To review the analytical methods for carious and erosive demineralization an initial search of peer-reviewed scientific literature from the digital library database of PubMed/Medline indexed journals ...published up to early 2022 was carried out based on keywords relevant to the topic criteria including bibliographic citations from the papers to gather the most updated information. This current review aims to provide an updated overview of the advantages, limitations, and potential applications of direct and indirect research methods available for studying various dynamic stages of carious and erosive demineralization in enamel and dentin. This paper categorizes and describes the most suitable, frequently adopted and widely used quantitative and qualitative techniques in in vitro/in vivo research which are well-established, emerging, or comparatively novel techniques that are being explored for their potential validation.
To date, there is a very limited literature on the use of systems ideas and methodologies as a basis for developing curriculum or courses. To fill the gap, this study has made several contributions ...by employing systems theory and thinking in analysing issues related to higher education. Industry 4.0 is reshaping the future of education, which opens up our vision and makes us to consider what knowledge and skills students should possess after they have graduated from college, when to accelerate workforce reskilling and what is the building blocks and connections of education supply chain. In this study, it is the first time the concept of ‘education supply chain’ is proposed and coined. Furthermore, our research has led us to view educational systems and configurations, such as international mobility and transnationalization, as outcomes of enduring power related to industrial revolutions. Finally, a curriculum structure based on system thinking is proposed. We engage our inquiry with transformations that are happening around higher education and position our research on the benefits of sharing of global intellectual resource and top talents through transnational mobility and education joint ventures in the context of Industry 4.0.
Computer-aided drug discovery has been around for decades, although the past few years have seen a tectonic shift towards embracing computational technologies in both academia and pharma. This shift ...is largely defined by the flood of data on ligand properties and binding to therapeutic targets and their 3D structures, abundant computing capacities and the advent of on-demand virtual libraries of drug-like small molecules in their billions. Taking full advantage of these resources requires fast computational methods for effective ligand screening. This includes structure-based virtual screening of gigascale chemical spaces, further facilitated by fast iterative screening approaches. Highly synergistic are developments in deep learning predictions of ligand properties and target activities in lieu of receptor structure. Here we review recent advances in ligand discovery technologies, their potential for reshaping the whole process of drug discovery and development, as well as the challenges they encounter. We also discuss how the rapid identification of highly diverse, potent, target-selective and drug-like ligands to protein targets can democratize the drug discovery process, presenting new opportunities for the cost-effective development of safer and more effective small-molecule treatments.
A challenge for cognitive research is the better understanding of how motor activity influences and is influenced by other cognitive domains. We developed a preliminary study to investigate whether ...tracking motor functioning in virtual reality provides useful insight on cognitive functioning. We chose the flankers task as an assessment measure and built a VR environment into which seven participants completed more than 1250 trials. In addition to classical results of the flankers task showing that incongruent stimuli induce slower responses than others., we also identified how individuals are able to correct their initially incorrect motor response. This indicator may shed new light into the functioning of cognitive control in the future. We discuss the potential offered by virtual reality technology for cognitive assessment through embodied considerations of cognition.
Structure-based virtual ligand screening is emerging as a key paradigm for early drug discovery owing to the availability of high-resolution target structures
and ultra-large libraries of virtual ...compounds
. However, to keep pace with the rapid growth of virtual libraries, such as readily available for synthesis (REAL) combinatorial libraries
, new approaches to compound screening are needed
. Here we introduce a modular synthon-based approach-V-SYNTHES-to perform hierarchical structure-based screening of a REAL Space library of more than 11 billion compounds. V-SYNTHES first identifies the best scaffold-synthon combinations as seeds suitable for further growth, and then iteratively elaborates these seeds to select complete molecules with the best docking scores. This hierarchical combinatorial approach enables the rapid detection of the best-scoring compounds in the gigascale chemical space while performing docking of only a small fraction (<0.1%) of the library compounds. Chemical synthesis and experimental testing of novel cannabinoid antagonists predicted by V-SYNTHES demonstrated a 33% hit rate, including 14 submicromolar ligands, substantially improving over a standard virtual screening of the Enamine REAL diversity subset, which required approximately 100 times more computational resources. Synthesis of selected analogues of the best hits further improved potencies and affinities (best inhibitory constant (K
) = 0.9 nM) and CB
/CB
selectivity (50-200-fold). V-SYNTHES was also tested on a kinase target, ROCK1, further supporting its use for lead discovery. The approach is easily scalable for the rapid growth of combinatorial libraries and potentially adaptable to any docking algorithm.
In 2018, the National Library of Budva decided to start building a digital library with the desire to expand the existing offer of online services and to take into account the needs of the modern ...audience, which is increasingly using digital content. Some time after the launch of the Digital Library of Budva, questions naturally arose about the effectiveness of invested resources and further directions of development that require factual answers. Although the contents of the native profile were set, the assumption was that the new presentation channel would attract the audience outside the local geographical framework, which was confirmed by the analysis of one-year use and users of the Digital Library. The experiential observation that its attendance directly correlates with visibility in the media and on social networks was also confirmed. Quantitative statistical methods offered by Google Analytics were used for traffic analysis. The presented analysis of users and patterns of use of the Digital Library of Budva gives a picture only in basic outlines. However, this is the first attempt of a Montenegrin library to process and present one field of its activity in the language and methods of modern webometry and library statistics.
Digital Library of Georgia Mastrovita, Mandy L; Hakes, Deborah
The Georgia library quarterly,
04/2021, Letnik:
58, Številka:
2
Journal Article
Recenzirano
Eight institutions (and nine projects) are recipients of the eighth set of service grants awarded in a program intended to broaden partner participation in the Digital Library of Georgia (DLG). The ...DLG solicited proposals for historic digitization projects in a statewide call, and applicants submitted proposals for projects with a cost of up to $7,500.00. DLG staff will provide free digitization, metadata, and hosting services so that more of Georgia's diverse history can be found online for free. The Georgia Historical Records Advisory Council (GHRAC) presented this subgranting program with the 2018 Award for Excellence in Archival Program Development by a State Institution.
Health care providers are adopting information and communication technologies (ICTs) to enhance their services. Telemedicine is one of the services that rely heavily on ICTs to enable remote patients ...to communicate with health care professionals; in this case, the patient communicates with the health care professional for a follow-up or for a consultation about his or her health condition. This communication process is referred to as an e-consultation. In this paper, telemedicine services refer to health care services that use ICTs, which enable patients to share, transfer, and communicate data or information in real time (ie, synchronous) from their home with a care provider-normally a physician-at a clinical site. However, the use of e-consultation services can be positively or negatively influenced by external or internal factors. External factors refer to the environment surrounding the system as well as the system itself, while internal factors refer to user behavior and motivation.
This review aims to investigate the barriers and the facilitators that influence the use of home consultation systems in the health care context. This review also aims to identify the effectiveness of Home Online Health Consultation (HOHC) systems in improving patients' health as well as their satisfaction with the systems.
We conducted a systematic literature review to search for articles-empirical studies-about online health consultation in four digital libraries: Scopus, Association for Computing Machinery, PubMed, and Web of Science. The database search yielded 2518 articles; after applying the inclusion and exclusion criteria, the number of included articles for the final review was 45. A qualitative content analysis was performed to identify barriers and facilitators to HOHC systems, their effectiveness, and patients' satisfaction with them.
The systematic literature review identified several external and internal facilitators and barriers to HOHC systems that were used in the creation of a HOHC framework. The framework consists of four requirements; the framework also consists of 17 facilitators and eight barriers, which were further categorized as internal and external influencers on HOHC.
Patients from different age groups and with different health conditions benefited from remote health services. HOHC via video conferencing was effective in delivering online treatment and was well-accepted by patients, as it simulated in-person, face-to-face consultation. Acceptance by patients increased as a result of online consultation facilitators that promoted effective and convenient remote treatment. However, some patients preferred face-to-face consultation and showed resistance to online consultation. Resistance to online consultation was influenced by some of the identified barriers. Overall, the framework identified the facilitators and barriers that positively and negatively influenced the uptake of HOHC systems, respectively.
This is an exploratory study to model the determinants of actual use of a digital library system. To do so, a research model was developed using Delone and McLean’s information system success model ...and explained as an empirical study. Data were collected from 978 respondents using a structured questionnaire from four different universities of Malaysia. The findings showed that the quality factors of digital library systems have a strong influence on satisfaction, behavioral intention, and variance in actual use. Information quality is the strongest predictor to measure user satisfaction, and satisfaction has a strong effect on students’ behavioral intention to use the system. In addition, user satisfaction and behavioral intention to use the system also have a strong positive relationship with the actual use of a digital library system. In brief, behavioral intentions are greatly influenced by system quality, information quality and service quality.
PDF
