Temporary hemiepiphysiodesis (TH) using an eight-Plate implant is one of the most common surgeries used for the correction of coronal angular deformities around the knee in adolescents. However, few ...studies have focused on children aged less than 10 years treated with TH using an eight-Plate implant. The purpose of this study was to investigate the efficacy, correction velocity, and complications of TH with an eight-Plate implant as well as the occurrence of rebound and risk factors in this population.
This retrospective study included a total of 135 physes (101 knees) from 66 children (mean age of 4.69 years old, range from 1 to 10 years old) who underwent TH with an eight-Plate implant to correct coronal genu angular deformities in our hospital. Related clinical factors were recorded and analysed by multivariable linear and logistic regression models.
The mean deformity correction period was 13.26 months, and the mean follow-up after eight-Plate removal was 12.71 months. In all, 94.06% (95/101 knees) of the genu angular deformities were completely corrected. Non-idiopathic genu angular deformity was found to be an independent risk factor for deformity correction failure (odds ratio (OR) = 2.47). The femoral correction velocity was significantly higher than the tibial correction velocity (1.28° vs. 0.83° per month, p < 0.001). After adjustment for other factors, younger children had higher correction velocities in the distal femur; however, genu valgum and idiopathic deformities were associated with higher correction velocities in the proximal tibia. In addition, we found three (3/101, 2.97%) knees with genu valgum that experienced rebound after removal of the eight-Plate, while five (5/101, 4.95%) knees with non-idiopathic genu angular deformity experienced screw loosening. No other complications were found, and non-idiopathic deformity was the only risk factor for complications (OR = 3.96). No risk factor was found for rebound in our study.
TH using an eight-Plate implant is an effective procedure for coronal genu angular deformities with a low incidence of complications and rebound in patients younger than 10 years old. For this population, TH using an eight-Plate should be considered as soon as the deformity stops responding to conservative treatments. The parents of children younger than 10 years of age with non-idiopathic deformities should be informed preoperatively that the deformity may be prone to correction failure or screw loosening after eight-Plate implantation.
The apoptosis and autophagy play an important role in the pathogenesis of sepsis-induced cardiac dysfunction. Previous studies have demonstrated that melatonin protects against cardiac dysfunction ...during sepsis. In addition, silent information regulator 1 (SIRT1) is a therapeutic target for sepsis-induced myocardial dysfunction. The aims of this study were to investigate whether SIRT1 was involved in melatonin's cardioprotection during sepsis and the mechanisms.
In this study, twenty-four male C57BL/6 mice were randomly assigned to four groups: Control group, LPS group, LPS + Melatonin group and LPS + Melatonin + EX527 group. Mice were treated with lipopolysaccharide for 8 h with or without melatonin or EX527. The cardiac function, myocardial injury biomarkers, cardiac histopathology, cardiomyocyte apoptosis, autophagosome as well as the protein expressions of SIRT1, cleaved caspase-3, LC3-II/LC3-I ratio and p62 in the myocardium were assayed.
The results demonstrated that melatonin significantly improved cardiac function, decreased creatine kinase (CK) and creatine kinase-MB (CK-MB) levels, attenuated myocardial architecture destruction, inhibited cardiomyocyte apoptosis and increased cardiac autophagy as compared with the LPS group. In addition, melatonin significantly increased SIRT1 protein expression in the myocardium of mice with sepsis, while inhibition of SIRT1 by EX527 abolished melatonin's cardioprotection during sepsis.
In this study, we found that melatonin protected against sepsis-induced cardiac dysfunction by regulating apoptosis and autophagy via activation of SIRT1 in mice.
The proposed mechanisms of melatonin's cardioprotection against cardiac dysfunction during sepsis. Melatonin activates SIRT1 signaling pathway and then regulates apoptosis and autophagy in the myocardium of mice with sepsis, which contributes to improving sepsis-induced cardiac dysfunction. Display omitted
Strongly coupled Nafion molecules and ordered porous CdS networks are fabricated for visible‐light photoelectrochemical (PEC) hydrogen evolution. The Nafion layer coating shifts the band position of ...CdS upward and accelerates charge transfer in the photoelectrode/electrolyte interface. It is highly expected that the strong coupling effect between organic and inorganic materials will provide new routes to advance PEC water splitting.
To compare radiofrequency ablation (RFA) with or without transcatheter arterial chemoembolization (TACE) in the treatment of hepatocellular carcinoma (HCC).
A randomized controlled trial was ...conducted on 189 patients with HCC less than 7 cm at a single tertiary referral center between October 2006 and June 2009. Patients were randomly asssigned to receive TACE combined with RFA (TACE-RFA; n = 94) or RFA alone (n = 95). The primary end point was overall survival. The secondary end point was recurrence-free survival, and the tertiary end point was adverse effects.
At a follow-up of 7 to 62 months, 34 patients in the TACE-RFA group and 48 patients in the RFA group had died. Thirty-three patients and 52 patients had developed recurrence in the TACE-RFA group and RFA group, respectively. The 1-, 3-, and 4-year overall survivals for the TACE-RFA group and the RFA group were 92.6%, 66.6%, and 61.8% and 85.3%, 59%, and 45.0%, respectively. The corresponding recurrence-free survivals were 79.4%, 60.6%, and 54.8% and 66.7%, 44.2%, and 38.9%, respectively. Patients in the TACE-RFA group had better overall survival and recurrence-free survival than patients in the RFA group (hazard ratio, 0.525; 95% CI, 0.335 to 0.822; P = .002; hazard ratio, 0.575; 95% CI, 0.374 to 0.897; P = .009, respectively). There were no treatment-related deaths. On logistic regression analyses, treatment allocation, tumor size, and tumor number were significant prognostic factors for overall survival, whereas treatment allocation and tumor number were significant prognostic factors for recurrence-free survival.
TACE-RFA was superior to RFA alone in improving survival for patients with HCC less than 7 cm.
In resource-constrained mobile ad hoc network, geographical routing algorithms are relatively attractive routing algorithms. Due to the movement of nodes, energy exhaustion and the presence of ...obstacles, routing holes may occur. The existing routing algorithm only considers bypassing routing void through right-hand or left-hand criteria, and forwards data at the boundary of the hole. However, such a routing algorithm may lead to the expansion of the routing hole and even cause the paralysis of the network. This paper proposes a new greedy forwarding improvement routing method for mobile ad hoc network. In the greedy forwarding phase, the reliable communication area is calculated, and then the quality of the link is evaluated according to the relative displacement between the nodes and the maintenance time of the link. Then, according to the quality of the link, the distance between the candidate node and the destination node, and the number of the neighbor nodes, the metric value is obtained, and the node with the large metric value is selected as the next hop. When a routing hole occurs, the waiting forwarding mode is used for a period of time. After a period of time, when the current node is still a routing hole node, we can use the right-hand rule and the left-hand criteria, and the bypass mode is performed simultaneously. By considering three factors of the deflection angle and the maintenance time of the link and the remaining energy of the node, the forwarding node as the next hop with the highest priority value is selected in each direction. The experimental results show that compared with the existing GPSR, EMGR and EDGR, the proposed algorithm reduces the energy consumption of the network, improves the delivery rate of data packets, reduces the network delay and prolongs the network lifetime.
Abstract
Potato is the third most important staple food crop. To address challenges associated with global food security, a hybrid potato breeding system, aimed at converting potato from a ...tuber-propagated tetraploid crop into a seed-propagated diploid crop through crossing inbred lines, is under development. However, given that most diploid potatoes are self-incompatible, this represents a major obstacle which needs to be addressed in order to develop inbred lines. Here, we report on a self-compatible diploid potato, RH89-039-16 (RH), which can efficiently induce a mating transition from self-incompatibility to self-compatibility, when crossed to self-incompatible lines. We identify the
S
-
l
ocus
i
nhibitor
(
Sli
) gene in RH, capable of interacting with multiple allelic variants of the pistil-specific S-ribonucleases (S-RNases). Further,
Sli
gene functions like a general S-RNase inhibitor, to impart SC to RH and other self-incompatible potatoes. Discovery of
Sli
now offers a path forward for the diploid hybrid breeding program.
In the application environment having dense distribution of marginal wireless sensor network (WSN), the data transmission process will generate a large number of conflicts, which will result in loss ...of transmission data and increase of transmission delay. The multi-path data transmission method can effectively solve the problem of large data loss and transmission delay caused by collisions. A new approach of multi-path reliable transmission for application of marginal WSN (named RCB-MRT) is proposed in this paper. It adopts redundancy mechanism to realize the reliability of data transmission, and uses concurrent woven multi-path technology to improve the transmission efficiency of data packets. Firstly, it divides the data packets that the sensor node needs to transmit into several sub-packets with data redundancy, and then forwards the sub-packets to the aggregation node through multi-path by the intermediate nodes of marginal environment. The results of our experimental tests show that the proposed multi-path reliable transmission method can effectively reduce data packet loss rate, reduce transmission delay and increase network lifetime. The method is very useful for the applications of marginal wireless sensor network.
Intelligent condition monitoring and fault diagnosis by analyzing the sensor data can assure the safety of machinery. Conventional fault diagnosis and classification methods usually implement ...pretreatments to decrease noise and extract some time domain or frequency domain features from raw time series sensor data. Then, some classifiers are utilized to make diagnosis. However, these conventional fault diagnosis approaches suffer from the expertise of feature selection and they do not consider the temporal coherence of time series data. This paper proposes a fault diagnosis model based on Deep Neural Networks (DNN). The model can directly recognize raw time series sensor data without feature selection and signal processing. It also takes advantage of the temporal coherence of the data. Firstly, raw time series training data collected by sensors are used to train the DNN until the cost function of DNN gets the minimal value; Secondly, test data are used to test the classification accuracy of the DNN on local time series data. Finally, fault diagnosis considering temporal coherence with former time series data is implemented. Experimental results show that the classification accuracy of bearing faults can get 100%. The proposed fault diagnosis approach is effective in recognizing the type of bearing faults.
Background and Aim
Considering the limitation of varying acid suppression of proton pump inhibitors, this study was aimed to assess the efficacy, safety, and dose–effect relationship of keverprazan, ...a novel potassium‐competitive acid blocker, in the treatment of duodenal ulcer (DU) compared with lansoprazole.
Methods
A randomized, double‐blind, double‐dummy, multicenter, low‐dose, high‐dose, and positive‐drug parallel‐controlled study was conducted to verify the non‐inferiority of keverprazan (20 or 30 mg) to lansoprazole of 30 mg once daily for 4 to 6 weeks and dose–effect relationship of keverprazan in the treatment of patients with active DU confirmed by endoscopy.
Results
Of the 180 subjects randomized, including 55 cases in the keverprazan_20 mg group, 61 cases in the keverprazan_30 mg group, and 64 cases in the lansoprazole_30 mg group, 168 subjects (93.33%) completed the study. The proportions of healed DU subjects in the keverprazan_20 mg, keverprazan_30 mg, and lansoprazole_30 mg groups were respectively 87.27%, 90.16%, and 79.69% at week 4 (P = 0.4595) and were respectively 96.36%, 98.36%, and 92.19% at week 6 (P = 0.2577). The incidence of adverse events in the keverprazan_20 mg group was lower than that in the lansoprazole_30 mg (P = 0.0285) and keverprazan_30 mg groups (P = 0.0398).
Conclusions
Keverprazan was effective and non‐inferior to lansoprazole in healing DU. Based on the comparable efficacy and safety data, keverprazan of 20 mg once daily is recommended for the follow‐up study of acid‐related disorders. (Trial registration number: ChiCTR2100043455.)
Edge computing technology can be used to the Internet of Vehicles (IOV) to solve the mobile characteristics of vehicles and the limited communication range between roadside units and vehicles. New ...method of edge computing-based data adaptive return in IOV is proposed in this article. The transmission strategy can be determined by adaptive estimating the vehicle movement, the amount of data returned, the maximum transmission delay, and effective life of link. And the factors, such as speed, direction, and position of the vehicles, are comprehensively considered and these factors can be measured by the stability effect value when adaptive designing the auxiliary transmission strategy. At the same time, greedy selection method is used when constructing the data return link, and the neighbor node as the relay node with the maximum stability and efficiency value is chosen. Our experimental results show our method in terms of performance on transmission delay and packet delivery rate is better than other ones.
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