There is substantial evidence supporting the role of certain oral bacteria species in the onset and progression of periodontitis. Nevertheless, results of independent-culture diagnostic methods ...introduced about a decade ago have pointed to the existence of new periodontal pathogens. However, the data of these studies have not been evaluated together, which may generate some misunderstanding on the actual role of these microorganisms in the etiology of periodontitis. The aim of this systematic review was to determine the current weight of evidence for newly identified periodontal pathogens based on the results of “association” studies. This review was conducted and reported in accordance with the PRISMA statement. The MEDLINE, EMBASE, and Cochrane databases were searched up to September 2013 for studies (1) comparing microbial data of subgingival plaque samples collected from subjects with periodontitis and periodontal health and (2) evaluating at least 1 microorganism other than the already-known periodontal pathogens. From 1,450 papers identified, 41 studies were eligible. The data were extracted and registered in predefined piloted forms. The results suggested that there is moderate evidence in the literature to support the association of 17 species or phylotypes from the phyla Bacteroidetes, Candidatus Saccharibacteria, Firmicutes, Proteobacteria, Spirochaetes, and Synergistetes. The phylum Candidatus Saccharibacteria and the Archaea domain also seem to have an association with disease. These data point out the importance of previously unidentified species in the etiology of periodontitis and might guide future investigations on the actual role of these suspected new pathogens in the onset and progression of this infection.
JEL Classification System
Journal of economic literature,
03/2019, Letnik:
57, Številka:
1
Journal Article
Recenzirano
The categories listed below are used to classify books, book reviews, journal articles, and dissertations indexed in JEL, JEL on CD, and EconLit. New changes to the classification system appear as ...soon as possible on www.econlit.org . The JEL classification system may be used freely for scholarly purposes. We suggest the following format: “JEL: A10, B10, etc.”
Study Objective: To determine the prognostic significance of a new score (CO-RABS), formulated by our Institute to classify the covid patients into mild, moderate, severe cases and also to compare it ...with the conversion AIIMS based classification. Patients and Methods: This is a retrospective study in which we have collected data from the medical records of patients who were admitted in our Hospital with covid infection during 2nd and 3rd waves of the pandemic. We have taken Comorbidities (CO), Respiratory rate (R), Age (A), Blood pressure (B) and SpO2 (S) of the patients at the time of admission to calculate an overall score (Abbreviated as CO-RABS). Basing on this score, the patients were classified into mild, moderate and severe cases. We then compared our CO-RABS score based classification with AIIMS classification using a statistical software. Results: We studied 727 patients (440 men, 287 women) and 99 patients died due to covid related complications. The ability to predict the prognosis was higher for our newly formulated CO-RABS score when compared to AIIMS classification. (AUC of CO-RABS 0.88 vs 0.82 of AIIMS; p < 0.05). Conclusion: The ability of CO-RABS score to predict the prognosis of covid infection is higher than that of AIIMS/ICMR classification. Hence it can be used as a supportive tool in the covid management protocol along with all the other conversion modes of treatment.
Aim
The microbial differences between peri‐implantitis and periodontitis in the same subjects were examined using 16S rRNA gene clone library analysis and real‐time polymerase chain reaction.
...Materials and methods
Subgingival plaque samples were taken from the deepest pockets of peri‐implantitis and periodontitis sites in six subjects. The prevalence of bacteria was analysed using a 16S rRNA gene clone library and real‐time polymerase chain reaction.
Results
A total of 333 different taxa were identified from 799 sequenced clones; 231 (69%) were uncultivated phylotypes, of which 75 were novel. The numbers of bacterial taxa identified at the sites of peri‐implantitis and periodontitis were 192 and 148 respectively. The microbial composition of peri‐implantitis was more diverse when compared with that of periodontitis. Fusobacterium spp. and Streptococcus spp. were predominant in both peri‐implantitis and periodontitis, while bacteria such as Parvimonas micra were only detected in peri‐implantitis. The prevalence of periodontopathic bacteria was not high, while quantitative evaluation revealed that, in most cases, prevalence was higher at peri‐implantitis sites than at periodontitis sites.
Conclusions
The biofilm in peri‐implantitis showed a more complex microbial composition when compared with periodontitis. Common periodontopathic bacteria showed low prevalence, and several bacteria were identified as candidate pathogens in peri‐implantitis.
JEL Classification System
Journal of economic literature,
12/2018, Letnik:
56, Številka:
4
Journal Article
Recenzirano
The categories listed below are used to classify books, book reviews, journal articles, and dissertations indexed in JEL, JEL on CD, EconLit. New changes to the classification system appear as soon ...as possible on www.econlit.org . The JEL classification system may be used freely for scholarly purposes. We suggest the following format: “JEL: A10, B10, etc.”
Category:
Other
Introduction/Purpose:
Historical concept of flatfoot as posterior tibial tendon dysfunction (PTTD) has been questioned. Recently, the consensus group published a new classification ...system and recommended renaming PTTD to Progressive Collapsing Foot Deformity (PCFD). The new PCFD classification could be effective in providing comprehensive information on the deformity. To date, there has been no study reporting intra- and interobserver reliability and the frequency of each class in PCFD classification.
Methods:
This was a single-center, retrospective study conducted from prospectively collected registry data. A consecutive cohort of PCFD patients evaluated from February 2015 to October 2020 was included, consisting of 92 feet in 84 patients. Classification of each patient was made utilizing characteristic clinical and radiographic findings by three independent observers. Frequencies of each class and subclass were assessed. Intraobserver and interobserver reliabilities were analyzed with Cohen's Kappa and Fleiss' kappa, respectively.
Results:
Mean sample age was 54.4, 38% was male and 62% were female. 1ABC (25.4%) was most common subclass followed by 1AC (8.7%) and 1ABCD (6.9%). Only small percentage of patients had isolated deformity. Class A was the most frequent component (89.5%), followed by C in 86.2% of the cases. Moderate interobserver reliability (Fleiss` Kappa=0.561, p<0.001, 95% CI 0.528-0.594) was found for overall classification. Very good intraobserver reliability was found (Cohen`s Kappa=0.851, P<0.001, 95% CI 0.777-0.926).
Conclusion:
Predominantly, 49.3% of patients had a presentation dominantly involving the hindfoot (A) with various combinations of midfoot and/or forefoot deformity (B), (C) with or without subtalar joint involvement (D). Despite limitations due to inherent subjectivity which may account for moderate interobserver agreement, the new system may potentially cover all possible combinations of the PCFD, providing a comprehensive description and guiding treatment in a systematic and individualized manner.
Background/AimsTo validate the prognostic performance of the American Joint Committee on Cancer (AJCC) eighth edition classification for ocular adnexal lymphoma (OAL).MethodsWe performed a ...retrospective review of 140 consecutive patients treated for primary OAL between March 2010 and September 2017. Associations between T/N/M categories at presentation and disease-related outcomes, including relapse, progression-free survival (PFS) and overall survival (OS) were evaluated.ResultsSeventy-nine women and 61 men (median age, 52 (range 20–84) years; median follow-up, 57 (range 7–131) months) were included. Histological subtypes included mucosa-associated lymphoid tissue lymphoma (92.1%, n=129), diffuse large B-cell lymphoma (5.0%, n=7), follicular lymphoma (1.4%, n=2) and mantle cell lymphoma (1.4%, n=2). Patients with ≥T2 disease had significantly higher risks of overall relapse (unadjusted HR)=4.32, p=0.016), decreased PFS (uHR=5.19, p=0.004) and decreased OS (uHR=9.21, p=0.047). Patients with ≥N1 disease had significantly higher risks of overall relapse (uHR=9.17, p<0.001) and decreased PFS (uHR=9.24, p<0.001). M1 disease was significantly associated with higher risks of overall relapse (uHR=3.62, p=0.036), decreased PFS (uHR=5.13, p=0.001) and decreased OS (uHR=9.24, p=0.013). On considering TNM categories as continuous data, the uHRs for per level increase in T, N and M categories were 1.77, 1.83 and 2.30 for overall relapse and 1.72, 1.87 and 2.78 for decreased PFS, respectively (p<0.05 for each comparison).ConclusionThe T, N and M categories of the AJCC eighth edition classification have prognostic value for relapse and survival among patients with primary OAL. Particularly, nodal/metastatic involvement at presentation indicated less favourable outcome.
Purpose To develop a classification and grading system for myopic maculopathy. Design Development and evaluation of a classification system for myopic maculopathy based on observational case series. ...Methods A comprehensive set of myopic macular lesions was defined via literature review and through consensus meetings among retinal specialists and clinician scientists. A classification of myopic maculopathy was formulated based on fundus photographs and a modified Delphi process and consensus. Inter- and intraobserver reproducibility, assessed as agreement (%) and weighted kappa values, were evaluated. One hundred retinal photographs with myopia and myopic macular lesions were selected from case series at the High Myopia Clinic of the Tokyo Medical and Dental University, Tokyo, Japan. Results We defined 5 categories of myopic maculopathy including “no myopic retinal degenerative lesion” (Category 0), “tessellated fundus” (Category 1), “diffuse chorioretinal atrophy” (Category 2), “patchy chorioretinal atrophy” (Category 3), and “macular atrophy” (Category 4). Three additional features to supplement these categories were defined as “plus” lesions, namely, lacquer cracks, myopic choroidal neovascularization, and Fuchs spot. Posterior staphyloma was considered as a further, important sign of myopic retinopathy. The intraobserver agreement was ≥85% and the corresponding weighted kappa statistic was ≥0.6 between observations. After a brief training session, interobserver kappa statistics reached the predefined satisfactory level (≥0.4), considered as above moderate agreement. Conclusions We propose a classification system for myopic maculopathy that was found to be reproducible. Applying a uniform classification in different studies will facilitate communication and comparison of findings from clinical trials and epidemiologic studies.
JEL Classification System
Journal of economic literature,
09/2018, Letnik:
56, Številka:
3
Journal Article
Recenzirano
The categories listed below are used to classify books, book reviews, journal articles, and dissertations indexed in JEL, JEL on CD, EconLit. New changes to the classification system appear as soon ...as possible on www.econlit.org . The JEL classification system may be used freely for scholarly purposes. We suggest the following format: “JEL: A10, B10, etc.”
Objectives: The International Classification of Diseases for Perinatal Mortality (ICD-PM) system is a globally used classification based on the International Statistical Classification of Diseases ...and Related Health Problems (ICD-10) codes. Moreover, it focuses on the time of death and maternal conditions. Here, we analyzed perinatal deaths by using the ICD-PM system. Methods: This is a retrospective study, performed between January 1, 2020, and March 30, 2022, in Bursa. Perinatal characteristics and the causes of perinatal deaths were recorded. The perinatal deaths were classified according to the ICD-PM system and descriptives were given. Results: The majority of perinatal death cases (119 cases) occurred in the antepartum period. The leading cause of antepartum deaths was unspecified causes (62.2%) followed by fetal growth disorders (9.3%). A total of 63 (53.7%) mothers were healthy (M5) while 27 (22.7%) mothers had medical or surgical conditions (M4). Acute intrapartum events (33.4%) were the commonest cause of intrapartum deaths followed by unspecified causes (26.6%). When neonatal deaths were analyzed, low birth weight/prematurity constitute 59.6% of neonatal deaths. The largest proportion of mothers was healthy in the intrapartum (40%) while maternal complications of pregnancy (M2) was the most commonest classification for neonatal deaths. Conclusions: ICD-PM is a globally used system for classifying perinatal deaths. The time of perinatal death used in this system provides focus on interventions in perinatal care and it encourages comparison between perinatal care centers. We suggest that we might use resources truly to prevent perinatal deaths in our country by using this system.
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