Sirtuiny (SIRT) są deacetylazami histonów zależnymi od NAD
, które odgrywają istotną rolę w funkcjonowaniu organizmu ludzkiego. Przypisuje się im udział w licznych procesach zachodzących w komórkach ...m.in. w potranslacyjnej modyfikacji białek, wyciszaniu transkrypcji genów, indukowaniu procesów naprawczych, a także w regulacji procesów metabolicznych. Wykazano również, że sirtuiny odgrywają istotną rolę w obniżaniu poziomu reaktywnych form tlenu, jak również w stymulacji wzrostu komórek, ich starzeniu się i śmierci. Tak szeroki zakres procesów, na które mają wpływ sirtuiny powoduje, że sirtuiny stały się obiektem wielu badań mających na celu szczegółowe poznanie mechanizmów ich działania i roli jaką odgrywają.
Celem opracowania było zebranie i usystematyzowanie informacji dotyczących sirtuin, głównie z ostatnich 10 lat, zarówno tych dotyczących organizmu ludzkiego, jak i opartych na wynikach badań na modelach zwierzęcych, czy liniach komórkowych. W artykule omówiono budowę, funkcję i rolę biologiczną jaką sirtuiny odgrywają w procesach komórkowych.
Nonlinear Dynamical Systems and Control presents and develops an extensive treatment of stability analysis and control design of nonlinear dynamical systems, with an emphasis on Lyapunov-based ...methods. Dynamical system theory lies at the heart of mathematical sciences and engineering. The application of dynamical systems has crossed interdisciplinary boundaries from chemistry to biochemistry to chemical kinetics, from medicine to biology to population genetics, from economics to sociology to psychology, and from physics to mechanics to engineering. The increasingly complex nature of engineering systems requiring feedback control to obtain a desired system behavior also gives rise to dynamical systems. Wassim Haddad and VijaySekhar Chellaboina provide an exhaustive treatment of nonlinear systems theory and control using the highest standards of exposition and rigor. This graduate-level textbook goes well beyond standard treatments by developing Lyapunov stability theory, partial stability, boundedness, input-to-state stability, input-output stability, finite-time stability, semistability, stability of sets and periodic orbits, and stability theorems via vector Lyapunov functions. A complete and thorough treatment of dissipativity theory, absolute stability theory, stability of feedback systems, optimal control, disturbance rejection control, and robust control for nonlinear dynamical systems is also given. This book is an indispensable resource for applied mathematicians, dynamical systems theorists, control theorists, and engineers.
W artykule rozpatrywane jest pojęcie antyprzysłowia, główne etapy jego rozwoju i analizy jako zjawiska lingwistycznego. Określono problem badania i opracowań leksykograficznych antyprzysłów we ...współczesnym języku białoruskim. Opisano historię rozwoju, skład, podstawowe sfery użycia, grupy tematyczne, odmiany prototypów (tekstów wyjściowych), najbardziej produktywne sposoby derywacji, związek z treścią tekstu wyjściowego, typy strukturalne oraz formy wariacyjne białoruskich antyprzysłów.
The fourth edition of this highly-successful, concise text contains twenty percent new data. Also included now are chapters on (19)F-NMR and (31)P-NMR as well as references to important Raman bands. ...Contains nearly 500 illustrations.
Retoričke vještine važne su za propovjednika jer se riječ Božja prenosi govorom. Od samih početaka kršćanske tradicije i svetoga Augustina ističe se kako elokvencija može pomoći propovjedniku da ...lakše dođe do svojih vjernika. U ovome radu analizira se i uspoređuje nekoliko izabranih propovijedi dviju najvećih kršćanskih vjeroispovijesti: katoličke i protestantske, kako bi se utvrdilo postoje li značajne retoričke razlike među propovjednicima. Primijenila se deskriptivna retorička analiza koja je uključila strukturu propovijedi, stil (izbor riječi i figura) te govorničku izvedbu (u-porabu neverbalnih i prozodijskih znakova tijekom propovijedi). Analiza je pokazala da među propovjednicima postoje određene razlike, ali su one u manjoj mjeri uvjetovane pripadnošću vjeroispovijesti, a više ovise o govorničkim vještinama svakoga pojedi-noga propovjednika.
Rhetorical skills are important for preachers because the word of God is spread by speech. From the beginning of Christianity and Saint Augustine, it has been emphasized that eloquence can help preachers reach the faithful. The paper analyses and compares sermons of the two largest Christian faiths: Roman-Catholic and Protestant, to determine whether there are significant rhetorical differences between their preachers. Descriptive rhetorical analysis of sermons was conducted, which included the structure, style (choice of words and figures), and speech delivery (use of nonverbal and prosodic signs during sermons). The analysis showed that there are certain rhetorical differences between preachers, but they are conditioned more by the rhetorical skills of an individual preacher than religious affiliation.
Hope accompanies man in the pursuit of fulfilling something that is essential and necessary for human existence. It counteracts the sense of loss of the most important values for a human being. ...A lack of hope leads people to despair; and thus often to make decisions leading to irreversible life situations. Hope lets people pass through the most difficult moments and periods of life. On the one hand; it shapes the existential vision of a human being; filled with his trust; faith in a better; favorable destiny; and on the other - affects his sense of transcendence; which pervades comfort. Hope improves human life. And although there is no hope without fear; it is the way of seeking the meaning of life. Hope is a force that especially protects those who are on the verge of despair that takes the sense of bleakness. As a rational being assigned to the structure of personality of every human being; it can be perceived in several contradictory dimensions. Hope is the cause that improves all dimensions of every human life. It realizes itself through the world of values to which a human is heading without which he cannot shape the quality of his life. Hope has its own structure through which one should understand a certain system of peculiar properties coming with different strength into mutual relations; which are both its elements and constitute the whole that decide for the individual and unique character of the sense of hope in the case of every human being. The question arises about the meaning of hope; its place and role in pedagogical processes; in which the conscious subjects are people that are brought up and raised. The pedagogy of hope is an attempt to penetrate the essence of particularly important elements/factors supporting the development of the human personality.
ilj rada je utvrditi organizacijsku strukturu i organizacijsku kulturu uspješnog građevinskog poduzeća s područja Bosne i Hercegovine. Također, rad pruža uvid u njihovu međuovisnost i utjecaj koji ...imaju na cjelokupno poslovanje poduzeća. Anketnim upitnikom ispitane su glavne dimenzije organizacijske strukture: centralizacija, formalizacija, specijalizacija i standardizacija. Organizacijska kultura ispitana je pomoću instrumenta za procjenu organizacijske kulture, predstavljenog od strane Camerona i Quinna (OCAI), te učinkovitost poslovanja pomoću ključnih pokazatelja izvršenja, predstavljenih od strane Nortona i Kaplana: financijski pokazatelji, klijenti, unutarnji poslovni procesi i inovacije i učenje. Nakon što je potvrđena pouzdanost korištenih mjernih ljestvica izračunom Cronbach alfa koeficijenta, indeksom relativne važnosti - RII utvrđeno je koje dimenzije organizacijske strukture i kulture, te koji pokazatelji učinkovitosti imaju najveći utjecaj na oblikovanje poslovnog sustava poduzeća. Prema subjektivnom mišljenju djelatnika u istraživačkom uzorku, poduzeće može okarakterizirati kao hijerarhijsko, visoko formalizirano i strukturirano te orijentirano prema klijentima.
Povrchová prospekce a následný archeologický výzkum prokázaly západně od obce Suchomasty na Berounsku existenci rozsáhlého středověkého sídliště fungujícího přibližně od přelomu 9. a 10. století až ...do závěru 15. století. Povrchovými sběry byly na části jeho plochy získány četné hrudky, slitky a několik fragmentů předmětů z neželezných kovů, z nichž nejzajímavější je část malého zvonu. Tyto nálezy spolehlivě dokládají intenzivní metalurgické aktivity. Na základě výsledků analýz chemického složení vybraných artefaktů a slitků a zhodnocení sídelně-historických souvislostí je hypoteticky klademe někam do 12. či 13. století. Studie se pokouší zařadit sídliště u Suchomast do širších regionálních sídelně-historických souřadnic a ukazuje, že nabízí jeden z příkladů složité proměny struktury venkovského sídliště v průběhu středověku.
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