Business angel early stage decision making Maxwell, Andrew L.; Jeffrey, Scott A.; Lévesque, Moren
Journal of business venturing,
03/2011, Letnik:
26, Številka:
2
Journal Article
Recenzirano
Using 150 interactions between entrepreneurs and potential investors, we study early stage business angel decision making. We show that contrary to the majority of past research that suggests they ...should, angel investors do not use a fully compensatory decision model wherein they weight and score a large number of attributes. Rather, they use a shortcut decision making heuristic known as elimination-by-aspects to reduce the available investment opportunities to a more manageable size. If an opportunity is diagnosed with a fatal flaw, it is rejected in the first stage of the decision making process, but all opportunities with no fatal flaws do progress beyond that stage.
The past decade has witnessed an increasing interaction between experiment and theory in the field of molecular spectroscopy. On the computational side, ongoing developments of hardware and software ...have moved computational spectroscopy from a highly specialized research area to a general tool for researchers in different fields of chemical science. However, since its dawn, computational spectroscopy has been characterized by the dichotomies of qualitative and quantitative description, and of interpretation and accuracy. Indeed, the analysis of experiments is seldom straightforward because of the subtle interplay of several different effects, which are not easy to evaluate and isolate, and/or the complexity of the system under consideration. Often, the accuracy has to be set aside for a more qualitative analysis that will provide the means for a broad interpretation. In such a scenario, the most recent advances in theoretical treatments as well as computational tools have opened the way to the reconciliation of accuracy and interpretability, resulting in unequivocal analyses and assignments of experimental spectra and their unbiased interpretation. This Review aims at being a comprehensive, authoritative, critical, and readable account of general interest to the chemistry community because of the wealth of qualitative and quantitative information that can be obtained from spectroscopic investigations. Limiting ourselves to rotational and vibrational spectroscopy, emphasis will be put on accuracy and interpretability as well as on the routes toward their reconciliation and integration.
High-Resolution Native Mass Spectrometry Tamara, Sem; den Boer, Maurits A; Heck, Albert J. R
Chemical reviews,
04/2022, Letnik:
122, Številka:
8
Journal Article
Recenzirano
Odprti dostop
Native mass spectrometry (MS) involves the analysis and characterization of macromolecules, predominantly intact proteins and protein complexes, whereby as much as possible the native structural ...features of the analytes are retained. As such, native MS enables the study of secondary, tertiary, and even quaternary structure of proteins and other biomolecules. Native MS represents a relatively recent addition to the analytical toolbox of mass spectrometry and has over the past decade experienced immense growth, especially in enhancing sensitivity and resolving power but also in ease of use. With the advent of dedicated mass analyzers, sample preparation and separation approaches, targeted fragmentation techniques, and software solutions, the number of practitioners and novel applications has risen in both academia and industry. This review focuses on recent developments, particularly in high-resolution native MS, describing applications in the structural analysis of protein assemblies, proteoform profiling ofamong othersbiopharmaceuticals and plasma proteins, and quantitative and qualitative analysis of protein–ligand interactions, with the latter covering lipid, drug, and carbohydrate molecules, to name a few.
The construction of lower class vertical housing is a solution provided by Jakarta government to solve the problem of slums and densely populated settlements. Residents were relocated to the ...apartment unit that was built with the aim of providing a comfortable residence, but many residents who complained about the flats could not accommodate their activities. In residential design, the activities and needs of residents must be accommodated in the dwelling so that it can function optimally. This research is aimed at finding spatial arrangements that are suitable for the needs of residents in simple rental apartments. This research was conducted in 'Rusunawa' Tambora, which was completed in 2015, by examining one unit of each tower within three towers. Research uses qualitative methods with data collection through observation, and is written descriptively to describe more detailed results. The results showed that the spatial system and existing layout were still not suitable, especially in terms of space hierarchy, and in terms of space facilities, so it needed adjustments to make spatial arrangements that could facilitate the needs of residents.
The flat bands that appear in some twisted van der Waals heterostructures provide a setting in which strong interactions between electrons lead to a variety of correlated phases1–20. In particular, ...heterostructures of twisted double bilayer graphene host correlated insulating states that can be tuned by both the twist angle and an external electric field11–14. Here, we report electrical transport measurements of twisted double bilayer graphene with which we examine the fundamental role of spontaneous symmetry breaking in its phase diagram. The metallic states near each of the correlated insulators exhibit abrupt drops in their resistivity as the temperature is lowered, along with associated nonlinear current–voltage characteristics. Despite qualitative similarities to superconductivity, the simultaneous reversals in the sign of the Hall coefficient point instead to spontaneous symmetry breaking as the origin of the abrupt resistivity drops, whereas Joule heating seems to underlie the nonlinear transport. Our results suggest that similar mechanisms are probably relevant across a broader class of semiconducting flat band van der Waals heterostructures.Transport measurements show that spontaneous symmetry breaking plays a crucial role in the correlated insulating and metallic states in twisted double bilayer graphene.
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