Oxidative stress and cardiomyocyte apoptosis play critical roles in doxorubicin (DOX)-induced cardiotoxicity. Previous studies indicated that fibronectin type III domain-containing 5 (FNDC5) and its ...cleaved form, irisin, could preserve mitochondrial function and attenuate oxidative damage as well as cell apoptosis, however, its role in DOX-induced cardiotoxicity remains unknown. Our present study aimed to investigate the role and underlying mechanism of FNDC5 on oxidative stress and cardiomyocyte apoptosis in DOX-induced cardiotoxicity. Cardiomyocyte-specific FNDC5 overexpression was achieved using an adeno-associated virus system, and then the mice were exposed to a single intraperitoneal injection of DOX (15 mg/kg) to generate DOX-induced cardiotoxicity. Herein, we found that FNDC5 expression was downregulated in DOX-treated murine hearts and cardiomyocytes. Fndc5 deficiency resulted in increased oxidative damage and apoptosis in H9C2 cells under basal conditions, imitating the phenotype of DOX-induced cardiomyopathy in vitro, conversely, FNDC5 overexpression or irisin treatment alleviated DOX-induced oxidative stress and cardiomyocyte apoptosis in vivo and in vitro. Mechanistically, we identified that FNDC5/Irisin activated AKT/mTOR signaling and decreased DOX-induced cardiomyocyte apoptosis, and moreover, we provided direct evidence that the anti-oxidant effect of FNDC5/Irisin was mediated by the AKT/GSK3β/FYN/Nrf2 axis in an mTOR-independent manner. And we also demonstrated that heat shock protein 20 was responsible for the activation of AKT caused by FNDC5/Irisin. In line with the data in acute model, we also found that FNDC5/Irisin exerted beneficial effects in chronic model of DOX-induced cardiotoxicity (5 mg/kg, i.p., once a week for three times, the total cumulative dose is 15 mg/kg) in mice. Based on these findings, we supposed that FNDC5/Irisin was a potential therapeutic agent against DOX-induced cardiotoxicity.
A critical bottleneck that hinders major performance improvement in lithium‐ion and sodium‐ion batteries is the inferior electrochemical activity of their cathode materials. While significant ...research progresses have been made, conventional single‐phase cathodes are still limited by intrinsic deficiencies such as low reversible capacity, enormous initial capacity loss, rapid capacity decay, and poor rate capability. In the past decade, layer‐based heterostructured cathodes acquired by combining multiple crystalline phases have emerged as candidates with a huge potential to realize performance breakthrough. Herein, recent studies on the structural properties, electrochemical behaviors, and synthesis route optimizations of these heterostructured cathodes are summarized for in‐depth discussions. Particular attention is paid to the latest mechanism discoveries and performance achievements. This review thus aims to promote a deeper understanding of the correlation between the crystal structure of cathodes and their electrochemical behavior, and offers guidance to design advance cathode materials from the aspect of crystal structure engineering.
The exploration of novel heterostructured cathodes has been recently regarded as the key to achieve a substantial performance leap in lithium‐ion and sodium‐ion batteries. Here, the challenges facing conventional single‐phase crystalline are introduced, and then, the properties, strengths, and recent achievements in various heterostructured cathodes are provided for in‐depth analysis and forecast.
Demands for large‐scale energy storage systems have driven the development of layered transition‐metal oxide cathodes for room‐temperature rechargeable sodium ion batteries (SIBs). Now, an abnormal ...layered‐tunnel heterostructure Na0.44Co0.1Mn0.9O2 cathode material induced by chemical element substitution is reported. By virtue of beneficial synergistic effects, this layered‐tunnel electrode shows outstanding electrochemical performance in sodium half‐cell system and excellent compatibility with hard carbon anode in sodium full‐cell system. The underlying formation process, charge compensation mechanism, phase transition, and sodium‐ion storage electrochemistry are clearly articulated and confirmed through combined analyses of in situ high‐energy X‐ray diffraction and ex situ X‐ray absorption spectroscopy as well as operando X‐ray diffraction. This crystal structure engineering regulation strategy offers a future outlook into advanced cathode materials for SIBs.
An abnormal layered‐tunnel heterostructure Na0.44Co0.1Mn0.9O2 cathode material induced by chemical element substitution is described. The crystal‐structure engineering strategy that was used gives an outlook into high‐performance sodium ion batteries.
The poor prognosis of patients with acute myocardial infarction is partially attributed to a large number of cardiomyocyte apoptosis, necrosis, limited cardiac healing and angiogenesis, and cardiac ...dysfunction. Immune cells dysfunction leads to nonhealing or poor healing of wounds after acute myocardial infarction. Toll-like receptor 9 (TLR9) as an essential part of the innate immune system plays a vital role in regulating cardiomyocyte survival and wound healing. During hypoxia, High Mobility Group Box 1 (HMGB1), as the typical damage-associated molecular patterns (DAMPs) or alarmin, is rapidly released extracellularly and translocates from the nucleus to bind with cytoplasmic TLR9. However, the mechanism by which TLR9 interacts with HMGB1 and regulates myocardial damage remains unclear. Our current study found that the survival rate of TLR9KO mice with a higher rate of cardiac rupture was significantly lower than that in WT mice after 28 days post-operation. The effect of TLR9 knockout on insufficient wound healing in experimental MI was caused by a diminished number of myofibroblast and defective matrix synthetic capability. Moreover, the increased myocardial apoptotic cells and decreased angiogenic capacity were found in TLR9 knockout mice after MI. The results showed contrary in Recombinant Human High Mobility Group Box 1 (rhHMGB1) treated WT mice and similarity after applying rhHMGB1 in TLR9KO mice. This study demonstrates that TLR9 is essential for the repair of infarcted myocardium and interaction of HMGB1 and TLR9 is involved in the survival of myocardial cells, wound healing, and angiogenesis after myocardial infarction.
The low salt adsorption capacities (SACs) of benchmark carbon materials (usually below 20 mg g–1) are one of the most challenging issues limiting further commercial development of capacitive ...deionization (CDI), an energetically favorable method for sustainable water desalination. Sodium superionic conductor (NASICON)-structured NaTi2(PO4)3 (NTP) materials, especially used in combination with carbon to prepare NTP/C materials, provide emerging options for higher CDI performance but face the problems of poor cycling stability and dissolution of active materials. In this study, we report the development of the yolk–shell nanoarchitecture of NASICON-structured NTP/C materials (denoted as ys-NTP@C) using a metal–organic framework@covalent organic polymer (MOF@COP) as a sacrificial template and space-confined nanoreactor. As expected, ys-NTP@C exhibits good CDI performance, including exemplary SACs with a maximum SAC of 124.72 mg g–1 at 1.8 V in the constant-voltage mode and 202.76 mg g–1 at 100 mA g–1 in the constant-current mode, and good cycling stability without obvious performance degradation or energy consumption increase over 100 cycles. Furthermore, X-ray diffraction used to study CDI cycling clearly exhibits the good structural stability of ys-NTP@C during repeated ion intercalation/deintercalation processes, and the finite element simulation shows why yolk–shell nanostructures exhibit better performance than other materials. This study provides a new synthetic paradigm for preparing yolk–shell structured materials from MOF@COP and highlights the potential use of yolk–shell nanoarchitectures for electrochemical desalination.
Hypoxia of solid tumor compromises the therapeutic outcome of photodynamic therapy (PDT) that relies on localized O
molecules to produce highly cytotoxic singlet oxygen (
O
) species. Herein, we ...present a safe and versatile self-assembled PDT nanoagent, i.e., OxgeMCC-r single-atom enzyme (SAE), consisting of single-atom ruthenium as the active catalytic site anchored in a metal-organic framework Mn
Co(CN)
with encapsulated chlorin e6 (Ce6), which serves as a catalase-like nanozyme for oxygen generation. Coordination-driven self-assembly of organic linkers and metal ions in the presence of a biocompatible polymer generates a nanoscale network that adaptively encapsulates Ce6. The resulted OxgeMCC-r SAE possesses well-defined morphology, uniform size distribution and high loading capacity. When conducting the in situ O
generation through the reaction between endogenous H
O
and single-atom Ru species of OxgeMCC-r SAE, the hypoxia in tumor microenvironment is relieved. Our study demonstrates a promising self-assembled nanozyme with highly efficient single-atom catalytic sites for cancer treatment.
A simple wet chemical process followed by high temperature calcination has been successfully used to coat Li-ion conductive Li4Ti5O12 on the surface of Ni-rich LiNi0.8Co0.1Mn0.1O2. Physicochemical ...characterization results indicate that a Li4Ti5O12 with a thickness of about 2–3 nm was uniformly distributed on the surface of microspheres, without inducing significant change of the structure and morphology. Electrochemical test results show that proper content of Li4Ti5O12 coating layer can greatly improve the cycling performance and rate capability of Ni-rich LiNi0.8Co0.1Mn0.1O2 for the improved Li+ ions diffusion rate and suppressed side reactions between electrode and electrolyte. Notably, the 1 wt% Li4Ti5O12 coated sample exhibits excellent cycling stability with the capacity retention of 75.86% at 1 C after 170 cycles when cycled between 2.7 and 4.3 V at 25 °C, while that is only 39.40% for bare LiNi0.8Co0.1Mn0.1O2.
Structural instability and inferior storage property are bottlenecks of the Ni-rich cathodes. Herein, a coating and doping co-modified Ni-rich cathode, in which La and Al is homogeneously doped in ...the inner and an epitaxial layer is distributed in the outer surface region of secondary particle, is constructed. The outer surface layer tightly integrates a La2O3 coating layer, an epitaxial grown LaAl doped atomic structure and a Ni concentration gradient into the bulk phase. The La and Al act as a pillar ion enlarging c axis spacing and a positively charged center, enhancing Li+ transportation and suppressing the phase transition. The outer surface region with La-enriched layer and decreased Ni concentration suppresses the side reactions between organic electrolyte and oxidizing Ni4+ and improves the storage stability in air. During cycling, the modified material exhibits enhanced rate capability and cycling stability with capacity retention of 80.0% after 480 cycles at 10C in the cell potential range of 2.7–4.3 V.
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•Ni-rich cathode is modified with synergy of coating and doping by La and Al.•Lower lattice expansion and higher Li+ transportation due to La doping.•The coating layer suppresses erosion of electrolyte and improve storage stability.
A novel compact low-profile circularly polarized Fabry-Perot resonator (CP-FPR) antenna fed by a linearly polarized microstrip patch tilting by 45 ° with respect to the axes is presented. The FP ...cavity consists of a partially reflective surface formed by cross-slot frequency selective surface (FSS) and a nonstandard artificial magnetic conductor (AMC) acting as reflective ground plane. Its profile is reduced to a quarter of a wavelength. For verification, a prototype antenna is designed and simulated by HFSS. Reasonable agreement between the simulated and measured results is observed. The prototype has a common frequency bandwidth of 6.4% for S 11 ≤ - 10 dB, gain-drop ≤ 3 dB, and axial ratio ≤ 3 dB.
Due to the highest theoretical specific capacity of 4200 mA h g−1 for Li4.4Si, silicon(Si)-based materials could fulfill the increasing demands of high-energy lithium-ion batteries (LIBs). However, ...the intrinsic huge volume expansion during the lithiation/delithiation process results in rapid capacity decay and short cycle life and restricts the satisfactory electrical performance of Si-based anodes. Binder plays an important role of maintaining the contact integrity between active material, conductive additive and the current collector, thereby reducing the pulverization of the Si particles during charge/discharge. Here, the review systematically summarizes the synthesis methods, design principles and working mechanisms, including chemical composition, superstructure, and various interactions between different functional moieties of synthetic binders and natural biomass binders, to reveal the structure-composition-performance relationship, offer practical solutions to challenging problems associated with defects of Si-based electrode materials in LIBs and aim at exploiting new family of binders that could be used in industrial level as well as providing design principles for other electrode binders in rechargeable batteries.
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•Working mechanisms and design principles of Si-based anodes binders are presented.•Synergistic strategy of combining binders with anode structure design is discussed.•Synthesis methods, applied anodes, ICE and cycling performance are listed.
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