We present a rare clinical case of renal cell carcinoma from the collection tubules-carcinoma of Bellini. A 69 years old patient, enters in our department with symptoms of massive hematuria. From the ...studies carried out-blood tests, CT and cystoscopy there are no data of neo process of lower urinary tract, but shows horseshoe-shaped kidney, cystic deformation of the left kidney and aortic dissection. A left radical nephroureterectomy was performed, with preoperative diagnosis of renal tumor at stage T3. The histopathological diagnosis was Bellini duct carcinoma of papillary tubular type. The patient currently remains disease –free.
A comprehensive guide to Bellini's NORMA, featuring Principal Characters in the opera, Brief Story Synopsis, Story Narrative with Music Highlight Examples, and an insightful and in depth Commentary ...and Analysis by Burton D. Fisher, noted opera author and lecturer.
Dalla met. del XVIII secolo la passione crescente per il “recitar cantando”, favorisce in Italia una straordinaria proliferazione di architetture per lo spettacolo, che vengono realizzate nelle ...grandi città, ma anche in molti centri minori. Lo strumento fondamentale per il controllo del progetto è rappresentato dalla Geometria, che si esplica nella sperimentazione di molteplici tracciati per la determinazione del miglior schema iconografico e ortografico. I procedimenti geometrici utilizzati dai progettisti di teatri non sempre però sono espliciti. La comprensione di una specifica configurazione geometrico-costruttiva può essere così raggiunta solo attraverso il rilievo dell’architettura nei modi e con le tecniche dell’indagine scientifica, in un serrato confronto con le passate “ culture” della misura e della rappresentazione. In questa ottica viene proposto uno studio del Teatro Petrarca di Arezzo, realizzato nel 1833 su progetto dell’architetto fiorentino Vittorio Bellini.
Although collecting duct carcinoma is a subtype of renal cell carcinoma, several studies implicate association with urothelial carcinoma. The coexistence of collecting duct carcinoma and another ...renal neoplasm is rare. Endemic nephropathy is a renal disease causing chronic renal failure. It is highly associated with urothelial neoplasm and occurs in endemic villages in Bosnia, Croatia, Bulgaria, Romania and Serbia. Recent studies have confirmed the important role of exposure to aristolochic acid as an etiologic factor. We present three cases of collecting duct carcinoma with literature overview. In one case, we describe collecting duct carcinoma with metachronous urothelial carcinoma of the pyelon and urinary bladder in an endemic nephropathy patient. To our knowledge, this is the first case report describing this coexistence. Certain similarities between collecting duct carcinoma and urothelial carcinoma were found, e.g., higher incidence in female compared to male, higher mean age, and multifocal and multicentric occurrence of the tumor. Our observations support the hypothesis that collecting duct carcinoma and urothelial carcinoma could be connected.
Introduction: Collecting duct carcinomas (CDC), also known as Bellini’s tumors, are a rare and aggressive subtype of renal cell carcinoma. Therefore, there are very few data about their management, ...and there is no standard therapy for this malignancy. We report the outcome of CDC patients treated on institutions belonging to the ‘Grupo Centro’ of Genitourinary Tumors, a novel networking cooperative group in Spain. Material and Methods: Patients with CDC diagnosed between 1995 and 2015 were included. They had to have an appropriate follow-up, as well as available tissue for further correlative studies. Demographic baseline features and therapy outcomes were collected in a retrospective fashion. Approval for this data collection was obtained from a central ethical committee. Results: A total of 43 patients were analysed, with a median overall survival (OS) of 14 months (95% CI: 9.2–18.8 months). 29 of them (67.4%) were diagnosed as localized disease, and 14 (32.6%) as metastatic disease. For the subgroup of patients diagnosed without metastases, median relapse-free survival (RFS) is 22 months (95% CI: 12.4–35.6 months), and median OS, 53 months (95% CI: 35.5–84.3 months). For the subgroup of patients with metastatic disease, median OS is 6 months (95% CI: 4.1–7.8 months). 16 patients (55.2%) with stage IV disease received systemic therapy, mainly platinum-based chemotherapy, with a response rate of 12.5% and a median progression-free survival (PFS) of 2 months. Conclusions: CDC of the kidney is a malignancy with poor prognosis and few responses to therapy. Median OS of our group in the metastatic setting is similar to what has been observed in previous series. There is a clear need to improve the armamentarium we have for the systemic approach of patients with advanced CDC.
The world-renowned musicologist Richard Taruskin has devoted
much of his career to helping listeners appreciate Russian and
Soviet music in new and sometimes controversial ways. Defining
Russia ...Musically represents one of his landmark achievements:
here Taruskin uses music, together with history and politics, to
illustrate the many ways in which Russian national identity has
been constructed, both from within Russia and from the Western
perspective. He contends that it is through music that the powerful
myth of Russia's "national character" can best be understood.
Russian art music, like Russia itself, Taruskin writes, has "always
been tinged or tainted ... with an air of alterity--sensed,
exploited, bemoaned, reveled in, traded on, and defended against
both from within and from without." The author's goal is to explore
this assumption of otherness in an all-encompassing work that
re-creates the cultural contexts of the folksong anthologies of the
1700s, the operas, symphonies, and ballets of the 1800s, the
modernist masterpieces of the 1900s, and the hugely fraught but
ambiguous products of the Soviet period. Taruskin begins by showing
how enlightened aristocrats, reactionary romantics, and the
theorists and victims of totalitarianism have variously fashioned
their vision of Russian society in musical terms. He then examines
how Russia as a whole shaped its identity in contrast to an "East"
during the age of its imperialist expansion, and in contrast to two
different musical "Wests," Germany and Italy, during the formative
years of its national consciousness. The final section, expanded
from a series of Christian Gauss seminars presented at Princeton in
1993, focuses on four individual composers, each characterized both
as a self-consciously Russian creator and as a European, and each
placed in perspective within a revealing hermeneutic scheme. In the
culminating chapters--Chaikovsky and the Human, Scriabin and the
Superhuman, Stravinsky and the Subhuman, and Shostakovich and the
Inhuman--Taruskin offers especially thought-provoking insights, for
example, on Chaikovsky's status as the "last great
eighteenth-century composer" and on Stravinsky's espousal of
formalism as a reactionary, literally counterrevolutionary
move.
The three earliest - all eighteenth-century - illustrated accounts of birds' eggs were by Luigi Marsili (or Marsigli): Danubius Pannonico-Mysicus, Giuseppe Zinanni (or Ginanni): Delle Uova e dei Nidi ...degli Uccelli, and Jacob Theodor Klein: Ova avium plurimarum ad naturalem magnitudinem delineata et genuinis coloribus picta. Marsili's account describes and illustrates the nests and eggs of just 15 different birds (whose identity is sometimes uncertain), which together with 59 plates of birds forms part of a multi-disciplinary account of the River Danube. Zinanni's volume (which also includes an appendix on grasshoppers) describes the nests and eggs of 106 birds, and is more extensive and accurate since he shot the adult birds attending nests from which the illustrated eggs were collected. Zinanni's book includes 34 black-and-white engraved plates each with between one and nine eggs of species that (excluding domesticated or exotic species) were probably those that occurred around his home in north-east Italy. Klein's volume includes 145 coloured plates of eggs - the first published coloured images of eggs - and his classification of birds based on feet and toes. We present some biographical information and details of each author's career and a summary of their books' contents. The text of Zinanni's volume is the most "philosophical" of the three and includes a discussion - based on the writings of Lorenzo Bellini and Antonio Vallisneri - of what he calls "airways" within the egg that have apparently not been noticed or commented on by subsequent researchers.
Chemotherapy for collecting duct carcinoma (CDC) has demonstrated only limited efficacy in the advanced setting. The present study evaluated the activity of targeted therapies in metastatic CDC.
We ...evaluated a cohort of 384 consecutive patients with metastatic renal cell carcinoma (mRCC). The characteristics of patients with CDC were compared against those of the remaining cohort. All patients with CDC were treated with targeted therapies.
Thirteen patients with advanced CDC were referred to our Center (incidence: 3.4% of all mRCC). Median age was 57 and 62 years in the CDC and non-CDC groups, respectively. The overall disease control in the CDC population was 23%, and median overall survival was 4 (95% confidence interval(CI)=2.4-5.6) months. Three patients obtained a satisfying response (disease control lasting 6-33 months).
CDC has a poor prognosis compared to non-CDC renal cell carcinoma. Treatment for CDC represents a future challenge and targeted therapies may play a role in selected cases.
The arts can provide unique ways for determining how people not directly involved in medicine were viewing and informing others about physical and mental disorders. With operas, one need only think ...about how various perturbations of madness have been portrayed. Somnambulism has long been a particularly perplexing disorder, both to physicians and the laity, and it features in a number of operas. Two mid-nineteenth-century masterpieces are examined in detail in this contribution: Verdi's Macbeth and Bellini's La Sonnambula. In the former, the sleepwalking scene is faithful to what Shakespeare's had written early in the seventeenth century, a time of witchcraft, superstition, and the belief that nocturnal wanderings might be caused by guilt. In Bellini's opera, in contrast, the victim is an innocent girl who suffers from a quirk of nature, hence eliciting sympathy and compassion. By examining the early literature on somnambulism and comparing this disorder in these operas, we can see how thinking about this condition has changed and, more generally, how music was helping to generate new ways of thinking about specific diseases and medicine.
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