iRefWeb is a resource that provides web interface to a large collection of protein-protein interactions aggregated from major primary databases. The underlying data-consolidation process, called ...iRefIndex, implements a rigorous methodology of identifying redundant protein sequences and integrating disparate data records that reference the same peptide sequences, despite many potential differences in data identifiers across various source databases. iRefWeb offers a unified user interface to all interaction records and associated information collected by iRefIndex, in addition to a number of data filters and visual features that present the supporting evidence. Users of iRefWeb can explore the consolidated landscape of protein-protein interactions, establish the provenance and reliability of each data record, and compare annotations performed by different data curator teams. The iRefWeb portal is freely available at http://wodaklab.org/iRefWeb .
The term "retroactive avoidance" refers to a special class of effects of future stimulus presentations on past behavioral responses. Specifically, it refers to the anticipatory avoidance of aversive ...stimuli that were unpredictable through random selection after the response. This phenomenon is supposed to challenge the common view of the arrow of time and the direction of causality. Preliminary evidence of "retroactive avoidance" has been published in mainstream psychological journals and started a heated debate about the robustness and the true existence of this effect. A series of seven experiments published in 2014 in the Journal of Consciousness Studies (Maier et al., 2014) tested the influence of randomly drawn future negative picture presentations on avoidance responses based on key presses preceding them. The final study in that series used a sophisticated quantum-based random stimulus selection procedure and implemented the most severe test of retroactive avoidance within this series. Evidence for the effect, though significant, was meager and anecdotal, Bayes factor (BF.sub.10) = 2. The research presented here represents an attempt to exactly replicate the original effect with a high-power (N = 2004) preregistered multi-lab study. The results indicate that the data favored the null effect (i.e., absence of retroactive avoidance) with a BF.sub.01 = 4.38. Given the empirical strengths of the study, namely its preregistration, multi-lab approach, high power, and Bayesian analysis used, this failed replication questions the validity and robustness of the original findings. Not reaching a decisive level of Bayesian evidence and not including skeptical researchers may be considered limitations of this study. Exploratory analyses of the change in evidence for the effect across time, performed on a post-hoc basis, revealed several potentially interesting anomalies in the data that might guide future research in this area.
In illuminated leaves, mitochondria are thought to Introduction play roles in optimizing photosynthesis. However, the roles of the cytochrome pathway (CP) and alternative oxidase (AOX) in ...photosynthesis, in particular in the redox state of the photosynthetic electron transport chain, are not separately characterized. We examined the effect of specific inhibition of two respiratory pathways, CP and AOX, on photosynthetic oxygen evolution and the redox state of the photosynthetic electron transport chain in broad bean (Vicia faba L.) leaves under various light intensities. Under saturating photosynthetic photon flux density (PPFD; 700 micromol photon/square m/s), inhibition of either pathway caused a decrease in the steady-state levels of the photosynthetic O2 evolution rate and the PSII operating efficiency, Phisub(II). Because these inhibitors, at the concentrations applied to the leaves, had little effect on photosynthesis in the intact chloroplasts, two respiratory pathways are essential for maintenance of high photosynthetic rates at saturating PPFD. CP or AOX inhibition affected to Chl fluorescence parameters (e.g. photochemical quenching and non-photochemical quenching) differently, suggesting that CP and AOX contribute to photosynthesis in different ways. At low PPFD (100 micromol photon/square m/s), only the inhibition of AOX, not CP, lowered the photosynthetic rate and Phisub(II). AOX inhibition also decreased the Phisub(II)/Phisub(I) ratio even at low PPFD levels. These data suggest that AOX inhibition caused the over-reduction of the photosynthetic electron transport chain and induced the cyclic, electron flow around PSI (CEF-PSI) even at the low PPFD. Based on these results, we discuss possible roles for CP and AOX in the light.
Resumen En este artículo se revisan algunos elementos que intervienen en la conformación de la subjetividad de los estudiantes al interior del contexto escolar chileno. El objetivo, en ese sentido, ...es bosquejar algunas hipótesis en torno al impacto del plano normativo en el perfil del estudiante cuando está confrontado a la dimensión del rendimiento escolar. Para este fin se toma como marco de análisis la noción de gubernamentalidad desarrollada por Michel Foucault (2006), que atiende a la puesta en forma de un marco administrativo dirigido a la esfera de la población en complemento con la dimensión individual. De este modo, y teniendo a la base la experiencia chilena, se analizan algunos dispositivos del cotidiano escolar que, al alero de un marco normativo basado en principios de inclusión, no discriminación y al mismo tiempo de modernización en sus mecanismos de gestión, actúan como campo de regulación y administración de aquellas conductas que, por su desajuste frente a las expectativas de rendimiento educativo, se vuelven objetos de patologización, intervención, corrección y medicalización. El lugar de la psicometría y su relación con el individuo como célula de análisis, la pertinencia de los saberes psi, como enclave clínico-terapéutico al interior de la trama escolar son, entre otros, algunos de los resultados preliminares que contribuyen este análisis.
Abstract This article reviews some elements that intervene in the conformation of the subjectivity of students within the Chilean school context. The objective, in this sense, is to outline some hypotheses about the impact of the normative level in the student’s profile when confronted with the dimension of school performance. For this purpose, the notion of governmentality developed by Michel Foucault is taken as a framework for analysis, which attends to the setting up of an administrative framework aimed at the sphere of the population in complement with the individual dimension. Based on the Chilean experience, the paper analyzes some dispositif of the daily school that act as field of regulation and administration of those behaviors that, due to their mismatch with the expectations of educational performance, become objects of pathologization, intervention, correction, and medicalization. This situation is produced under the umbrella of a regulatory framework based on principles of inclusion, non-discrimination and at the same time of modernization in its management mechanisms. Some of the preliminary results that contribute to this analysis are the place of psychometry and its relationship with the individual as a cell of analysis; and the relevance of ‘psy knowledge’, as a “clinical-therapeutic” enclave within the school framework.
Thermal energy storage is a crucial aspect of many industrial and energy-related applications, and Phase Change Materials (PCM) have emerged as a promising solution to the problem of storing heat ...energy in a compact and efficient form. However, the low thermal conductivity of PCM limits its applications, necessitating the development of innovative approaches to enhance their performance. This research article presents a novel approach for improving the thermal conductivity of PCM by incorporating a hybrid nanoparticle made of aluminium oxide (nAl2O3) and Graphene nano Platelets (GnP) together with fins. The selection of nanoparticles is made using Multi-Criteria Decision Making (MCDM) techniques. Moreover, the study compared conventional methods of measuring the thermophysical properties of the PCM, such as Differential Scanning Calorimetry (DSC), with the T-history method. Finally, the performance of the hybrid nano-PCM composite was analysed through numerical analysis of a latent heat storage unit having tapered fins stacked with the hybrid nano-PCM composite. The results indicate that the incorporation of hybrid nanoparticles can significantly alter the thermophysical characteristics of the base PCM. Moreover, the T-history method provides a reliable and cost-effective alternative to conventional methods for measuring the thermo-physical properties of the hybrid nanocomposite. Finally, the numerical analysis of the latent heat storage unit having tapered fins stacked with nano-PCM composite confirms the significant improvement in melting rate and highlights the potential of the hybrid nano-PCM composite for various industrial and energy-related applications.
•Enhancing the effective thermal conductivity of PCM by introducing a hybrid nanomaterial composed of nAl2O3 and GnP.•Experimental characterization of hybrid nano-PCM composite.•Checking the feasibility of the T-history method over DSC.•Numerical evaluation of LHS unit with heat transfer augmentation features such as tapered fins and hybrid nano-PCM composite.
Single-pair differential synthetic aperture radar interferometry (DInSAR) as well as more advanced methods, such as persistent scatterer interferometry (PSI), allow vertical displacements to be ...detected at the sub-centimeter level. Since 2014 free SAR data—Sentinel-1—have been collected systematically under the COPERNICUS program at a high temporal resolution and with global coverage. Such an open-access policy greatly helps build a wide user-community and develop diverse SAR-based applications. In this study conventional single-pair DInSAR and the PSI techniques were employed to monitor the vertical displacements of the newly constructed D8 highway, more specifically the part passing through the České Středohoří Mountains, where, during highway construction, a massive landslide occurred in June 2013. For both DInSAR and PSI, free Sentinel-1 radar data were used; moreover, the conventional single-pair DInSAR workflow was processed using freely available SNAP software. Results from the radar interferometry were validated using in situ techniques, such as geodetic measurements, 3D inclinometers, and laser scanning. Both approaches proved their ability to achieve reliable results in detecting vertical displacement “hotspots”. Additionally, in terms of absolute values, the PSI interferometry corresponds very well with the in situ measurements. This study also shows that open-source solutions (free data and SW) provided under the COPERNICUS program bring a great potential for monitoring vertical displacements.
National rankings of hospitals rely on outcomes-based evaluation to assess the performance of surgical programs, particularly those performing high-risk elective surgical procedures such as open ...aortic repair. Various classification systems exist for tracking outcomes, but increasingly the International Classification of Diseases, Tenth Revision-based Agency for Healthcare Research and Quality Patient Safety Indicators (PSIs) are used as a publicly reported comparison measure of hospital quality performance. We sought to critically evaluate the accuracy of the existing vehicles to assess open aortic repair outcomes in an established program.
This is a case-control study of patients who underwent open abdominal aortic aneurysm repair at the Johns Hopkins Medical Institutions from 2004 to 2018. Patients' characteristics and outcomes were collected as part of a prospectively maintained retrospective database. For each case, hemorrhagic, cardiac, respiratory, renal, wound, and thromboembolic complications were identified with the unique definitions used for open abdominal aortic aneurysm repair by the American College of Surgeons National Surgical Quality Improvement Program (NSQIP) database, the Society for Vascular Surgery Vascular Quality Initiative (VQI) database, and the Agency for Healthcare Research and Quality PSI initiative.
Of the 154 patients included in the study, 79 (51.0%) were identified as having a complication as defined by the VQI, 46 (29.7%) according to the NSQIP, and 15 (9.7%) according to the PSI system (P < .001). Patients most likely to incur a complication in the PSI system were those with a pararenal or more extensive aneurysm, with baseline congestive heart failure, requiring a supramesenteric clamp (all P < .01), or with an aneurysm >6.5 cm in diameter (P = .02). The NSQIP and VQI systems both identified more postoperative hemorrhagic, respiratory, renal, and wound complications than the PSI system did (P < .05). The VQI system identified the most renal complications (52; P < .001); factors unique to incurring a complication in the VQI include use of a suprarenal clamp and performance of an aortorenal bypass procedure as part of the repair (P < .01). Particularly weak correlation was noted between the PSI system and the VQI with respect to renal outcomes (ρ = 0.163).
The PSI system identified fewer important complications than either of the clinically focused databases, with the VQI capturing the most postoperative events, mostly because of its stringent definition of renal injury. We conclude that the PSI system should not form the basis of grading hospital performance in comparing clinically relevant complications of open aortic surgery programs.
Photosynthetic characteristics in rice (Oryza sativa L.) leaves were examined after treatment with low temperature (15 deg C) and high irradiance (1,500 mu mol quanta m(-2) s(-1)). Decreases in ...quantum efficiencies in PSII (phi PSII) and PSI (phi PSI) and in the rate of CO2 assimilation were observed with a decrease in the maximal quantum efficiency of PSII (Fv/Fm) by simultaneous measurements of Chl fluorescence, P700(+) absorbance and gas exchange. The decreases in phi PSII were most highly correlated with those in CO2 assimilation. Although the initial (the activity immediately measured upon extraction) and total (the activity following pre-incubation with CO2 and Mg(2+)) activities of ribulose-1,5-bisphosphate (RuBP) carboxylase/oxygenase (Rubisco) decreased slightly, the maximal activity (the activity following treatment with SO4(2-)) of Rubisco remained almost constant. These results indicate that the decrease in CO2 assimilation rate with the decreasing Fv/Fm was not caused by a decrease in Rubisco activity but rather by a decrease in RuBP regeneration capacity which resulted from the decrease in the rate of the linear electron transport. On the other hand, the decrease in (phi PSI was very small and the ratio of phi PSI to phi PSII increased. The de-epoxidation state of xanthophyll cycle pigments also increased. Thus, the cyclic electron transport around PSI occurred in photoinhibited leaves.
•441 influenza virus infections from a Swiss Hospital were included.•During 4 influenza seasons, 238 infections due to influenza A virus; 203 due to b.•30-day mortality was 6.0% and independently ...associated with A virus.•qSOFA≥2 points showed a very good accuracy (0.89).•Hospital-acquired infection was a predictor of worst outcome.
Influenza infections have been associated with high morbidity. The aims were to determine predictors of mortality among patients with influenza infections and to ascertain the role of quick Sequential Organ Failure Assessment (qSOFA) in predicting poor outcomes.
All adult patients with influenza infection at the Hospital of Jura, Switzerland during four influenza seasons (2014/15 to 2017/18) were included. Cepheid Xpert Xpress Flu/RSV was used during the first three influenza seasons and Cobas Influenza A/B and RSV during the 2017/18 season.
Among 1684 influenza virus tests performed, 441 patients with influenza infections were included (238 for influenza A virus and 203 for B). The majority of infections were community onset (369; 83.7%). Thirty-day mortality was 6.0% (25 patients). Multivariate analysis revealed that infection due to A virus (P 0.035; OR 7.1; 95% CI 1.1–43.8), malnutrition (P < 0.001; OR 25.0; 95% CI 4.5–138.8), hospital-acquired infection (P 0.003; OR 12.2; 95% CI 2.3–65.1), respiratory insufficiency (PaO2/FiO2 < 300) (P < 0.001; OR 125.8; 95% CI 9.6–1648.7) and pulmonary infiltrate on X-ray (P 0.020; OR 6.0; 95% CI 1.3–27.0) were identified as predictors of mortality. qSOFA showed a very good accuracy (0.89) equivalent to other more specific and burdensome scores such as CURB-65 and Pneumonia Severity Index (PSI).
qSOFA performed similarly to specific severity scores (PSI, CURB-65) in predicting mortality. Infection by influenza A virus, respiratory insufficiency and malnutrition were associated with worse prognosis.
Poetic Confluence Wooffitt, Robin
Journal of Anomalous Experience and Cognition,
07/2022, Letnik:
2, Številka:
1
Journal Article
Recenzirano
Odprti dostop
This paper is an exploratory sociological analysis of poetic confluence, a spontaneous telepathic phenomenon that occurs in everyday social interaction. In poetic confluence, one person’s talk ...exhibits an enigmatic relationship to another’s unstated thoughts or imagery at that moment. The analyses draw from an empirical approach called Conversation Analysis, a formal qualitative method for the analysis of naturally occurring interaction in everyday life. In Conversation Analysis, talk-in-interaction is analyzed as coordinated and sequentially organized action. The focus on the action orientation of talk informs this analysis, treating poetic confluence as a form of social action. The data are (unavoidably) anecdotal accounts of experiences. Although the techniques of Conversation Analysis cannot be applied to anecdotal reports, its methodological principles and substantive focus can inform a systematic analysis of anecdotal data. A case is made for the robustness of poetic confluence via analysis of recurrent properties found in examples from three corpora of candidate cases. The analysis identifies three interpersonal functions of poetic confluence: its role in restoring mutual attention; its affiliative, affective function; and its role as a mechanism for managing threats to social propriety, or keeping “face.” In the discussion, alternative skeptical explanations are assessed; the empirical approach is framed in terms of Cardeña’s (2019) observations on the metaphoric quality of some psi phenomena and Carpenter’s (2012) first sight theory, and some suggestions are offered for further research on social interaction and psi phenomena.
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