Twilight of empire Chernev, Borislav
Twilight of empire,
2017, 20170516, 2017, 2017-05-16, 2017-06-16
eBook
Borislav Chernev, through an insightful and in-depth analysis of primary sources and archival material, argues that although its duration was short lived, the Brest-Litovsk settlement significantly ...affected the post-Imperial transformation of East Central Europe.
Background
Breast cancer is the most common cancer among women. Despite of the progress of medicine and develop of treatment, it is still the second couse of death among women. To reduce the risk of ...getting breast cancer, the more ofen teratement is "preventive mastectomies" which completely remove the breast gland by healty women that are in the "high risk" group.
Material and Methods
To conduct the research I develop a survey, written by my own. The study included 252 women from Poland over the age of 18.
Results
The opinion about the performance of preventive mastectomies in case of women in "high risk" was very diverse. Only 13% of interviewees were convinced that they would have the surgery and up to 29% could not give an answer. Most woman (86%) are convinced that breast cancer is genetically determined. That mastectomy can be a way to prevent breast cancer agrees 69% of respondents. More than half of respondents (52%) don't know if such surgery is in Poland available. Only half of the respondents could indicate the place where an examination of an increased risk of breast cancer can be made (49%). 81% of respondents examine there breasts at least with one method, and 19% did not check it at all.
Conclusions
The knowledge about the heredity of cancer and the availability of treatments is insufficient. Women are not convinced that they would have gone to radical preventive treatment, and they are afraid of many consequences connected with it. It is essential to educate the public including the medical stuff in this scope. It is also important that the patient together with his doctor examined all the possible options for limiting the risk of cancer.
Background: Breast cancer (BC) is a leading cause of cancer related death worldwide. Unfortunately, data concerning clinicopathologic features of this malignancy in non-developed countries is scarce. ...This study aims to characterize a cohort of Guatemalan female patients with non-metastatic BC and to determine risk factors for overall survival (OS). Methods: We retrieved data on consecutive patients from the Instituto Guatemalteco de Seguridad Social that were treated from 2008 to 2014. Clinical features and long-term outcomes were retrieved from medical records. Univariate and multivariate Cox regression analyses were conducted to identify variables associated with OS. Results: 954 BC patients were identified during the time frame. A total of 436 women (46%) were younger than 50 years old. BC molecular subtypes categorized 537 patients (56.3%) with luminal A disease, 186 (19.5%) patients with triple negative tumors, 153 cases (16.1%) with HER-2 enriched tumors, and 78 patients (8.2%) with luminal B tumors. Clinical stage at presentation was stage I: 4.7% (n=45); stage II: 48.1% (n=459), and stage III: 47.2% (n=450). The overall 5-year survival rate was 75.2% (95% Confidence Interval: 72.0–78.3). In the multivariate analysis clinical stage, triple negative tumors and HER2 enriched tumors were independently associated with poor survival. Conclusion: The majority of patients with non-metastatic BC are diagnosed with advanced disease and many of them are younger than 50 years old. OS in this cohort of Guatemalan patients is lower than that reported in developed countries.
Background: Breast cancer (BC) is a leading cause of cancer related death worldwide. Unfortunately, data concerning clinicopathologic features of this malignancy in non-developed countries is scarce. ...This study aims to characterize a cohort of Guatemalan female patients with non-metastatic BC and to determine risk factors for overall survival (OS). Methods: We retrieved data on consecutive patients from the Instituto Guatemalteco de Seguridad Social that were treated from 2008 to 2014. Clinical features and long-term outcomes were retrieved from medical records. Univariate and multivariate Cox regression analyses were conducted to identify variables associated with OS. Results: 954 BC patients were identified during the time frame. A total of 436 women (46%) were younger than 50 years old. BC molecular subtypes categorized 537 patients (56.3%) with luminal A disease, 186 (19.5%) patients with triple negative tumors, 153 cases (16.1%) with HER-2 enriched tumors, and 78 patients (8.2%) with luminal B tumors. Clinical stage at presentation was stage I: 4.7% (n=45); stage II: 48.1% (n=459), and stage III: 47.2% (n=450). The overall 5-year survival rate was 75.2% (95% Confidence Interval: 72.0–78.3). In the multivariate analysis clinical stage, triple negative tumors and HER2 enriched tumors were independently associated with poor survival. Conclusion: The majority of patients with non-metastatic BC are diagnosed with advanced disease and many of them are younger than 50 years old. OS in this cohort of Guatemalan patients is lower than that reported in developed countries.
Objective: mastectomy after breast cancer produces several postural and biomechanical alterations in the frontal and sagittal plane. Such changes lead to disturbed kinematics of the spine, muscle ...imbalance and altered foot weight bearing. This study aims to describe body balance alterations after mastectomy based on the baropodometric analysis of their mean pressure and static load. Methodology: a descriptive correlational research was carried out. Foot weight-bearing properties were identified in 17 patients who have undergone a mastectomy. An Ecosanit Foot pressure plate was used to measure foot load at anatomical position and keeping the feet together. Results: 17 female patients who had undergo mastectomy with a mean age of 54.16 years took part on the research. Patients who have had a dominant-side mastectomy demonstrated significant greater mean pressure at anatomical position when compared to those patients who have had a non-dominant side mastectomy (227.2 ± 22.16 versus 175.6 ± 14.95, p =0.05). There was no significant difference for static load between the patients who have had a dominant side mastectomy and patients who have had a non dominant side mastectomy at anatomical position (52.43 ± 4.069 versus 49.69 ± 4.094, respectively). Conclusion: the current results of our research showed the unbalanced weight distribution in patients after mastectomy. Consequently, it describes the postural and muscular alterations, and the static and dynamic imbalance in breast cancer patients.
To investigate the clinical implications of 17β-estradiol (E2) in estrogen receptor α (ERα)-negative female cancer progression as well as the underlying biological mechanisms.
Clinical data from 306 ...locally-advanced cervical cancer (stage IIB-IVA) patients were analyzed in order to investigate the relationships between age, serum E2 levels, and treatment outcomes. Clinical samples, ERα-negative cervical and breast cancer cell lines, and mouse xenograft models of cervical and breast cancers were employed in order to elucidate the mechanisms responsible for the E2- and pregnancy-mediated progression of cervical and breast cancers, with a focus on the role of myeloid-derived suppressor cells (MDSC).
Younger patients with elevated E2 levels showed significantly shorter progression-free survival (
= 0.040) and overall survival (
= 0.039). The exogenous E2 treatment stimulated the mobilization of MDSC from bone marrow and directly augmented their suppressive activities, leading to the progression of ERα-negative cervical and breast cancers. The co-administration of an anti-Gr-1 neutralizing antibody with E2 prevented the E2-mediated induction of MDSC, and attenuated E2-mediated tumor growth in cervical and breast cancer xenografts. Significantly increased MDSC numbers and enhanced tumor growth were observed during pregnancy in mice with cervical or breast cancer. Significantly increased MDSC numbers were also observed during pregnancy in cervical cancer patients.
E2 facilitates the progression of ERα-negative cervical or breast cancer under non-pregnant and pregnant conditions by inducing MDSC. MDSC inhibition therapy may have therapeutic efficacy in premenopausal or pregnant female cancer patients.
The Bay of Brest (BB) is a mixed, tide-dominated estuarine system. The shore terraces of this bay are occupied by modern free-living (calcareous) coralline algae locally termed “maerl”, organized in ...bed-like morphologies (rhodolith deposits). Cores retrieved from around the bay reveal fossilized primitive maerl beds of Holocene age, interbedded in sandy-silt sedimentation. The alternation between biogenic constructions and estuarine sedimentation may provide evidence of varying environmental conditions of the late-Holocene period. This paper mainly focuses on the results of chronostratigraphic and bio-sedimentological interpretations of coring data collected in less than 15 m of water depth in an attempt to decipher the main stages of maerl colonization in the bay. In particular, this study raises several significant points allowing to draw links between centennial to millennial-scale climatic changes in marine estuary sedimentation and episodes within the development of maerl biocenoses. The paleo-bathymetry of the coastal terraces has not changed significantly over the last 5000 years. Yet, the first maerl occurrence only appeared around 2000 cal yr B.P., likely showing that the environmental conditions were not favorable for their emergence prior to that time. Pioneer maerl beds developed on coarse shell deposits inherited from the paleostorms affecting the Atlantic coasts during the colder climatic period of the Iron Age (3100–1950 cal yr B.P.). The accumulations then aggraded at various and discontinuous rates, sometimes reaching up to 2.1 m/kyr. Maerl beds temporarily disappeared in the southern part of the Bay of Brest when sedimentation rates increased throughout the bay during the Dark-Age cold period (1375–1250 cal yr B.P.), suggesting that maerl formations could not keep up with sedimentation rate exceeded a certain threshold. Muddy sedimentation conditions also dramatically changed on two occasions, with the establishment of coarse storm levels, set at the intervals 825–600 cal yr B.P. (MWP) and 113–0 cal yr B.P. But maerl deposits reseed the environment as a result of each new cold period, demonstrating the persistence of such coralline algae against drastic palaeoenvironmental changes in coastal areas.
•Stratigraphy of late-Holocene estuarine sediments reveals interbedded maerl beds.•First maerl occurrence in the Bay of Brest is dated around 2000 cal yr BP.•Development of maerl beds coincides with the onset of colder and drier climates.•Maerl building phases are disrupted by periods of climate deterioration.•Coarse sedimentary deposits are associated with increased paleostorm activity.
Nitrogen stable isotope ratios (δ15N) of organic material have successfully been used to track food-web dynamics, nitrogen baselines, pollution, and nitrogen cycling. Extending the δ15N record back ...in time has not been straightforward due to a lack of suitable substrates in which δ15N records are faithfully preserved, thus sparking interest in utilizing skeletal carbonate-bound organic matter (CBOM) in mollusks, corals, and foraminifera. Here we test if calcite Pecten maximus shells from the Bay of Brest and the French continental shelf can be used as an archive of δ15N values over a large environmental gradient and at a high temporal resolution (approximately weekly). Bulk CBOM δ15N values from the growing tip of shells collected over a large nitrogen isotope gradient were strongly correlated with adductor muscle tissue δ15N values (R2=0.99, n=6, p<0.0001). We were able to achieve weekly resolution (on average) over the growing season from sclerochronological profiles of three shells, which showed large seasonal variations up to 3.4‰. However, there were also large inter-specimen differences (up to 2.5‰) between shells growing at the same time and location. Generally, high-resolution shell δ15N values follow soft-tissue δ15N values, but soft-tissues integrate more time, hence soft-tissue data are more time-averaged and smoothed. Museum-archived shells from the 1950s, 1965, and 1970s do not show a large difference in δ15N values through time despite expected increasing N loading to the Bay over this time, which could be due to anthropogenic N sources with contrasting values. Compiling shell CBOM δ15N data from several studies suggests that the offset between soft-tissue and shell δ15N values (Δtissue-shell) differs between calcite and aragonite shells. We hypothesize that this difference is caused by differences in amino acids used in constructing the different minerals, which should be specific to the CaCO3 polymorph being constructed. Future work should use compound specific isotope analyses (CSIA) to test this hypothesis, and to determine whether certain amino acids could specifically track N sources or possibly identify amino acids that are more resistant to diagenesis in fossil shells. In conclusion, bivalve shell CBOM δ15N values can be used in a similar manner to soft-tissue δ15N values, and can track various biogeochemical events at a very high-resolution.
ResumenEnrique Carlos Romero Brest fue desde la década de 1930 hasta 1980 un actor clave en la Educación Física. Él cumplió diversos roles en el Estado argentino, pero un lugar en el que se destacó ...fue en la construcción de lazos y redes transnacionales que organizó y en algunos de los casos dirigió. Desde estos espacios se pusieron en circulación varias propuestas disciplinares y se demandó a los gobiernos de la región por el estado de la disciplina. Además, escribió artículos en revistas nacionales e internacionales y dictó conferencias en diversos países. Es por ello, que este trabajo busca analizar las redes que fue construyendo y los diferentes enfoques conceptuales que promovióen sus escritos. AbstractEnrique Carlos Romero Brest was from the 1930s to the 1980s a key actor in Physical Education. He fulfilled various roles in the Argentine State, but one place where he stood out was in the construction of transnational ties and networks that he organized and in some cases led. From these spaces,several disciplinary proposals were put into circulation and the governments of the region were sued for the state of discipline. In addition, he wrote articles in national and international journals and gave conferences in various countries. That is why this work seeks to analyze the networks he was building and the different conceptual approaches he promoted in his writings.
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