The aim of this study is to investigate the potential antioxidant and anti-inflammatory effects of thymoquinone (TQ) to improve acute bacterial prostatitis (ABP) induced by Pseudomonas aeruginosa.
A ...total of 42 male Wistar albino rats were divided into 7 groups as follows: control, ABP (24, 48, and 72 h), and TQ-ABP (24, 48, and 72 h). The prostate tissue samples were assayed for prostate tissue malondialdehyde (MDA) and nitric oxide (NO) levels, and catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPX) activities. Sections were examined for characteristic histological changes, and a histological scoring system was used.
When the ABP groups given TQ (24, 48, and 72 h) were compared to the ABP groups not given TQ, the levels of MDA and NO and the GPX activity were found to be significantly lower in the groups given TQ. Concerning SOD values, the TQ-ABP-72 group was lower in comparison with the ABP-72 and control groups, but statistically higher than the TQ-ABP-48 group (p < 0.05). Concerning CAT activity, only the TQ-ABP-72 and ABP-72 groups had a significant difference with the control group. TQ improved prostate histology significantly only in the TQ-ABP-24 group compared to the ABP-24 group (p < 0.001).
Our study demonstrated for the first time that ABP induced by P. aeruginosa had an oxidative effect on prostate tissue and could regress following TQ administration as shown with the biochemical and histological findings.
Objective The deterioration of seminal parameters in men with varicocele suggests a vascular lesion producing progressive damage to the testes over time. The aim of this study was to analyze the ...relationship between the duration of infertility in infertile men with varicocele and the postoperative sperm counts to determine whether the infertility period is a parameter for predicting the pregnancy rate. Methods The medical records of 574 patients with palpable varicoceles were retrospectively reviewed. According to the duration of unprotected intercourse without conception (infertility period), the patients were divided into 4 groups: group 1, 0-3 years (n = 353); group 2, 3-6 years (n = 132); group 3, 6-9 years (n = 47); and group 4, >9 years (n = 42). The mean age of these groups was 28.5 ± 5.3 years (range 19-58), 30 ± 4.9 years (range 22-52), 31.6 ± 4.1 years (range 25-42), and 36.4 ± 4.2 years (range 29-50), respectively. The preoperative and postoperative total motile sperm counts (TMCs) and postoperative pregnancy rates among these groups were compared statistically, including multivariate analysis. Results An overall spontaneous pregnancy rate of 41.3% was achieved after microscopic varicocelectomy. The greatest pregnancy rate was achieved in group 1 (43.9%) and the lowest pregnancy rate in group 4 (31.7%; P < .05). The mean postoperative TMC in these groups was 34.9 ± 3.5 × 106 and 24.6 ± 1.7 × 106 , the only statistically significant difference in terms of postoperative TMC and pregnancy among the 4 groups. Conclusions According to our data, the pregnancy rates and TMCs after varicocelectomy correlate negatively with the infertility period. This finding supports the perspective that varicocele has deleterious effects on the testicular biology over time.
Abstract
Objective. Metabolic syndrome plays a significant role in the development of benign prostate hyperplasia (BPH) and overactive bladder (OAB). Non-alcoholic fatty liver disease (NAFLD) is ...accepted as the hepatic component of metabolic syndrome. This study investigated the association of NAFLD with BPH and OAB. Material and methods. In total, 702 men with BPH and 529 women with and without OAB were recruited into the study in a cross-sectional risk factor analysis. All male and female patients were separated into two groups, with or without NAFLD. An overnight fasting blood profile was obtained and whole abdominal ultrasound was performed by a blinded radiologist in each patient to measure hepatic steatosis. Results. NAFLD was diagnosed in 387 (55.8%) of 702 men with BPH. Statistically significantly higher prostate volumes were found in men with NAFLD in comparison to without (p = 0.018). The female population included 207 women with NAFLD and 322 women without. OAB was found in 75.8% and 52.4% of women with and without NAFLD (p = 0.022). Conclusions. NAFLD is associated with BPH in men and with OAB in women. These findings confirm the hypothesis that BPH is an aspect of the metabolic syndrome and support the hypothesis that OAB is an aspect of the metabolic syndrome.
Bu çalışmamızda selim prostat hiperplazili hastalarda mesane içine büyüyen prostat (İPP) ile prostat hacmi
arasındaki ilişkiyi araştırmayı ve İPP derecesi ile prostat hacminin belirti ve klinik ...bulgular üzerine etkilerini
incelemeyi amaçladık.
Alt üriner sistem belirtileri olan ve selim prostat hiperplazisi olduğu düşünülen 83 hasta, uluslararası prostat
semptom skorlaması (IPSS), üroflovmetri ile değerlendirildi. Prostat hacmi, İPP ve artık idrar miktarı ultrason ile
değerlendirildi. Ultrason sonuçları, üroflov ölçütleri ve IPSS, prostat hacmi ve IPP derecesine göre yapılan gruplar
arasında karşılaştırıldı.
İPP hastaların %57,8'inde tespit edildi. İPP, prostat hacmi 40 cc'den yüksek olanlarda daha fazla izlendi
(%77,1, p=0,005). Prostat hacmi 40 cc'den fazla olan hastaların, maksimum idrar akımı (Qmax) ve hayat kaliteleri
anlamlı olarak düşük; yaş ve IPSS'leri ise prostat hacmi 40 cc'den az olanlara göre anlamlı olarak yüksek tespit
edildi. İPP saptanan hastalarda prostat hacmi ve IPSS'de İPP saptanmayan hastalara oranla anlamlı artış izlendi.
Hastalar İPP vertikal boyutuna (Grup 1: 0-4,9 mm, Grup 2: 5-9,9 mm, Grup 3: >10 mm) göre sınıflandığında; 1. grup
ile 3. grup arasında prostat hacmi, IPSS ve artık idrar miktarı açısından anlamlı farklılık saptandı. Qmax ve IPSS,
prostat hacmi ve İPP, prostat hacmi ve IPSS arasında anlamlı ilişki tespit edildi.
İPP'nin, değerlendirilen ölçütler içinde sadece prostat hacmi ve IPSS'de anlamlı farklılığa yol açtığı izlendi.
İstatistiksel anlamlılık olmaksızın İPP'li hastalarda Qmax, artık idrar miktarı ve hayat kalitesi daha kötüydü. Artık
idrar miktarı dışında incelenen ölçütler ile prostat hacmi arasındaki ilişki, İPP ile olan ilişkiden daha yüksekti. Artmış
prostat hacimli hastalar İPP'ye daha yatkın olmaktadır. İPP ile prostat hacmi arasındaki bu yüksek ilişki, İPP'li
hastalardaki kötü kliniğin sebebinin artmış prostat hacmi kaynaklı olabileceğini düşündürmektedir.
Introduction: In this study, we aimed to investigate the relation between intravesical prostatic protrusion
(IPP) and prostate volume in patients with benign prostate hyperplasia and effects of IPP grade and prostate
volume on clinical signs.
Materials and Methods: We evaluated 83 consecutive patients with LUTS suggestive of BPH via the
international prostate symptom score (IPSS) and uroflowmetry parameters. The volume of prostate, IPP and
postvoid urine were also measured by transabdominal ultrasound. Ultrasound findings, uroflowmetry results
and IPSS were compared between groups constituted according to prostate volume and IPP grade.
Results: IPP was detected in 57.8% of the patients. IPP was seen higher (77.1%) in the patients with a
prostate volume higher than 40 cc (p=0,005). Patients with prostate volumes higher than 40 cc had
significantly higher age, IPSS, and lower maximum urine flow (Qmax), quality of life (Qol). Patients with IPP
had significantly higher prostate volume and IPSS than patients without IPP. When patients were grouped
according to IPP vertical size (Group 1: 0-4.9 mm, Group 2: 5-9.9 mm, Group 3: >10 mm); significant
differences were found between first and third group in prostate volume, IPSS and postvoid urine. There were
significant correlation between Qmax and IPSS, prostate volume and IPSS, prostate volume and IPP.
Conclusion: IPP caused statistically significant difference in prostate volume and IPSS. The other
parameters like uroflow, postvoid urine and quality of life were worse in patients who had IPP with no
statistically significance. Except postvoid urine, the correlation was higher between the investigated
parameters and prostate volume than IPP. Patients with higher prostate volumes tend to have IPP, because of
this high correlation with prostate volume; we thought that worsening symptoms and findings with IPP was
due to the elevating prostate volumes.
