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  • 11β-hydroxysteroid dehydrog... 11β-hydroxysteroid dehydrogenases: A growing multi-tasking family
    Gomez-Sanchez, Elise P.; Gomez-Sanchez, Celso E. Molecular and cellular endocrinology, 04/2021, Letnik: 526
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    This review briefly addresses the history of the discovery and elucidation of the three cloned 11β-hydroxysteroid dehydrogenase (11βHSD) enzymes in the human, 11βHSD1, 11βHSD2 and 11βHSD3, an ...
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  • Structural and Functional B... Structural and Functional Biology of Aldo-Keto Reductase Steroid-Transforming Enzymes
    Penning, Trevor M; Wangtrakuldee, Phumvadee; Auchus, Richard J Endocrine reviews, 2019-April, Letnik: 40, Številka: 2
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    Abstract Aldo-keto reductases (AKRs) are monomeric NAD(P)(H)-dependent oxidoreductases that play pivotal roles in the biosynthesis and metabolism of steroids in humans. AKR1C enzymes acting as ...
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3.
  • Targeted Synthesis and Char... Targeted Synthesis and Characterization of a Gene Cluster Encoding NAD(P)H-Dependent 3α-, 3β-, and 12α-Hydroxysteroid Dehydrogenases from Eggerthella CAG:298, a Gut Metagenomic Sequence
    Mythen, Sean M; Devendran, Saravanan; Méndez-García, Celia ... Applied and environmental microbiology, 04/2018, Letnik: 84, Številka: 7
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    Gut metagenomic sequences provide a rich source of microbial genes, the majority of which are annotated by homology or unknown. Genes and gene pathways that encode enzymes catalyzing ...
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4.
  • Structure-based rational de... Structure-based rational design of hydroxysteroid dehydrogenases for improving and diversifying steroid synthesis
    Liu, Zhiyong; Zhang, Rongzhen; Zhang, Wenchi ... Critical reviews in biotechnology, 07/2023, Letnik: 43, Številka: 5
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    A group of steroidogenic enzymes, hydroxysteroid dehydrogenases are involved in steroid metabolism which is very important in the cell: signaling, growth, reproduction, and energy homeostasis. The ...
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5.
  • Engineering 7β-Hydroxystero... Engineering 7β-Hydroxysteroid Dehydrogenase for Enhanced Ursodeoxycholic Acid Production by Multiobjective Directed Evolution
    Zheng, Ming-Min; Chen, Ke-Cai; Wang, Ru-Feng ... Journal of agricultural and food chemistry, 02/2017, Letnik: 65, Številka: 6
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    Ursodeoxycholic acid (UDCA) is the main active ingredient of natural bear bile powder with multiple pharmacological functions. 7β-Hydroxysteroid dehydrogenase (HSDH) is a key biocatalyst for the ...
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6.
  • Discovery of tauroursodeoxy... Discovery of tauroursodeoxycholic acid biotransformation enzymes from the gut microbiome of black bears using metagenomics
    Song, Can; Wang, Bochu; Tan, Jun ... Scientific reports, 04/2017, Letnik: 7, Številka: 1
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    Tauroursodeoxycholic acid (TUDCA) has been used to treat many diseases effectively. 7α-hydroxysteroid dehydrogenase (7α-HSDH) and 7β-hydroxysteroid dehydrogenase (7β-HSDH) are two key enzymes that ...
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7.
  • Structural and functional c... Structural and functional characterization of a novel acidophilic 7α‐hydroxysteroid dehydrogenase
    Tang, Shijin; Pan, Yinping; Lou, Deshuai ... Protein science, 20/May , Letnik: 28, Številka: 5
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    7α‐Hydroxysteroid dehydrogenase (7α‐HSDH) is an NAD(P)H‐dependent oxidoreductase belonging to the short‐chain dehydrogenases/reductases. In vitro, 7α‐HSDH is involved in the efficient ...
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8.
  • 11β-hydroxysteroid dehydrog... 11β-hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid action
    Chapman, Karen; Holmes, Megan; Seckl, Jonathan Physiological reviews 93, Številka: 3
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    Glucocorticoid action on target tissues is determined by the density of "nuclear" receptors and intracellular metabolism by the two isozymes of 11β-hydroxysteroid dehydrogenase (11β-HSD) which ...
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9.
  • Perilipins: a diversity of ... Perilipins: a diversity of intracellular lipid droplet proteins
    Itabe, Hiroyuki; Yamaguchi, Tomohiro; Nimura, Satomi ... Lipids in health and disease, 04/2017, Letnik: 16, Številka: 1
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    Intracellular lipid droplets (LDs) are found in a wide variety of cell types and have been recognized as organelles with unique spherical structures. Although LDs are not stable lipid-depots, they ...
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10.
  • Structural and biochemical ... Structural and biochemical characterization of 20β-hydroxysteroid dehydrogenase from Bifidobacterium adolescentis strain L2-32
    Doden, Heidi L.; Pollet, Rebecca M.; Mythen, Sean M. ... The Journal of biological chemistry, 08/2019, Letnik: 294, Številka: 32
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    Anaerobic bacteria inhabiting the human gastrointestinal tract have evolved various enzymes that modify host-derived steroids. The bacterial steroid-17,20-desmolase pathway cleaves the cortisol side ...
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