The aim of this study was to determine the expression of the P53 gene and testicular weight of male mice (Mus musculus) given Bulo forest honey and exposed to cigarette smoke. The experimental ...animals used in this study were 24 male mice which were divided into 4 treatment groups, each group consisting of 6 mice. Mice in group P0 were considered as control group (without treatment), while mice in group 1 (P1) were exposed to 2 cigarettes smoke, while mice in groups 2 (P2) and 3 (P3) were exposed to 2 cigarettes smoke and given Bulo forest honey at a dose of 0.8 ml/day and 0.4 mL/day, respectively. The data obtained were analyzed using one way ANOVA followed by using the Least Significant Difference (LSD) test. The results showed that Bulo forest honey administration did not statistically affect (P0.05) the ratio of testicular weight and P53 gene expression in male mice (Mus musculus) exposed to cigarette smoke for 30 days. It is concluded that the administration of Bulo forest honey at dose of 0.8 mL and 0.4 mL has not been able to increase the testicular weight ratio and reduce the expression of the P53 gene in male mice.
Marketing strategy is needed in developing original products. Sumbawa forest honey is an original product from West Nusa Tenggara, Indonesia. The problems marketing are fluctuating price and the ...availability of other honey product as competitors. The purpose of this research was to identify the top priorities strategy marketing of this honey. The data analysis using A’WOT. It’s combination of SWOT and AHP analysis. SWOT analysis was employed to identify strengths, weaknesses, opportunities, and threats in marketing of Sumbawa forest honey. AHP (Analitycal Hierarchy Process) analysis was performed to determine priority on alternative of marketing strategy of Sumbawa forest honey. The finding of this research showed that SO strategy was the top priority strategies in marketing of Sumbawa forest honey with value 0.580. The top three priorities on alternative of strategies are packaging the Sumbawa forest honey hygienically and attractively (0.343), maintains the quality and purity of Sumbawa forest honey (0.275), and partnering with financial institutions (0,125).
Background: Cleft palate is a craniofacial disorder with definitive therapy using the V–Y pushback technique palatoplasty, which has the impact of leaving the bone exposed on the palate with long ...wound healing and a high risk of infection. Forest honey has high antioxidants and the ability to accelerate wound healing. Purpose: This study aims to determine the effect of forest honey on vascular endothelial growth factor (VEGF) expression to accelerate the wound healing process after palatoplasty biopsy. Methods: Posttest only control group design using Sprague Dawley palatoplasty was performed on 15 rats which were divided into three groups, namely the honey treatment (KP), Aloclair as a positive control (KPP), and aquadest as a negative control (KKN). As much as 25 mg of honey was given therapeutically, and VEGF expression analysis post-biopsy palatoplasty was measured using the ELISA test. ANOVA analysis was carried out to determine the significant differences between each treatment, and in silico analysis was conducted to determine the compounds’ role in honey on the mechanism of VEGF expression. Results: Statistical analysis of VEGF expression in the KP group was 41.10 ng/ml ± 0.26, the KKP was 39.57 ± 0.27, while the KKN was 33.26 ± 0.62 (p≤ 0.01). In silico study, genistein (C15H10O5) targets several signaling pathways such as PI3K-Akt, AMPK, and mTOR, affecting accelerated proliferation and angiogenesis. Conclusion: In wound healing acceleration, forest honey induced VEGF expression through the genistein mechanism of angiogenesis and cell proliferation.
The physicochemical propertis of forest honey (Apis dorsata) become one of the supporting qualities of honey. Good honey can be viewed from the quality of honey which refers to the Indonesian ...National Standard (SNI). Therefore, this research aims to determine the physicochemical properties of forest honey from the village of Bonto Manurung, Maros district, Tompobulu village, Pangkep district and Paranglompoa village, Gowa district in accordance with the SNI. The results showed that the best physicochemical properties of honey were from the village of Bonto Manurung, Gowa district which had a moisture content of 19.19 %b/b, ash content of 0.045 %b/b, viscosity of 14.82 poise , acidity is 42.43 mL N NaOH/kg, reducing sugar is 69 %b/b and HMF levels are 2.99 mg/kg. As for the analysis of metallic impurities, all samples examined forest honey is not contaminated by metals arsenic (As), cadmium (Cd) and lead (Pb).
This study aims to analyze the cost of production and the financial feasibility of a forest honeybee business in the Kupang Regency. Research respondents are forest bee seekers with a 51-100 trees ...ownership scale. The sampling of respondents was determined by purposive sampling as many as 60 farmers. The data collection method is a survey to collect primary data from respondents and secondary data from related agencies. Financial feasibility analysis uses the criteria of net present value (NPV), benefit-cost ratio (BCR), internal rate of return (IRR), the payback period of credit (PPC), followed by a break event point (BEP). The results showed that the cost of production was Rp. 44,827/kg with an NPV value of Rp 20,905,525 (NPV > 0), an IRR of 74% (IRR > 24%), a Net B/C ratio of 1.1 (B/C ratio > 1), a BEP of 2,438 kg and Payback period for 10.8 months.
Background: Malnutrition is a crucial issue that contributes to approximately 45% of deaths among children under 5 years old and even >50% of deaths when accompanied by diarrhea. Several studies have ...stated that the use of honey can overcome cases of infertility due to malnutrition.
Methods: An infertile female rat model with a degenerative ovary was induced with malnutrition through a 5-day food fasting but still had drinking water. The administration of (T1) 30% (v/v) and (T2) 50% (v/v) forest honey (
Apis dorsata) were performed for ten consecutive days, whereas the (T+) group was fasted and not administered forest honey and the (T−) group has not fasted and not administered forest honey. Superoxide dismutase, malondialdehyde, IL-13 and TNF-α cytokine expressions, and ovarian tissue regeneration were analyzed.
Results: Antioxidant activity (SOD) was significantly different (
p<0.05) in T1 (65.24±7.53), T2 (74.16±12.3), and T− (65.09±6.56) compared with T+ (41.76±8.51). Oxidative stress (MDA) was significantly different (
p<0.05) in T1 (9.71±1.53), T2 (9.23±0.96), and T− (9.83±1.46) compared with T+ (15.28±1.61). Anti-inflammatory cytokine (IL-13) expression was significantly different (
p<0.05) in T1 (5.30±2.31), T2 (9.80±2.53), and T− (0.30±0.48) compared with T+ (2.70±1.57). Pro-inflammatory cytokine (TNF-α) expression was significantly different (
p<0.05) in T1 (4.40±3.02), T2 (2.50±1.65), and T− (0.30±0.48) compared with T+ (9.50±1.78). Ovarian tissue regeneration was significantly different (
p<0.05) in T− (8.6±0.69) and T2 (5.10±0.99) compared with T1 (0.7±0.95) and T+ (0.3±0.67).
Conclusion: The 10-day administration of 50% (v/v) forest honey can be an effective therapy for ovarian failure that caused malnutrition in the female rat model.
Honey is a sweet, syrup-like substance that bees (Apis sp.) produce from the nectar of flowering plants. The aim of this study was to examine the physicochemical properties and antioxidant activities ...of multifloral honey (Apis dorsata forest honey) and (Apis cerana cultivated honey) from Kerinci, Jambi. The analysis consist of the intensity of colour, pH, viscosity, water content, ash content, sugar content, HMF content, acidity and antioxidant activity. The results showed that forest honey had light amber colour while cultivated honey had extra light amber colour. The pH, viscosity, water content, sugar content, HMF content, and acidity in forest honey were still in compliance with SNI standard, but the ash content was higher than the SNI standard. Cultivated honey had pH, sugar content, and HMF content in the range of SNI standar. However, the viscosity, water content, ash content, and acidity in cultivated honey were not in compliance with SNI standar. Forest honey and cultivated honey had antioxidant capacities about 16,74 mgVCE/g and 16,60 mgVCE/g, respectively. Meanwhile the antioxidant activity were 63,80% and 63,28%, respectively. Forest honey had more physicochemical aspects that were still in compliance with SNI standards compared to cultivated honey. The antioxidant activities of Kerinci honey, both forest honey and cultivated honey, were higher than the results of previous honey studies in other location.
Background: Effective plaque control can be achieved mechanically (by toothbrushing), but there are alternatives such as mouthwashes. However, recently, mouthwashes have been shown to have adverse ...effects on oral health. Honey is an herbal medicine that is easy to find, and it has antibacterial and has no side effects on oral health. Objectives: This study aimed to determine the effect of rinsing with a 10% forest honey mouthwash on the dental plaque score of children aged 9–12 years. Methods: The study was quasi-experimental and used a pre- and posttest, control group design. A total of 52 children (students 9–12 years) were divided into two groups with identical mean plaque scores. The control group rinsed with distilled water and the test group rinsed with a forest honey (10%) solution. The children were instructed to rinse three times daily for 30 s with 10 ml of mouthwash and to continue for 4 days. The data were analyzed using the dependent and independent t-test. Results: The results showed a significant difference in the dental plaque score for the test group (P < 0.001): the pretest average was 2.22 ± 0.59 and the posttest (after 4 days of rinsing) was 1.51 ± 0.57. The dental plaque score for the control group (rinsing with distilled water) showed an insignificant increase (P > 0.05) from the pretest (2.18 ± 0.73) to the posttest (2.22 ± 0.89). Conclusion: Rinsing with a forest honey solution has a positive effect on the reduction of dental plaque in children aged 9–12 years.
Honey samples from the seven most common honey types in Slovenia were screened for total phenolic content by the modified Folin–Ciocalteu method, for potential antioxidant activity using the ferric ...reducing antioxidant power (FRAP) assay and by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method for antiradical activity. In addition the colour characteristics of honey samples were analysed. The results of the study showed that total phenolic content, antioxidant activity and colour parameters differ widely among different honey types. Phenolic content expressed as gallic acid equivalent ranged from 44.8
mg/kg in acacia honey to 241.4
mg/kg in fir honey. Antioxidant activity was the lowest in the brightest acacia and lime honeys and the highest in darker honeys, namely fir, spruce and forest. The colour of the Slovenian honeys, analysed in this study was very variable and ranged from pale yellow to dark brown. Correlations between the parameters analysed were found to be statistically significant (
p
<
0.05).
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