In recent years, with the development of diversified social values, new requirements put forward to the university students’ social responsibility consciousness education. And the evaluation of to ...the social responsibility consciousness of the college students is putting on the agenda. In this study, AHP-fuzzy comprehensive evaluation method was used to establish the evaluation model of the social responsibility consciousness of the college students with student-based, which is used to assessment the social responsibility consciousness of the college students with student-based, to reflect advantages and disadvantages of the system of the social responsibility consciousness of the college students with student-based. Thus decision-making basis is provided to the education and training of the social responsibility consciousness of the college students with student-based. The building of the model has great theoretical and practical value on the integrated assessment of the social responsibility consciousness of the college students with student-based.
In the elderly, brain structural deficits and gait disturbances due to cerebral small vessel disease (CSVD) have been well demonstrated. The relationships among CSVD, brain atrophy, and motor ...impairment, however, are far from conclusive. Particularly, the effect of CSVD on subcortical nuclear atrophy, motor performance of upper extremities, and associating patterns between brain atrophy and motor impairment remains largely unknown. To address these gaps, this study recruited 770 community‐dwelling subjects (35–82 years of age), including both CSVD and non‐CSVD individuals. For each subject, four motor tests involving upper and lower extremities were completed. High‐resolution structural MRI was applied to extract gray matter (GM) volume, white matter volume, cortical thickness, surface area, and subcortical nuclear (caudate, putamen, pallidum, and thalamus) volumes. The results showed worse motor performance of lower extremities but relatively preserved performance of upper extremities in the CSVD group. Intriguingly, there was a significant association between the worse performance of upper extremities and atrophy of whole‐brain GM and pallidum in the CSVD group but not in the non‐CSVD group. In addition, mediation analysis confirmed a functional CSVD‐to‐“brain atrophy”‐to‐“motor impairment” pathway, that is, a mediating role of thalamic atrophy in the CSVD effect on walking speed in the elderly, indicating that CSVD impairs walking performance through damaging the integrity of the thalamus in aging populations. These findings provide important insight into the functional consequences of CSVD and highlight the importance of evaluating upper extremities functions and exploring their brain mechanisms in CSVD populations during aging.
Phase‐change materials (PCMs) are used in several energy recycling utilization systems due to their latent‐heat‐storage and ‐release ability. However, the inability of PCMs to release heat at ...temperatures below their freezing point limits their application in distributed energy utilization systems. This paper reports optically‐triggered low‐temperature heat release in PCMs based on a solid–liquid phase change (PC) controlled by the trans–cis (E–Z) photo‐isomerization of azobenzene. To achieve this, a photo‐responsive alkyl‐grafted Azo is incorporated into tetradecane (Ted) to create a photo‐sensitive energy barrier for the PC. The Azo/Ted composite exhibits controllable supercooling (4.04–8.80 °C) for heat storage and achieves synchronous heat release of PC enthalpy and photo‐thermal energy. In addition, the Azo reduces the crystallization of Ted by intercalating into its molecular alignment. Furthermore, under light illumination, the Azo/Ted composite releases considerable heat (207.5 J g−1) at relatively low temperatures (−1.96 to −6.71 °C). The temperature of the annular device fabricated for energy utilization increases by 4 °C in a low‐temperature environment (−5 °C). This study will pave the way for the design of advanced distributed energy systems that operate by controlling the energy storage/release of PCMs over a wide range of temperatures.
Phase‐change composites with high energy density, light‐controlled energy storage and utilization, and synchronous release phase‐change enthalpy and photo‐thermal energy at low temperatures are developed. An advanced energy system fabricated by an annular device containing this composite material enables optically triggered energy utilization and distribution, leading to the exceptional energy storage/release controllability of PCMs.
It is uncertain whether rare
variants are associated with stroke and dementia in the general population and whether they lead to alterations in cognitive function. This study aims to determine the ...associations of rare
variants with prevalent and incident stroke and dementia, as well as cognitive function changes.
In the prospective community-based Shunyi Study, a total of 1007 participants were included in the baseline analysis. For the follow-up analysis, 1007 participants were included in the stroke analysis, and 870 participants in the dementia analysis. All participants underwent baseline brain magnetic resonance imaging, carotid ultrasound, and whole exome sequencing. Rare
variants were defined as variants with minor allele frequency <1%. A total of 137 rare
carriers were enrolled in the baseline study. At baseline, rare
variant carriers had higher rates of stroke (8.8% versus 5.6%) and dementia (2.9% versus 0.8%) compared with noncarriers. After adjustment for associated risk factors, the epidermal growth factor-like repeats (EGFr)-involving rare
variants were associated with a higher risk of prevalent stroke (odds ratio OR, 2.697 95% CI, 1.266-5.745;
=0.040) and dementia (OR, 8.498 95% CI, 1.727-41.812;
=0.032). After 5 years of follow-up, we did not find that the rare
variants increased the risk of incident stroke and dementia. There was no statistical difference in the change in longitudinal cognitive scale scores.
Rare
EGFr-involving variants are genetic risk factors for stroke and dementia in the general Chinese population.
This study aims to investigate the temporal and spatial patterns of structural brain injury related to deep medullary veins (DMVs) damage.
This is a longitudinal analysis of the population-based ...Shunyi cohort study. Baseline DMVs numbers were identified on susceptibility-weighted imaging. We assessed vertex-wise cortex maps and diffusion maps at both baseline and follow-up using FSL software and the longitudinal FreeSurfer analysis suite. We performed statistical analysis of global measurements and voxel/vertex-wise analysis to explore the relationship between DMVs number and brain structural measurements. A total of 977 participants were included in the baseline, of whom 544 completed the follow-up magnetic resonance imaging (age 54.97±7.83 years, 32% men, mean interval 5.56±0.47 years). A lower number of DMVs was associated with a faster disruption of white matter microstructural integrity, presented by increased mean diffusivity and radial diffusion (β=0.0001 and SE=0.0001 for both,
=0.04 and 0.03, respectively), in extensive deep white matter (threshold-free cluster enhancement
<0.05, adjusted for age and sex). Of particular interest, we found a bidirectional trend association between DMVs number and change in brain volumes. Specifically, participants with mild DMVs disruption showed greater cortical enlargement, whereas those with severe disruption exhibited more significant brain atrophy, primarily involving clusters in the frontal and parietal lobes (multiple comparison corrected
<0.05, adjusted for age, sex, and total intracranial volume).
Our findings posed the dynamic pattern of brain parenchymal lesions related to DMVs injury, shedding light on the interactions and chronological roles of various pathological mechanisms.
The excessive use or abuse of pesticides and veterinary drugs leads to residues in food, which can threaten human health. Therefore, there is an extremely urgent need for multi-analyte analysis ...techniques for the detection of pesticide and veterinary drug residues, which can be applied as screening techniques for food safety monitoring and detection. Recent developments related to rapid multi-residue detection methods for pesticide and veterinary drug residues are reviewed herein. Methods based on different recognition elements or the inherent characteristics of pesticides and veterinary drugs are described in detail. The preparation and application of three broadly specific recognition elements-antibodies, aptamers, and molecular imprinted polymers-are summarized. Furthermore, enzymatic inhibition-based sensors, near-infrared spectroscopy, and SERS spectroscopy based on the inherent characteristics are also discussed. The aim of this review is to provide a useful reference for the further development of rapid multi-analyte analysis of pesticide and veterinary drug residues.
Epidemiological data of cerebral small vessel disease (CSVD) in the general population of China are lacking. We report on the prevalence of lacunes, white matter hyperintensity (WMH), and cerebral ...microbleeds (CMBs) in a community-based sample in China and compare the results with those of other studies.
This was a cross-sectional analysis of the population-based Shunyi Study in China. A total of 1,211 stroke-free participants (mean age, 55.6±9.3 years; 37.4% men) with available 3 Tesla (3T) magnetic resonance images were included in this analysis. Demographic information and risk factor data were assessed. The overall and age-specific prevalence of lacunes, WMH, and CMBs was evaluated. Associations between cardiovascular risk factors and the presence of these lesions were analyzed by multiple logistic regression.
Our study showed a prevalence of 14.5% for lacunes, 72.1% for periventricular hyperintensity (PVH), 65.4% for deep white matter hyperintensity (DWMH), and 10.6% for CMBs. When compared with other community-based samples, individuals in the same age group showed a higher burden of lacunes and a relatively lower prevalence of CMBs. Advanced age was independently associated with the prevalence of these CSVD markers, while the presence of hypertension increased the risk of lacunes, PVH/DWMH, and CMBs in deep or infratentorial locations.
A higher burden of lacunes but a relatively lower prevalence of CMBs was observed in this Chinese population. This notable result highlights the challenge of CSVD prevention in China. Chinese have a risk factor profile for CSVD similar to those in other populations.
Aims: The relationship between central arterial stiffness and aging-related intracranial arteriopathy is not well investigated in the general population. In a population-based study, we investigated ...arterial stiffness in relation to intracranial atherosclerotic stenosis and intracranial arterial dolichoectasia. Methods: This study was a cross-sectional analysis on 1,123 subjects (aged 56.0±9.3 years, 37.9% men) of the population-based Shunyi study in China. Arterial stiffness was assessed by measuring brachial-ankle pulse wave velocity (baPWV). Intracranial atherosclerotic stenosis and intracranial arterial dolichoectasia were evaluated via brain magnetic resonance angiography. Multivariate regression models were constructed to investigate the association between baPWV and intracranial large artery diseases. Results: Increased baPWV was significantly associated with higher prevalence of intracranial atherosclerotic stenosis (odds ratio for the highest quartile of baPWV compared with the lowest quartile, 3.66 95% confidence interval, 1.57– 8.54), after adjustment for cardiovascular risk factors in multivariate analysis. BaPWV was not associated with the presence of basilar artery dolichoectasia and dilation of basilar artery and internal carotid artery. When the diameters of intracranial arteries were regarded as continuous variables, increased baPWV was inversely related to the internal carotid artery diameter in fully adjusted models (β±SE, −0.083±0.042, p = 0.047). Conclusions: This population-based study demonstrates that arterial stiffness was more likely associated with intracranial stenotic arteriopathy other than intracranial dilative arteriopathy.
ABSTRACT
Solid-state fermentation with Agaricus brasiliensis and Agaricus bisporus on whole grain wheat was carried out. Phenolic compounds and antioxidant properties of fermented wheat were ...determined. The results showed that the maximum values of polyphenols contents in wheat fermented with A. brasiliensis and A. bisporus reached, respectively (3.16 ± 0.21) and (3.93 ± 0.23) mg GAE/g, which were 2.90 and 3.61 times of unfermented control. By employing ultra performance liquid chromatography coupled to mass spectrometry (UPLC-MS), 18 kinds of phenolic compounds were identified from fermented wheat. Compared with control, only 4-hydroxy-benzaldehyde was the same compound. It indicated that fermentation with the two fungi changed polyphenols contents and phenolic compounds composition in wheat to a great extent. Among these phenolic compounds, except for 4-hydroxy-benzaldehyde, 4-hydroxy-benzoic acid and β-N-(γ-glutamyl)-4-formylphenylhydrazine, other 15 kinds of phenolic compounds were first identified from mushroom samples (including fruit bodies, mycelia and fermentation products). DPPH radical scavenging capacity, reducing power, ferrous ion chelating ability and inhibition of lipid peroxidation of fermented wheat were significantly stronger than control (P < 0.05).
The study investigated the effects of solid-state fermentation with Agaricus fungi on phenolic compounds and antioxidant properties of wheat.
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