Background This study focuses on determining the prognostic and predictive value of the comprehensive prognostic nutrition index (FIDA) in individuals undergoing treatment for Non-Small-Cell Lung ...Carcinoma (NSCLC). Methods This retrospective analysis encompassed 474 of NSCLC patients treated from January 2010 through December 2019. Employing the Lasso-COX regression approach, eight blood parameters were identified as significant prognostic indicators. These parameters contributed to the formulation of the comprehensive prognostic nutrition index FIDA. Utilizing X-tile software, the patient cohort was categorized into either a high or low FIDA group based on an established optimal threshold. The cohort was then randomly segmented into a training set and a validation set using SPSS software. Subsequent steps involved conducting univariate and multivariate regression analyze to develop a prognostic nomogram. The effectiveness of this nomogram was evaluated by calculating the AUC. Results Analysis of survival curves for both the training and validation sets revealed a poorer prognosis in the high FIDA group compared to the low FIDA group. This trend persisted across various subgroups, including gender, age, and smoking history, with a statistical significance (p<0.05). Time-dependent ROC and diagnostic ROC analyses affirmed that FIDA serves as an effective diagnostic and prognostic marker in NSCLC. Moreover, Cox regression multivariate analysis established FIDA as an independent prognostic factor for NSCLC. The prognostic nomogram, integrating FIDA and clinical data, demonstrated substantial prognostic utility and outperformed the traditional TNM staging systemin predicting overall survival (OS). Conclusion FIDA emerges as a dependable predictor of outcomes for patients with NSCLC. It offers a practical, cost-effective tool for prognostication in regular clinical applications.
A comparison between fast ion measurements and sawtooth models in the Mega Amp Spherical Tokamak (MAST) is extended to include fast ion deuterium-alpha (FIDA) data. It is concluded that FIDA data ...cannot be used to distinguish between three alternative models used in the plasma transport/fast particle code TRANSP/NUBEAM to simulate fast ion redistribution during sawteeth. For FIDA lines-of-sight that probe the sawtoothing region, at each sawtooth crash there is an overall drop in the emission of up to 60%. Data from passive FIDA lines-of-sight (i.e. with emission resulting from neutralisation by thermal neutrals in the plasma periphery rather than beam neutrals) show a sudden increase in the emission following sawtooth crashes. The subsequent decay in the emission in these passive channels indicates that redistributed passing fast ions are rapidly lost from the edge region, probably as a result of charge-exchange reactions with edge neutrals.
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