Background: Sports-related concussion (SRC) is an injury with important implications, especially in collision and contact sports, and has a high symptom burden. Student athletes face particular ...psychosocial challenges, especially female students with pre-existing anxiety/depression are at increased risk for SRC, and have a higher symptom burden before and after injury.
Objectives: Describing female SRC presenting features at a collegiate campus-based sports medicine service; examining the association of prior concussion history (PCONC) and pre- existing anxiety/depression (PMHDx) with SRC.
Methods: A retrospective cohort and statistical analysis (including corrected effect sizes) of Sport Concussion Assessment Tool (versions 3/5) data (Step 1: PCONC and PMHDx history; Step 2: symptom evaluation) of collegiate female athletes with SRC between 2012 and 2018.
Results: Forty females with SRC were identified (age 23 ± 3). The five most frequent symptoms were headache (n = 34; 85%), feeling slowed down (n = 33; 83%), pressure in head (n = 33; 83%), don't feel right (n = 32; 80%) and fatigue/low-energy (n = 32; 80%). These five symptoms also had the highest self-rated severity (median (IQR): headache (3 (2-4)), feeling slowed down (3 (1-4)), fatigue/low-energy (3 (1-5)), don't feel right (3 (1-4)) and pressure in head (3 (2-4)). PMHDx (n = 8; 62.9 vs 38.6; p = 0.0192; Hedges' gs = 0.95; large ES), and not PCONC (n = 13; 51.0 vs 39.8; p = 0.2183; Hedges' gs = 0.48; small ES) was associated with increased mean total symptom severity.
Conclusion: Headache, feeling slowed down, pressure in head, don't feel right and fatigue/low-energy had the highest symptom burden. Total symptom severity was no different in those with and without PCONC, but significantly higher in those with PMHDx.
The selection of a specific site of attachment by a copepod parasite is determined by a set of mostly unknown factors. The spatial distribution of Nemesis lamna on the gill filaments of white sharks ...Carcharodon carcharias was investigated. The complete set of left gills
of 11 hosts was examined and the location, orientation and gender of each copepod noted. N. lamna exhibited a prevalent of 100% and a mean intensity of 74 individuals per shark. There was no relationship between the size of the host and the number of filaments per hemibranch or the
number of N. lamna attached to the host. Only 13.7% of the variation in number of individuals per hemibranch was due to the variation in the number of filaments per hemibranch, and most specimens (33.6%) were collected from the fourth holobranch. Most N. lamna (86.5%) were attached
to the dorsal and ventral quarters of the hemibranchs, of which 63.1% were attached to the outer hemibranchs. There was no site preference in terms of their position on the filaments, but most were attached with their cephalothoraces facing the incoming respiratory water flow, especially those
attached to the proximal quarter. The N. lamna infrapopulations on white sharks are aggregated, which is probably due to the need to reproduce.
Interactions between the pharmaceutical industry and physicians have been discussed in numerous publications; however, most articles are limited to surveys and self-report data and often focus on ...academic or training contexts. We describe the role of pharmaceutical representatives and the use of samples in community-based family practices, using data obtained by directly observing clinical encounters.
We collected detailed descriptive field notes of the direct observations of 53 primary care clinicians and 1588 patient encounters in 18 purposefully selected Nebraska family practices. We used a comparative case study design, that used depth interviews of clinicians and office staff, and included details of the interactions with pharmaceutical representatives and the use of samples in clinical encounters.
Individual providers and practices displayed noticeable variation in their approaches to drug representatives and samples. We found formal strategies and policies in a minority of practices. Generally there was little structure in the organization and distribution of sample medications at the office level, and detailed patient education regarding these drugs was rarely observed in patient encounters. Nevertheless, samples were used in almost 20% of observed encounters, at times as starter dosages, but often as complete courses of treatment. The benefits derived from contact with the pharmaceutical industry varied substantially, but most often included free medication samples, meals, and patient education materials.
Clinicians have a complex symbiosis with the pharmaceutical industry and need to critically evaluate their handling of samples and their contact with pharmaceutical representatives to optimize this relationship and ensure quality patient care. Clinics with specific policies for interactions with drug companies appear to derive more satisfaction from their encounters.
A
bstract
Using a data sample of 980 fb
−
1
collected with the Belle detector at the KEKB asymmetric-energy
e
+
e
−
collider, we study for the first time the singly Cabibbo-suppressed decays
$$ ...{\Omega}_c^0\to {\Xi}^{-}{\pi}^{+} $$
Ω
c
0
→
Ξ
−
π
+
and Ω
−
K
+
and the doubly Cabibbo-suppressed decay
$$ {\Omega}_c^0\to {\Xi}^{-}{K}^{+} $$
Ω
c
0
→
Ξ
−
K
+
. Evidence for an
$$ {\Omega}_c^0 $$
Ω
c
0
signal in the
$$ {\Omega}_c^0 $$
Ω
c
0
→
Ξ
−
π
+
mode is reported with a significance of 4
.
5
σ
including systematic uncertainties. The ratio of branching fractions to the normalization mode
$$ {\Omega}_c^0 $$
Ω
c
0
→
Ω
−
π
+
is measured to be
$$ \mathcal{B}\left({\Omega}_c^0\to {\Xi}^{-}{\pi}^{+}\right)/\mathcal{B}\left({\Omega}_c^0\to {\Omega}^{-}{\pi}^{+}\right)=0.253\pm 0.052\left(\textrm{stat}.\right)\pm 0.030\left(\textrm{syst}.\right). $$
B
Ω
c
0
→
Ξ
−
π
+
/
B
Ω
c
0
→
Ω
−
π
+
=
0.253
±
0.052
stat
.
±
0.030
syst
.
.
No significant signals of
$$ {\Omega}_c^0\to {\Xi}^{-}{K}^{+} $$
Ω
c
0
→
Ξ
−
K
+
and Ω
−
K
+
modes are found. The upper limits at 90% confidence level on ratios of branching fractions are determined to be
$$ \mathcal{B}\left({\Omega}_c^0\to {\Xi}^{-}{K}^{+}\right)/\mathcal{B}\left({\Omega}_c^0\to {\Omega}^{-}{\pi}^{+}\right)<0.070 $$
B
Ω
c
0
→
Ξ
−
K
+
/
B
Ω
c
0
→
Ω
−
π
+
<
0.070
and
$$ \mathcal{B}\left({\Omega}_c^0\to {\Omega}^{-}{K}^{+}\right)/\mathcal{B}\left({\Omega}_c^0\to {\Omega}^{-}{\pi}^{+}\right)<0.29. $$
B
Ω
c
0
→
Ω
−
K
+
/
B
Ω
c
0
→
Ω
−
π
+
<
0.29
.
A
bstract
We present the first measurement of the branching fraction of the singly Cabibbo-suppressed (SCS) decay
$$ {\Lambda}_c^{+} $$
Λ
c
+
→ pη
′ with
η
′
→ ηπ
+
π
−
, using a data sample ...corresponding to an integrated luminosity of 981 fb
−
1
, collected by the Belle detector at the KEKB
e
+
e
−
asymmetric-energy collider. A significant
$$ {\Lambda}_c^{+} $$
Λ
c
+
→ pη
′ signal is observed for the first time with a signal significance of 5.4
σ
. The relative branching fraction with respect to the normalization mode
$$ {\Lambda}_c^{+} $$
Λ
c
+
→ pK
−
π
+
is measured to be
$$ \frac{\mathcal{B}\left({\Lambda}_c^{+}\to p\eta^{\prime}\right)}{\mathcal{B}\left({\Lambda}_c^{+}\to {pK}^{-}{\pi}^{+}\right)}=\left(7.54\pm 1.32\pm 0.73\right)\times {10}^{-3}, $$
B
Λ
c
+
→
pη
′
B
Λ
c
+
→
pK
−
π
+
=
7.54
±
1.32
±
0.73
×
10
−
3
,
where the uncertainties are statistical and systematic, respectively. Using the world-average value of
$$ \mathcal{B}\left({\Lambda}_c^{+}\to {pK}^{-}{\pi}^{+}\right) $$
B
Λ
c
+
→
pK
−
π
+
= (6
.
28
±
0
.
32)
×
10
−
2
, we obtain
$$ \mathcal{B}\left({\Lambda}_c^{+}\to p\eta^{\prime}\right)=\left(4.73\pm 0.82\pm 0.46\pm 0.24\right)\times {10}^{-4}, $$
B
Λ
c
+
→
pη
′
=
4.73
±
0.82
±
0.46
±
0.24
×
10
−
4
,
where the uncertainties are statistical, systematic, and from
$$ \mathcal{B}\left({\Lambda}_c^{+}\to {pK}^{-}{\pi}^{+}\right) $$
B
Λ
c
+
→
pK
−
π
+
, respectively.
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