Despite increasing research attention to healthcare marketing in academia and the concerted effort of the pharmaceutical industry to market its latest products, limited research has explored the ...effect of launch time on individuals' drug choices. Building upon findings in medical literature that many newly launched drugs are indeed no better than existing ones, this study found that the majority of consumers consistently prefer older drugs when both options are claimed equally safe and/or effective. The reason is that consumers disregard declarative information and, instead, make their own inferences. Although there is a small segment that chooses the newer option for what they infer to be its higher efficacy, most consumers believe that an older drug is both safer and more efficacious. Further, promotion‐focused consumers are more likely to choose newer drugs. The underlying mechanism for how promotion focus affects choice is identified. A sample of practicing doctors cross‐validated our findings, which have implications for practitioners in the pharmaceutical industry.
Abstract
Curbing the COVID-19 pandemic remains an ongoing global challenge.
Institutions often release information about confirmed COVID-19 cases by
citing the total number of cases (e.g., 100,000), ...their (relative) frequency
(e.g., 100 per 1,000,000), or occasionally their proportion (e.g., 0.0001)
in a region. I compared the effect of these three presentation formats —
total cases, frequency, and proportion — on people’s perceived risk. I found
people perceived a higher risk of COVID-19 from a total-cases format than
from frequency formats when the denominators are relatively small, and the
lowest risk from a proportion format. Correspondingly, people underestimated
total infections when given frequency and overestimated frequency when given
total number of cases. Additional comparisons were made among mathematically
equivalent variations of frequency formats (e.g., 1 in 100, 10 in 1,000,
1,000 in 10,000, etc.). The results provided qualified support for
denominator neglect, which seems to occur in bins into which denominators
are grouped (e.g., 1–1000, 10000–100000), such that only across bins could
participants perceive differences. Finally, a mixed format of proportion and
total cases reduced perceived risks from total cases alone, while a mixed
format of frequency and total cases failed to produce similar results. I
conclude by providing concrete suggestions regarding COVID-19 information
releases.
Bambusoideae is the only subfamily that contains woody members in the grass family, Poaceae. In phylogenetic analyses, Bambusoideae, Pooideae and Ehrhartoideae formed the BEP clade, yet the internal ...relationships of this clade are controversial. The distinctive life history (infrequent flowering and predominance of asexual reproduction) of woody bamboos makes them an interesting but taxonomically difficult group. Phylogenetic analyses based on large DNA fragments could only provide a moderate resolution of woody bamboo relationships, although a robust phylogenetic tree is needed to elucidate their evolutionary history. Phylogenomics is an alternative choice for resolving difficult phylogenies.
Here we present the complete nucleotide sequences of six woody bamboo chloroplast (cp) genomes using Illumina sequencing. These genomes are similar to those of other grasses and rather conservative in evolution. We constructed a phylogeny of Poaceae from 24 complete cp genomes including 21 grass species. Within the BEP clade, we found strong support for a sister relationship between Bambusoideae and Pooideae. In a substantial improvement over prior studies, all six nodes within Bambusoideae were supported with ≥0.95 posterior probability from Bayesian inference and 5/6 nodes resolved with 100% bootstrap support in maximum parsimony and maximum likelihood analyses. We found that repeats in the cp genome could provide phylogenetic information, while caution is needed when using indels in phylogenetic analyses based on few selected genes. We also identified relatively rapidly evolving cp genome regions that have the potential to be used for further phylogenetic study in Bambusoideae.
The cp genome of Bambusoideae evolved slowly, and phylogenomics based on whole cp genome could be used to resolve major relationships within the subfamily. The difficulty in resolving the diversification among three clades of temperate woody bamboos, even with complete cp genome sequences, suggests that these lineages may have diverged very rapidly.
A novel tobacco rods-derived carbon (TC) has been prepared by hydrothermal carbonization and potassium hydroxide activation strategy for supercapacitors application. The physicochemical properties of ...TC are investigated by X-ray diffraction, Raman spectra, Scanning electron microscopy, Nitrogen adsorption–desorption isotherms, X-ray photoelectron spectroscopy, and four-probe tests. Results show TC derived from different tobacco rods possesses similar properties, such as amorphous state, high specific surface area, hierarchical porous structure, numerous heteroatom groups, and good electrical conductivity. The electrochemical characteristics of TC are examined via cyclic voltammetry, galvanostatic charge–discharge, and electrochemical impedance spectroscopy measurements. In a three-electrode system, TC exhibits high capacitance with 286.6 F g−1 at 0.5 A g−1, excellent rate performance with 212.1 F g−1 even at 30 A g−1, and outstanding cyclic stability with 96% capacitance retention after 10,000 cycles at 5 A g−1. Furthermore, TC supercapacitor devices can deliver an energy density of 31.3 Wh kg−1 at 0.5 A g−1 and power density of 11.8 kW kg−1 at 15 A g−1. Therefore, this novel concept of tobacco use, namely tobacco rods from cigarette (the harmful) to high-performance carbon for supercapacitors (the beneficial), is an extremely promising strategy for developing high-performance carbon from renewable sources, and supporting the tobacco control.
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•Tobacco rods (TR) from different producing places were used as precursors.•TR-derived carbon (TC) was prepared by hydrothermal carbonization and KOH activation.•TC possesses high SSA, hierarchical porous structure, and numerous heteroatom groups.•TC exhibits high capacitance, excellent rate performance, and long-term stability.•TR from cigarette to high-performance carbon is a novel concept of tobacco use.
Wave-particle duality is the most fundamental description of the nature of a quantum object, which behaves like a classical particle or wave depending on the measurement apparatus. On the other hand, ...entanglement represents nonclassical correlations of composite quantum systems, being also a key resource in quantum information. Despite the very recent observations of wave-particle superposition and entanglement, whether these two fundamental traits of quantum mechanics can emerge simultaneously remains an open issue. Here we introduce and experimentally realize a scheme that deterministically generates entanglement between the wave and particle states of two photons. The elementary tool allowing this achievement is a scalable single-photon setup which can be in principle extended to generate multiphoton wave-particle entanglement. Our study reveals that photons can be entangled in their dual wave-particle behavior and opens the way to potential applications in quantum information protocols exploiting the wave-particle degrees of freedom to encode qubits.Here the authors experimentally realize a scheme that deterministically generates entanglement between the wave and particle states of two photons using a scalable all-optical scheme. They achieve this result by first showing generation of controllable single-photon wave-particle superposition states.
Abstract In this work, we investigate the impact of energetic coherence in nonthermal reservoirs on the performance of the Otto cycle. We first focus on the situation where the working substance is a ...qubit. Due to the existence of coherence of nonthermal reservoir, various anomalous operating regimes such as the engine and refrigerator with efficiencies exceeding Carnot limits, as well as the hybrid refrigerator that can simultaneously achieve cooling and supplying work to an external agent, can occur. We demonstrate that the energetic coherence of the system’s steady state plays a significant role in determining the cycle’s functions by adding an additional stroke implementing dephasing and phase modulation operations in the cycle. The energetic coherence of the system is necessary to trigger the reservoir’s coherence to exert influences on the cycle. We decompose the thermodynamic quantities to the components arising from the populations and coherence of the system, and find that the reservoir’s coherence impacts the cycle from two aspects: one is the modification of the system’s steady-state populations or temperatures, and the other is the direct contributions to the heat in the interaction between the system and reservoirs. We then explore the scenario where the working substance is two identical qubits, and the reservoirs are common to them. We show that the degenerate coherence of the system in the steady state can enhance the performances of the cycle as different machines. Additionally, the energetic coherence of the reservoir modifies the functions of the cycle still through the energetic coherence of the system rather than their degenerate coherence.
Abstract
The present study explores incompressible, steady power law nanoliquid comprising gyrotactic microorganisms flow across parallel plates with energy transfer. In which only one plate is ...moving concerning another at a time. Nonlinear partial differential equations have been used to model the problem. Using Liao's transformation, the framework of PDEs is simplified to a system of Ordinary Differential Equations (ODEs). The problem is numerically solved using the parametric continuation method (PCM). The obtained results are compared to the boundary value solver (bvp4c) method for validity reasons. It has been observed that both the results are in best settlement with each other. The temperature, velocity, concentration and microorganism profile trend versus several physical constraints are presented graphically and briefly discussed. The velocity profile shows positive response versus the rising values of buoyancy convection parameters. While the velocity reduces with the increasing effect of magnetic field, because magnetic impact generates Lorentz force, which reduces the fluid velocity.
The minimal time a system needs to evolve from an initial state to its one orthogonal state is defined as the quantum speed limit time, which can be used to characterize the maximal speed of ...evolution of a quantum system. This is a fundamental question of quantum physics. We investigate the generic bound on the minimal evolution time of the open dynamical quantum system. This quantum speed limit time is applicable to both mixed and pure initial states. We then apply this result to the damped Jaynes-Cummings model and the Ohimc-like dephasing model starting from a general time-evolution state. The bound of this time-dependent state at any point in time can be found. For the damped Jaynes-Cummings model, when the system starts from the excited state, the corresponding bound first decreases and then increases in the Markovian dynamics. While in the non-Markovian regime, the speed limit time shows an interesting periodic oscillatory behavior. For the case of Ohimc-like dephasing model, this bound would be gradually trapped to a fixed value. In addition, the roles of the relativistic effects on the speed limit time for the observer in non-inertial frames are discussed.
Electrically driven molecular light emitters are considered to be one of the promising candidates as single-photon sources. However, it is yet to be demonstrated that electrically driven ...single-photon emission can indeed be generated from an isolated single molecule notwithstanding fluorescence quenching and technical challenges. Here, we report such electrically driven single-photon emission from a well-defined single molecule located inside a precisely controlled nanocavity in a scanning tunneling microscope. The effective quenching suppression and nanocavity plasmonic enhancement allow us to achieve intense and stable single-molecule electroluminescence. Second-order photon correlation measurements reveal an evident photon antibunching dip with the single-photon purity down to g
(0) = 0.09, unambiguously confirming the single-photon emission nature of the single-molecule electroluminescence. Furthermore, we demonstrate an ultrahigh-density array of identical single-photon emitters.Molecular emitters offer a promising solution for single-photon generation. Here, by exploiting electronic decoupling by an ultrathin dielectric spacer and emission enhancement by a resonant plasmonic nanocavity, the authors demonstrate electrically driven single-photon emission from a single molecule.
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