This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:
To evaluate the effects of chloroquine (CQ) and hydroxychloroquine (HCQ) as:
an antiviral treatment on death ...and time to clearance of the virus from clinical samples and recovery in people with COVID‐19;
a prophylactic treatment on prevention of COVID‐19 in people at risk of SARS‐CoV‐2 exposure;
a prophylactic treatment on prevention of COVID‐19 in people who have been exposed to SARS‐CoV‐2.
A 63 year old female patient presented with one week history of reduced appetite, weakness, nausea, polyuria and occasional vomiting on a back ground of recurrent urinary tract infection and ...hypothyroidism. She appeared lethargic and dehydrated. The arterial blood gas showed a picture of diabetic ketoacidosis (DKA) which was treated according to the protocol. Viral polymerase chain reaction (PCR) for COVID-19 was positive. The diagnosis of new onset type one diabetes made on the basis of specific antibodies test. Computerized Tomography (CT) of abdomen excluded pancreatic cancer as a cause of new onset diabetes. Hence, the patient was labelled as type one diabetes mellitus induced by COVID-19 virus. She was treated accordingly and sent home on insulin. Follow-up appointment was arranged in the diabetes center of the hospital.
Background
The long‐term sequalae of COVID‐19 remain poorly characterized. We assessed persistent symptoms in previously hospitalized patients with COVID‐19 and assessed potential risk factors.
...Methods
Data were collected from patients discharged from 4 hospitals in Moscow, Russia between 8 April and 10 July 2020. Participants were interviewed via telephone using an ISARIC Long‐term Follow‐up Study questionnaire.
Results
2,649 of 4755 (56%) discharged patients were successfully evaluated, at median 218 (IQR 200, 236) days post‐discharge. COVID‐19 diagnosis was clinical in 1291 and molecular in 1358. Most cases were mild, but 902 (34%) required supplemental oxygen and 68 (2.6%) needed ventilatory support. Median age was 56 years (IQR 46, 66) and 1,353 (51.1%) were women. Persistent symptoms were reported by 1247 (47.1%) participants, with fatigue (21.2%), shortness of breath (14.5%) and forgetfulness (9.1%) the most common symptoms and chronic fatigue (25%) and respiratory (17.2%) the most common symptom categories. Female sex was associated with any persistent symptom category OR 1.83 (95% CI 1.55 to 2.17) with association being strongest for dermatological (3.26, 2.36 to 4.57) symptoms. Asthma and chronic pulmonary disease were not associated with persistent symptoms overall, but asthma was associated with neurological (1.95, 1.25 to 2.98) and mood and behavioural changes (2.02, 1.24 to 3.18), and chronic pulmonary disease was associated with chronic fatigue (1.68, 1.21 to 2.32).
Conclusions
Almost half of adults admitted to hospital due to COVID‐19 reported persistent symptoms 6 to 8 months after discharge. Fatigue and respiratory symptoms were most common, and female sex was associated with persistent symptoms.
Word cloud showing persistent symptoms 6–8 months since hospital discharge in people previously hospitalised with COVID‐19.
Objective: Analyze the impact of confinement due to the global and health crisis of COVID-19 on an applicant for international protection with low vision Methods: For data collection, the role list, ...MOHOST registration and a semi-structured interview adapted to know the impact of occupations during confinement have been used. Conclusion: The results obtained indicate that the user has maintained optimal occupational performance although many of the occupations have been affected by the confinement caused by COVID-19. However, the user has carried out a routine regarding personal self-care, health maintenance, and leisure activities such as reading and academics such as language study. It is necessary to highlight the role of Occupational Therapy in this group, since it allows understanding the occupational needs of the person and the environment, promoting participation in occupations in a balanced way and according to the reality of the moment.
Objetivos: Analizar el impacto del confinamiento debido a la crisis sanitaria y mundial del COVID-19 en una persona solicitante de protección internacional con baja visión. Métodos: para la recogida de datos se utilizó el listado de roles, el registro de MOHOST y una entrevista semiestructurada adaptada para conocer el impacto de las ocupaciones durante el confinamiento. Conclusión: los resultados obtenidos indicaron que el usuario mantuvo un desempeño ocupacional óptimo aunque muchas de las ocupaciones se vieron afectadas por el confinamiento causado por el COVID-19. Aun así, el usuario llevó a cabo una rutina en lo referente al autocuidado personal, mantenimiento de la salud, actividades de ocio como la lectura y de tipo académico como el estudio de idiomas. Es necesario destacar el rol de la Terapia Ocupacional en este colectivo, ya que permite entender las necesidades ocupacionales de la persona y el entorno, promoviendo la participación en ocupaciones de manera equilibrada y acorde a la realidad del momento.
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