We report two cases of endocrine cell carcinoma of the rectum. Case 1: A 61-year-old man operated on for a carcinoma of the rectum (Ra) was found to have liver tumors during surgery. So an anterior ...resection of the rectum and a partial hepatectomy were performed. Postoperative histological examination revealed endocrine cell carcinoma of the rectum and metastasis to the liver. Carcinomatous cachexia progressed rapidly about two and a half months after the surgery and the patient died about four months postoperatively. The autopsy revealed multiple metastatic foci in the liver, pleura, peritoneum, left adrenal gland, and skin. Case 2: A 76-year-old woman with carcinoma of the rectum (Rb) which was found to be endocrine cell carcinoma by preoperative histological study required operation for intestinal obstruction. During operation, liver tumors were detected and an abdomino-perineal amputation of the rectum was performed. Although one-shot hepatic arterial infusion therapy with FAM was performed after surgery, a computed tomographic scan of the abdomen showed multiple masses in the liver two months after the operation. The patient remained alive for six months after the surgery. Endocrine cell carcinoma has a very poor prognosis with rapid hematogenous or lymphogenous metastasis. In the treatment of the disease, surgery combined with chemotherapy according to small cell carcinomas of the lung which is also appropriate for the stage of the disease has to be considered.
We investigated the adenoma-carcinoma sequence in intraductal papillary-mucinous neoplasm from the aspect of genetic changes. The formalin-fixed paraffin-embedded tumors and surrounding normal ...pancreatic tissues from patients with 16 intraductal papillary-mucinous adenoma of the pancreas (IPMA) and 10 intraductal papillary-mucinous carcinoma of the pancreas (IPMC) were provided for DNA extraction after microdissection. SSCP-DNA sequencing analysis demonstrated K-ras mutations at codon 12 in 75% of IPMA and 70% of IPMC, while those at codon 13 were observed neither in IPMA nor IPMC. There were no characteristic K-ras mutation types in IPMA and IPMC and no significant differences in incidence of K-ras mutations between the two categories. The frequencies of p53 mutations analyzed by SSCP-DNA sequencing were not high in IPMA (18.8%) and IPMC (30%), showing no significant difference between them. LOHs of APC in IPMA and IPMC were infrequent (6.3 and 20%, respectively) and showed no significant difference in incidence between the two categories. The LOH frequencies of DCC in IPMA and IPMC were 31.3 and 40%, respectively, and were not statistically different from each other. Taken together, genetic changes such as K-ras, p53, APC and DCC mutations may not be associated with adenoma-carcinoma sequence in intraductal papillary-mucinous neoplasm of pancreas.
Orientador: Reginaldo Guirardello
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Engenharia Química
Made available in DSpace on 2018-08-18T13:21:06Z (GMT). No. of bitstreams: 1
...Yamada_ShinobuTomas_D.pdf: 3876142 bytes, checksum: 951723c2abec9e70853595542ea18fe3 (MD5)
Previous issue date: 2011
Resumo: Esta tese apresenta a cinética e a fluidodinâmica do processo Fischer Tropsch realizado nos softwares científicos Fortran (Formula Translation) e CFX (Fluidodinâmica Computacional) da AEA Technology plc. O presente trabalho é uma simulação computacional de um sistema catalítico, multifásico, multicomponente e não isotérmico com topologia tridimensional, baseado em catalisador de cobalto suportado, recheio de esferas de aço e meio reacional formado por pseudocomponentes, gás combustível - GLP, nafta - gasolina - diesel, ceras de baixo - médio - alto peso molecular e vapor de água, além do gás de síntese (CO + H2) não convertido. As modelagens da cinética de reação e do balanço de massa estão estruturadas na linguagem de programação Fortran com modelos matemáticos da tecnologia Fischer Tropsch e as modelagens dos balanços de energia, momento e turbulência pelo software computacional CFX, com geometria baseada no Reator Arge Sasol em Leito Fixo composto por cinco domínios (recheio - meio reacional - entrada - saída - parede) e um subdomínio (catalisador), configuradas numa malha com mais de cinco milhões de elementos e um milhão de nós. A cinética é o modelo esquematizado por Sarup-Wojciechowski (1989) com a constante cinética definida pela expressão modificada da lei de Arrhenius. A modelagem da fluidodinâmica é tratada pelas equações de Navier Stokes e turbulência através do modelo k-? e "disperse phase zero equation", complementados pela biblioteca de propriedades fisico-químicas Diadem DIPPR, artigos científicos e experimentos em planta piloto realizados na Unidade de Industrialização do Xisto - Petrobras, São Mateus do Sul - (PR)
Abstract: This thesis presents the fluid dynamics and the kinetics of Fischer Tropsch Process in a fixed bed reactor accomplished in the scientific software Fortran (Formula Translation) and CFX (Computational Fluid Dynamics) of AEA Technology plc. The current work is a computational simulation of the catalytic system, multiphase, multicomponent and non isothermal with 3D topology, that is based on the cobalt supported catalyst, column random packing and the reaction mean treated on pseudo components concept, fuel gas - PLG, naphtha - gasoline - diesel oil, low - medium - high molecular weight waxes and water steam, besides non converted syngas (CO + H2). The kinetics reaction modelling and mass balance are structured in Fortran programming language with mathematic models of Fischer Tropsch technology. Also the energy balance, momentum and turbulence phenomena are structured by CFX, with geometry based on the Arge Sasol Fixed Bed Reactor consisted for five domains (packing - reaction media - in- out - wall) and one subdomain (catalyst), configured in a mesh with more than five million of elements and one million of nodes. The kinetic models are schematized by Sarup-Wojciechowski (1989) equation and the kinetic constant defined according to a modified expression of the Arrhenius law. The modelling of the fluid dinamics are considered on the Navier Stokes fundamental equations and turbulence phenomena through k-? and "disperse phase zero equation", complemented by the physical-chemicals library property Diadem DIPPR, scientifc articles and data referred to pilot plant experiments performed in the Unidade de Industrialização do Xisto - Petrobras, located in São Mateus do Sul - (PR)
Doutorado
Desenvolvimento de Processos Químicos
Doutor em Engenharia Química
The purpose of this paper is to contribute for curriculum development in education of the area of students' residence in Japanese overseas school for geographical education attached importance to ...Students' “international understanding education”. In order to get this purpose the auther caught what students of Japanese school in Bangkok talked about thinking of the area of their residence, 1) living in Bangkok, 2) image of Thailand (about Thai culture—Thai cooking, Thai language), 3) image of South East Asia. The results were as follows, 1) Having lived in Sukhumvit Road, the students have hardly come in contact with Thai culture and people. They have lived in only Japanese community in Bangkok. 2) There is their individual difference whether they have taste for Thai cooking. But they all feel very hot in Thailand. And studying Thai language is difficult for almost Japanese students, except some of Thailand-born Japanese. 3) They show a friendly feeling for the countries around Thailand, Malaysia, Shingapore, Indonesia, in the friendly relations between Japan and South East Asia. It is nessesary for all Japanese people in Bangkok to try to understand culture and society about the area of their residence, because Japanese students are menber of Japanese community in Bangkok, which exerts a influence upon their understanding of the area of residence. The other hand, in Japanese school, the teacher should develop instructional materials for education about culture and society of the area of their residence positively. Besides it is effecitve to take up such their cross cultural experience as they employ Thai maid or Thai driver at home. Japanese school's curriculum and practice, developed in difffferent regions all over the world, will be good for curriculum development in geographical education coped with “internationalization”
We studied the characteristics of anti-human leukocyte antigen (HLA) antibodies developed after transfusion of platelets and red blood cells using leukocyte-removal filters in 14 patients with acute ...leukemia treated in our hospital from 1990 to 1992. A nonfilter group of 10 patients similarly multitransfused with acute leukemia treated from 1984 to 1986 were also studied. In the filter group, Class I anti-HLA antibodies were developed in 14% (2 of 14) of patients. The sera of these two patients showed the HLA specificities anti-B55+B56 and anti-A19, respectively. Refractoriness to platelet transfusion did not occur in these patients. In the nonfilter group, Class I anti-HLA antibodies developed in 20% (2 of 10) of patients. These sera contained multispecific anti-HLA antibodies. Both patients showed refractoriness to platelets transfusion. All four patients who developed anti-HLA antibodies had a history of pregnancy.
One can estimate the age of pyroclastic fall unit by means of the observation of soil profile on it. At first each fall unit must be distinguished, and next the age of each unit should be determined ...based on the following principles. 1) When living trees are found on the uppermost pyroclastic soil unit, the age of this unit can be estimated by means of the dendrometry. 2) The age of pyroclastic fall unit can be roughly estimated by the degree of soil profile development on it as shown by the following standard. Age of weathering Soil horizon sequence Within 100 years C or (A)/C 100-500 years (A)/C, A/C or A/(B)/C 500-1500 years A/(B)/C or A/B/C Over 1500 years Complete A/B/C profile 3) The humus content of the volcanic soils must be responsible for the weathering age of it, so the humus content or the value of the humic acid extracted from the humic layer may be useful to estimate the weathering age of pyroclastic fall unit, though the mass-wasting and the artificial disturbance of soil materials should be kept in mind. 4) When the pyroclastic fall unit is intercalated within peat layer, one can estimate the age of the unit by determining the depth of the peat layer on it, supposing that the accumulating rate of peat is constant (1cm per 10 years). According to the same way, the age of the pyroclastic unit overlain by the aceolian soil layer can be estimated. 5) When any carbonized materials or prehistoric implements including obsidian tools. made by aborigines are found within the volcanic soil unit, the age of the pyroclastics can be estimated by means of 14C dating, the thickness of hydration layer of obsidian tool and the cultural chronology of the implements, etc. 6) Moreover, if one can obtain the ancient record of volcanic activity, the chronology of the pyroclastic fall unit determined by the above mentioned methods can get undoubtedly more accuracy.
When a volcano eruptes, its pyroclastics are deposited over the surface of the earth, so the depositional features of the pyroclastics tell us the history of volcanic activities. Therefore, if we ...wish to investigate the tephrochronology of pyroclastics which spread over the surface of the earth, the following works should be done. 1) At first, we must classify the sorts of the pyroclastics which spread over the surface of the earth and study the characteristics of each pyroclastic. Then we must research their areal distribution and the sources of their eruptions. 2) Next, we must determine the time of eruption of those pyroclastics, and in this case the following principles should be adopted as fundamental ideas. a) When natural trees grow on pyroclastic forming the surface soil, we can estimate the age of the pyroclastic by means of calculation of their annual ring. b) When pyroclastic falls on peat lands, peat begins to develop on the pyroclastic. As the annual rate of increase of the peat layer thickness is considered to be constant, so by determining the depth of the peat layer growing on the pyroclastic, we can estimate the time when the pyroclastic was deposited. c) When we find carbonized trees in a layer of pyroclastic, we can estimate the age of the pyroclastic by means of determining the 14C of those carbonized trees. d) When we find a prehistoric site in a layer of pyroclastic, we can estimate the age of the pyroclastic by determining the age of the prehistoric site by archaeologists. e) When we find obsidian stone implements made by aborigines in a layer of pyroclastic, we can estimate the age of the pyroclastic by determining the thickness of the hydrated surface layer which has been formed outside the obsidian. f) Moreover, if we can correlate the age which has been estimated by means of the above mentioned methods to ancient records of the volcanic activity, we may possibly estimte still more accurately the age of the pyroclastic.
At least four genes involved in DNA mismatch repair (MMR), hMSH2, hMLH1, hPMS1 and hPMS2, have been cloned and characterized. These genes have been demonstrated to be altered in the germline of ...patients with hereditary non-polyposis colorectal cancer (HNPCC). HNPCC is an autosomal dominant disease characterized by a preponderance of proximal colon, young age of onset, increased multiplicity, and improved stage-specific survival. In this study, we examined the expression of hMSH2 protein in sporadic colorectal cancer (CRC). As a result, the frequency of right-sided CRC and multiple CRCs were significantly higher in the patients with hMSH2-negative CRC than in those with hMSH2-positive CRC. The rate of p53 positivity was significantly lower in the hMSH2-negative tumours than that in the hMSH2-positive tumours. The disease-free survival rate tended to be higher in the patients with hMSH2-negative CRC than in the patients with hMSH2-positive CRC. Our findings suggest that both the clinicopathological and biological features of hMSH2-negative sporadic CRC seemed to be similar to those of HNPCC. To clarify the mechanism of carcinogenesis in HNPCC and sporadic CRC, further investigations of genetic alterations caused by MMR genes will be needed.
A CASE OF BOCHDALEK HERNIA WITH GASTRIC VOLVULUS SUNAMI, Takeshi; KANEMURA, Mizuyuki; YAMADA, Shinobu ...
Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association),
2003/01/25, Letnik:
64, Številka:
1
Journal Article
Odprti dostop
A 51-year-old man admitted for epigastralgia and repeated vomiting was diagnosed with diaphragmatic hernia with gastric volvulus based on chest radiography, contrast radiography of the upper ...gastrointestinal tract, barium enema, and abdominal computed tomography (CT). Surgery used an abdominal approach. The stomach, left part of the transverse colon, and greater omentum were displaced into the left thoracic cavity through a defect in the posterolateral part of the left diaphragm (Bochdalek foramen). Mesenterioaxial volvulus of the stomach was also confirmed. The Bochdalek foramen was closed and the stomach was fixed to the abdominal wall. In the 2 years since surgery, the man remains well and symptom-free.
A multi-center cooperative clinical trial was undertaken to evaluate the safety and efficacy of weekly taxol (TXL) therapy combined with short-premedication as a pretreatment in an effort to ...determine if TXL can be used in ambulatory treatment. TXL was administered at 60 mg/m2 to patients with advanced recurrent breast cancer once a week without a rest or with a rest for 1 week after treatment for 3 weeks. A total of 36 patients were finally enrolled. The site of recurrence was the local region in 8 patients, lung/pleura in 24, liver in 9, bone in 16, lymph nodes in 15, epicardium in 2, and brain metastasis in 2. The response was CR in 2, PR in 12, NC in 9, PD in 8, and NE in 5, with a response rate of 45.2%. Grade 4 anorexia was reported as non-hematotoxicity. All other adverse reactions, such as myalgia/arthralgia and peripheral neuropathy, were mild (grade 1 or 2). Hematotoxic effects observed in this study included only grade 3 leukopenia in 5 patients, neutropenia in 4, and decreases in hemoglobin in 1.
PDF
