaptic function and memory performance in mice.
Accumulation of hTau triggers JAK2‐dependent STAT1 dimerization, activation and nuclear translocation.
STAT1 activation directly suppresses N‐methyl‐D‐aspartate receptor expression.
Downregulation of STAT1 rescues hTau‐induced N‐methyl‐D‐aspartate receptor suppression.
Tau accumulation, one hallmark of Alzheimer's disease, induces synaptic impairment by activating JAK2/STAT1 signaling, which transcriptionally suppresses N‐methyl‐D‐aspartate receptors. Downregulation of STAT1 ameliorates synaptic function and memory performance in mice.
Ferroptosis is a newly discovered form of programmed cell death, which has unique biological effects on metabolism and redox biology. In this study, the prognostic value of ferroptosis‐related genes ...was investigated in lower‐grade gliomas (LGG). We downloaded the ferroptosis‐related genes from the FerrDb dataset. Univariate Cox and LASSO regression analyses were applied to identify genes correlated with overall survival (OS). Subsequently, 12 ferroptosis‐related genes were screened to establish the prognostic signature using stepwise multivariate Cox regression. According to the median value of risk scores, patients were divided into low‐ and high‐risk subgroups. The Kaplan‐Meier curves showed the high‐risk group had a lower OS. The predictive power of the risk model was validated using the CGGA. Functional analysis revealed that the terms associated with plasma membrane receptor complex, immune response and glutamate metabolic process were primarily related to the risk model. Moreover, we established a nomogram that had a strong forecasting ability for the 1‐, 3‐ and 5‐year OS. In addition, we compared the risk scores between different clinical features. We also detected infiltration of macrophages and monocytes in different subgroups. Overall, our study identified the prognostic signature of 12 ferroptosis‐related genes, which has the potential to predict the prognosis of LGG.
Current approaches to treating inflammatory bowel disease focus on the suppression of overactive immune responses, the removal of reactive intestinal oxygen species, and regulation of the intestinal ...flora. However, owing to the complex structure of the gastrointestinal tract and the influence of mucus, current small-molecule and biologic-based drugs for treating colitis cannot effectively act at the site of colon inflammation, and as a result, they tend to exhibit low efficacies and toxic side effects. In this study, nanogel-based multistage NO delivery microcapsules are developed to achieve NO release at the inflammation site by targeting the inflammatory tissues using the nanogel. Surprisingly, oral administration of the microcapsules suppresses the growth of pathogenic bacteria and increases the abundance of probiotic bacteria. Metabolomics further show that an increased abundance of intestinal probiotics promotes the production of metabolites, including short-chain fatty acids and indole derivatives, which modulate the intestinal immunity and restore the intestinal barrier via the interleukin-17 and PI3K-Akt signaling pathways. This work reveals that the developed gas therapy strategy based on multistage NO delivery microcapsules modulates the intestinal microbial balance, thereby reducing inflammation and promoting intestinal barrier repair, ultimately providing a new therapeutic approach for the clinical management of colitis.
Environmental stress at high altitudes drives the development of distinct adaptive mechanisms in plants. However, studies exploring the genetic adaptive mechanisms of high-altitude plant species are ...scarce. In the present study, we explored the high-altitude adaptive mechanisms of plants in the Himalayas through whole-genome resequencing. We studied two widespread members of the Himalayan endemic alpine genus
(Zingiberaceae):
(a selfing species) and
(an outcrossing species). These species are distributed widely in the Himalayas with distinct non-overlapping altitude distributions;
is distributed at higher elevations, and
occurs at lower elevations. Compared to
,
exhibited higher levels of linkage disequilibrium, Tajima's
, and inbreeding coefficient, as well as lower recombination rates and genetic diversity. Approximately 96.3% of the genes in the reference genome underwent significant genetic divergence (
≥ 0.25). We reported 58 completely divergent genes (
= 1), of which only 17 genes were annotated with specific functions. The functions of these genes were primarily related to adapting to the specific characteristics of high-altitude environments. Our findings provide novel insights into how evolutionary innovations promote the adaptation of mountain alpine species to high altitudes and harsh habitats.
A new zinc compound, together with a corresponding series of Zn-4f heterometallic coordination polymers, namely, Zn(H2PBDA)(PBDA)n (1), {Ln2(PBDA)2·2H2O Zn2(PBDA)2Cl2}n H2PBDA = 3-(pyridin-3-yl-oxy) ...benzene-1,2-dicarboxylic acid, and Ln = Pr(2), Nd(3), Eu(4), Gd(5), Dy(6), Ho(7), Er(8) have been hydrothermally synthesized and characterized systematically. Polymers 2-8 feature two-dimensional (2D) 4,4 networks, containing the original 1D heterometallic double stranded chains composed of Ln2Zn2(PBDA)2 entities. The extensive hydrogen bonding and π-π stacking interactions were observed to stabilize the extended architectures. The luminescence emission spectra of the polymers vary depending on the lanthanide(III) ion present. Informative magnetic susceptibility measurements show that the same carboxylate bridging fashion of the PBDA ligand results in the different magnetic properties occurring within the heterometallic coordination polymers. In addition, polymer 6 exhibits an interesting slow magnetic relaxation behavior at lower temperatures.
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