Power consumption is one of the major issues associated with deploying a wireless sensor to monitor natural environments in the real world. It is not practical to frequently replace the battery of a ...sensor that is located in a remote mountainous area. While considering to save valuable energy, the sensor must be able to detect a particular event in a timely manner and report data. To satisfy these requirements, in this paper, we present a wireless sensor system, termed SMARTCONE, which is designed to monitor the slope movement and minimize the standby power consumption, while remaining active to detect events. Multiple SMARTCONEs need to synchronously change their operation modes to collect the physical parameters and transmit raw vibration data simultaneously. SMARTCONE is consuming a power of only 0.05 mA at 3.6 V in standby mode, which is significantly less than that consumed by the previous design. As far as we know, SMARTCONE is an unprecedented instrument for the monitoring of slope movement; no other instruments can achieve such a low-energy consumption while being triggered by external vibration and managed remotely. These complicated issues are considered while designing the SMARTCONE, whose performance is then evaluated. In order to prevent redundant effort and to reduce the entry-level knowledge required by the users who wish to design a system, and to promote the use of this design for monitoring natural environments, we would like to open source the design of SMARTCONE for the public. It can be modified for use in other applications to satisfy their requirements without the need to build from scratch.
The assessment of childhood health experience helps to identify the risk of depression among older people. Poor childhood experience is generally associated with depression in adulthood. However, ...whether such association can be extended to older people' life remains unclear. The history of parental mental health was obtained from 2014 CHARLS Wave 3 (Life History Survey) data while other data from 2011 CHARLS Wave 1 baseline data. The study involves 4,306 respondents. The depression was assessed by the Chinese version of Center for Epidemiologic Studies Depression scales (CES-D) using logistic regression model. More than 40% of older people suffered from depression, 25% of whom experienced poor childhood self-reported health. Nearly 20% of their mothers and more than 10% of their fathers had a history of poor mental health. Poor childhood health experiences have shown to be associated with higher odds of depression (good self-reported health OR: 0.732,
= 0.000, 95% CI: 0.633-0.847; poor mother's mental health OR: 1.391,
= 0.001, 95% CI: 1.138-1.699; poor father's mental health OR: 1.457,
= 0.003, 95% CI: 1.141-1.862). There is a high rate of depression among the older adults in China. In China, older people with poor childhood health experiences are more likely to suffer from depression.
For a frequency diverse array (FDA) antenna, the combination of time-modulated and nonlinear distributed frequency offset is proposed to realize time-invariant spatial fine focusing beampatterns. The ...distribution of the nonlinear function is optimized by using artificial bee colony algorithm, and the resultant frequency offset is termed as time-modulated optimized frequency offset (TMOFO). In addition to design a TMOFOFDA in realistic situations, the interval-based tolerance analysis is introduced to predict the impact of frequency-offset uncertainties or errors on the time-invariant spatial focusing beampattern. The spatial focusing performance of the TMOFO-FDA is compared with an analytical FDA scheme based on a time-modulated logarithmically increasing frequency offset (TMLFO). Numerical examples of a ten-element linear FDA with λ 0 /2 element spacing in the presence of mutual coupling effects based on the TMOFO and the TMLFO are reported and compared. The comparative results between the ideal TMLFO and TMOFO show that, in range-angle plane the size of the focal spot for TMOFO-FDA is reduced by about 70% compared to that for TMLFO-FDA. The side lobe level is reduced about 49%. The comparative results from IA-based beampattern tolerance analysis also reveal the superiority of the TMOFO-FDA scheme.
Programmed cell death (PCD) induced by endoplasmic reticulum (ER) stress is implicated in variousplant physiological processes, yet its mechanism is still elusive. An activation of caspase-3-like ...enzymatic activity was clearly demonstrated but the role of the two known plant proteases with caspase-3-like activity, cathepsin B and proteasome subunit PBA1, remains to be established.
Both genetic downregulation and chemical inhibition were used to investigate the function of cathepsin B and PBA1 in ER-stress-induced PCD (ERSID). Transcript level and activity labelling of cathepsin B were used to assess activation. To study tonoplast rupture, a plant PCD feature, both confocal and electronic microscopies were used.
Cathepsin B downregulation reduced reactive oxygen species (ROS) accumulation and ERSID without affecting the induction of the unfolded protein response (UPR), but downregulation of PBA1 increased UPR and ERSID. Tonoplast rupture was not altered in the cathepsin B mutant and cathepsin B activation was independent of vacuolar processing enzyme (VPE). VPE activity was independent of cathepsin B.
ERSID is regulated positively by cathepsin B and negatively by PBA1, revealing a complex picture behind caspase-3-like activity in plants. Cathepsin B may execute its function after tonoplast rupture and works in parallel with VPE.
The poor outcomes in retinoblastoma necessitate new treatments. Salinomycin is an attractive candidate, and has demonstrated selective anti-cancer properties in different cancer types. This work ...addressed the efficacy of salinomycin in retinoblastoma models and probe the associated mechanisms. Cellular functional assays were conducted to determine the effects salinomycin in vitro. Xenograft retinoblastoma mouse model was established to investigate the efficacy of salinomycin in vivo. Biochemical assays were conducted to analyze the mechanism of salinomycin’s action focusing on mitochondrial functions, energy reduction-related signaling pathways. Salinomycin has positive effects towards retinoblastoma cells regardless of heterogeneity through suppressing growth and inducing apoptosis. Salinomycin also specifically inhibits cells displaying stemness and highly invasive phenotypes. Using retinoblastoma xenograft mouse model, we show that salinomycin at non-toxic dose effectively inhibits growth and induces apoptosis. Mechanistic studies show that salinomycin inhibits mitochondrial respiration via specifically suppressing complex I and II activities, reduces mitochondrial membrane potential and decreases energy reduction, followed by induction of oxidative stress and damage, AMPK activation and mTOR inhibition. Our study highlights that adding salinomycin to the existing treatment armamentarium for retinoblastoma is beneficial.
•Kinking do not follow the direction of maximum circumferential stress.•T-stress can indicate the possibility of kinking via positive-negative transition.•Wulff-like curve shows the preferring ...direction of crack kinking.
Crack branching in graphene under complex stresses is investigated by molecular dynamics simulations and boundary-layer models. Using the maximum energy release rate (MERR) criterion, an analogy of Wulff curve is plotted considering the anisotropic fracture toughness of hexagonal graphene, which shows the direction of crack kinking (local bump on the curve) is consistent with that of the weak fracture toughness (along zigzag edge). The angle of crack kinking prefers 0°/30°/60°, rather than the angle predicted by maximum circumferential stress criterion. The T-stress along crack front, obtained by the over-deterministic method, can indicate the possibility of kink by its transformation between positive and negative, especially for zigzag cracks. This study incorporates Wulff-like curve and MERR criterion to provide an accurate prediction of nanocrack paths in graphene.
The long-term pulmonary function and related physiological characteristics of COVID-19 survivors have not been studied in depth, thus many aspects are not understood.
COVID-19 survivors were ...recruited for high resolution computed tomography (HRCT) of the thorax, lung function and serum levels of SARS-CoV-2 IgG antibody tests 3 months after discharge. The relationship between the clinical characteristics and the pulmonary function or CT scores were investigated.
Fifty-five recovered patients participated in this study. SARS-CoV-2 infection related symptoms were detected in 35 of them and different degrees of radiological abnormalities were detected in 39 patients. Urea nitrogen concentration at admission was associated with the presence of CT abnormalities (P = 0.046, OR 7.149, 95% CI 1.038 to 49.216). Lung function abnormalities were detected in 14 patients and the measurement of D-dimer levels at admission may be useful for prediction of impaired diffusion defect (P = 0.031, OR 1.066, 95% CI 1.006 to 1.129). Of all the subjects, 47 of 55 patients tested positive for SARS-CoV-2 IgG in serum, among which the generation of Immunoglobulin G (IgG) antibody in female patients was stronger than male patients in infection rehabilitation phase.
Radiological and physiological abnormalities were still found in a considerable proportion of COVID-19 survivors without critical cases 3 months after discharge. Higher level of D-dimer on admission could effectively predict impaired DLCO after 3 months discharge. It is necessary to follow up the COVID-19 patients to appropriately manage any persistent or emerging long-term sequelae.
Key Scientific Research Projects of Henan Higher Education Institutions
Previous studies have shown systemic lupus erythematosus (SLE) patients had a significantly higher prevalence of thyroid diseases and hypothyroidism than matched controls, and some case reports ...showed SLE may occur after Hashimoto's thyroiditis (HT).
This study aimed to investigate the subsequent risk of SLE in patients with HT.
In this retrospective cohort study done by the Taiwan National Health Insurance Research Database, the HT group (exposure group) and the non-HT group (comparator group) were propensity score matched at a ratio of 1:2 by demographic data, comorbidities, medications, and the index date. We used Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Several sensitivity analyses were done for cross-validation of our findings.
We identified 15,512 HT patients and matched 31,024 individuals. The incidence rate ratio of SLE was 3.58 (95% CI, 2.43-5.28; p < 0.01). Several sensitivity analyses show adjusted hazard ratio (aHR) (CIs) of 4.35 (3.28-5.76), 4.39 (3.31-5.82), 5.11 (3.75-6.98), and 4.70 (3.46-6.38), consistent with the results of the main model.
Our study showed an increased risk of SLE in the HT group after adjustment for baseline characteristics, comorbidities, and medical confounders compared with the reference group.
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