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zadetkov: 219
1.
  • mGlu2/3 receptor antagonism... mGlu2/3 receptor antagonism: A mechanism to induce rapid antidepressant effects without ketamine-associated side-effects
    Witkin, Jeffrey M. Pharmacology, biochemistry and behavior, March 2020, 2020-03-00, Letnik: 190
    Journal Article
    Recenzirano

    The consensus that ketamine can produce rapid-onset antidepressant effects in patients combined with the recent approval of S(+)-ketamine (esketamine, Spravato) as an antidepressant, has fueled the ...
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  • Synthesis of (−)-11‑O‑Deben... Synthesis of (−)-11‑O‑Debenzoyltashironin: Neurotrophic Sesquiterpenes Cause Hyperexcitation
    Ohtawa, Masaki; Krambis, Michael J; Cerne, Rok ... Journal of the American Chemical Society, 07/2017, Letnik: 139, Številka: 28
    Journal Article
    Recenzirano

    11-O-Debenzoyltashironin (1) is a member of the neurotrophic sesquiterpenes, trace plant metabolites that enhance neurite outgrowth in cultured neurons. We report its synthesis in six steps from a ...
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Dostopno za: UL
5.
  • Curcumin, an active constiuent of the ancient medicinal herb Curcuma longa L.: some uses and the establishment and biological basis of medical efficacy
    Witkin, Jeffrey M; Li, Xia CNS & neurological disorders drug targets, 06/2013, Letnik: 12, Številka: 4
    Journal Article
    Recenzirano

    The root extract, curcumin (diferuloylmethane), is a constituent of the ancient herbal medicine Jiawei-Xiaoyaosan that has been used for dyspepsia, stress, and mood disorders. Curcumin engenders a ...
Preverite dostopnost
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  • Is there a biochemical basi... Is there a biochemical basis for purinergic P2X3 and P2X4 receptor antagonists to be considered as anti-seizure medications?
    Witkin, Jeffrey M.; Shafique, Hana; Smith, Jodi L. ... Biochemical pharmacology, April 2024, 2024-Apr, 2024-04-00, 20240401, Letnik: 222
    Journal Article
    Recenzirano

    Display omitted Patients with epilepsy require improved medications. Purinergic receptors were identified as late as 1976 and are slowly emerging as potential drug targets for the discovery of ...
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  • GABAkines – Advances in the... GABAkines – Advances in the discovery, development, and commercialization of positive allosteric modulators of GABAA receptors
    Cerne, Rok; Lippa, Arnold; Poe, Michael M. ... Pharmacology & therapeutics (Oxford), June 2022, 2022-06-00, 20220601, Letnik: 234
    Journal Article
    Recenzirano
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    Positive allosteric modulators of γ-aminobutyric acid-A (GABAA) receptors or GABAkines have been widely used medicines for over 70 years for anxiety, epilepsy, sleep, and other disorders. Traditional ...
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8.
  • The biology of Nociceptin/O... The biology of Nociceptin/Orphanin FQ(N/OFQ) related to obesity, stress, anxiety, mood, and drug dependence
    WITKIN, Jeffrey M; STATNICK, Michael A; RORICK-KEHN, Linda M ... Pharmacology & therapeutics (Oxford), 03/2014, Letnik: 141, Številka: 3
    Journal Article
    Recenzirano
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    Nociceptin/Orphanin FQ (N/OFQ) is a 17 amino acid peptide that was deorphanized in 1995. The generation of specific agonists, antagonists and receptor deficient mice and rats has enabled progress in ...
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  • Prediction of human efficac... Prediction of human efficacious antidepressant doses using the mouse forced swim test
    Yuen, Eunice; Swanson, Steven; Witkin, Jeffrey M. Pharmacology, biochemistry and behavior, October 2017, 2017-Oct, 2017-10-00, 20171001, Letnik: 161
    Journal Article
    Recenzirano

    The forced swim test (FST) is a commonly used preclinical animal behavioural model for prediction of antidepressant activity in humans. While the FST may qualitatively predict efficacy, less is known ...
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zadetkov: 219

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