Targeted urinalysis has been suggested to improve screening efficiency in adults. However, there is no well-defined target population in children yet, with limited information on the risk factors for ...urinalysis abnormalities.
Children from infants to 17 years old were randomly selected. Dipstick urinalysis was initially performed. Among those who were abnormal, a repeat dipstick or dipstick with microscopic urinalysis was performed for confirmation.
In total, 70,822 children were included, with 37,866 boys and 32,956 girls. Prevalence of abnormal urinalysis was 4.3%. Age was significantly associated with abnormal urinalysis, with the highest prevalence among 12-14-year-olds. Girls were 2.0 times more likely to exhibit abnormalities. Compared with children whose guardians had a college degree or higher, those whose guardians had a high school degree or lower had a higher likelihood of abnormalities. Geographic location was also associated with abnormal results.
Girls, children aged 12-14 years old, and children whose guardians had a low educational level and children in certain geographic locations were significantly associated with abnormal urinalysis. Identification of children at high risk would contribute to targeted urinalysis screening.
Mineral oil is the primary insulation dielectrics of power transformers. Multiple gas components can be generated due to the decomposition of insulation oil in response to the high electric field ...strength and high temperature. To detect trace gas components, such as C2H2, C2H4 and CH4, is beneficial to assess the healthy status of transformers and prevent the occurrence of faults. Although Ti3C2O2 shows potential in the sensing of polar gas molecules, the hydrocarbons gas molecules in insulating oil are difficult to be sensed by intrinsic Ti3C2O2. A Pd-doped Ti3C2O2 structure is proposed to increase the adsorption ability for the decomposition gas molecules in insulating oil. Firstly, the binding energy of Ti3C2O2 and Pd on four different doping sites was simulated. It is found that the substrate structure with Hole site doping has the finest stability. Secondly, the structure of the substrate with C2H2, C2H4 and CH4 gases adsorption was simulated. It indicates that C2H2 and C2H4 can form stable chemical bonds with the proposed substrate. In order to evaluate the conductivity and transfer electrons of the proposed substrate after the gas adsorption, the DOS, HOMO-LUMO, and DCD analysis were performed. The results show that after Pd doping, the adsorption energy of C2H2 and C2H4 is 5.076 and 4.750 times higher than that of the intrinsic Ti3C2O2, respectively. The transfer charge is 5.019 and 3.767 times higher than that of the intrinsic Ti3C2O2, respectively. Meanwhile, the work function analysis was performed to estimate the validation of proposed Pd-doped Ti3C2O2 as a FET-type gas sensor. The desorption time and the role of temperature on the regulation of desorption is analyzed at last. This work demonstrated that the Pd-doped Ti3C2O2 shows promising potential in improving the detection efficiency of hydrocarbons gas molecules.
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The chelate copper-based anticancer drug bleomycin (BLM) is usually believed to bind metal ions especially Cu(ii) to generate the "activated BLM" for DNA cleavage. Herein, BLM and L-menthol (LM) ...co-loaded hollow mesoporous Cu
S nanoparticles (HMCu
S NPs) with surface folic acid (FA) modification were formulated to construct an intelligent NIR-responsive nanoplatform for synergistic tumor targeted chemo-phototherapy. With the tumor targeting ability of the folate receptor (FR)-positive, FA-HMCu
S/BLM/LM could pinpoint tumor cells efficiently. Under NIR irradiation, the versatile HMCu
S would be bound to exploit the merits of phototherapy (including PTT and PDT-like effects) for cancer treatment. Meanwhile, benefiting from the controllable "solid-liquid" (S-L) phase transition feature of LM as a gatekeeper, FA-HMCu
S/BLM/LM offered a platform for simultaneous NIR-mediated temperature-responsive BLM and copper ion release, which further initiated the generation of the "activated BLM". As a matter of course, the remarkable synergistic combination of Cu-dependent chemo-phototherapy in vitro and in vivo by such a smart all-in-one drug delivery nanoplatform developed here provided information for advancing nanotherapy in biomedical fields.
•A novel N2S-NiFe modified by -NH2 and -SH was designed.•The highest CO yield of N2S-NiFe reached 12412.23 μmol g−1 h−1.•Rich defect trap site caused by the introduction of amino and sulfhydryl ...groups obtained rapid charge transfer and effective space charge separation.•The DFT calculations revealed that Ni-Fe bimetallic center boosted the charge separation and CO2 molecules are more inclined to adsorb at Niov sites.
In this study, a Ni-Fe metal-organic framework modified by –NH2 and –SH was synthesized using a simple hydrothermal process for enhancing photocatalytic CO2 reduction. As expected, the N2S-NiFe (NH2-BDC/H4DSBDC, 2:1) displayed excellent photocatalytic CO2 reduction activity and high CO selectivity (12412.23 μmol g−1 h−1) under visible light irradiation (λ ≥ 420 nm), which is 5 times that of NiFe-MOF. Notably, the excellent photocatalytic performance of N2S-NiFe can benefit from the rich defect trap site caused by the introduction of amino and sulfhydryl groups, accelerating charge transfer and promoting space charge separation, as supported by the photo-electrochemical properties. To better understand the CO2 adsorption mechanism, density functional theory calculations were performed, which revealed that the Niov site has more negative adsorption energy compared with the Feov site. This study provides a simple strategy to establish efficient photocatalysts for CO2 reduction through the modification of organic ligands.
•Angelica root rot can be suppressed by P. polymyxa YF and B. tequilensis SY89.•P. polymyxa YF and B. tequilensis SY89 can function by inhibiting and degrading ENN B.•The GFP-tagged strains of YF and ...SY89 can colonize in Angelica root.•Antagonistic bacteria have significant disease control effect.
Fusarium avenaceum is the predominant pathogen associated with Angelica sinensis root rot, which results in mycotoxin contamination of Angelica, most prominently Enniatin B (ENN B). This study aimed to isolate bacteria capable of combating various phytopathogenic fungi and degrading ENN B to reduce Angelica root rot. Through co-culture with F. avenaceum, the bacterial strains YF and SY89 were isolated from Angelica rhizosphere soil for their antifungal activities. They were identified as Paenibacillus polymyxa and Bacillus tequilensis based on their morphological characteristics and phylogenetic trees constructed using the 16 S rDNA genes sequence. The strains YF and SY89 could produce antimicrobial substance such as surfactin, fengycin, iturin, polyketide synthases and non ribosomal polypeptide synthase detected by Polymerase Chain Reaction (PCR). In addition, strain P. polymyxa YF and B. tequilensis SY89 showed a prominent ability to inhibit synthesis and degrade ENN B in F. avenaceum suspensions and standard samples. The inhibition rate reached 61.93% and 77.64%, respectively, and the degradation rate reached 60.32% and 76.03%, respectively. Angelica pot experiments were conducted to further evaluate the strains YF and SY89 culture ability to promote plant growth and control Angelica root rot to assess its potential agricultural use. The results indicated that strains YF and SY89 could produce IAA and siderophores, which significantly promoted Angelica roots growth. In addition, strains YF and SY89 have the potential to increase the activity of resistant enzymes, thereby inhibiting F. avenaceum infection. The disease index of Angelica roots treated by strain YF and SY89 decreased by 65.38% and 61.54%, respectively. To further elucidate the antagonistic mechanism of YF and SY89, we examined their colonization pattern in the Angelica root using a green fluorescent protein (GFP) marker. The results indicated that YF and SY89 mainly colonized the root surface before migrating into the roots interior part. The present study demonstrated that P. polymyxa YF and B. tequilensis SY89 showed promising prospects for use as a biological control agent against Angelica root rot and ENN B inhibition under field conditions.
Digital reading promotion service is a service way for libraries to provide readers with a series of digital resources, enjoy the service functions, and share the experience of using them in various ...digital reading platforms, which is to meet the reading interests and reading needs of more readers, and is also the focus of the current library work. In the era of new media, the characteristics of digital reading are subtly changing the readers’ needs for reading environment, reading content, and reading style. Libraries should keep pace with the development of the times and provide readers with diversified, intelligent, and targeted digital reading platforms. The digital reading platform should continuously improve the digital reading service functions, broaden the service scope and dissemination channels, and finally realize the diversification, interest, and intelligence of digital reading service. This paper takes the digital reading platform of libraries in the region as the research theme and carries out research work on libraries. The province is divided into three regions according to the geographical map: southeastern region, central region, and northwestern region. The digital reading platforms of 14 prefecture-level public libraries and 58 libraries of higher education institutions in each region were accessed. Firstly, we check the construction of digital resources within the library websites, secondly, we count the opening of digital reading platform functions, and finally, we check the opening of digital reading platforms. Through the research, it is found that there are problems of unbalanced distribution of digital reading resources in regional libraries; unattractive design of readers’ interface and inadequate reading service functions; lack of continuous training of readers’ guidance; insufficient publicity and promotion; low efficiency of staff in responding to consultation; and low degree of platform openness and weak awareness of sharing. Finally, the problems found in the research are summarized, and the solution measures for the regional digital reading platform are proposed. Libraries in the digital era should give priority to systems that can manage all library resources comprehensively and effectively, adapt to more flexible library workflows, and enable libraries to provide better services to users.
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•The pathogen F. oxysporum of C. pilosula wilt disease can be suppressed by three strains.•Antagonistic bacteria have significant disease control effect.•Antagonistic bacteria can ...colonize the roots of C. pilosula.•Antagonistic bacteria can promote the growth of C. pilosula.
Codonopsis pilosula wilt disease caused by Fusarium oxysporum poses a serious threat to the commercial quality and yield of C. pilosilua crops in China. In this study, three selected isolates of antagonistic bacteria, Paenibacillus polymyxa YF, Bacillus amyliquefaciens HT, and Bacillus velezensis BQ, were evaluated for their potential ability to control C. pilosula wilt disease. All three strains could colonize the roots of C. pilosula. However, strain BQ had the strongest colonization ability, in that its colonization abundance was stable at 5.2 × 103 CFU/g. Pot experiments showed that each of these three strains may contribute to enhancing C. pilosula’s growth in terms of its plant height, root length, root fresh weight, and root dry weight. All three antagonistic strains were able to effectively suppress the mycelial growth of F. oxysporum by 45 % to 65 %, with strain YF outperforming the other two strains. Similarly, 1 % sterile supernatant filtrate of each strain was capable of reducing by 40 %∼50 % the germination of F. oxysporum conidia. Pot experiments also demonstrated that strain YF was best able to ameliorate symptoms of C. pilosula wilt disease, whereas strain BQ was best able to prevent them. Similar results were obtained from ex vivo experiments, in that the strain YF was superior to the other two strains to ameliorate symptoms, while strain BQ was superior to the other two strains to prevent them. Analysis of resistance enzyme activity revealed that both peroxidase (POD) and phenylalanine ammonia-lyase (PAL) in C. pilosula roots increased significantly, by 4.5–4.7 and 1.7–1.9 times, in response to the three bacterial strain treatments. And resistance enzyme activity of all three bacterial strain treatments were significantly higher than F. oxysporum treatment and the co-treatment group (F. oxysporum + Antagonistic bacteria treatment groups).
To study the origin ofdwarfing genes used in barley breeding inChina, pedigree data of more than 350 dwarfand semi-dwarf cultivars and entriesdeveloped since 1950 were collected. Theresults showed ...that 68.4% of them werederivatives of just six accessions:`Chibadamai' (CBDM), `Xiaoshanlixiahuang'(XSLXH), `Cangzhouluodamai' (CZLDM),`Aiganqi' (AGQ), `Zhepi 1' and `Yanfu Aizao3' (YFAZ 3). Therefore, these sixaccessions are considered the main donorsof dwarfing genes to barley cultivars bredin China. `CBDM', `XSLXH' and `CZLDM' arelandraces and were used between 1950 and1980. `AGQ', `Zhepi 1' and `YFAZ 3' arereleased cultivars used since 1980. `CBDM',`XSLXH', `CZLDM' and `AGQ' carry the samedwarfing gene uzu on chromosome arm3HL. `Zhepi 1' and `YFAZ 3' likely aremutations at the sdw 1 locus.PUBLICATION ABSTRACT
Developmental evaluation of deaf children before cochlear implantation (CI) has not been given enough attention.
This study was designed to evaluate the comprehensive developmental performance of ...deaf children who are CI candidates.
The medical records of pediatric candidates for CI were reviewed. Five hundred children (287 boys; median age: 21.00 months; range: 6-72 months) with a diagnosis of severe-to-profound hearing loss were included. Preoperative developmental evaluation, including gross motor, fine motor, adaptability, language and social skill were retrieved. Comprehensive developmental performances including verbal and nonverbal skill were assessed. Multivariate linear regression analysis was used to analyze the related developmental factors.
Compared with normal developmental metrics, deaf children had developmental delay (p < .001), which occurred in not only the verbal but also nonverbal skill (all p < .05). Of the 500 deaf children, 50 (10%) had normal performance; the majority (51.6%) had mild neurological dysfunction. Of all the sub-developments, language developed worst (normal rate: 4.2%) and gross motor developed best (normal rate: 42%). Age of intervention was a risk factor for the developmental level of deaf children (β = −0.340, p < .05).
Pediatric candidates for CI had both verbal and nonverbal developmental delay. Age of intervention was a risk factor for the developmental level.
Comprehensive developmental evaluation of deaf children before cochlear implantation (CI) should be paid enough attention. Early intervention for improving hearing was of significance.
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