1,4-Dioxane has historically been used to stabilize chlorinated solvents and more recently has been found as a contaminant of numerous consumer and food products. Once discharged into the ...environment, its physical and chemical characteristics facilitate migration in groundwater, resulting in widespread contamination of drinking water supplies. Over one-fifth of U.S. public drinking water supplies contain detectable levels of 1,4-dioxane. Remediation efforts using common adsorption and membrane filtration techniques have been ineffective, highlighting the need for alternative removal approaches. While the data evaluating human exposure and health effects are limited, animal studies have shown chronic exposure to cause carcinogenic responses in the liver across multiple species and routes of exposure. Based on this experimental evidence, the U.S. Environmental Protection Agency has listed 1,4-dioxane as a high priority chemical and classified it as a probable human carcinogen. Despite these health concerns, there are no federal or state maximum contaminant levels for 1,4-dioxane. Effective public health policy for this emerging contaminant requires additional information about human health effects, chemical interactions, environmental fate, analytical detection, and treatment technologies. This review highlights the current state of knowledge, key uncertainties, and data needs for future research on 1,4-dioxane.
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•1,4-Dioxane is an emerging environmental contaminant and a probable carcinogen.•The de minimis cancer risk level is exceeded at 7% of U.S. drinking water sites.•The physicochemical properties challenge detection and remediation of 1,4-dioxane.•This review presents data needed to set an enforceable drinking water standard.
Human papillomavirus (HPV) is a necessary but insufficient cause of a subset of oral squamous cell carcinomas (OSCCs) that is increasing markedly in frequency. To identify contributory, secondary ...genetic alterations in these cancers, we used comprehensive genomics methods to compare 149 HPV-positive and 335 HPV-negative OSCC tumor/normal pairs. Different behavioral risk factors underlying the two OSCC types were reflected in distinctive genomic mutational signatures. In HPV-positive OSCCs, the signatures of APOBEC cytosine deaminase editing, associated with anti-viral immunity, were strongly linked to overall mutational burden. In contrast, in HPV-negative OSCCs, T>C substitutions in the sequence context 5'-ATN-3' correlated with tobacco exposure. Universal expression of HPV
and
oncogenes was a sine qua non of HPV-positive OSCCs. Significant enrichment of somatic mutations was confirmed or newly identified in
,
,
,
,
,
,
,
,
,
,
,
,
,
,
,
, and
Of these, many affect host pathways already targeted by HPV oncoproteins, including the p53 and pRB pathways, or disrupt host defenses against viral infections, including interferon (IFN) and nuclear factor kappa B signaling. Frequent copy number changes were associated with concordant changes in gene expression. Chr 11q (including
) and 14q (including
and
) were recurrently lost in HPV-positive OSCCs, in contrast to their gains in HPV-negative OSCCs. High-ranking variant allele fractions implicated
,
, and
mutations as candidate driver events in HPV-positive cancers. We conclude that virus-host interactions cooperatively shape the unique genetic features of these cancers, distinguishing them from their HPV-negative counterparts.
Women rabbis have been depicted in fiction for close to fifty years. In the second decade and then in the beginning of the third decade of the twenty-first century over a dozen fictional women rabbis ...appear as central or important characters in novels, short stories, and on the silver screen. Most of them make their first appearance. This article takes note of the authors of these works, and then looks at the characters themselves, contrasting their “fictional” experiences with the published experiences of “real-life” women rabbis. It discusses these fictional women rabbis in terms of their theology/sense of tradition; religious/educational backgrounds; gender identification; and where that information is dealt with in the storyline, how these women address some of the challenges facing women rabbis such as dressed for success; pay inequity; and matters of sexual harassment. This is followed by a section on how women regard success in the rabbinate. A caveat: the real-lived experiences of women rabbis, their definitions of success and their joys/concerns/issues/disquiets are not necessarily the subjects that concern writers of fiction that feature women rabbis as characters.
The ratio of the lengths of the second and fourth fingers (2D:4D) may serve as a marker for prenatal androgen signaling. Because people are typically unaware of their 2D:4D, its use allows possible ...effects of early sex hormone regimes and socialization to be disentangled. We conducted a meta-analysis on relationships between 2D:4D and sexual orientation in men and women in 18 independent samples of men and 16 independent samples of women. Collectively, these samples comprised 1,618 heterosexual men, 1,693 heterosexual women, 1,503 gay men, and 1,014 lesbians. In addition to identifying the normative heterosexual sex difference in 2D:4D for both hands, we found that heterosexual women had higher (more feminine) left- and right-hand 2D:4D than did lesbians, but we found no difference between heterosexual and gay men. Moderator analyses suggested that ethnicity explained some between-studies variation in men. These results add to a literature suggesting that early sex hormone signaling affects sexual orientation in women, and highlight the need for further research exploring the relationships among 2D:4D, sexual orientation, and ethnicity in men.
Metal-poor stars are important tools for tracing the early history of the Milky Way, and for learning about the first generations of stars. Simulations suggest that the oldest metal-poor stars are to ...be found in the inner Galaxy. Typical bulge surveys, however, lack low metallicity (Fe/H < -1.0) stars because the inner Galaxy is predominantly metal-rich. The aim of the Pristine Inner Galaxy Survey (PIGS) is to study the metal-poor and very metal-poor (VMP, Fe/H < -2.0) stars in this region. In PIGS, metal-poor targets for spectroscopic follow-up are selected from metallicity-sensitive CaHK photometry from the CFHT. This work presents the ~250 deg^2 photometric survey as well as intermediate-resolution spectroscopic follow-up observations for ~8000 stars using AAOmega on the AAT. The spectra are analysed using two independent tools: ULySS with an empirical spectral library, and FERRE with a library of synthetic spectra. The comparison between the two methods enables a robust determination of the stellar parameters and their uncertainties. We present a sample of 1300 VMP stars -- the largest sample of VMP stars in the inner Galaxy to date. Additionally, our spectroscopic dataset includes ~1700 horizontal branch stars, which are useful metal-poor standard candles. We furthermore show that PIGS photometry selects VMP stars with unprecedented efficiency: 86%/80% (lower/higher extinction) of the best candidates satisfy Fe/H < -2.0, as do 80%/63% of a larger, less strictly selected sample. We discuss future applications of this unique dataset that will further our understanding of the chemical and dynamical evolution of the innermost regions of our Galaxy.
Abstract
We present an estimate of the occurrence rate of hot Jupiters (7
R
⊕
≤
R
p
≤ 2
R
J
, 0.8 ≤
P
b
≤ 10 days) around early-type M dwarfs based on stars observed by the Transiting Exoplanet ...Survey Satellite (TESS) during its primary mission. We adopt stellar parameters from the TESS Input Catalog and construct a sample of 60,819 M dwarfs with 10.5 ≤
T
mag
≤ 13.5, effective temperatures 2900 ≤
T
eff
≤ 4000 K, and stellar masses 0.45 ≤
M
*
≤ 0.65
M
⊙
. We conduct a uninformed transit search using a detection pipeline based on the box least square search and characterize the searching completeness through an injection and recovery experiment. We combine a series of vetting steps including light centroid measurement, odd/even and secondary eclipse analysis, rotation and transit period synchronization tests as well as inspecting the ground-based photometric, spectroscopic, and imaging observations. Finally, we find a total of nine planet candidates, all of which are known TESS objects of interest. We obtain an occurrence rate of 0.27% ± 0.09% for hot Jupiters around early-type M dwarfs that satisfy our selection criteria. Compared with previous studies, the occurrence rate of hot Jupiters around early-type M dwarfs is smaller than all measurements for FGK stars, although they are consistent within 1
σ
–2
σ
. There is a trend that the occurrence rate of hot Jupiters has a peak at G dwarfs and falls toward both hotter and cooler stars. Combining results from transit, radial velocity, and microlensing surveys, we find that hot Jupiters around early-type M dwarfs possibly show a steeper decrease in the occurrence rate per logarithmic semimajor axis bin (
dN
/
d
log
10
a
) when compared with FGK stars.
Background The value of the left internal mammary artery (LIMA) graft is well established. However, the incremental value of a second IMA graft is controversial. Despite reports of improved survival ...with bilateral IMA (BIMA) grafting, the Society of Thoracic Surgeons reports its use in 4% of coronary artery bypass graft operations. We report the influence of BIMA vs SIMA grafting on hospital and late mortality in comparable groups. Methods Retrospective review was conducted of 4584 consecutive isolated coronary artery bypass graft operations (2369 SIMA and 2215 BIMA) performed from 1972 to 1994. The influence of the second IMA was assessed by multivariate analyses of risk factors associated with hospital and late mortality and by propensity score analysis that compares patients with similar baseline characteristics for receiving a second IMA graft. All patients were monitored clinically to assess outcomes. Results Hospital mortality was 4.5% for SIMA vs 2.6% for BIMA patients ( p = 0.001). When stratified by propensity score to undergo BIMA grafting, no difference in hospital mortality was found. Multivariate analyses showed SIMA grafting was significantly associated with late but not hospital mortality. Survival curves after 52,572 patient-years of follow-up (mean, 11.5 years; range, 6 weeks to 32 years) demonstrated improved long-term survival for BIMA vs SIMA patients in all quintiles except those with the greatest propensity for SIMA, wherein late survival was comparable between groups. In matched groups, survival favored BIMA patients ( p = 0.001). Conclusions BIMA grafting offers a long-term survival advantage over SIMA grafting in propensity-matched groups.
Polycomb group proteins are essential for early development in metazoans, but their contributions to human development are not well understood. We have mapped the Polycomb Repressive Complex 2 (PRC2) ...subunit SUZ12 across the entire nonrepeat portion of the genome in human embryonic stem (ES) cells. We found that SUZ12 is distributed across large portions of over two hundred genes encoding key developmental regulators. These genes are occupied by nucleosomes trimethylated at histone H3K27, are transcriptionally repressed, and contain some of the most highly conserved noncoding elements in the genome. We found that PRC2 target genes are preferentially activated during ES cell differentiation and that the ES cell regulators OCT4, SOX2, and NANOG cooccupy a significant subset of these genes. These results indicate that PRC2 occupies a special set of developmental genes in ES cells that must be repressed to maintain pluripotency and that are poised for activation during ES cell differentiation.
We have used data from the Sloan Digital Sky Survey (SDSS) Data Release 5 to explore the overall structure and substructure of the stellar halo of the Milky Way using image4 million color-selected ...main-sequence turnoff stars with image and image. We fit oblate and triaxial broken power law models to the data, and found a 'best-fit' oblateness of the stellar halo image, and halo stellar masses between galactocentric radii of 1 and 40 kpc of image M sub(image). The density profile of the stellar halo is approximately image, where -image. Yet, we found that all smooth and symmetric models were very poor fits to the distribution of stellar halo stars because the data exhibit a great deal of spatial substructure. We quantified deviations from a smooth oblate/triaxial model using the rms of the data around the model profile on scales image100 pc, after accounting for the (known) contribution of Poisson uncertainties. Within the DR5 area of the SDSS, the fractional rms deviation capital sigma /total of the actual stellar distribution from any smooth, parameterized halo model is image40%: hence, the stellar halo is highly structured. We compared the observations with simulations of galactic stellar halos formed entirely from the accretion of satellites in a cosmological context by analyzing the simulations in the same way as the SDSS data. While the masses, overall profiles, and degree of substructure in the simulated stellar halos show considerable scatter, the properties and degree of substructure in the Milky Way's halo match well the properties of a 'typical' stellar halo built exclusively out of the debris from disrupted satellite galaxies. Our results therefore point toward a picture in which an important fraction of the stellar halo of the Milky Way has been accreted from satellite galaxies.