Cardiovascular diseases remain the leading cause of death worldwide. The rapid development of flexible sensing technologies and wearable pressure sensors have attracted keen research interest and ...have been widely used for long‐term and real‐time cardiovascular status monitoring. Owing to compelling characteristics, including light weight, wearing comfort, and high sensitivity to pulse pressures, physiological pulse waveforms can be precisely and continuously monitored by flexible pressure sensors for wearable health monitoring. Herein, an overview of wearable pressure sensors for human pulse wave monitoring is presented, with a focus on the transduction mechanism, microengineering structures, and related applications in pulse wave monitoring and cardiovascular condition assessment. The conceptualizations and methods for the acquisition of physiological and pathological information related to the cardiovascular system are outlined. The biomechanics of arterial pulse waves and the working mechanism of various wearable pressure sensors, including triboelectric, piezoelectric, magnetoelastic, piezoresistive, capacitive, and optical sensors, are also subject to systematic debate. Exemple applications of pulse wave measurement based on microengineering structured devices are then summarized. Finally, a discussion of the opportunities and challenges that wearable pressure sensors face, as well as their potential as a wearable intelligent system for personalized healthcare is given in conclusion.
The current advances of wearable pressure sensors for human pulse wave monitoring are presented, with a focus on the transduction mechanism, microengineering structures, and related applications in pulse wave monitoring and cardiovascular condition assessment. The biomechanics of arterial pulse waves, the working mechanism of various wearable pressure sensors, as well as opportunities and challenges are also concluded.
Osteoprotegerin (OPG) is supposed to participate in the development of atherosclerosis and cardio-cerebrovascular disease. However, the results of research on relationship between OPG and ischemic ...stroke (IS) are controversial. Therefore, we carried out the first systematic review and meta-analysis to evaluate prognostic effect of osteoprotegerin in patients with IS.
We comprehensively searched databases of PubMed, Embase, and the Cochrane Library through 21 August 2023 to identify observational studies that evaluated effect of OPG on poor functional outcome (modified Rankin Scale mRS Score of 3-6) and mortality in patients with IS. Adjusted odds ratios (aOR) with a 95% confidence interval (CI) of each included study were used as much as possible to assess the pooled effect.
Five studies that enrolled 4,506 patients in total fulfilled our inclusion criteria. Three studies were included in the pooled analysis for each endpoint since one of the included studies had provided data on poor functional outcome as well as mortality. OPG was neither associated with poor functional outcome (aOR 1.29, 95% CI 0.90-1.85) nor with mortality (aOR 1.57, 95% CI 0.90-2.74) in patients with IS.
There is insufficient evidence to demonstrate the correlation between OPG and mortality or poor functional outcome in IS patients. OPG cannot be applied to predict worse neurological function in IS patients based on the current evidence.
Streptococcus suis is one of the most common zoonotic pathogens, in humans and can cause meningitis, endocarditis, arthritis and sepsis. Human cases of Streptococcus suis infection have been reported ...worldwide, and most of those cases occurred in Asia. Hearing loss is the most common sequela of Streptococcus suis meningitis. Streptococcus suis infection complicated with acute cerebral infarction has rarely been reported. Therefore, to provide a reference for this disease, we reported a case of acute multiple brain infarctions associated with Streptococcus suis infection. In our report, a 69yearold male patient had Streptococcus suis meningitis and sepsis, which were associated with multiple acute cerebral infarctions in the pons and bilateral frontotemporal parietal occipital lobes. After treatment, the patient exhibited cognitive impairment, dyspraxia and irritability. There are limited case reports of cerebral infarction associated with Streptococcus suis infection, and further research is needed to determine the best treatment method.
Synthesis of covalent organic frameworks (COFs) with desirable organic units furnishes advanced materials with unique functionalities. As an emerging class of two‐dimensional (2D) COFs, ...sp2‐carbon‐conjugated COFs provide a facile platform to build highly stable and crystalline porous polymers. Herein, a 2D olefin‐linked COF was prepared by employing nanographene, namely, dibenzohi,stovalene (DBOV), as a building block. The DBOV‐COF exhibits unique ABC‐stacked lattices, enhanced stability, and charge‐carrier mobility of ≈0.6 cm2 V−1 s−1 inferred from ultrafast terahertz photoconductivity measurements. The ABC‐stacking structure was revealed by the high‐resolution transmission electron microscopy and powder X‐ray diffraction. DBOV‐COF demonstrated remarkable photocatalytic activity in hydroxylation, which was attributed to the exposure of narrow‐energy‐gap DBOV cores in the COF pores, in conjunction with efficient charge transport following light absorption.
Dibenzohi,stovalene‐based covalent organic frameworks form 2D ABC stacking sp2 carbon lattices with robust olefin linkage. The resulting 2D unique structure exhibits high photoconductivity, charge‐carrier mobility and photocatalytic activity in hydroxylation attributed to the narrow‐energy‐gap nanographene cores as active sites.
As one of main obstacles in the treatment and prognosis of hepatocellular carcinoma (HCC), multidrug resistance (MDR) is usually associated with the overexpression of the drug efflux pump ...P-glycoprotein (P-gp/ABCB1) which is responsible for reducing the intracellular concentration of chemotherapeutic agents. In current work, we discovered the novel role of miR-491-3p in ABCB1-mediated multidrug resistance in HCC and revealed the underlying mechanism in which miR-491-3p downregulated the expression of ABCB1 and its transcription factor Sp3 by directly targeting their 3′-UTR. Moreover, overexpressing ABCB1 or Sp3 reversed the sensitivity to chemotherapeutics in Hep3B cells induced by miR-491-3p, confirming miR-491-3p/Sp3/ABCB1 regulatory loop plays an important role in enhancing the drugs sensitivity of HCC. Meanwhile, the discovery of that the expression level of miR-491-3p was inversely correlated with that of ABCB1 and Sp3 in HCC cell lines and clinical samples pointed out the possibility of miR-491-3p in clinical use. In summary, our results reveal a pivotal role of miR-491-3p in the regulation of MDR in HCC, and suggest the potential application of miR-491-3p as a therapeutic strategy for modulating MDR in cancer cells.
•MiR-491-3p inhibits both post-transcriptional level and transcriptional level of ABCB1.•The miR-491-3p/ABCB1/Sp3 regulatory loop increases the sensitivity of HCC cells to chemotherapeutics.•New therapeutic strategies targeted on the miR-491-3p/ABCB1/Sp3 axis may enhance the efficacy of chemotherapy against HCC.
Preoperative anxiety is a psychological state that commonly occurs before surgery and may have a negative impact on postoperative outcomes. This study aimed to investigate the effects of preoperative ...anxiety on postoperative sleep quality and recovery outcomes among patients undergoing laparoscopic gynecological surgery.
The study was conducted as a prospective cohort study. A total of 330 patients were enrolled and underwent laparoscopic gynecological surgery. After assessing the patient's preoperative anxiety score on the APAIS scale, 100 patients were classified into the preoperative anxiety (PA) group (preoperative anxiety score > 10) and 230 patients into the non-preoperative-anxiety (NPA) group (preoperative anxiety score ≤ 10). The Athens Insomnia Scale (AIS) was assessed on the night before surgery (Sleep Pre 1), the first night after surgery (Sleep POD 1), the second night after surgery (Sleep POD2), and the third night after surgery (Sleep POD 3). Postoperative pain was evaluated by the Visual Analog Scale (VAS), and the postoperative recovery outcomes and adverse effects were also recorded.
The AIS score in the PA group was higher than that of the NPA group at Sleep-pre 1, Sleep POD 1, Sleep POD 2, and Sleep POD 3 (
< 0.05). The VAS score was higher in the PA group than in the NPA group within 48 h postoperatively (
< 0.05). In the PA group, the total dosage of sufentanil was significantly higher, and more rescue analgesics were required. Patients with preoperative anxiety showed a higher incidence of nausea, vomiting, and dizziness than those without preoperative anxiety. However, there was no significant difference in the satisfaction rate between the two groups.
The perioperative sleep quality of patients with preoperative anxiety is worse than that of patients without preoperative anxiety. Moreover, high preoperative anxiety is related to more severe postoperative pain and an increased requirement for analgesia.
SUMMARY
Using modelled and simulated data for comparison of several methods to compute GPS strain rate fields in terms of their precision and robustness reveals that least‐squares collocation is ...superior. Large scale (75°E–135°E and 20°N–50°N) analyses of 1° grid sampling data and decimated 50 per cent data by resampling (then erasing data in two 5°× 10° region) reveal that the Delaunay method has poor performance and that the other three methods show high accuracy. The correlation coefficients between theoretical results and calculated results obtained with different errors in input data show that the order in terms of robustness, from good to bad, is least‐squares collocation, spherical harmonics, multisurface function and the Delaunay method. The influence of data sparseness on different methods shows that least‐squares collocation is better than spherical harmonics and multisurface function when sample data are distributed from a 2° grid to a 1° grid. Analysis to medium scale (90°E–120°E, 25°N–40°N) in 1°–0.5° grid sampling data reveals that least‐squares collocation is superior to other methods in terms of robustness and sensitivity to data sparseness, but their difference is slight. Strain rate results obtained for the Chinese mainland using GPS data from 1999 to 2004 show that the spherical harmonics method has edge effects and that its value and range increase concomitantly with increased sparseness. The multisurface function method shows non‐steady‐state characteristics; the errors of results increase concomitantly with increased sparseness. The least‐squares collocation method shows steady characteristics. The errors of results show no significant increase even though 50 per cent of input data are decimated by resampling. The spherical harmonics and multisurface function methods are affected by the geometric distribution of input data, but the least‐squares collocation method is not.
Patients received kidney transplantation (KTR) have a low seroconversion rate after vaccination. Our objective was to compare the seroconversion rates and adverse effects of additional different ...vaccinations in KTR patients in existing studies. Databases such as PubMed, Cochrane Library, Web of Science, Embase, ClinicalTrials.gov and others. Three high-quality RCT were included and showed no statistical difference in seroconversion rates between the two vaccines (RR = 0.930.76,1.13). There was no statistical difference in seroconversion rates between the sexes, for men (RR = 0.930.69,1.25) and women (RR = 0.910.62,1.33). Among the adverse effects there was no statistically significant difference in fever (RR = 1.060.44,2.57), while for injection site pain there was a statistically significant difference (RR = 1.141.18,1.84). There was no significant difference in seroconversion rates in patients with KTR who received the two additional vaccines. Patients injected with the viral vector vaccine were less painful than those injected with the mRNA vaccine.
The mechanisms underlying secondary brain injury in remote areas remains unclear. This study aimed to investigate the relationship between vascular tortuosity and thalamic volume. Methods: In this ...study, we retrospectively analyzed sixty-five patients with unilateral middle cerebral artery occlusion (MCAO) who underwent magnetic resonance angiography. We compared the vascular tortuosity in patients with MCAO and controls, and analyzed the relationship between vascular tortuosity and thalamic volume. Results: Compared with controls, the MCAO group exhibited a significantly smaller thalamus volume on the affected side (5874 ± 183 mm3 vs. 5635 ± 383 mm3, p < 0.0001). The vascular tortuosity of the posterior cerebral artery (PCA) was higher in the MCAO group than in the controls (82.8 ± 17.3 vs. 76.7 ± 17.3, p = 0.040). Logistic regression analysis revealed that PCA tortuosity was an independent risk factor for reduced thalamic volume after MCAO (p = 0.034). In the subgroup analysis, only the 4-7-day group was not statistically different in thalamic volume between the MCAO and control groups. In the MCAO group, patients older than 60 years and female patients had a more tortuous PCA. Conclusion: Reduced thalamic volume after MCAO was associated with a tortuous PCA. After MCAO, PCA tortuosity increased more significantly in patients aged >60 years and in female patients.
Wheat leaf rust (also known as brown rust), caused by the fungal pathogen
Puccinia triticina
Erikss. (Pt), is one by far the most troublesome wheat disease worldwide. The exploitation of resistance ...genes has long been considered as the most effective and sustainable method to control leaf rust in wheat production. Previously the leaf rust resistance gene
Lr65
has been mapped to the distal end of chromosome arm 2AS linked to molecular marker
Xbarc212
. In this study,
Lr65
was delimited to a 0.8 cM interval between flanking markers
Alt-64
and
AltID-11
, by employing two larger segregating populations obtained from crosses of the resistant parent Altgold Rotkorn (ARK) with the susceptible parents Xuezao and Chinese Spring (CS), respectively. 24 individuals from 622 F
2
plants of crosses between ARK and CS were obtained that showed the recombination between
Lr65
gene and the flanking markers
Alt-64
and
AltID-11
. With the aid of the CS reference genome sequence (IWGSC RefSeq v1.0), one SSR marker was developed between the interval matched to the
Lr65
-flanking marker and a high-resolution genetic linkage map was constructed. The
Lr65
was finally located to a region corresponding to 60.11 Kb of the CS reference genome. The high-resolution genetic linkage map founded a solid foundation for the map-based cloning of
Lr65
and the co-segregating marker will facilitate the marker-assisted selection (MAS) of the target gene.
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