The self-assembled nanobelt photocatalysts (
SQAP-C4
and
SQAP-C8
) with quinacridone containing butyl and octyl side chains as electron donors and pyridine dicarboxylic acid as an acceptor were ...firstly developed for efficient hydrogen evolution.
SQAP-C4
without the loading of cocatalyst Pt exhibited a superior H
2
evolution reaction rate of 656 μmol h
−1
g
−1
and excellent stability.
Self-assembled nanobelt photocatalysts with quinacridone containing different alkyl chains as donor and pyridine dicarboxylic acid as acceptor were firstly developed for H
2
evolution.
SQAP-C4
without cocatalyst of Pt exhibited HER of 656 μmol h
−1
g
−1
.
•EZH2 was overexpressed in SS patients and the expression level positively correlated with severity of pathological damage to the SGs.•Inhibition of EZH2 alleviated SS-like disease in NOD mice by ...decreasing the percentage and pro-inflammatory-factor secretion of CD4+ and CD8+ T cells.•EZH2 may be a potential target for the clinical treatment of SS.
We analyzed RNA-SEQ data and found that EZH2 gene expression in salivary glands (SGs) of Sjögren's syndrome (SS) patients was up-regulated and correlated with pathological injury. In this study, we sought to determine if inhibiting EZH2 would ameliorate SS-like disease in NOD/Ltj (NOD) mice.
We analyzed RNA-SEQ data of SGs of patients with SS from data obtained from the GEO database to explore the correlation between EZH2 gene expression and the progression of SS. Inhibition of EZH2 in the NOD mice was achieved by intraperitoneal administration of GSK343 using both a preventative and a therapeutic model. The effects of GSK343 on SGs secretion and pathological damage, as well as the levels and functions of T cells, B cells, Myeloid-derived suppressor cells (MDSCs), and other immune cells were evaluated.
The expression levels of the gene encoding EZH2 in the SGs of SS patients were significantly higher than the non-SS sicca patients, and the expression levels were positively correlated with the severity of the SGs pathological damage. GSK343 treatment significantly increased the salivary flow rate and pathological damage of the SGs in the NOD mice compared to the control mice. In addition, GSK343 significantly inhibited the number and pro-inflammatory-factor secretion of CD4+ and CD8+ T cells and inhibited the increase in the Th1/Th2 cell ratio caused by SS. RNA-SEQ data also showed that EZH2 inhibited several inflammatory pathways during the pathogenesis of SS.
EZH2 expression was up-regulated in the submandibular gland tissue of SS patients.Inhibition of EZH2 alleviated SS-like disease in NOD mice, suggesting that EZH2 might be a potential target for the clinical treatment of SS.
A hybrid ground source heat pump system is utilized to meet the energy demands of the first nearly-zero energy office building located in the cold region of China. The simulation result shows that ...the heating, cooling and lighting demands of the building could be reduced to 25 kWh/m2 yr with the utilization of high-performance envelopes and the hybrid renewable energy system. A ground loop consisting of two rectangular fields of 70 borehole heat exchangers is utilized together with the solar energy system to meet the building's energy demand. During the system commissioning phase, from 1 July to 15 August 2014, the inlet and outlet water temperatures of the heat pump unit and boreholes were collected and analysed. The coefficient of performance (COP) of the heat pump unit could reach 5.0 in cooling operation strategy, which satisfies the energy reduction requirement and meets the room temperature standard.
•The first building that was built with nearly zero energy target as 25 kWh/m2 yr.•Ground source heat pump system is utilized to cover the cooling demands in 2014 summer.•Heat exchange result of single U-tube and double U-tube are compared in summer.•Test result on a typical day show the COP of heat pump unit could reach to 5.
As a new software design paradigm, microservices structure an application as a collection of services that are independently deployable and loosely coupled. A key step of migrating ...non‐microservices‐based systems to microservices‐based systems is the identification of microservices in the target application. Traditional approaches to identify microservices, however, usually suffer from lack of full automation and low effectiveness. This paper puts forward an expert system to identify microservices automatically from legacy systems by leveraging the similarity of RESTful APIs. The system consists of three major parts. The first part calculates the candidate topic similarity and the response message similarity of APIs, and the overall similarity is obtained through their combination. Afterwards, the second part constructs a graph of API similarities with API as the node and the overall similarity as the weight. The third part employs a graph‐based clustering algorithm to identify candidate microservices from the API similarity graph. Experiments conducted on open‐source projects demonstrate the effectiveness of our system.
To date, our understanding of the role of abnormal hippocampal volume in imaging studies of insomnia disorders (ID) has remained in apparent contradiction. Given that hippocampal function can be ...mapped to anatomically defined substructures, the hippocampal substructure volume can be examined in detail at present. In this study, we examined the volumes of hippocampal substructures between IDs and healthy controls (HC) to accurately find hippocampal markers of ID. First, we used the automated hippocampal substructure module in FreeSurfer6.0 to inspect T1-weighted magnetic resonance images between 22 IDs and 30 HC. Then, 12 hippocampal substructures were computed. Volumetric assessment was performed at the hippocampal substructure level between groups. Our study revealed significant reduced volume of the bilateral fimbria in IDs compared with HC (
p
< 0.05/12, Bonferroni corrected), although there was no difference in the total volume of hippocampus. In addition, the correlation analysis showed that the total hippocampal volume of the left hemisphere was negatively correlated with Pittsburgh Sleep Quality Index (PSQI) scores. With regard to hippocampal substructure results, negative correlations were detected between bilateral fimbria volume and clinical variables (i.e., PSQI, SDS, and SAS) in all subjects. Taken together, we revealed marked differences in the volume of the hippocampal substructure between IDs and HC, which provided a more accurate structural imaging marker for the pathological of ID.
In order to guarantee the economic and reliable operation of renewable Distributed Generators (DGs) in microgrids, a decentralized optimization strategy for DGs power allocation is proposed in this ...paper. According to the method, all processes and parameters are designed in a fully distributed way. To achieve decentralization and to maintain the balance between power supply and load demand, a load demand–power generation equivalent forecasting method is proposed to improve the strategy through replacing information of load demand by predicted power output, which removes the load prediction center and load sensor devices. The data of historical power generation, which is used for prediction, has already satisfied the balance constraint between power supply and load demand. Therefore, when the balance between the real power output and the predicted power output is gained, the balance constraint of power supply and load demand is achieved. Meanwhile, the uncertainty and forecasting errors of renewable generation are taken into account in the cost functions to optimize the expense of DG operation comprehensively. Then, the proposed algorithm is expounded in detail and the convergence is proved by eigenvalue perturbation theory. Finally, various cases are simulated to verify the accuracy and effectiveness of the proposed method. In summary, the proposed method are effective tools for DGs economic power allocation and the decentralization of microgrid system.
Hand, foot, and mouth disease (HFMD) caused by enterovirus A71 (EV-A71) infection, currently lacks specific preventive and therapeutic interventions. Here, we demonstrated that Pien Tze Huang (PZH) ...could dose-dependently inhibit EV-A71 replication at the cellular level, resulting in significant reductions in EV-A71 virus protein 1 (VP1) expression and viral yields in Vero and human rhabdomyosarcoma cells. More importantly, we confirmed that PZH could protect mice from EV-A71 infection for the first time, with Ribavirin serving as a positive control. PZH treatment reduced EV-A71 VP1 protein expression, viral yields in infected muscles, and improved muscle pathology. Additionally, we conducted a preliminary mechanism study using quantitative proteomics. The results suggested that the suppression of the PI3K/AKT/mTOR and NF-κB signaling pathways may contribute to the anti-EV-A71 activity of PZH. These findings provide strong evidence supporting the potential therapeutic application of PZH for EV-A71 infection management.
Dysfunction of the sleep-wake transition is considered to be associated with the pathology of patients with primary insomnia (PI). Previous animal study had reported that brain circuits between the ...striatum and cortex can regulate sleep-wake transitions. So far, few studies have systematically explored the structural connectivity of the striatum-centered circuits and their potential roles in patients with PI. In this study, we chosen the striatum as the seed and 10 priori target regions as masks to assess the structural connectivity by using seed-based classification with a diffusion tensor imaging (DTI) probabilistic tractography method. Track strengths of the striatum-centered circuits were compared between 22 patients with PI (41.27 ± 9.21 years) and 30 healthy controls (HC) (35.2 ± 8.14 years). Pittsburgh Sleep Quality Index (PSQI) was used to measure the sleep quality in all participants. Lower track strengths (left striatum- anterior cingulate cortex (ACC), left striatum- dorsal anterior cingulate cortex (dACC), left striatum-Hippocampus, and right striatum-Hippocampus
)
were observed in patients with PI compared to HC. Additionally, the lower track strengths of brain circuits mentioned above were negatively correlated with PSQI. Taken together, our findings revealed the lower tract strength of frontostriatal circuits in patients with PI and HC, which provided the implications of the system-level structural connections of frontostriatal circuits in the pathology of PI. We suggested that the track strengths of the frontostriatal circuits calculated from DTI can be the potential neuroimaging biomarkers of the sleep quality in patients with PI.
•We extended the implications of NAc in sleep regulation from animals to ID patients.•The enlarged volume of right NAc was found in ID patients.•Abnormal RSFC between bilateral NAc and mPFC were ...found in ID patients.
Insomnia disorder (ID) is a prevalent sleep disorder, which seriously affects people's daily life and was found to be associated with increased frequency of sleep stage shifts. Previous findings had revealed the critical role of the nucleus accumbens (NAc) in sleep-wake transition. However, the neuroimaging studies of the NAc in patients with ID have been rare. We hypothesized that structural and functional abnormalities of the NAc would be implicated in ID.
Twenty-six ID patients and 36 matched healthy controls (HC) were included in the current study. The volumes and corresponding resting-state functional connectivity (RSFC) of the bilateral NAc were compared between the two groups. The abnormal RSFC in ID were then correlated with Pittsburgh Sleep Quality Index (PSQI).
Compared with HC, ID patients showed significantly increased volume of right NAc. Several brain regions showed increased RSFC with the NAc in ID patients, such as medial prefrontal cortex (mPFC), anterior cingulate cortex (ACC), caudate and putamen. Meanwhile, the occipital gyrus and temporal gyrus showed decreased RSFC with the NAc. Additionally, the increased RSFC strength between bilateral NAc and left mPFC was significant correlated with PSQI scores in ID patients.
Dysfunctions of the NAc-mPFC circuit were found in ID patients, which were associated with sleep quality measured by PSQI. The two patterns of increase and decrease of RSFC in ID patients observed in our study may reflect the state of hyperarousal and potential impairment of cognitive function in the patients, respectively. It is hoped that our study focusing on NAc-mPFC circuits could provide new insights for the neural mechanisms of ID and potential novel therapeutic targets for treatment of ID patients.
Crescents involving more than 50% of glomeruli in IgA nephropathy (IgAN) signify a rapid deterioration of renal function. However, little is known about the prognosis of IgAN patients presenting ...crescents in less than 50% of glomeruli. We aimed to investigate the clinicopathological characteristics and outcomes of IgAN patients with different proportions of crescents.From January 2000 to December 2011, biopsy-proven primary IgAN patients with histological crescents formation were enrolled in this retrospective cohort study. The patients were divided into 4 groups on the basis of crescent proportion as follows: <5%, 5% to 9%, 10% to 24%, and ≥25%. The primary endpoint was defined as the doubling of baseline serum creatinine (SCr) and/or end-stage renal disease (ESRD), and the secondary endpoint was death.A total of 538 crescent-featured IgAN patients were followed up and included in the analysis. The median crescent proportion was 8.0%. An increasing crescent proportion was associated with a reduced estimated glomerular filtration rate (eGFR), decreased level of hemoglobin, and increased amount of urine protein excretion. After a median follow-up period of 51 months (range 12-154 months), the endpoint events-free survival rate of the above 4 groups were 69.9%, 47.7%, 43.8%, and 40.6%, respectively (Log rank=13.7, P= 0.003), when we incorporated death with renal outcome as a composite endpoint. Multivariate Cox regression analyses adjusting for eGFR, hypertension, proteinuria, and the Oxford-MEST classification demonstrated the predictive significance of an increasing crescent proportion with renal survival and mortality (each increase by 5% log-transformed: HR=1.51, 95% CI 1.08-2.11, P = 0.02). Further comparisons of patients with small proportions of crescents (<5%) and those absent of such pathological lesion showed that the 2 groups of patients had comparable prognosis.An increasing crescent proportion was identified as an independent predictor for unfavorable clinical outcomes in IgAN. Therefore, a small proportion of crescents, over 5% particularly, should be paid more attention in clinical practice.
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