IntroductionFast Healthcare Interoperability Resources (FHIR), is a standard for exchanging data. It is a common framework that makes it easier to read, write, and transfer medical data, such as ...patient information securely. SMART is a platform that builds upon the FHIR specification and provides developers with a set of APIs to create applications on top of FHIR. These applications range from retrieving a patient‘s medication history, to evaluating a patient‘s risk of cardiac arrest. The aim of this project was to help individual doctors, small teams of developers, or large medical organisations, who may not be familiar with FHIR, to discover the capabilities of SMART APIs and build applications for this next generation of digital healthcare.MethodAs part of a joint collaboration between GOSH and UCL computer science (CS), through the industry exchange network programme. CS Students developed a web application using Django, a framework written in Python that employs a model-template-view (MTV) pattern. The client-side templates were built using React. The application’s back-end encapsulates the app’s logic; and interacts with the data persistency layer- a SQLite database. The code snippets are run by querying the SMART STU3 Sandbox.ResultsA functional web application was developed that collates a catalogue of modular SMART functions that a developer can use to implement in their own application. The platform allows non-coders to explore SMART on FHIR components and develop prototype applications. It has a library of runnable code snippets that can act as a helpful tool and reference when building SMART applications.ConclusionThis application supports the development of SMART applications that adhere to FHIR standards in data interoperability, for developers who lack specific knowledge of FHIR standards. Such resources are likely to be of increasing importance as NHS organisations begin to develop customised local programmes using SMART on FHIR.
Dietary protein dilution (DPD) promotes metabolic-remodelling and -health but the precise nutritional components driving this response remain elusive. Here, by mimicking amino acid (AA) supply from a ...casein-based diet, we demonstrate that restriction of dietary essential AA (EAA), but not non-EAA, drives the systemic metabolic response to total AA deprivation; independent from dietary carbohydrate supply. Furthermore, systemic deprivation of threonine and tryptophan, independent of total AA supply, are both adequate and necessary to confer the systemic metabolic response to both diet, and genetic AA-transport loss, driven AA restriction. Dietary threonine restriction (DTR) retards the development of obesity-associated metabolic dysfunction. Liver-derived fibroblast growth factor 21 is required for the metabolic remodelling with DTR. Strikingly, hepatocyte-selective establishment of threonine biosynthetic capacity reverses the systemic metabolic response to DTR. Taken together, our studies of mice demonstrate that the restriction of EAA are sufficient and necessary to confer the systemic metabolic effects of DPD.
Pharmacophore-based virtual screening is an effective, inexpensive and fast approach to discovering useful starting points for drug discovery. In this study, we developed a pharmacophore model for ...the main proteinase of severe acute respiratory syndrome coronavirus (SARS-CoV). Then we used this pharmacophore model to search NCI 3D database including 250, 251 compounds and identified 30 existing drugs containing the pharmacophore query. Among them are six compounds that already exhibited anti-SARS-CoV activity experimentally. This means that our pharmacophore model can lead to the discovery of potent anti-SARS-CoV inhibitors or promising lead compounds for further SARS-CoV main proteinase inhibitor development.
Unusual skeletal substitution reactions (such as the example shown right) are characteristic of the reactivity of cyclic borataphosphazenes towards halide ion agents with counterions such as BF4−, ...AsF6−, and SbF6−. In other cases (AlCl4− and GaCl4−) stable borazine–phosphazene hybrid rings are formed.
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