Psoriasis is a chronic inflammatory dermatological disease with complex pathogenesis in which many immune system cells, including keratinocytes, play a role. Many genes regulate the proliferation of ...keratinocytes and other immune cells that have essential roles in the pathogenesis of psoriasis. The expressions of EREG, PTPN1, and SERPINB7 genes were shown as upregulated in psoriatic skins in a few studies previously.
We aimed to evaluate the expressions of these genes in psoriatic lesional skin and compared them with non-lesional adjacent skin of the same patients and normal skin of healthy controls.
Our results revealed that the expressions of EREG and PTPN1 genes were upregulated, whereas the SERPINB7 gene expression was down regulated in the psoriatic skin of the patients than normal skin of controls. Moreover, the expression level of the SERPINB7 gene was also negatively correlated with the severity of the disease among patients.
According to our results, overexpression of EREG and PTPN1 genes, and decreased expression of SERPINB7 gene may lead to the development of psoriasis.
This study aims to determine socialization situations via sport-based physical activity among students at a school of physical education and sports in terms of their demographic features. The ...population of the study comprises of 480 students studying in different departments at School of Physical Education and Sports at University of Yozgat Bozok during 2017-2018 academic year. The sample of the study comprises of 300 students selected based on convenience sampling method and studying at different departments of School of Physical Education and Sports at University of Yozgat Bozok during 2017-2018 academic year. Personal information form and socialization via sport-based physical activity developed by Yildirim was used as a data collection tool in this search. Frequency analysis, arithmetic mean, t test, Anova test and post-hoc tests were used in the data analysis. The findings of the study demonstrate that significant differences were found between socialization sub-dimensions and sport-based physical activity in terms of gender, monthly expenses, academic department and sports branch varibles (p<.05).
Objective:The type of fluid that should be used in uncontrollable hemorrhages remains an area of research. This study was designed to compare the effects of resuscitation with Ringer’s lactate (RL) ...solution versus a normal saline (NS) solution on hemodynamics, renal tissue histopathology, coagulation, and apoptosis in a rat model of hemorrhagic shock.Methods:The study employed groups designated as the control, hemorrhage, NS, and RL groups. Heart rate, mean arterial pressure, and respiratory rate were monitored. Annexin A5 values were assayed, rotational thromboelastometry analysis was performed, and excised kidney tissue samples were histopathologically analyzed.Results:Blood pressure levels were found to be significantly higher in the control group than those measured in the other groups. While the clotting time (CT) and clot formation time (CFT) in the hemorrhage group were significantly longer than those in the control and RL groups, the CT and CFT measured in the control group were significantly shorter compared to the RL group. The mean Annexin A5 level was in the hemorrhage group, which was significantly higher compared to the other groups. In the renal histopathological evaluation, the scores of proximal tubular injury, distal renal tubular injury, and interstitial renal tubular injury were found to be significantly lower in the control group compared to the other groups.Conclusion:This study demonstrated that NS or RL can be used safely to improve the hemodynamic symptoms resulting from hemorrhagic shock as a means to reduce apoptosis, and to decrease findings in favor of coagulopathy in bedside coagulation tests during the early stages of hemorrhagic shock until the time of starting a blood transfusion.
The aim of this study was to develop a valid and reliable measurement tool to measure teacher candidates' perception of technological value orientations. Design/Methodology/ It was conducted based on ...data from 400 teacher candidates for explanatory factor analysis (EFA) and 680 teacher candidates for confirmatory factor analysis (CFA) in the 2018-2019 academic year. Expert opinions were sought for the content validity and face validity of the scale as well as the EFA and CFA were conducted for construct validity. EFA yielded a three-factor solution consisting of 12 items that accounted for 53.17% of total variance. These factors were labeled as "Negative Impact on Friendship, Honesty, and Responsibility", "Negative Impact on Overall Values", and "Positive Impact on Access to Information and Benevolence". Cronbach's Alpha internal consistency coefficient of the scale was found to be 0.75. Besides, findings from the CFA indicated that Technological Value Orientation Perception Scale of Teacher Candidates is of adequate fit with 12 items under a three-factor construct. In addition, the convergent and discriminant validity results also supported the three-factor structure. This scale could of help researchers to measure the perception of prospective teachers about the impact of technology on value-orientations and to plan desired studies accordingly.
The surge in fossil fuel consumption, culminating in global warming and climate change, compels nations to implement protective measures. Consequently, the concepts of “sustainable growth” and the ...“green economy” have gained prominence in response to heightened environmental consciousness. In light of these imperatives, nations have embarked on the formulation of sustainable and environmentally conscious policies, with the dual objective of safeguarding the environment and fostering economic growth. These factors have collectively contributed to the growing significance of energy policies within European nations, spurring a burgeoning momentum in research areas pertaining to energy efficiency and energy productivity. While extant literature has demonstrated the positive environmental impact of energy productivity, there exists a paucity of research pertaining to its economic implications. Energy productivity, defined as achieving equivalent or greater output with reduced energy consumption, bears the potential to influence economic output, thereby exerting cascading effects on various facets of the economy, including growth and exports. The principal aim of this study is to highlight that the augmentation of energy productivity can yield not only environmental advantages but also economic benefits. To achieve this objective, we conduct econometric analyses on panel data spanning the years 2000 to 2020 across the 27 member states of the European Union. Specifically, we explore the effects of energy productivity on diverse economic parameters, encompassing economic growth, high technology exports, medium and high technology exports, total exports, and trade volume. Employing the Driscoll-Kraay standard errors estimator, our findings evince that energy productivity exerts statistically significant and positive influences on economic growth, medium and high technology exports, total exports, and trade volume.
The purpose of this study is to determine the sport participate motivation of the students who are attending physical education and sports college and to compare them according to the demographic ...variables. The universe of the research is composed of 480 students who are studying different programs in Bozok University Physical Education and Sports School in 2017-2018 academic year. The sample of the research consists of 180 students who are determined using random sampling technique. As a data collection tool in the research, personal information form and Gill et al. (1983) and Oyar et al. (2001) used the Sport Participation Motivation Scale, adapted to the Turkish population. The data were transferred to the SPSS 18 package program for analysis. Frequency and percentage analyzes, t test, Anova analysis and post hoc tests were used in the statistical analysis of the data.
As a result of the analyzes performed, statistically significant differences were determined between the motivations of physical education and sports college students to participate in sports according to the variables of gender, age, department of education and sports branch (p < .05). It was determined that male students have higher motivation to participate in sports than female students. Students between the ages of 18-22 have a higher motivation to participate in sports than students between the ages of 23-27. Physical education and sports teaching department students were found to have higher motivation to participate in sports than the students of the coaching education department and the sports management department. Students who are engaged in team sports have higher motivation to participate in sports than students who are engaged in individual sports.
Pachydermoperiostosis is a rare syndrome that affects the skin and skeletal system. Mutations in the gene encoding hydroxyprostaglandin
dehydrogenase (HPGD) are thought to play a role in disease ...etiopathogenesis. The disease is typically seen in males and is characterized by skin
thickening (pachydermia), clubbing, and subperiosteal new bone formation. A 57-year-old male patient was admitted to our clinic with growth
complaints of growth his hands, feet, and face. He had a prominence of forehead lines and fist-sized round bulges on his torso and face. The
patient’s history also indicated that he was clinically followed up for neurofibromatosis 1 (NF1). No mutations in the HPGD and SLCO2A1 genes
were identified. This is the first case in the literature that reviews pachydermoperiostosis and NF together. The coexistence of skin findings of
two different diseases in the same patient indicates that both diseases may be related to different genetic pathways.
Introduction. Coronavirus 2019 disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has spread to more than 200 countries worldwide. We aimed to present ...acute pancreatitis (AP) cases caused by SARS-CoV-2 viral infection. Methods. The study was conducted retrospectively between April 2020 and June 2020 in Necmettin Erbakan University Meram, Medical Faculty Hospital, and 150 hospitalized patients diagnosed with COVID-19 were included. The degree of acute pancreatitis was determined according to the Atlanta classification. Organ failures of the patients were evaluated in terms of respiratory, cardiovascular, and nephrology according to the modified Marshall scoring (MMS) system, and CTSI (Balthazar score) and Imrie score were determined. Modified Marshall score≥2 was considered organ failure. Results. A total of 29 patients were diagnosed with acute pancreatitis. All 29 patients with pancreatitis had respiratory failure during hospitalization. After the diagnosis of pancreatitis, there was no change in respiratory failure. According to the Atlanta classification, 19 patients had mild AP and 10 patients had moderate AP. Patients with acute pancreatitis were scored according to the CTSI (Balthazar score), and there were no patients with ≥6 severe pancreatitis. The CTSI score of 4 patients was 3. In addition, the Imrie score of the patients was determined and 8 patients with Imrie score≥3 were identified. Conclusion. The rate of pancreatic damage in SARS-CoV-2 infection was found to be 19% (n=29) in our study. In our study, we highlight acute pancreatitis as a complication associated with COVID-19 and the importance of pancreatic evaluation in patients with COVID-19 and abdominal pain is demonstrated.
Aim: We could not find a study in the literature based on physical examination findings, ultrasonography (USG) and magnetic resonance imaging
(MRI) in the treatment of pilonidal sinus. In this study, ...we aimed to accomplish a classification based on clinical findings, ultrasonographic and
magnetic resonance to provide objective criteria for diagnosis, treatment, and recurrence follow-up of pilonidal sinus.
Method: This study included patients who presented to Necmettin Erbakan University Meram Medical Faculty, the clinic of general surgery and were
diagnosed with pilonidal sinus disease between 2015 and 2016. After receiving medical history, physical examination was carried out. Then MRI
and USG of the patients were ordered, and the relationship of pilonidal sinus with skin, subcutaneous tissues and surrounding were recorded and
analyzed. Patients were categorized as 3 groups based on average of the sum of depth and width on MRI and USG imaging. Patients with acute abscess
considered as stage 2 according to the navicular region classification were not categorized.
Results: Patients were divided into three groups according to average of the sum of width and depth on USG. It was found that duration of
hospitalization, work absence and frequency of operation increased as the mean values increased. Status of being operated was statistically significantly
different (p=0.007).
Conclusion: Patients with average of the sum of width and depth on MRI and USG;
Stage 1: <15 mm.
Stage 2: 15-30 mm.
Stage 3: >30 mm.
In conclusion; we obtained a significant classification based on MRI and USG. We concluded that informing the patients classified according to MRI
and USG on treatment procedure would be meaningful. This study will guide further studies to be conducted with a larger number of patients.
As marine cargo traffic continues to grow, ports are experiencing increasing problems with congestion. To address this issue without requiring significant capital investment, neighboring ports can ...share their capacity to meet the rising demand for cargo throughput. While there are many planning level studies on inter-port cooperation, there is a scarcity of operational-level studies, and there is currently no available dry port integrated cooperation scheme for port clusters that utilizes a microsimulation approach. This study aims to contribute to the existing literature by proposing a conceptual port integration scheme that includes a dry port for improved coordination between ports in clusters. The discrete event simulation (DES) approach was used to construct three representative microsimulation models with dry port integration considering vessel transfer policies and no-cooperation scenario. The outputs of the models were evaluated using performance metrics (vessel delays, storage capacities, and the number of serviced vessels) using t-test statistics. The results show that the cooperation scheme with the vessel transfer policy and the strategic management of vessel transfer can significantly reduce the vessel operation delay by over 39% for the no-cooperation scenario with an integrated dry port and this value is further improved to 62% if a simulation-based port selection module (PSM) is used for vessel transfer policy. Additionally, the mean number of containers of the average of two port storages decreased by 40% and further decreased by 69% with the PSM. In terms of decision-making performance for vessel transfer decisions with varying quay lengths, PSM was determined to be superior to the vessel transfer policy considering the number of vessels in port queues. The proposed conceptual port integration model and approach can assist decision-makers in evaluating the effectiveness of different cooperation schemes and vessel transfer policies for adjacent ports in port clusters.
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